LOCUS       NM_015261               7369 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens non-SMC condensin II complex subunit D3 (NCAPD3),
            transcript variant 1, mRNA.
ACCESSION   NM_015261 XM_166201
VERSION     NM_015261.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7369)
  AUTHORS   Yang,F., Zheng,Y., Luo,Q., Zhang,S., Yang,S. and Chen,X.
  TITLE     Knockdown of NCAPD3 inhibits the tumorigenesis of non-small cell
            lung cancer by regulation of the PI3K/Akt pathway
  JOURNAL   BMC Cancer 24 (1), 408 (2024)
   PUBMED   38566039
  REMARK    GeneRIF: Knockdown of NCAPD3 inhibits the tumorigenesis of
            non-small cell lung cancer by regulation of the PI3K/Akt pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7369)
  AUTHORS   Jing,Z., Liu,Q., Xie,W., Wei,Y., Liu,J., Zhang,Y., Zuo,W., Lu,S.,
            Zhu,Q. and Liu,P.
  TITLE     NCAPD3 promotes prostate cancer progression by up-regulating EZH2
            and MALAT1 through STAT3 and E2F1
  JOURNAL   Cell Signal 92, 110265 (2022)
   PUBMED   35085770
  REMARK    GeneRIF: NCAPD3 promotes prostate cancer progression by
            up-regulating EZH2 and MALAT1 through STAT3 and E2F1.
REFERENCE   3  (bases 1 to 7369)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7369)
  AUTHORS   Yuan,C.W., Sun,X.L., Qiao,L.C., Xu,H.X., Zhu,P., Chen,H.J. and
            Yang,B.L.
  TITLE     Non-SMC condensin I complex subunit D2 and non-SMC condensin II
            complex subunit D3 induces inflammation via the IKK/NF-kappaB
            pathway in ulcerative colitis
  JOURNAL   World J Gastroenterol 25 (47), 6813-6822 (2019)
   PUBMED   31885422
  REMARK    GeneRIF: NCAPD2 and NCAPD3 expression levels have been confirmed to
            be significantly up-regulated in the intestinal mucosa of patients
            with active ulcerative colitis. In vitro, the data suggested that
            silencing NACPD2 and NACPD3 could depress the expression of
            IL-1beta, IL-6 and TNF-alpha. Further, knockdown of NACPD2 and
            NACPD3 could remarkably suppress IKK nucleation and NF-kappaB
            volume.
REFERENCE   5  (bases 1 to 7369)
  AUTHORS   Ward,J.R., Vasu,K., Deutschman,E., Halawani,D., Larson,P.A.,
            Zhang,D., Willard,B., Fox,P.L., Moran,J.V. and Longworth,M.S.
  TITLE     Condensin II and GAIT complexes cooperate to restrict LINE-1
            retrotransposition in epithelial cells
  JOURNAL   PLoS Genet 13 (10), e1007051 (2017)
   PUBMED   29028794
  REMARK    GeneRIF: Condensin II(CAP-D3 and CAP-H2) and GAIT subunits
            associate with L1 RNA in a co-dependent manner, independent of
            IFN-gamma. These findings suggest that cooperation between the
            Condensin II and GAIT complexes may facilitate a novel mechanism of
            L1 repression, thus contributing to the maintenance of genome
            stability in somatic cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7369)
  AUTHORS   Onn,I., Aono,N., Hirano,M. and Hirano,T.
  TITLE     Reconstitution and subunit geometry of human condensin complexes
  JOURNAL   EMBO J 26 (4), 1024-1034 (2007)
   PUBMED   17268547
REFERENCE   7  (bases 1 to 7369)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 7369)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 7369)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 7369)
  AUTHORS   Ono,T., Losada,A., Hirano,M., Myers,M.P., Neuwald,A.F. and
            Hirano,T.
  TITLE     Differential contributions of condensin I and condensin II to
            mitotic chromosome architecture in vertebrate cells
  JOURNAL   Cell 115 (1), 109-121 (2003)
   PUBMED   14532007
  REMARK    GeneRIF: The CAP-D3 subunit of the condensin II complex implicated
            in chromosome assembly and segeregation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001775.4.
            
            On Aug 7, 2019 this sequence version replaced NM_015261.2.
            
            Summary: Condensin complexes I and II play essential roles in
            mitotic chromosome assembly and segregation. Both condensins
            contain 2 invariant structural maintenance of chromosome (SMC)
            subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain
            different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC
            subunits that define condensin II (Ono et al., 2003 [PubMed
            14532007]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098398.1, D29954.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534548.7/ ENSP00000433681.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AP001775.4         97487-97591         c
            106-260             AP001775.4         94196-94350         c
            261-423             AP001775.4         90560-90722         c
            424-608             AP001775.4         83894-84078         c
            609-773             AP001775.4         82937-83101         c
            774-835             AP001775.4         82769-82830         c
            836-923             AP001775.4         82488-82575         c
            924-1057            AP001775.4         80224-80357         c
            1058-1130           AP001775.4         78524-78596         c
            1131-1256           AP001775.4         77671-77796         c
            1257-1509           AP001775.4         77279-77531         c
            1510-1566           AP001775.4         76767-76823         c
            1567-1656           AP001775.4         76441-76530         c
            1657-1730           AP001775.4         68290-68363         c
            1731-1865           AP001775.4         67641-67775         c
            1866-2086           AP001775.4         66314-66534         c
            2087-2278           AP001775.4         58960-59151         c
            2279-2376           AP001775.4         58528-58625         c
            2377-2492           AP001775.4         58262-58377         c
            2493-2600           AP001775.4         54702-54809         c
            2601-2715           AP001775.4         52447-52561         c
            2716-2823           AP001775.4         52259-52366         c
            2824-3062           AP001775.4         50844-51082         c
            3063-3142           AP001775.4         49932-50011         c
            3143-3280           AP001775.4         42542-42679         c
            3281-3414           AP001775.4         42094-42227         c
            3415-3614           AP001775.4         41621-41820         c
            3615-3725           AP001775.4         35406-35516         c
            3726-3908           AP001775.4         33517-33699         c
            3909-4075           AP001775.4         31954-32120         c
            4076-4215           AP001775.4         31553-31692         c
            4216-4293           AP001775.4         30643-30720         c
            4294-4368           AP001775.4         26914-26988         c
            4369-4429           AP001775.4         26765-26825         c
            4430-7369           AP001775.4         23738-26677         c
FEATURES             Location/Qualifiers
     source          1..7369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..7369
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /note="non-SMC condensin II complex subunit D3"
                     /db_xref="GeneID:23310"
                     /db_xref="HGNC:HGNC:28952"
                     /db_xref="MIM:609276"
     exon            1..105
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..4538
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     condensin-2 complex subunit D3"
                     /codon_start=1
                     /product="condensin-2 complex subunit D3 isoform 1"
                     /protein_id="NP_056076.1"
                     /db_xref="CCDS:CCDS31723.1"
                     /db_xref="GeneID:23310"
                     /db_xref="HGNC:HGNC:28952"
                     /db_xref="MIM:609276"
                     /translation="MVALRGLGSGLQPWCPLDLRLEWVDTVWELDFTETEPLDPSIEA
                     EIIETGLAAFTKLYESLLPFATGEHGSMESIWTFFIENNVSHSTLVALFYHFVQIVHK
                     KNVSVQYREYGLHAAGLYFLLLEVPGSVANQVFHPVMFDKCIQTLKKSWPQESNLNRK
                     RKKEQPKSSQANPGRHRKRGKPPRREDIEMDEIIEEQEDENICFSARDLSQIRNAIFH
                     LLKNFLRLLPKFSLKEKPQCVQNCIEVFVSLTNFEPVLHECHVTQARALNQAKYIPEL
                     AYYGLYLLCSPIHGEGDKVISCVFHQMLSVILMLEVGEGSHRAPLAVTSQVINCRNQA
                     VQFISALVDELKESIFPVVRILLQHICAKVVDKSEYRTFAAQSLVQLLSKLPCGEYAM
                     FIAWLYKYSRSSKIPHRVFTLDVVLALLELPEREVDNTLSLEHQKFLKHKFLVQEIMF
                     DRCLDKAPTVRSKALSSFAHCLELTVTSASESILELLINSPTFSVIESHPGTLLRNSS
                     AFSYQRQTSNRSEPSGEINIDSSGETVGSGERCVMAMLRRRIRDEKTNVRKSALQVLV
                     SILKHCDVSGMKEDLWILQDQCRDPAVSVRKQALQSLTELLMAQPRCVQIQKAWLRGV
                     VPVVMDCESTVQEKALEFLDQLLLQNIRHHSHFHSGDDSQVLAWALLTLLTTESQELS
                     RYLNKAFHIWSKKEKFSPTFINNVISHTGTEHSAPAWMLLSKIAGSSPRLDYSRIIQS
                     WEKISSQQNPNSNTLGHILCVIGHIAKHLPKSTRDKVTDAVKCKLNGFQWSLEVISSA
                     VDALQRLCRASAETPAEEQELLTQVCGDVLSTCEHRLSNIVLKENGTGNMDEDLLVKY
                     IFTLGDIAQLCPARVEKRIFLLIQSVLASSADADHSPSSQGSSEAPASQPPPQVRGSV
                     MPSVIRAHAIITLGKLCLQHEDLAKKSIPALVRELEVCEDVAVRNNVIIVMCDLCIRY
                     TIMVDKYIPNISMCLKDSDPFIRKQTLILLTNLLQEEFVKWKGSLFFRFVSTLIDSHP
                     DIASFGEFCLAHLLLKRNPVMFFQHFIECIFHFNNYEKHEKYNKFPQSEREKRLFSLK
                     GKSNKERRMKIYKFLLEHFTDEQRFNITSKICLSILACFADGILPLDLDASELLSDTF
                     EVLSSKEIKLLAMRSKPDKDLLMEEDDMALANVVMQEAQKKLISQVQKRNFIENIIPI
                     IISLKTVLEKNKIPALRELMHYLREVMQDYRDELKDFFAVDKQLASELEYDMKKYQEQ
                     LVQEQELAKHADVAGTAGGAEVAPVAQVALCLETVPVPAGQENPAMSPAVSQPCTPRA
                     SAGHVAVSSPTPETGPLQRLLPKARPMSLSTIAILNSVKKAVESKSRHRSRSLGVLPF
                     TLNSGSPEKTCSQVSSYSLEQESNGEIEHVTKRAISTPEKSISDVTFGAGVSYIGTPR
                     TPSSAKEKIEGRSQGNDILCLSLPDKPPPQPQQWNVRSPARNKDTPACSRRSLRKTPL
                     KTAN"
     exon            106..260
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            261..423
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            424..608
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            609..773
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            774..835
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            836..923
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1057
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1130
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1256
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1509
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1566
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1656
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1730
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1865
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2086
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2278
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2376
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2492
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2600
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2715
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2823
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..3062
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3142
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3280
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3414
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3614
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3725
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3908
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4075
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4215
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            4216..4293
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            4294..4368
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            4369..4429
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     exon            4430..7369
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5015..5020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /note="hexamer: AATAAA"
     polyA_site      5040
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /note="major polyA site"
     regulatory      5749..5754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /note="hexamer: TATAAA"
     polyA_site      5775
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
     regulatory      7350..7355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
                     /note="hexamer: AGTAAA"
     polyA_site      7369
                     /gene="NCAPD3"
                     /gene_synonym="CAP-D3; CAPD3; hCAP-D3; hcp-6; hHCP-6;
                     MCPH22"
ORIGIN      
        1 gaaagttgag cacggcggcg gcgagccggt gccctgggat catggtggcg ttgcggggcc
       61 ttggtagcgg cctgcagccc tggtgtccgc tggatcttag actcgaatgg gttgacacag
      121 tgtgggaact ggatttcaca gagactgagc ctttggatcc cagcatagaa gcagagatca
      181 tagagactgg attggctgca ttcacaaaac tctatgaaag ccttttaccc tttgctactg
      241 gagaacatgg atctatggag agtatctgga ccttcttcat tgagaacaat gtttcccata
      301 gtacactggt ggcattgttc tatcattttg ttcaaatagt tcataagaag aatgtcagtg
      361 tacagtatcg agaatatggc cttcatgccg ctgggcttta ctttttgcta ctagaagtac
      421 caggcagtgt agccaatcaa gtattccacc cagtgatgtt tgacaaatgc attcagactc
      481 taaagaagag ctggccccag gaatctaact tgaatcggaa aagaaagaaa gaacagccta
      541 agagctctca ggctaacccc gggaggcata gaaaaagggg aaagccaccc aggagagaag
      601 atattgagat ggatgaaatt atagaagaac aagaagatga gaatatttgt ttttctgccc
      661 gggacctttc tcaaattcga aatgccatct ttcacctttt aaagaatttt ttaaggcttc
      721 tgccaaagtt ttccttgaaa gaaaagccac aatgtgtaca gaattgtata gaggtctttg
      781 tttcattaac taattttgag ccagttcttc atgaatgtca tgttacacaa gccagagctc
      841 ttaaccaagc aaaatacata ccagaactgg cttattatgg attgtatttg ctgtgctctc
      901 ccattcatgg agaaggagat aaggtcatca gttgtgtttt ccatcaaatg ctcagtgtaa
      961 tattaatgtt agaagttggt gaaggatccc atcgtgcccc ccttgctgtt acctcccaag
     1021 tcatcaactg tagaaaccag gcggtccagt ttatcagcgc ccttgtggat gaattaaagg
     1081 agagtatatt cccagtcgtc cgtatcttac tgcagcacat ctgtgccaag gtggtagata
     1141 aatcagagta tcgtactttt gcagcccagt ccctagtcca gctgctcagt aaacttcctt
     1201 gtggggaata cgctatgttc attgcctggc tttacaaata ctcccgaagt tccaagatcc
     1261 cacaccgggt ttttactctt gatgttgtct tagctctgtt agaactgcct gaaagagagg
     1321 tggataacac cctctccttg gagcatcaga agttcttaaa gcataagttc ctggtgcagg
     1381 aaattatgtt tgatcgttgc ttagacaagg cgcctactgt ccgcagcaag gcactgtcca
     1441 gctttgcaca ctgtctggag ttgactgtta ccagtgcgtc ggagagtatc ctggagctcc
     1501 tgattaacag tcctacgttt tctgtaatag agagtcaccc tggtacctta ctgagaaatt
     1561 catcagcttt ttcctaccaa aggcagacat ctaaccgttc cgaaccctca ggggagatca
     1621 acatagacag cagtggtgaa acagttggat ctggagaaag atgtgtcatg gcaatgctga
     1681 gaaggaggat cagggatgag aagaccaacg ttaggaagtc tgcactgcag gtattagtga
     1741 gtattttgaa acactgtgat gtctcaggca tgaaggaaga cctgtggatt ctgcaggacc
     1801 agtgtcggga ccctgcagtg tctgtccgga agcaggccct ccagtctctt actgaactcc
     1861 ttatggctca gcctagatgc gtgcagatcc agaaagcctg gttgcggggg gtggtcccgg
     1921 tggtgatgga ctgcgagagc actgtgcagg agaaggccct ggagttcctg gaccagctgc
     1981 tgctgcagaa catccggcat cacagtcatt ttcactctgg ggacgacagc caggtcctcg
     2041 cctgggcgct tcttactctc ctcaccaccg aaagccagga actgagccga tatttaaata
     2101 aggcttttca tatctggtcc aagaaagaaa aattctcacc cacttttata aacaatgtaa
     2161 tatctcacac tggcacggaa cattcggcac ctgcctggat gctgctctcc aagattgctg
     2221 gctcctcacc caggctggac tacagcagaa taatacaatc ttgggagaaa atcagcagtc
     2281 agcagaatcc caattcaaac accttaggac atattctctg tgtgattggg catattgcaa
     2341 agcatcttcc taagagcacc cgggacaaag tgactgatgc tgtcaagtgt aagctgaatg
     2401 gatttcagtg gtctctagag gtgatcagtt cagctgttga cgccttgcag aggctttgta
     2461 gagcatctgc agagacacca gcagaggagc aggaattgct gacgcaggtg tgtggggatg
     2521 tactctccac ctgcgagcac cgcctctcca acatcgttct caaggagaat ggaacaggga
     2581 atatggacga agacctgttg gtgaagtaca tttttacctt aggggatata gcccagctgt
     2641 gtccagccag ggtggagaag cgcatcttcc ttctgattca gtccgtcctg gcttcgtctg
     2701 ctgatgctga ccactcacca tcatctcaag gcagcagtga ggccccagcg tctcagccac
     2761 ccccccaggt cagaggttct gtcatgccct ctgtgattag agcacatgcc atcattacct
     2821 taggtaagct gtgcttacag cacgaggatc tggcaaagaa gagcatccca gccctggtgc
     2881 gagagctcga ggtgtgtgag gacgtggctg tccgcaacaa cgtcatcatt gtaatgtgcg
     2941 atctctgcat tcgctacacc atcatggtgg acaagtatat tcccaacatc tccatgtgtc
     3001 tgaaggattc cgacccattc atccggaagc agacactcat cttgcttacc aatctcttgc
     3061 aggaggaatt tgtgaaatgg aagggctccc tgttcttccg atttgtcagc actctgatcg
     3121 attcacaccc agacattgcc agcttcgggg agttttgcct ggctcacctg ttactgaaga
     3181 ggaaccctgt catgttcttc caacacttca ttgaatgtat ttttcacttt aataactatg
     3241 agaagcatga gaagtacaac aagttccccc agtcagagag agagaagcgg ctgttttcat
     3301 tgaagggaaa gtcaaacaaa gagagacgaa tgaaaatcta caaatttctt ctagagcact
     3361 tcacagatga acagcgattc aacatcactt ccaaaatctg ccttagtatt ttggcgtgct
     3421 ttgctgatgg catcctaccc ctggacctgg acgccagtga gttactctca gacacgtttg
     3481 aggtcctcag ctcaaaggag atcaagcttt tggcaatgag atctaaacca gacaaagacc
     3541 tccttatgga agaagatgac atggccttgg caaatgtagt catgcaggaa gctcagaaga
     3601 agctcatctc acaagttcag aagaggaatt tcatagaaaa tattattcca attatcatct
     3661 ccctgaagac tgtgctggag aaaaataaga tcccagcttt gcgggaactc atgcactatc
     3721 tcagggaggt gatgcaggat taccgagatg agctcaagga cttctttgca gttgacaaac
     3781 agctggcatc agagcttgag tatgacatga agaagtacca ggaacagctg gtccaggagc
     3841 aggagctagc aaaacatgca gatgtggccg ggacggctgg aggtgctgag gtggcacctg
     3901 tggcacaggt tgccctgtgt ttagaaacag tgccagttcc tgctggccaa gaaaaccctg
     3961 ccatgtcacc tgccgtgagc cagccctgca cacccagggc aagtgctggc catgtagcag
     4021 tatcatctcc tacacctgaa acagggccat tgcagaggtt gctgcccaaa gccaggccca
     4081 tgtccctgag caccattgca atcctgaatt ctgtcaagaa agccgtggag tcaaagagca
     4141 ggcatcggag tcggagctta ggagtgctgc ctttcacttt aaattctgga agcccagaaa
     4201 aaacgtgcag tcaggtgtct tcatacagtt tggagcaaga gtcgaatggc gagattgagc
     4261 acgtgaccaa gcgggccatc agcacccccg agaagagcat cagtgatgtc acgtttggag
     4321 caggggtcag ttacatcggg acaccacgga ctccgtcgtc agccaaagag aaaattgaag
     4381 gccggagtca aggaaatgac atcttatgtt tatcactgcc tgataaaccg cccccacagc
     4441 ctcagcagtg gaatgtgcgg tctcccgcca ggaataaaga cactccagcc tgcagcagga
     4501 ggtccctccg aaagacccct ctgaaaacag ccaactaaac agcgcctccc accagtgtcc
     4561 aggcaggcag gagcccttga ggaagcagtc tcgtgtcctc cgtgtgaagg cagctggatc
     4621 acttcccgca gtccttgggc agcgctttgc tgtggaacac gagagctcct cctcaggggc
     4681 ctggcactca ccttctattc tgtatgatgt atttggttaa acactgtcaa ataatagaga
     4741 tgtgccagat ttagattttc ttaccctaat ctgtttaata ttgtaacttt attccatttg
     4801 aaagtgtcaa gcccattcag ataagctata atctggtctt taaggaacac aactttaaaa
     4861 ctgcagcttt cttttatata aatcaagcct ctgttaactt gaattcctta tagtacatat
     4921 tttcccatct gtaatgacga aattttgatt ctaatatttt ttctattatt tataagtgca
     4981 aattttttaa aaaagtgtac agctttctaa aagtaataaa ggtttagcat aaatacagcc
     5041 ttccagtagt caataggatt tttctgtttt tagaacagag ctcttattgg taatcatttt
     5101 aattttacat aaagcatgtt tgtttgttag aggaatgaaa ccaaatcttc cctattagaa
     5161 aaaagatgat tgtcttgaag ggcagttcat ctgtgcccag gcagaggcgg tgtgctttcc
     5221 ctaacagaca tgaacagcat cccttcttgg gaaaaaatgg ctttgcagcc ttccccagag
     5281 cagcactgcc gatttgtgca gccctctgtt aagggctgct cccatgatgg gggaacagct
     5341 tgagtctctt ctgttagcac tagtgggtaa actgaatgct atttttgttc aacaatatcc
     5401 agaaagaaat gcagttggtt tgttttttaa tcccagtatt acaaaagcaa aagtacaaag
     5461 tgatgatgtg cgttggttgg tttgggggat gggatgccac tgagatctgc ccactgccat
     5521 cccaagtggg aaccgcaaca caggtgggct cggtggcgga gaggcgcagc actgctcttg
     5581 agcacacagg ctgacctcct gcccagcact gacttccctg gtggatgggt gattgatagc
     5641 atttttagtg tgcatgccta accactgaaa tgctaggaag aagagacaaa cccaacgtaa
     5701 gagcaaataa caaagaatga agcaatgttt gggttttttt gaagctttta taaatgaggt
     5761 taaacaaatg ccaaattacg gtgtgttagt acaagtctgt agcatctgtg tacagcaaca
     5821 tccatccaaa ggcagaatca cagcctcgta tcggcctcga gtcttgagtc acattcatat
     5881 cttaaaatac acgagtattc cttttccgtc tagtctcagt tataggcagc tacttcccag
     5941 actctacttt cacttctctc tactttttca gacctggttc ccatggcact agtgtagaag
     6001 gttttagggt ataagaagag ggggcaataa ggctacccta tcactatgac aaccaagaag
     6061 gaggctggag cgtgaatccc caacgctgag ggtggggagc catccctctc taccaaggtg
     6121 gcaatgatgg agggaacttg catgctaagc atccaggatg ccatgcagca gacaccaggg
     6181 agcactgagc cactgctgga gcatttcctg cctctgccag gcggcctgcg gcaaagtgtt
     6241 tcacataact aaaaaaagtc aacacagtct catgtatgca attaaaaaaa agctgtcaaa
     6301 gtataaaaaa cccaagacac tggaagctga aagacaaggt gagtagtgag agccattctc
     6361 caggcacaca gtggagtgct ccttctcagc agctccttgc tttacagcac ttcagtcctg
     6421 agtccagcac ggcagggcat gtgaggctga gaacacctgc tcttgaagaa cacaggcttc
     6481 tgagtgatgt tgctaatgtc cccccacaaa tgggagcagt gtctccggcg gatgaaaaat
     6541 ttaaagtcaa aattagaaaa ctgcttttga ttcaggcgtt tcactttcct ccccgccagg
     6601 cctttcacct ggctgctcca cctgacgttc tttaaaaggc tggactggcc gccactccat
     6661 catggtttgt tttgaaatgc gacagagcct gtggcgtctg ggtgctttct ctgtggcaaa
     6721 gaggaacagt gggatccatt ttcttttaaa aatgttattg tacttgacag acttgatttc
     6781 gcaattgcct ttggccttag acaatcttaa caaataatta aacaaactta aaaaaaaaaa
     6841 atagcattgg gggccctatt ttgtgagcca tccataacca aaaagaggtc tgttacagga
     6901 gcccaaagct gggacgctac atggaagaca ccagtgtccc tgcagtgccc acctgagagc
     6961 tgtgctggat gaagcaaggg ccacgtgagt aaagctcact gggacacagc cactgccagg
     7021 gcccaaggat ggcagggcct cctggcagac agcgaggcaa cagtgagcta gagcgggggc
     7081 gcctggcgca accccaggag ctgactggca tctgtgtatg tacatctgag ggcttctggg
     7141 tggcctctgg gtacagactg tcctagtcat ctcaggaaga ggcagttcaa agctaacctg
     7201 agaggtttct tttgaagaga tgcaaactga tttcaacatt gcttaactgg aatttttaaa
     7261 ggtttcctaa gcaactatgg tctgatgtgt agacagtatg agttcccttg tgaaaaaggc
     7321 taaaacttgt gtgagaaaag gaacatcaca gtaaacttcc atgagagga
//
