LOCUS       NM_004386               6402 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens neurocan (NCAN), mRNA.
ACCESSION   NM_004386
VERSION     NM_004386.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6402)
  AUTHORS   Assmann,A., Richter,A., Schutze,H., Soch,J., Barman,A.,
            Behnisch,G., Knopf,L., Raschick,M., Schult,A., Wustenberg,T.,
            Behr,J., Duzel,E., Seidenbecher,C.I. and Schott,B.H.
  TITLE     Neurocan genome-wide psychiatric risk variant affects explicit
            memory performance and hippocampal function in healthy humans
  JOURNAL   Eur J Neurosci 53 (12), 3942-3959 (2021)
   PUBMED   32583466
  REMARK    GeneRIF: Neurocan genome-wide psychiatric risk variant affects
            explicit memory performance and hippocampal function in healthy
            humans.
REFERENCE   2  (bases 1 to 6402)
  AUTHORS   Wu,M.J., Yuan,C., Lu,L.L., An,B.Q., Xuan,S.Y. and Xin,Y.N.
  TITLE     Role of NCAN rs2228603 polymorphism in the incidence of
            nonalcoholic fatty liver disease: a case-control study
  JOURNAL   Lipids Health Dis 15 (1), 207 (2016)
   PUBMED   27887608
  REMARK    GeneRIF: NCAN rs2228603 is not a risk factor for the incidence of
            NAFLD in Chinese population. The dual and opposite role of T
            variant in protecting liver with a higher level of HDL was found.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6402)
  AUTHORS   Boonvisut,S., Nakayama,K., Makishima,S., Watanabe,K., Miyashita,H.,
            Lkhagvasuren,M., Kagawa,Y. and Iwamoto,S.
  TITLE     Replication analysis of genetic association of the NCAN-CILP2
            region with plasma lipid levels and non-alcoholic fatty liver
            disease in Asian and Pacific ethnic groups
  JOURNAL   Lipids Health Dis 15, 8 (2016)
   PUBMED   26758378
  REMARK    GeneRIF: This study aims to analyze the influences of
            single-nucleotide polymorphism in the NCAN-CILP2 region on
            non-alcoholic fatty liver disease and plasma lipid levels in the
            Asian and Pacific ethnic groups.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6402)
  AUTHORS   Dannlowski,U., Kugel,H., Grotegerd,D., Redlich,R., Suchy,J.,
            Opel,N., Suslow,T., Konrad,C., Ohrmann,P., Bauer,J., Kircher,T.,
            Krug,A., Jansen,A., Baune,B.T., Heindel,W., Domschke,K.,
            Forstner,A.J., Nothen,M.M., Treutlein,J., Arolt,V., Hohoff,C.,
            Rietschel,M. and Witt,S.H.
  TITLE     NCAN Cross-Disorder Risk Variant Is Associated With Limbic Gray
            Matter Deficits in Healthy Subjects and Major Depression
  JOURNAL   Neuropsychopharmacology 40 (11), 2510-2516 (2015)
   PUBMED   25801500
  REMARK    GeneRIF: NCAN genotype is associated with limbic gray matter
            alterations in healthy and subjects with major depression in brain
            areas implicated in emotion perception and regulation
REFERENCE   5  (bases 1 to 6402)
  AUTHORS   Raum,H., Dietsche,B., Nagels,A., Witt,S.H., Rietschel,M.,
            Kircher,T. and Krug,A.
  TITLE     A genome-wide supported psychiatric risk variant in NCAN influences
            brain function and cognitive performance in healthy subjects
  JOURNAL   Hum Brain Mapp 36 (1), 378-390 (2015)
   PUBMED   25220293
  REMARK    GeneRIF: current data demonstrate that common genetic variation in
            NCAN influences both neural processing and cognitive performance in
            healthy subjects.
REFERENCE   6  (bases 1 to 6402)
  AUTHORS   Retzler,C., Gohring,W. and Rauch,U.
  TITLE     Analysis of neurocan structures interacting with the neural cell
            adhesion molecule N-CAM
  JOURNAL   J Biol Chem 271 (44), 27304-27310 (1996)
   PUBMED   8910306
REFERENCE   7  (bases 1 to 6402)
  AUTHORS   Milev,P., Maurel,P., Haring,M., Margolis,R.K. and Margolis,R.U.
  TITLE     TAG-1/axonin-1 is a high-affinity ligand of neurocan,
            phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM
  JOURNAL   J Biol Chem 271 (26), 15716-15723 (1996)
   PUBMED   8663515
REFERENCE   8  (bases 1 to 6402)
  AUTHORS   Rauch,U., Grimpe,B., Kulbe,G., Arnold-Ammer,I., Beier,D.R. and
            Fassler,R.
  TITLE     Structure and chromosomal localization of the mouse neurocan gene
  JOURNAL   Genomics 28 (3), 405-410 (1995)
   PUBMED   7490074
REFERENCE   9  (bases 1 to 6402)
  AUTHORS   Friedlander,D.R., Milev,P., Karthikeyan,L., Margolis,R.K.,
            Margolis,R.U. and Grumet,M.
  TITLE     The neuronal chondroitin sulfate proteoglycan neurocan binds to the
            neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and
            inhibits neuronal adhesion and neurite outgrowth
  JOURNAL   J Cell Biol 125 (3), 669-680 (1994)
   PUBMED   7513709
REFERENCE   10 (bases 1 to 6402)
  AUTHORS   Rauch,U., Karthikeyan,L., Maurel,P., Margolis,R.U. and
            Margolis,R.K.
  TITLE     Cloning and primary structure of neurocan, a developmentally
            regulated, aggregating chondroitin sulfate proteoglycan of brain
  JOURNAL   J Biol Chem 267 (27), 19536-19547 (1992)
   PUBMED   1326557
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC003110.1, CN282070.1, AB210004.1 and AC138430.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004386.2.
            
            Summary: Neurocan is a chondroitin sulfate proteoglycan thought to
            be involved in the modulation of cell adhesion and
            migration.[supplied by OMIM, Jul 2002].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB210004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252575.11/ ENSP00000252575.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC003110.1         15446-15460
            16-71               CN282070.1         1-56
            72-6400             AB210004.1         1-6329
            6401-6402           AC138430.2         13293-13294         c
FEATURES             Location/Qualifiers
     source          1..6402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..6402
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /note="neurocan"
                     /db_xref="GeneID:1463"
                     /db_xref="HGNC:HGNC:2465"
                     /db_xref="MIM:600826"
     exon            1..107
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            108..187
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..4080
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /note="chondroitin sulfate proteoglycan 3 (neurocan);
                     neurocan proteoglycan; neurocan core protein"
                     /codon_start=1
                     /product="neurocan core protein precursor"
                     /protein_id="NP_004377.2"
                     /db_xref="CCDS:CCDS12397.1"
                     /db_xref="GeneID:1463"
                     /db_xref="HGNC:HGNC:2465"
                     /db_xref="MIM:600826"
                     /translation="MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGS
                     GSVQAALAELVALPCLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVR
                     VAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGV
                     VFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRY
                     PITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGA
                     RAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRT
                     VYRFANRTGFPSPAERFDAYCFRAHHPTSQHGDLETPSSGDEGEILSAEGPPVRELEP
                     TLEEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTGEVWLST
                     VAPSPSDMGAGTAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASA
                     QPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWL
                     WPPTMVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEATVSAPSPAPWEAFPV
                     ATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPL
                     SLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVP
                     TETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAP
                     LGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAES
                     TTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQGTSGAS
                     VPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFELE
                     VLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMY
                     GCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGC
                     DRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIG
                     LNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNL
                     PYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRSNG
                     KWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNF
                     C"
     exon            188..589
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            590..764
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            765..892
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1186
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1774
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..3133
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3250
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3364
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3523
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3606
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3751
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3934
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..6402
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6381..6386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /note="hexamer: AATAAA"
     polyA_site      6402
                     /gene="NCAN"
                     /gene_synonym="CSPG3"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgcagg gcgcaggggc tggacccggc gcggagctgg ctgagtcgga gcgcagcgtc
       61 ctttgtgccc ggcggccgcc ccgggatgcg tccgagctag gagccagatc caggatgggg
      121 gccccgtttg tctgggcctt gggccttttg atgctgcaga tgctgctctt tgtggctggg
      181 gaacagggca cacaggatat caccgatgcc agcgaaaggg ggctccacat gcagaagctg
      241 gggtctgggt cagtgcaggc tgcgctggcg gagctggtgg ccctgccctg tctctttacc
      301 ctgcagccac ggccaagcgc agcccgagat gcccctcgga taaagtggac caaggtgcgg
      361 actgcgtcgg gccagcgaca ggacttgccc atcctggtgg ccaaggacaa tgtcgtgagg
      421 gtggccaaaa gctggcaggg acgagtgtca ctgccttcct acccccggcg ccgagccaac
      481 gccacgctac ttctggggcc actgagggcc agtgactctg ggctgtaccg ctgccaggtg
      541 gtgaggggca tcgaggatga gcaggacctg gtgcccttgg aggtgacagg tgttgtgttc
      601 cactaccgat cagcccggga ccgctatgca ctgaccttcg ctgaggccca ggaggcctgc
      661 cgtctcagct cagccatcat tgcagcccct cggcatctac aggctgcctt tgaggatggc
      721 tttgacaact gtgatgctgg ctggctctct gaccgcactg ttcggtatcc tatcacccag
      781 tcccgtcctg gttgctatgg cgaccgtagc agccttccag gggttcggag ctatgggagg
      841 cgcaacccac aggaactcta cgatgtgtat tgctttgccc gggagctggg gggcgaggtc
      901 ttctacgtgg gcccggcccg ccgcctgaca ctggccggcg cgcgtgcaca gtgccgccgc
      961 cagggtgccg cgctggcctc ggtgggacag ctgcacctgg cctggcatga gggcctggac
     1021 cagtgcgacc cgggctggct ggccgacggc agcgtgcgct acccgatcca gacgccgcgc
     1081 cggcgctgcg ggggcccagc cccgggcgtg cgcaccgtct accgcttcgc taaccggacc
     1141 ggcttcccct cacccgccga gcgcttcgac gcctactgct tccgagctca tcaccccacg
     1201 tcacaacatg gagacctaga gaccccatcc tctggggatg agggggagat tctgtcagca
     1261 gaggggcccc cagttagaga actggagccc accctggagg aggaagaggt ggtcacccct
     1321 gacttccagg agcctctggt gtccagtggg gaagaagaaa ccctgatttt ggaggagaag
     1381 caggagtctc aacagaccct cagccctacc cctggggacc ccatgctggc ctcatggccc
     1441 actggggaag tgtggctaag cacggtggcc cccagcccta gcgacatggg ggcaggcact
     1501 gcagcaagtt cacacacgga ggtggcccca actgacccta tgcctaggag aagggggcgc
     1561 ttcaaagggt tgaatgggcg ctacttccag cagcaggaac cggagccggg gctgcaaggg
     1621 gggatggagg ccagcgccca gccccccacc tcagaggctg cagtgaacca aatggagcct
     1681 ccgttggcca tggcagtcac agagatgttg ggcagtggcc agagccggag cccctgggct
     1741 gatctgacca atgaggtgga tatgcctgga gctggttctg ctggtggcaa gagctcccca
     1801 gagccctggc tgtggccccc taccatggtc ccacccagca tctcaggcca cagcagggcc
     1861 cctgtcctgg agctagagaa agccgagggc cccagtgcca ggccagccac cccagacctg
     1921 ttttggtccc ccttggaggc cactgtctca gctcccagcc ctgccccctg ggaggcattc
     1981 cctgtggcca cctccccaga tctccctatg atggccatgc tgcgtggtcc caaagagtgg
     2041 atgctaccac accccacccc catctccacc gaggccaata gagttgaggc acatggtgag
     2101 gccaccgcca cggctccacc ctcccctgct gcagagacca aggtgtattc cctgcctctc
     2161 tctttgaccc caacaggaca gggtggagag gccatgccca caacacctga gtcccccagg
     2221 gcagacttca gagaaactgg ggagaccagc cctgctcagg tcaacaaagc tgagcactcc
     2281 agctccagcc catggccttc tgtaaacagg aatgtggctg taggttttgt ccccactgag
     2341 actgccactg agccaacggg cctcaggggt atcccggggt ctgagtctgg ggtcttcgac
     2401 acagcagaaa gccccacttc tggcttgcag gccactgtag atgaggtgca ggacccctgg
     2461 ccctcagtgt acagcaaagg gctggatgca agttccccat ctgcccccct ggggagccct
     2521 ggagtcttct tggtacccaa agtcacccca aatttggagc cttgggttgc tacagatgaa
     2581 ggacccactg tgaatcccat ggattccaca gtcacgccgg cccccagtga tgctagtgga
     2641 atttgggaac ctggatccca ggtgtttgaa gaagccgaaa gcaccacctt gagccctcag
     2701 gtggccctgg atacaagcat tgtgacgccc ctcacgaccc tggagcaggg ggacaaggtt
     2761 ggagttccag ccatgtctac actgggctcc tcaagctccc aaccccaccc agagccagag
     2821 gatcaggtgg agacccaggg aacatcagga gcttcagtgc ctccgcatca gagcagtccc
     2881 ctagggaaac cggctgttcc tcctgggaca ccgactgcag ccagtgtggg cgagtctgcc
     2941 tcagtttcct caggggagcc tacggtaccg tgggacccct ccagcaccct gctgcctgtc
     3001 accctgggca tagaggactt cgaactggag gtcctggcag ggagcccggg tgtagagagc
     3061 ttctgggagg aggtggcaag tggagaggag ccagccctgc cagggacccc tatgaatgca
     3121 ggtgcggagg aggtgcactc agatccctgt gagaacaacc cttgtcttca tggagggaca
     3181 tgtaatgcca atggcaccat gtatggctgt agctgtgatc agggcttcgc cggggagaac
     3241 tgtgagattg acattgatga ctgcctctgc agcccctgtg agaatggagg cacctgtatt
     3301 gatgaggtca atggctttgt ctgcctttgc ctccccagct atgggggcag cttttgtgag
     3361 aaagacaccg agggctgtga ccgcggctgg cataagttcc agggccactg ttaccgctat
     3421 tttgcccacc ggagggcatg ggaagatgcc gagaaggact gccgccgccg ctccggccac
     3481 ctgaccagcg tccactcacc ggaggaacac agcttcatta atagctttgg gcatgaaaac
     3541 acgtggatcg gcctgaacga caggatcgtg gagagagatt tccagtggac ggacaacacc
     3601 gggctgcaat ttgagaactg gcgagagaac cagccggaca atttcttcgc gggtggcgag
     3661 gactgtgtgg tgatggtggc gcatgaaagc gggcgctgga acgatgtccc ctgcaactac
     3721 aacctaccct atgtctgcaa gaagggcaca gtgctctgtg gtccccctcc ggcagtggag
     3781 aatgcctcac tcatcggtgc ccgcaaggcc aagtacaatg tccatgccac tgtaaggtac
     3841 cagtgcaatg aaggatttgc ccagcaccat gtggccacca ttcgatgccg gagcaatggc
     3901 aagtgggaca ggccccaaat tgtctgcacc aaacccagac gttcacatcg gatgcggcga
     3961 caccaccacc accaccaaca ccaccaccag catcaccacc acaaatcccg caaggagcgc
     4021 agaaaacaca agaaacaccc aacggaggac tgggagaagg acgaagggaa tttctgctga
     4081 agaaccagaa aaaagaaagc acaacacctt tcccatgcct cctctggagc cttcgcctgg
     4141 ggagacagaa cccagagaga aacaagagag tccagaagtc cctgaacccc aaaccacatc
     4201 ccccacacac ataatccttt gtacaaagct cctcttttcc ctttttttac atacacaaga
     4261 tcctcttggc aggtggagcc aggtgtctga aaagttcatt ctcgtctggc tgaactctgg
     4321 gagtgtgtcc cagctgaggg aagcacaagt agcaaagctc attggtctgg tctcttgttt
     4381 gccaggctga ttgaagcagg ccttgatgag ggtgcatgag tgtatgtttg cattcacatg
     4441 aaggaattgc ttttcacacc agaaattcag acttagtcaa tgttggctga attcctaaat
     4501 ccaggaagaa gcctggacgt agggtcatta gctttgggaa tagaaggcta cacagaagca
     4561 cactgttttt gaacttgaca acagctctcc ctttaccctg gacttcagcc caagttccgt
     4621 ctttggtctt ggtggataaa cacacagtgt ggagatccca cgtactgcat tttagggatg
     4681 tttttaggac aacctccctc catgccttca gagttaggag tgagaatgat caaagcaata
     4741 tgtaggtgat ggagggagag tgtattgcta acccttccag gtctagtcca gcgctgagat
     4801 ttggtggttc tgcatgtgtg atgaatctct ttcacacaaa tagacgagag gatatttagg
     4861 gctagatgag cccagatttc ttccccctcc atctctcagg gagacaaaga acctccttcc
     4921 tggaccaagg aggtgctgcc aagttttcta gcccagtgca catacccagt ccttaagcag
     4981 acattggtag tgcccctgcc ctgggtccca ctcctgcccc accccaccct tgtccctggc
     5041 cattgcctgg tggtctagaa acacttaaaa cttgaagtag tgacacctac ctgcggtcat
     5101 attgtagaga gatgctcagt gttaaaactg aaacacacaa acacacacac acacacattt
     5161 ttctcttgta gattttaatt ttttaagtgg gaaagaactc accttgcctt cctcccccaa
     5221 atgtgcaacc tgtaaaaggt ctctccacac caggggccag gatccagttc cctcatctct
     5281 ggcaggaaag atccacagct tttcctccat gtctgttact cactttcagc agtccgggta
     5341 aaatctgtgg atcagggtta aaaaagcacc gtggagaatg gccctcttca ggaaagaaaa
     5401 ataagcaaat gaatggtcca cctaggggtt cagtaaagaa agaaatgtgt taactgagcc
     5461 tgaatccctt ctgggaagta ataatgacca ttgacaacta agaagtagac accatgctaa
     5521 agacttacat acaatctcct tgaatcttct caatagccca ttgacttaga aactgttact
     5581 ttcccatttt acacacagtg aaactgaggc tcagatataa aggaaaggta ctggcttgaa
     5641 gtcacaacca cgacaggagt aaggatttgg aataaggatt tggtcctgtt ttctggacca
     5701 aatccttact ctggctctgc ttacactttc tctccatcac caaatcctta ctccaaatcc
     5761 agaagtcaga gccaactccc atcttggttc tgacccaaat cctgctctgg actctggaga
     5821 ggagattgaa atataattgc accctcatac acatttagga aatggttaag aagtgtaaac
     5881 tgaaccctta tccttgtctt caatcttcct ccctgtagac atctatctta ttatggttat
     5941 tattcagaaa acccagggat acaggtttgt cttcttactt tgataactct tcttagttta
     6001 aaataataat aataacacat ctttggtcat ctatgtcaca caaaaatttt cctttgtttg
     6061 cggggggctg gggatgcagt gttttttggg gggtcttggt ttatgctccc tgcccttgag
     6121 cccctcagcc gtttgccctg cccccacctc ggctccatgg tgggaggggg ctctggtctt
     6181 ttctaaagtg ggcggtttgt cttttgatct ttcccttttg gatgtgcgtg tgtgtctgcg
     6241 tgtgccatgt gcgtggcacg catatgagtg tgtgtgcgtg tgaacggctt tgggtcctgc
     6301 tggttttgct gtgagctgca gtgttctgtg ggtctgtggt atctgacact gtggacatta
     6361 atgtacttct tggacatttt aataaatttt ttaacagttc aa
//
