LOCUS       NM_152299               3337 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens non-SMC condensin II complex subunit H2 (NCAPH2),
            transcript variant 2, mRNA.
ACCESSION   NM_152299
VERSION     NM_152299.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3337)
  AUTHORS   Hao,S.W., Li,T.R., Han,C., Han,Y. and Cai,Y.N.
  TITLE     Associations Between Levels of Peripheral NCAPH2 Promoter
            Methylation and Different Stages of Alzheimer's Disease: A
            Cross-Sectional Study
  JOURNAL   J Alzheimers Dis 92 (3), 899-909 (2023)
   PUBMED   36806511
  REMARK    GeneRIF: Associations Between Levels of Peripheral NCAPH2 Promoter
            Methylation and Different Stages of Alzheimer's Disease: A
            Cross-Sectional Study.
REFERENCE   2  (bases 1 to 3337)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3337)
  AUTHORS   Ogura,T., Azuma,K., Sato,J., Kinowaki,K., Takayama,K.I.,
            Takeiwa,T., Kawabata,H. and Inoue,S.
  TITLE     OCT1 Is a Poor Prognostic Factor for Breast Cancer Patients and
            Promotes Cell Proliferation via Inducing NCAPH
  JOURNAL   Int J Mol Sci 22 (21), 11505 (2021)
   PUBMED   34768935
  REMARK    GeneRIF: OCT1 Is a Poor Prognostic Factor for Breast Cancer
            Patients and Promotes Cell Proliferation via Inducing NCAPH.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3337)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3337)
  AUTHORS   Weyburne,E. and Bosco,G.
  TITLE     Cancer-associated mutations in the condensin II subunit CAPH2 cause
            genomic instability through telomere dysfunction and anaphase
            chromosome bridges
  JOURNAL   J Cell Physiol 236 (5), 3579-3598 (2021)
   PUBMED   33078399
  REMARK    GeneRIF: Cancer-associated mutations in the condensin II subunit
            CAPH2 cause genomic instability through telomere dysfunction and
            anaphase chromosome bridges.
REFERENCE   6  (bases 1 to 3337)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3337)
  AUTHORS   Onn,I., Aono,N., Hirano,M. and Hirano,T.
  TITLE     Reconstitution and subunit geometry of human condensin complexes
  JOURNAL   EMBO J 26 (4), 1024-1034 (2007)
   PUBMED   17268547
REFERENCE   8  (bases 1 to 3337)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 3337)
  AUTHORS   Ono,T., Losada,A., Hirano,M., Myers,M.P., Neuwald,A.F. and
            Hirano,T.
  TITLE     Differential contributions of condensin I and condensin II to
            mitotic chromosome architecture in vertebrate cells
  JOURNAL   Cell 115 (1), 109-121 (2003)
   PUBMED   14532007
  REMARK    GeneRIF: The CAP-H2 subunit of the condensin II complex implicated
            in chromosome assembly and segregation
REFERENCE   10 (bases 1 to 3337)
  AUTHORS   Schleiffer,A., Kaitna,S., Maurer-Stroh,S., Glotzer,M., Nasmyth,K.
            and Eisenhaber,F.
  TITLE     Kleisins: a superfamily of bacterial and eukaryotic SMC protein
            partners
  JOURNAL   Mol Cell 11 (3), 571-575 (2003)
   PUBMED   12667442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB498781.1, BC001937.1,
            BC009441.1 and U62317.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152299.3.
            
            Summary: This gene encodes one of the non-SMC subunits of the
            condensin II complex. This complex plays an essential role in
            mitotic chromosome assembly. Alternate splicing of this gene
            results in multiple transcript variants.[provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding region, compared to variant 1. The resulting protein
            (isoform 2) has a distinct C-terminus and is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.161380.1,
                                           SRR1660809.114216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420993.7/ ENSP00000410088.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DB498781.1         10-44
            36-1981             BC001937.1         1-1946
            1982-2027           BC009441.1         1949-1994
            2028-3337           U62317.2           115674-116983       c
FEATURES             Location/Qualifiers
     source          1..3337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..3337
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /note="non-SMC condensin II complex subunit H2"
                     /db_xref="GeneID:29781"
                     /db_xref="HGNC:HGNC:25071"
                     /db_xref="MIM:611230"
     exon            1..222
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1932
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     CAP-H2 subunit of the condensin II complex; kleisin beta;
                     chromosome-associated protein H2; CTA-384D8.36"
                     /codon_start=1
                     /product="condensin-2 complex subunit H2 isoform 2"
                     /protein_id="NP_689512.2"
                     /db_xref="CCDS:CCDS14094.2"
                     /db_xref="GeneID:29781"
                     /db_xref="HGNC:HGNC:25071"
                     /db_xref="MIM:611230"
                     /translation="MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISF
                     DEGKTTMNFIEAALLIQGSACVYSKKVEYLYSLVYQALDFISGKRRAKQLSSVQEDRA
                     NGVASSGVPQEAENEFLSLDDFPDSRTNVDLKNDQTPSEVLIIPLLPMALVAPDEMEK
                     NNNPLYSRQGEVLASRKDFRMNTCVPHPRGAFMLEPEGMSPMEPAGVSPMPGTQKDTG
                     RTEEQPMEVSVCRSPVPALGFSQEPGPSPEGPMPLGGGEDEDAEEAVELPEASAPKAA
                     LEPKESRSPQQSAALPRRYMLREREGAPEPASCVKETPDPWQSLDPFDSLESKPFKKG
                     RPYSVPPCVEEALGQKRKRKGAAKLQDFHQWYLAAYADHADSRRLRRKGPSFADMEVL
                     YWTHVKEQLETLRKLQRREVAEQWLRPAEEDHLEDSLEDLGAADDFLEPEEYMEPEGA
                     DPREAADLDAVPMSLSYEELVRRNVELFIATSQKFVQETELSQRIRDWEDTVQPLLQE
                     QEQHVPFDIHTYGDQLVSRFPQLNEWCPFAELVAGQPAFEVCRSMLASLQLANDYTVE
                     ITQQPGLEMAVDTMSLRLLTHQRAHKRFQTYAAPSMAQP"
     exon            223..324
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..380
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            381..465
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..534
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            535..614
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..760
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..844
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..975
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1047
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1114
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1222
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1276
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1347
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1420
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1489
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1539
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1641
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1791
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..3337
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /note="major polyA site"
     regulatory      3315..3320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
                     /note="hexamer: AATAAA"
     polyA_site      3337
                     /gene="NCAPH2"
                     /gene_synonym="CAPH2"
ORIGIN      
        1 gcattttcct gggcgggaac agcaaaatgg cgccagaact agtggcgggc tgaggacgcc
       61 gtacccctcg gaaggcagcc ctgcggtccc tttgccgccc gttccctccc ggacatggag
      121 gacgtggagg cgcgcttcgc ccacctcttg cagcccatcc gcgacctcac caagaactgg
      181 gaggtggacg tggcggccca gctgggcgag tatctggagg agctggatca gatctgcatt
      241 tcttttgacg aaggcaagac cacaatgaac ttcattgagg cagcgttgtt gatccagggc
      301 tctgcctgcg tctacagtaa gaaggtggaa tacctctact cactcgtcta ccaggccctt
      361 gatttcatct ctggaaagag gcgggccaag cagctctctt cggtgcagga ggacagggcc
      421 aatggggttg ccagctccgg ggtcccccag gaggcagaga atgagttcct gtcgctggat
      481 gacttccctg actcccggac taacgtggat ctcaagaatg atcagacgcc cagtgaggtc
      541 ctcatcatcc ccctcctgcc catggccctg gtggcccctg atgaaatgga gaagaacaac
      601 aatcccctgt acagccgtca gggtgaggtc ctggccagcc ggaaggattt caggatgaac
      661 acgtgcgttc cccaccccag aggggccttc atgttggagc cagagggcat gtcccccatg
      721 gaaccagcgg gcgtttcccc catgccaggg acccagaagg acaccgggag gactgaggag
      781 cagccaatgg aagtttccgt gtgcaggagc cctgtcccag cactcggctt ctcccaggag
      841 ccaggcccct ctccagaagg cccgatgccc ctgggtgggg gcgaggacga ggatgcagag
      901 gaggcagtag agcttcctga ggcctcggcc cccaaggccg ctctggagcc caaggagtcc
      961 aggagcccgc agcagagtgc tgccctgccc aggaggtaca tgctgcggga gcgggagggg
     1021 gccccagagc ctgcatcctg cgtgaaggag actccagacc cctggcagag cctggacccc
     1081 tttgactcct tggagtctaa gcccttcaag aaaggtaggc cttactctgt gcccccctgt
     1141 gtggaggagg ctctgggaca gaagcgcaag aggaagggcg ctgccaagct gcaggacttc
     1201 caccagtggt acctggctgc ctatgcagac catgccgaca gcaggcggct tcggcgaaag
     1261 ggtccgtcct ttgcagacat ggaggtcctg tactggacac acgtgaagga gcagttggaa
     1321 actctccgga agctgcagag gagggaggtg gctgagcagt ggctgcggcc tgcagaggag
     1381 gaccacctgg aggattccct ggaagacctg ggggcagcag atgactttct agagcctgag
     1441 gagtacatgg agcccgaggg agcagacccc agggaagccg ctgaccttga cgcagtgccg
     1501 atgtccctga gctacgagga gctggttcga aggaatgtgg agctcttcat cgccacctcc
     1561 cagaagtttg tccaggagac agagctgagc cagcgcatca gggactggga ggacacagtg
     1621 cagcctctgc tccaggagca ggagcagcat gtgccctttg acatccacac ctatggggac
     1681 cagctggtct cacggttccc ccagctcaat gagtggtgtc cctttgcgga gctggtggct
     1741 ggccagccgg ccttcgaggt gtgtcgttcc atgctggcct ccctgcagct ggccaatgac
     1801 tacacagtgg agataaccca gcagcccggg ctggagatgg ccgtggacac catgtccctg
     1861 agactgctca cgcaccagcg agcgcacaag cgcttccaga cctacgctgc cccctccatg
     1921 gcccagccct gagtggggag caccgaggca ggggtggggg aatgtgtact gaggagccgt
     1981 gtgtctgctc ctggctggcc cggcctaata aagcagtgtt gccatctcat cttcccccta
     2041 aaaacccttt tatgtacacc tgcgcagaga agagggctgc ctggcctccc tgggccgctg
     2101 gtacagatca cacacacaca cagattaaac gcagcccgtt taatgatggg gcccagactg
     2161 cagtggctca agacaggaca ctgcggaaag ccgccatgtg ccgccgcaca ctgtctgaga
     2221 tctgctcagc cgatctgctc cggccgtagt aatccgtgaa gaggccgtca gggttgagca
     2281 ggtagatggc aatggagtgg tccacgatgt agtcctggtc ctcatccttg gggcctgcat
     2341 tgtagtacac gcggtaactg tgactagcct gggcaacctg tttggtggag ccggtcagac
     2401 ccaacagtct tgggtggaag tcctggacgt agcgggccat ggcttcaacg tcgtcccgct
     2461 cggggtccac agtgatgaag acaggctgca ctggaggcaa accaggctct gcttccagct
     2521 gccgcaccac ctgcaccagc ttctccagct cgtctgggca gatgtcaggg cagtgagtga
     2581 agccaaagta catcagcacc cactggcccc ggaagtcagc cttgcagcga gcccggcctc
     2641 tgtgatccag caggtggaag tcgccctggc ccacagctgc ctggcgcagg gcttctgttc
     2701 gcttttgctg ctgcagcctc tccttctcag ccctcagggc cagccaggcc ccaccgagtc
     2761 cagccccgaa caggcctgtg atcagcagcc gggttcgaag cccagggccc tggggctggc
     2821 cctgcccacc tgtctctgca gggccctgcc ttgacaaaag ccaggacctc agatgcaggg
     2881 cctggcctcc cagggtccca gggaggaccc gaggcttgag ctgagagagc ctgtgccaag
     2941 ctgtggggct ccgagtcagc agcagcatgg atctgatgct cctggaaaca agcacaggcg
     3001 tcaggagcca gaagggaagg cccaggacag tgcctgggct gcccctgcga cttgagacca
     3061 gccacccatc tgaaggaccc agcccacgtt caggcttaac aggcatttgc agctgctcac
     3121 ctgagctcag aactccacct ccaccaaaca tccacacctg ggcaaccaca cctgtcactc
     3181 ctgtcctcta cctgggatca ccagcctgtc accgcaccct gccctgcacc tgcacctcag
     3241 caaggtgaac ctcttgctga cggaaagcat tccaagtgca tgccttgcct gaactaacca
     3301 cgttatctat ttgcaataaa cccatttctt aaaagga
//
