LOCUS       NM_014865               4825 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens non-SMC condensin I complex subunit D2 (NCAPD2), mRNA.
ACCESSION   NM_014865
VERSION     NM_014865.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4825)
  AUTHORS   Dong,X., Liu,T., Li,Z. and Zhai,Y.
  TITLE     Non-SMC condensin I complex subunit D2 (NCAPD2) reveals its
            prognostic and immunologic features in human cancers
  JOURNAL   Aging (Albany NY) 15 (14), 7237-7257 (2023)
   PUBMED   37498296
  REMARK    GeneRIF: Non-SMC condensin I complex subunit D2 (NCAPD2) reveals
            its prognostic and immunologic features in human cancers.
REFERENCE   2  (bases 1 to 4825)
  AUTHORS   He,J., Gao,R., Yang,J., Li,F., Fu,Y., Cui,J., Liu,X., Huang,K.,
            Guo,Q., Zhou,Z. and Wei,W.
  TITLE     NCAPD2 promotes breast cancer progression through E2F1
            transcriptional regulation of CDK1
  JOURNAL   Cancer Sci 114 (3), 896-907 (2023)
   PUBMED   35348268
  REMARK    GeneRIF: NCAPD2 promotes breast cancer progression through E2F1
            transcriptional regulation of CDK1.
REFERENCE   3  (bases 1 to 4825)
  AUTHORS   Li,Z., Zheng,Y., Wu,Z., Zhuo,T., Zhu,Y., Dai,L., Wang,Y. and
            Chen,M.
  TITLE     NCAPD2 is a novel marker for the poor prognosis of lung
            adenocarcinoma and is associated with immune infiltration and tumor
            mutational burden
  JOURNAL   Medicine (Baltimore) 102 (3), e32686 (2023)
   PUBMED   36701707
  REMARK    GeneRIF: NCAPD2 is a novel marker for the poor prognosis of lung
            adenocarcinoma and is associated with immune infiltration and tumor
            mutational burden.
REFERENCE   4  (bases 1 to 4825)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4825)
  AUTHORS   Jing,Z., He,X., Jia,Z., Sa,Y., Yang,B. and Liu,P.
  TITLE     NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1
            pathway and PARP-1/SIRT1 axis to promote colorectal cancer
  JOURNAL   Cancer Lett 520, 26-37 (2021)
   PUBMED   34229059
  REMARK    GeneRIF: NCAPD2 inhibits autophagy by regulating
            Ca(2+)/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote
            colorectal cancer.
REFERENCE   6  (bases 1 to 4825)
  AUTHORS   Ball,A.R. Jr., Schmiesing,J.A., Zhou,C., Gregson,H.C., Okada,Y.,
            Doi,T. and Yokomori,K.
  TITLE     Identification of a chromosome-targeting domain in the human
            condensin subunit CNAP1/hCAP-D2/Eg7
  JOURNAL   Mol Cell Biol 22 (16), 5769-5781 (2002)
   PUBMED   12138188
  REMARK    GeneRIF: Data show the CNAP1 C-terminal region defines a novel
            histone-binding domain that is responsible for targeting CNAP1, and
            possibly condensin, to mitotic chromosomes.
REFERENCE   7  (bases 1 to 4825)
  AUTHORS   Kimura,K., Cuvier,O. and Hirano,T.
  TITLE     Chromosome condensation by a human condensin complex in Xenopus egg
            extracts
  JOURNAL   J Biol Chem 276 (8), 5417-5420 (2001)
   PUBMED   11136719
REFERENCE   8  (bases 1 to 4825)
  AUTHORS   Schmiesing,J.A., Gregson,H.C., Zhou,S. and Yokomori,K.
  TITLE     A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a
            homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone
            H3 during the early stage of mitotic chromosome condensation
  JOURNAL   Mol Cell Biol 20 (18), 6996-7006 (2000)
   PUBMED   10958694
REFERENCE   9  (bases 1 to 4825)
  AUTHORS   Collas,P., Le Guellec,K. and Tasken,K.
  TITLE     The A-kinase-anchoring protein AKAP95 is a multivalent protein with
            a key role in chromatin condensation at mitosis
  JOURNAL   J Cell Biol 147 (6), 1167-1180 (1999)
   PUBMED   10601332
REFERENCE   10 (bases 1 to 4825)
  AUTHORS   Simon,M.A.
  TITLE     Racial, ethnic, and gender diversity and the resident operative
            experience. How can the Academic Orthopaedic Society shape the
            future of orthopaedic surgery?
  JOURNAL   Clin Orthop Relat Res (360), 253-259 (1999)
   PUBMED   10101332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006064.10, AK022511.1, CN307514.1, BC028182.1, D63880.1,
            AK128354.1 and AL548223.3.
            
            On Nov 23, 2018 this sequence version replaced NM_014865.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63880.1, SRR1803616.47571.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315579.10/ ENSP00000325017.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC006064.10        51183-51212
            31-322              AK022511.1         1-292
            323-755             CN307514.1         271-703
            756-1995            BC028182.1         738-1977
            1996-3261           D63880.1           2719-3984
            3262-4036           AK128354.1         3144-3918
            4037-4824           D63880.1           4760-5547
            4825-4825           AL548223.3         761-761
FEATURES             Location/Qualifiers
     source          1..4825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..4825
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /note="non-SMC condensin I complex subunit D2"
                     /db_xref="GeneID:9918"
                     /db_xref="HGNC:HGNC:24305"
                     /db_xref="MIM:615638"
     exon            1..53
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            54..203
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..4282
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /note="chromosome condensation-related SMC-associated
                     protein 1; XCAP-D2 homolog; chromosome-associated protein
                     D2"
                     /codon_start=1
                     /product="condensin complex subunit 1"
                     /protein_id="NP_055680.3"
                     /db_xref="CCDS:CCDS8548.1"
                     /db_xref="GeneID:9918"
                     /db_xref="HGNC:HGNC:24305"
                     /db_xref="MIM:615638"
                     /translation="MAPQMYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAF
                     QAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDD
                     TTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGF
                     DWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRP
                     TREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVG
                     EIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMR
                     NAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIV
                     QQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPL
                     QKETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIA
                     NTETTEDVKGRIYQLLAKASYKKAIILTREATGHFQESEPFSHIDPEESEETRLLNIL
                     GLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYL
                     QDAYSFSRKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLI
                     WSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILC
                     EFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVS
                     IGLDEKFPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKG
                     FVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKES
                     PAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTS
                     SETTMEEELGLVGATADDTEAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSN
                     PDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPN
                     LVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIA
                     ALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTE
                     SLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSA
                     FLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPS
                     TGSRYQPLASTASDNDFVTPEPRRTTRRHPNTQQRASKKKPKVVFSSDESSEEDLSAE
                     MTEDETPKKTTPILRASARRHRS"
     exon            204..279
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            280..338
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            339..520
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            521..663
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            664..791
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            792..915
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1063
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1261
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1396
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1484
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1665
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1790
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2030
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2205
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2290
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2424
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2557
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2642
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2810
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2983
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3095
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3219
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3375
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3553
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3648
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3729
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3913
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..4040
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4196
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4825
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4802..4807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /note="hexamer: AATAAA"
     polyA_site      4825
                     /gene="NCAPD2"
                     /gene_synonym="CAP-D2; CNAP1; hCAP-D2; MCPH21"
                     /note="major polyA site"
ORIGIN      
        1 ccttttcatt tcagcctgac tgccggaatc agagccgcgg gtgagatccc cagccctgtg
       61 agcctgtagg agtagaatgg ctccccaaat gtatgagttc catctgccat tatccccaga
      121 ggagttgttg aaaagtggag gggtgaatca gtatgttgtg caagaggtac tgtccatcaa
      181 acatcttcca ccacagctta gagcttttca ggctgccttt cgagctcagg ggcccctggc
      241 tatgctgcag cactttgata ctatctacag cattttgcat cactttcgaa gtatagatcc
      301 tggcctcaaa gaagatactc tgcaattcct gataaaagtg gtatcccgcc actcccagga
      361 gcttccagct atcctggatg atacaacttt gagtggatca gatagaaacg cccatctaaa
      421 tgccctcaaa atgaactgtt atgctctgat acgtctcctg gaatcctttg agaccatggc
      481 cagccagaca aaccttgtgg acctggacct tggtgggaag ggtaagaaag ctcggaccaa
      541 ggcagcccat ggctttgact gggaagaaga gaggcaacca attcttcagc ttttaacaca
      601 gctacttcag ttggacatcc gtcacctgtg gaaccactca ataattgaag aagaatttgt
      661 cagtttggtt actggctgtt gctaccgcct tctggagaat cccaccatta atcaccagaa
      721 gaaccgcccc actcgggaag ccataacaca cctgcttggt gtagccttga cccgttataa
      781 ccatatgctc agtgctacag tgaagatcat ccagatgctg cagcactttg aacacctggc
      841 acctgtactg gttgcagccg tgagtctatg ggcaactgac tatggaatga agagcatagt
      901 gggagagatt gtaagagaga ttggacaaaa gtgtccccaa gagctgagtc gagacccttc
      961 agggacaaag ggctttgcag cattcctgac agaactagca gaacgtgtcc cagctatcct
     1021 gatgtccagc atgtgcattt tgctagatca cctggatgga gaaaattaca tgatgcgtaa
     1081 tgctgtgctg gcagccatgg cggagatggt gctgcaggtt ctcagtggcg atcaactgga
     1141 agcagcagcc cgagacacca gagaccagtt cttggatact ttacaagccc atggccatga
     1201 tgtcaactcc tttgtgcgga gccgtgtttt gcagctcttc acccgaattg tccagcagaa
     1261 ggctctcccc ctgacacgtt tccaggcagt ggtggcttta gctgtgggac gtctggcaga
     1321 caagtcagtg ctagtatgta aaaatgccat ccagctgctg gccagttttc tagccaataa
     1381 tcctttctcc tgcaagctta gtgatgctga ccttgccgga ccactgcaga aggagaccca
     1441 gaaattacaa gagatgaggg cccagaggcg aactgcagca gcttctgcag tgctggaccc
     1501 agaggaggag tgggaagcca tgctgccaga gttgaagtct accctgcagc agcttctaca
     1561 gcttccccag ggagaggagg agattcctga gcaaattgcc aatacagaga caactgaaga
     1621 tgtgaaagga cgcatctatc aactgcttgc caaagctagt tacaaaaagg ccatcattct
     1681 cactcgagaa gccacaggcc acttccagga gtccgaaccc ttcagtcata tagacccaga
     1741 ggagtcagag gagaccaggc tcttgaatat cttaggactt atcttcaaag gcccagcagc
     1801 ttccacacaa gaaaagaatc cccgggagtc tacaggaaac atggtcacag gacagactgt
     1861 ctgtaaaaat aaacccaata tgtcggatcc tgaggaatcc aggggaaatg atgaactagt
     1921 gaagcaggag atgctggtac agtatctgca ggatgcctac agcttctccc ggaagattac
     1981 agaggccatt ggcatcatca gcaagatgat gtatgaaaac acaactacag tggtgcagga
     2041 ggtgattgaa ttctttgtga tggtcttcca atttggggta ccccaggccc tgtttggggt
     2101 gcgccgtatg ctgcctctca tctggtctaa ggagcctggt gtccgggaag ccgtgcttaa
     2161 tgcctaccgc caactctacc tcaaccccaa aggggactct gccagagcca aggcccaggc
     2221 tttgattcag aatctctctc tgctgctagt ggatgcctcg gttgggacca ttcagtgtct
     2281 tgaggaaatt ctctgtgagt ttgtgcagaa ggatgagttg aaaccagcag tgacccagct
     2341 gctgtgggag cgggccaccg agaaggtcgc ctgctgtcct ctggagcgct gttcctctgt
     2401 catgcttctt ggcatgatgg cacgaggaaa gccagaaatt gtgggaagca atttagacac
     2461 actggtgagc atagggctgg atgagaagtt tccacaggac tacaggctgg cccagcaggt
     2521 gtgccatgcc attgccaaca tctcggacag gagaaagcct tctctgggca aacgtcaccc
     2581 ccccttccgg ctgcctcagg aacacaggtt gtttgagcga ctgcgggaga cagtcacaaa
     2641 aggctttgtc cacccagacc cactctggat cccattcaaa gaggtggcag tgaccctcat
     2701 ttaccaactg gcagagggcc ccgaagtgat ctgtgcccag atattgcagg gctgtgcaaa
     2761 acaggccctg gagaagctag aagagaagag aaccagtcag gaggacccga aggagtcccc
     2821 cgcaatgctc cccactttcc tgttgatgaa cctgctgtcc ctggctgggg atgtggctct
     2881 gcagcagctg gtccacttgg agcaggcagt gagtggagag ctctgccggc gccgagttct
     2941 ccgggaagaa caggagcaca agaccaaaga tcccaaggag aagaatacga gctctgagac
     3001 caccatggag gaggagctgg ggctggttgg ggcaacagca gatgacacag aggcagaact
     3061 aatccgtggc atctgcgaga tggaactgtt ggatggcaaa cagacactgg ctgcctttgt
     3121 tccactcttg cttaaagtct gtaacaaccc aggcctctat agcaacccag acctctctgc
     3181 agctgcttca cttgcccttg gcaagttctg catgatcagt gccactttct gcgactccca
     3241 gcttcgtctt ctgttcacca tgctggaaaa gtctccactt cccattgtcc ggtctaacct
     3301 catggttgcc actggggatc tggccatccg ctttcccaat ctggtggacc cctggactcc
     3361 tcatctgtat gctcgtctcc gggaccctgc tcagcaagtg cggaaaacag cggggctggt
     3421 gatgacccac ctgatcctca aggacatggt gaaggtgaag gggcaggtca gcgagatggc
     3481 ggtgctgctc atcgaccccg agcctcagat tgctgccctg gccaagaact tcttcaatga
     3541 gctctcccac aagggcaacg caatctataa tctccttcca gatatcatca gccgcctgtc
     3601 agaccccgag ctgggggtgg aggaagagcc tttccacacc atcatgaaac agctcctctc
     3661 ctacatcacc aaggacaagc agacagagag cctggtggaa aagctgtgtc agcggttccg
     3721 cacatcccga actgagcggc agcagcgaga cctggcctac tgtgtgtcac agctgcccct
     3781 cacagagcga ggcctccgta agatgcttga caattttgac tgttttggag acaaactgtc
     3841 agatgagtcc atcttcagtg cttttttgtc agttgtaggc aagctgcgac gtggggccaa
     3901 gcctgagggc aaggctataa tagatgaatt tgagcagaag cttcgggcct gtcataccag
     3961 aggtttggat ggaatcaagg agcttgagat tggccaagca ggtagccaga gagcgccatc
     4021 agccaagaaa ccatccactg gttctaggta ccagcctctg gcttctacag cctcagacaa
     4081 tgactttgtc acaccagagc cccgccgtac tacccgtcgg catccaaaca cccagcagcg
     4141 agcttccaaa aagaaaccca aagttgtctt ctcaagtgat gagtccagtg aggaagatct
     4201 ttcagcagag atgacagaag acgagacacc caagaaaaca actcccattc tcagagcatc
     4261 ggctcgcagg cacagatcct aggaagtctg ttcctgtcct ccctgtgcag ggtatcctgt
     4321 agggtgacct ggaattcgaa ttctgtttcc cttgtaaaat atttgtctgt ctcttttttt
     4381 taaaaaaaaa aaaggccggg cactgtggct cacgcctgta atcccagcac tttgcgatac
     4441 caaggcgggt ggataacctg aggtagggag ttcgagacca gcctgaccaa catggagaaa
     4501 ccccatctct actaaaaata aaaaattagc cgggcgtatt ggcgtgcgcc tgtaatccca
     4561 gctactcaag aggctgaggc aggagaatcg cctgaaccca gaggcggagg ttgtagtgag
     4621 ccgaaatcac accattgcac tccagcttgg gcaacaatag cgaacctcca tctcaaatta
     4681 aaaaaaaaat gcctacacgc tctttaaaat gcaaggcttt ctcttaaatt agcctaactg
     4741 aactgcgttg agctgcttca actttggaat atatgtttgc caatctcctt gttttctaat
     4801 gaataaatgt ttttatatac tttta
//
