LOCUS       NM_004540               8041 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens neural cell adhesion molecule 2 (NCAM2), transcript
            variant 2, mRNA.
ACCESSION   NM_004540
VERSION     NM_004540.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8041)
  AUTHORS   Kim,W., Watanabe,H., Lomoio,S. and Tesco,G.
  TITLE     Spatiotemporal processing of neural cell adhesion molecules 1 and 2
            by BACE1 in vivo
  JOURNAL   J Biol Chem 296, 100372 (2021)
   PUBMED   33548223
  REMARK    GeneRIF: Spatiotemporal processing of neural cell adhesion
            molecules 1 and 2 by BACE1 in vivo.
REFERENCE   2  (bases 1 to 8041)
  AUTHORS   Parcerisas,A., Pujadas,L., Ortega-Gasco,A., Perello-Amoros,B.,
            Viais,R., Hino,K., Figueiro-Silva,J., La Torre,A., Trullas,R.,
            Simo,S., Luders,J. and Soriano,E.
  TITLE     NCAM2 Regulates Dendritic and Axonal Differentiation through the
            Cytoskeletal Proteins MAP2 and 14-3-3
  JOURNAL   Cereb Cortex 30 (6), 3781-3799 (2020)
   PUBMED   32043120
  REMARK    GeneRIF: NCAM2 Regulates Dendritic and Axonal Differentiation
            through the Cytoskeletal Proteins MAP2 and 14-3-3.
REFERENCE   3  (bases 1 to 8041)
  AUTHORS   Rasmussen,K.K., Falkesgaard,M.H., Winther,M., Roed,N.K.,
            Quistgaard,C.L., Teisen,M.N., Edslev,S.M., Petersen,D.L.,
            Aljubouri,A., Christensen,C., Thulstrup,P.W., Lo Leggio,L.,
            Teilum,K. and Walmod,P.S.
  TITLE     NCAM2 Fibronectin type-III domains form a rigid structure that
            binds and activates the Fibroblast Growth Factor Receptor
  JOURNAL   Sci Rep 8 (1), 8957 (2018)
   PUBMED   29895898
  REMARK    GeneRIF: These results reveal that the NCAM2 FnIII domains form a
            rigid structure that binds and activates FGFR in a manner related
            to, but different from NCAM1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8041)
  AUTHORS   Scholz,C., Steinemann,D., Malzer,M., Roy,M., Arslan-Kirchner,M.,
            Illig,T., Schmidtke,J. and Stuhrmann,M.
  TITLE     NCAM2 deletion in a boy with macrocephaly and autism: Cause,
            association or predisposition?
  JOURNAL   Eur J Med Genet 59 (10), 493-498 (2016)
   PUBMED   27596683
  REMARK    GeneRIF: Our reported case raises the questions whether the
            NCAM2-deletion is the true cause of the autism spectrum disorder or
            only a risk factor and whether there might be any connection in
            NCAM2 with skull-size
REFERENCE   5  (bases 1 to 8041)
  AUTHORS   Winther,M., Berezin,V. and Walmod,P.S.
  TITLE     NCAM2/OCAM/RNCAM: cell adhesion molecule with a role in neuronal
            compartmentalization
  JOURNAL   Int J Biochem Cell Biol 44 (3), 441-446 (2012)
   PUBMED   22155300
  REMARK    Review article
REFERENCE   6  (bases 1 to 8041)
  AUTHORS   Rasmussen,K.K., Kulahin,N., Kristensen,O., Poulsen,J.C.,
            Sigurskjold,B.W., Kastrup,J.S., Berezin,V., Bock,E., Walmod,P.S.
            and Gajhede,M.
  TITLE     Crystal structure of the Ig1 domain of the neural cell adhesion
            molecule NCAM2 displays domain swapping
  JOURNAL   J Mol Biol 382 (5), 1113-1120 (2008)
   PUBMED   18706912
  REMARK    GeneRIF: In the crystal structure, two Ig domains interact by
            domain swapping, as the two N-terminal beta-strands are
            interchanged.
REFERENCE   7  (bases 1 to 8041)
  AUTHORS   Schmitt-Ulms,G., Hansen,K., Liu,J., Cowdrey,C., Yang,J.,
            DeArmond,S.J., Cohen,F.E., Prusiner,S.B. and Baldwin,M.A.
  TITLE     Time-controlled transcardiac perfusion cross-linking for the study
            of protein interactions in complex tissues
  JOURNAL   Nat Biotechnol 22 (6), 724-731 (2004)
   PUBMED   15146195
REFERENCE   8  (bases 1 to 8041)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
REFERENCE   9  (bases 1 to 8041)
  AUTHORS   Alenius,M. and Bohm,S.
  TITLE     Differential function of RNCAM isoforms in precise target selection
            of olfactory sensory neurons
  JOURNAL   Development 130 (5), 917-927 (2003)
   PUBMED   12538518
REFERENCE   10 (bases 1 to 8041)
  AUTHORS   Paoloni-Giacobino,A., Chen,H. and Antonarakis,S.E.
  TITLE     Cloning of a novel human neural cell adhesion molecule gene (NCAM2)
            that maps to chromosome region 21q21 and is potentially involved in
            Down syndrome
  JOURNAL   Genomics 43 (1), 43-51 (1997)
   PUBMED   9226371
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC052946.1, AP001115.1 and
            AI207079.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004540.4.
            
            Summary: The protein encoded by this gene belongs to the
            immunoglobulin superfamily. It is a type I membrane protein and may
            function in selective fasciculation and zone-to-zone projection of
            the primary olfactory axons. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.145816.1,
                                           SRR1660807.53755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400546.6/ ENSP00000383392.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3486              BC052946.1         95-3580
            3487-4594           AP001115.1         6201-7308
            4595-4908           AI207079.1         5-318               c
            4909-8041           AP001115.1         7623-10755
FEATURES             Location/Qualifiers
     source          1..8041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.1"
     gene            1..8041
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /note="neural cell adhesion molecule 2"
                     /db_xref="GeneID:4685"
                     /db_xref="HGNC:HGNC:7657"
                     /db_xref="MIM:602040"
     exon            1..210
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2669
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; NCAM-2; N-CAM-2"
                     /codon_start=1
                     /product="neural cell adhesion molecule 2 isoform 2
                     precursor"
                     /protein_id="NP_004531.2"
                     /db_xref="CCDS:CCDS42910.1"
                     /db_xref="GeneID:4685"
                     /db_xref="HGNC:HGNC:7657"
                     /db_xref="MIM:602040"
                     /translation="MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTA
                     IGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQT
                     QEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISD
                     NRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSF
                     NATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDG
                     GPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITW
                     KRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKS
                     MYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLK
                     TYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELS
                     QTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYE
                     IRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPIL
                     EYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEF
                     SMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMC
                     GKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLT
                     EPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA"
     exon            211..285
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            286..492
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            493..636
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            637..774
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            775..892
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1053
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1199
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1350
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1538
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1635
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1809
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1929
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2051
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2232
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2437
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2557
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..8041
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3464..3469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /note="hexamer: AGTAAA"
     polyA_site      3486
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /note="major polyA site"
     regulatory      4878..4883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /note="hexamer: AACAAA"
     polyA_site      4908
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
     regulatory      8020..8025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
                     /note="hexamer: AGTAAA"
     polyA_site      8041
                     /gene="NCAM2"
                     /gene_synonym="NCAM21"
ORIGIN      
        1 actttgcgag gaggagcgcg cgggctgcgg gcggctgggg caccgcggga gcggcggcgg
       61 cggctctagc agaggcggcc ggggcagcga aaggttctct ctccagggct ggacttaata
      121 actttgaaac tgtccaccgg tgtcacgtcc tgaacatgag cctcctcctc tccttctacc
      181 tgctggggtt gcttgtcagt agcgggcaag ctcttcttca agtgacaatt tcacttagca
      241 aagtagagct tagtgttgga gaatctaaat tcttcacatg tacagcgatt ggtgaacctg
      301 aaagtataga ttggtataat cctcaaggag agaagataat ttcaacacag agggtagtag
      361 tgcaaaagga aggtgttagg tcacggttaa ccatctacaa tgcaaatata gaagatgcag
      421 ggatatatcg ttgtcaagca acagatgcca aaggacaaac acaagaagct acagtagttt
      481 tggaaattta ccaaaaactc actttcagag aagtggtatc tccacaagaa ttcaaacaag
      541 gagaagatgc agaagtggtt tgccgagtta gcagttcacc tgcacctgct gtcagctggt
      601 tgtatcataa tgaggaagtc accactattt ccgacaatcg gttcgctatg ttagcaaaca
      661 ataacctgca gattctcaac atcaataaaa gtgatgaagg tatatacaga tgtgaaggaa
      721 gagtggaggc caggggagaa attgacttcc gtgatatcat tgttattgtt aatgtgccgc
      781 cagcaatctc aatgcctcag aaatctttta atgccacagc agagagagga gaagaaatga
      841 cattttcctg cagggcctca ggctctccag aacccgccat ctcctggttc aggaatggca
      901 agctcattga agaaaatgag aagtacatat tgaaagggag caatacagaa ctcactgtca
      961 ggaacataat caatagtgat ggtggtcctt atgtctgcag ggccacaaat aaggcaggag
     1021 aagatgaaaa gcaagctttc ctccaagtct ttgtacagcc tcacataata cagcttaaaa
     1081 atgaaactac atatgagaat ggtcaagtca cactcgtatg tgatgcggaa ggggagccta
     1141 ttccagaaat cacttggaaa agagctgtgg atggcttcac gttcactgaa ggcgataaga
     1201 gcctggacgg ccgtatcgaa gtcaaagggc agcatggaag ctcatcactg catattaaag
     1261 atgtgaagtt gtcagattca gggagatatg actgtgaagc tgcaagcaga attggagggc
     1321 atcaaaagag catgtacctt gatattgaat atgcccccaa gtttatatca aaccaaacaa
     1381 tttattactc ttgggaagga aatcctatca atataagttg tgatgtgaaa tcgaatccac
     1441 cagcatcaat tcactggaga agagataaat tagtcttacc tgctaaaaac acgaccaatt
     1501 taaagactta tagtacagga agaaagatga tattagagat tgcacctaca tctgacaatg
     1561 actttggacg ctataattgc acagccacta atcatatagg aacaagattt caagaatata
     1621 ttcttgcttt ggctgacgtg ccatccagtc cctatggagt gaagatcata gagctgtcgc
     1681 agaccacggc caaggtttcc ttcaacaaac cggactccca tggaggtgta cctattcatc
     1741 actatcaggt ggatgtcaaa gaagtagcgt cagaaatctg gaaaattgta cgctcccatg
     1801 gagttcaaac aatggttgtt ttgaacaacc tggaaccaaa tacaacttat gaaatcaggg
     1861 ttgcagctgt aaatggaaag ggacaaggag actacagtaa aatagaaatc ttccaaacat
     1921 taccagttcg tgaaccaagt cctccatcca tacatggaca gccaagcagt ggaaagagct
     1981 ttaaactcag catcaccaaa caggacgatg gaggggcccc tattttggaa tacattgtga
     2041 aatatagaag taaagataag gaagaccaat ggctagagaa aaaagtgcaa ggaaataaag
     2101 accacatcat tttggagcat ctccagtgga ccatggggta tgaagttcag attacagctg
     2161 ccaatagatt gggatattct gaaccgacag tttatgaatt cagcatgcca ccaaagccca
     2221 acattattaa agacacgctg tttaatggtc ttgggcttgg agcagtaatt ggcctgggag
     2281 ttgctgcact gctgctaatt cttgtggtaa cagacgtcag ctgcttcttt attcggcaat
     2341 gtgggttgct gatgtgcatc actaggagaa tgtgtggaaa gaaaagtggc tccagtggca
     2401 aaagtaaaga actcgaagaa ggaaaagctg catacctgaa agatggatca aaagaaccaa
     2461 tagtggagat gagaacagag gatgaaagag ttactaatca cgaagatggg agcccagtaa
     2521 atgagccaaa tgaaaccaca ccactgacag aacctgaaaa attgccttta aaggaagaag
     2581 atgggaaaga agctctaaat ccagaaacta tagaaattaa agtttctaac gacatcattc
     2641 aatcaaaaga agacgacagc aaagcataac aacaatatta caggggcttg aacaacacta
     2701 cgaagagtat ttggattgcg tgaccctatg accaaaacta ttccattgac cttaatttct
     2761 tgggaaactt ctagcttgga atagcttgta cacatataca tatgatcaaa tactcctgcc
     2821 catgatccat tcccttttgt tattgttgtt gttgttgctg ttgttgttaa ttttgttaag
     2881 aatttcaata tcaagactga ctggcaccaa cactttggta ttcaatttga ttctatgact
     2941 gaagtactgg aatttattat gtggctaaag tgctctattt attaagaact atatttaata
     3001 ccaccaacaa atataggggt taaggaaaaa aaacgtgagc tacatgtgta agaaggccct
     3061 gcatgtgtat gagtcctatt ctgggcaaat agattcttaa agtggctttc aacttcaaga
     3121 tgaaggagct taataatggt tactcatttt atcaggggaa tttcagggaa cgtaggcgtc
     3181 aaagagccag ttatctttag cagatattaa aaattgaaaa ctttggagaa ctcatttcaa
     3241 gttatgattc agtgcatttt caacattgat ttttgataga ctgaagtgcc agatcaaaat
     3301 tgttacccat ttgaaagaat attagttgta tataaaatta gattagaaag actttctaaa
     3361 tctctatctc tttatatatg tcctattcat tcacaatgga ttatacaaaa aaaagtgtat
     3421 tgcaagtgaa ataatattga tttctgccct cagcttcaaa taaagtaaat tgaaatggga
     3481 acaatatcaa tatggtgtct tgatatattt ataaatatgt gattatcatt tatttttaaa
     3541 ataatttatc aaaaaacaag tctttagtgt tcaaatactt caaatcatat cctcagatat
     3601 atttttagcc catggtttta tataatcttt aagaactaat tttaccactg ttataggttc
     3661 accattaaat ataattggct aataaaaatt ttaaggttga ctaaattaag aagaaattat
     3721 ttaacatttt aatgtgccat aaaagagtaa atgataaata attaaatgcc actatgtgtt
     3781 ctattccgga tgttctagct agaagtcatt ttaagatttt gataaacaac tttggttgaa
     3841 gaaattcctt aagtattcaa cacaaacttt ctaatatctt ttgttagggt tataccagaa
     3901 taaaatgctt ctttacttcc aagctatgca agctcccaga ggtaatagag tgacacatga
     3961 tttaacttat atgtaaggtt taaaaaagta tttatcatta taaacataca taccatttgg
     4021 gagcaggttt attaaccttg agagccaaag gtttccttag gccctgtaac attcagaacc
     4081 tttggtgttt caggtggtat tatagctcaa atagtgacag gacagggaat gcgttccaaa
     4141 ggaatattgg agcaatttta acattgcaga aacctgctct gggtgtgtct ctctgtagag
     4201 ataacctgat gattattaaa tgtaaaatta aggcaactca tgaatatttt tatttacaaa
     4261 gtgcttgaaa ctcagccaag gagagaaaac taagtacttt tatataattc atcacttttc
     4321 tggctacagc aggacagaat atgaccatct tcgtttgaag gcaccaaatc gtcgcagtgt
     4381 ctttgccata agttgcaggg ttaaatgcgg gaatctctcc ttgcgttcct gtctggcgta
     4441 ttctgaagaa aagaacagaa ttcttgtgcc tacctaagaa tttgagtagt gtctaaacaa
     4501 acaaagcagt taggtcattt taactgactt gattatccaa ctggtctttg acagatttga
     4561 ctgttcatat ttagtttatg tttgtctgat catccagttt gctttatttt gctgtgtttt
     4621 attttgttgt ttgttttgtt ttgtaccagt gtactaaaac tagtcaaaat acttgaatta
     4681 gtttgtttgt gcaaagtgta caagcttagt aaagtgtcca tgaagcaata gccatgaatg
     4741 ctaattattt ctaaataggg ccacatggtt ttaaactaat gatggtgaaa gaaatacgat
     4801 gactgagaaa gtcatttcgc atgtttacta ttgttatatt cgtgctttac ttcaagagtg
     4861 cagaaatcat aataaataac aaactatttt tgtgttttct caatgtgaca tttctgtttc
     4921 tctcatttat tcggattttc cttgtaaaga aattgacata tatttcatat atatatacac
     4981 atatatatat atacacatat atatacatat atatatatga tgttaaattt cctgccactc
     5041 atgtggagta atgatctgaa attaacagat aatctgaagc taattatatt cagactattt
     5101 caagtgcact gtttcagttg cccgggtggt ccttacctct tgtccttgaa atccatgcca
     5161 tgctgaagca aggcaatact gtgataaagt atttttttta atatttcaat ggaatgctcc
     5221 aaatgattta taaaaatttc aaaataaaag atggcttgta gtaaattgta aaatatgagt
     5281 agaactgaaa taacctgttt cattcttatt ctagattaaa caaacatata catataacca
     5341 tataaatgtt atttttattg tctgagagta ctcttaaata ttagtataaa gtgtcaaaag
     5401 aattgactga atataagtac tgttaaaata atttgaaccc tatgatattt taaaccaaga
     5461 ggcaaagata tcacctaaaa cttggtattt cttgataggt taggtgcaat taggcagtga
     5521 caatctgtat tcaacaacat ataagaggaa agagtaatat cagaattttg acacaaatta
     5581 atgtgtcaac atattttaca atgattgtca aaggaattta agaattgtat ttttaaagat
     5641 ttatttatta tttttgtggg ctaagacatt gccattctat tgatactaat gtctaacatt
     5701 aatgtttctt gttttctttt atttttaata ttaataacta taaaagcatt tttcaaaggc
     5761 tatttgatcc agcacacttc atatggatct tagtctttga attaaatatt tatataaata
     5821 gattttatta atcaaattat ttatttgtgt gccaacaatt aattgtaact ttatgatcat
     5881 atctttgttt atgcttctta ttttaaataa ttaagatgta tctgtgcctt ttaattagca
     5941 tgacagtctg ctttattaaa agaaaaaaac tacaattaac atcattacta gtatattttg
     6001 cttagatttg agatactcaa atgatgctgt cttatttaca gtcagtaatt aagttcaatt
     6061 caaactattt taccttgaat ataaaatcta aatataataa actatactgt ataatttact
     6121 ttaattcatg tcaaaacaat tctttttata cacacacatg aaatattctt aatctgttct
     6181 gtattgtttt tctaaacaat aaatacattc tagatattgt tgaaattaaa ttttgccagt
     6241 tgtaagacaa agacaacaga taacttttga aaatcaagca aattactatg gtgtttcttg
     6301 ggtcttcatt attccattta tatatatttt ttatttcgaa taataaatca acctttattt
     6361 ttggcaataa gattatcact gacgaaaata tgtacagttc aagaagtaga aataatattt
     6421 tccattagtt aatttaggaa atattggaat agcatattat aattatttat gaggttccca
     6481 atgttgtttt tcacagaaaa taaggtaaac attcaactta aatcccccat gaagtttttt
     6541 catgctcata ctcataatca ttatcacata atgtgcttat tcaacaaact ttgtatctgg
     6601 atatattttt aacaataagt ttgttagcat tatttattta tctttagaga gaaaatattt
     6661 gcatctgttt atttaccctt tgaagcatta atacttagtc actcacattg aaattgcata
     6721 tggatgtatc aacataggct aaaattaaat tatggatgtc gcagaaatga aatacttcat
     6781 cttagaaggt aaaattttca agaaagtatt ttattcatgg acttaataat gtcttaagat
     6841 gaaacaattt tatgtccaaa tgagaaattt ataaaaagac ccacatatag tagttgctga
     6901 acaaacataa ttttcttcca gctcccatcc ttcctttttg aaaaattgaa tttacccatg
     6961 tagatgcagc tatttacaat tatacaagaa tgcgaataga ttaattatat cttctcatat
     7021 aaaggcaaag aattttatat tatatataat gctaaatatt tatttgataa cacaatattc
     7081 ttagaaaaat agtttattac tttaggattt tatctataac ataaatatat tatttgttat
     7141 tacctcttta aattttcatt ttatacaatt tttgagattc tggccacaca acattcagaa
     7201 ttattgctca tgtaaattta aatattgcta cttatttttt ttcttttctg aaatgaaaac
     7261 atgaatcttt tggcatctgt ttttagcctc ccatggaaga cagtaagcaa aaccatcact
     7321 gttggagaat ttcaaatcac aacccgacat aggagagtag agaaacaaag aaatgagtgg
     7381 atctagaaag gcaaactgaa ttgctatatt tggaatagct aagaaggacc tgactttgag
     7441 aagtgctaga ccagggacta ggaacgttgc ttagataaaa attatggccg attacactga
     7501 tgcgaaggag aaaacagtgt aacacagagg agaaagttaa cagagataga atctatgatt
     7561 taattttgca aatagttttt ttagagaaca acatgcatac tataaaagaa atgatactat
     7621 taagaacaaa cctacttgtt ccaactctta aagaaatatt catggtttag catttgcctc
     7681 taaaccctgt tagaaatatg tgaagttaga aataaaggtt tttttaaaaa aaaagctttt
     7741 ttggtatgtg aactgtatgc tgtgctcagt atgtactgaa acatactatc ttttattttc
     7801 tttaatttat atattccatt caaattctat attcttaagt tagctaccac aacgttttct
     7861 tattgtttca atatggtatg tcccaatgaa atgctgtata tatatgtcta aactgtaaaa
     7921 attatactgc aaatgttgaa gttttgtatt tatgagagac attgaaagta tggcttacag
     7981 tatatcaaac ttgtcacact tcaccatttg tatattaata gtaaagatac ttttacttta
     8041 a
//
