LOCUS       NM_001386291            4643 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens neural cell adhesion molecule 1 (NCAM1), transcript
            variant 8, mRNA.
ACCESSION   NM_001386291
VERSION     NM_001386291.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4643)
  AUTHORS   Martinez,A.L., Shannon,M.J., Sloan,T. and Mace,E.M.
  TITLE     CD56/NCAM mediates cell migration of human NK cells by promoting
            integrin-mediated adhesion turnover
  JOURNAL   Mol Biol Cell 35 (5), ar64 (2024)
   PUBMED   38507235
  REMARK    GeneRIF: CD56/NCAM mediates cell migration of human NK cells by
            promoting integrin-mediated adhesion turnover.
REFERENCE   2  (bases 1 to 4643)
  AUTHORS   Li,S., Zheng,S., Huang,X., Zhang,W., Liu,F. and Cao,Q.
  TITLE     Expression and Clinical Significance of CD30 and CD56 in
            Lymphoblastic Lymphoma: A Retrospective Analysis on
            Paraffin-Embedded Tissues by Immunohistochemistry
  JOURNAL   Fetal Pediatr Pathol 43 (2), 111-122 (2024)
   PUBMED   38213180
  REMARK    GeneRIF: Expression and Clinical Significance of CD30 and CD56 in
            Lymphoblastic Lymphoma: A Retrospective Analysis on
            Paraffin-Embedded Tissues by Immunohistochemistry.
REFERENCE   3  (bases 1 to 4643)
  AUTHORS   Yirmibes,S. and Balaban Adim,S.
  TITLE     A Comparative Study of CD56 and Smooth Muscle Actin Expression in
            Basal and Squamous Cell Carcinomas
  JOURNAL   Am J Dermatopathol 45 (12), 816-819 (2023)
   PUBMED   37982465
  REMARK    GeneRIF: A Comparative Study of CD56 and Smooth Muscle Actin
            Expression in Basal and Squamous Cell Carcinomas.
REFERENCE   4  (bases 1 to 4643)
  AUTHORS   Matejova,J., Fecskeova,L.K., Slovinska,L., Harvanova,D., Spakova,T.
            and Bzdilova,J.
  TITLE     Plasma-derived extracellular vesicle surface markers CD45, CD326
            and CD56 correlate with the stage of osteoarthritis: a primary
            study of a novel and promising diagnostic tool of the disease
  JOURNAL   Sci Rep 13 (1), 20071 (2023)
   PUBMED   37973964
  REMARK    GeneRIF: Plasma-derived extracellular vesicle surface markers CD45,
            CD326 and CD56 correlate with the stage of osteoarthritis: a
            primary study of a novel and promising diagnostic tool of the
            disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4643)
  AUTHORS   Darka Aslan,I., Sel,G., Barut,F., Baser Acikgoz,R., Balci,S.,
            Ozmen,U., Barut,A., Harma,M. and Harma,M.I.
  TITLE     Investigation of CD56, ADAM17 and FGF21 Expressions in the
            Placentas of Preeclampsia Cases
  JOURNAL   Medicina (Kaunas) 59 (6), 1145 (2023)
   PUBMED   37374349
  REMARK    GeneRIF: Investigation of CD56, ADAM17 and FGF21 Expressions in the
            Placentas of Preeclampsia Cases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4643)
  AUTHORS   Rossell,R.J., Malik,A., Helfrich,W., Kemshead,J.T. and Patel,K.
  TITLE     A discordance between the human muscle NCAM sequence and those seen
            in other NCAM cDNA clones
  JOURNAL   Biochim Biophys Acta 1130 (1), 95-96 (1992)
   PUBMED   1543753
REFERENCE   7  (bases 1 to 4643)
  AUTHORS   van Duijnhoven,H.L., Helfrich,W., de Leij,L., Roebroek,A.J., van de
            Ven,W.J., Healey,K., Culverwell,A., Rossell,R.J., Kemshead,J.T. and
            Patel,K.
  TITLE     Splicing of the VASE exon of neural cell adhesion molecule (NCAM)
            in human small-cell lung carcinoma (SCLC)
  JOURNAL   Int J Cancer 50 (1), 118-123 (1992)
   PUBMED   1339414
REFERENCE   8  (bases 1 to 4643)
  AUTHORS   Lanier,L.L., Chang,C., Azuma,M., Ruitenberg,J.J., Hemperly,J.J. and
            Phillips,J.H.
  TITLE     Molecular and functional analysis of human natural killer
            cell-associated neural cell adhesion molecule (N-CAM/CD56)
  JOURNAL   J Immunol 146 (12), 4421-4426 (1991)
   PUBMED   1710251
REFERENCE   9  (bases 1 to 4643)
  AUTHORS   Bello,M.J., Salagnon,N., Rey,J.A., Guichaoua,M.R.,
            Berge-Lefranc,J.L., Jordan,B.R. and Luciani,J.M.
  TITLE     Precise in situ localization of NCAM, ETS1, and D11S29 on human
            meiotic chromosomes
  JOURNAL   Cytogenet Cell Genet 52 (1-2), 7-10 (1989)
   PUBMED   2612216
REFERENCE   10 (bases 1 to 4643)
  AUTHORS   Dickson,G., Gower,H.J., Barton,C.H., Prentice,H.M., Elsom,V.L.,
            Moore,S.E., Cox,R.D., Quinn,C., Putt,W. and Walsh,F.S.
  TITLE     Human muscle neural cell adhesion molecule (N-CAM): identification
            of a muscle-specific sequence in the extracellular domain
  JOURNAL   Cell 50 (7), 1119-1130 (1987)
   PUBMED   2887295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FP884230.1, AP002853.4 and
            AP000880.4.
            
            Summary: This gene encodes a cell adhesion protein which is a
            member of the immunoglobulin superfamily. The encoded protein is
            involved in cell-to-cell interactions as well as cell-matrix
            interactions during development and differentiation. The encoded
            protein plays a role in the development of the nervous system by
            regulating neurogenesis, neurite outgrowth, and cell migration.
            This protein is also involved in the expansion of T lymphocytes, B
            lymphocytes and natural killer (NK) cells which play an important
            role in immune surveillance. This protein plays a role in signal
            transduction by interacting with fibroblast growth factor
            receptors, N-cadherin and other components of the extracellular
            matrix and by triggering signalling cascades involving FYN-focal
            adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and
            phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this
            gene, cell surface molecule CD56, plays a role in several
            myeloproliferative disorders such as acute myeloid leukemia and
            differential expression of this gene is associated with
            differential disease progression. For example, increased expression
            of CD56 is correlated with lower survival in acute myeloid leukemia
            patients whereas increased severity of COVID-19 is correlated with
            decreased abundance of CD56-expressing NK cells in peripheral
            blood. Alternative splicing results in multiple transcript variants
            encoding distinct protein isoforms. [provided by RefSeq, Aug 2020].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.44116.1,
                                           SRR1803616.24166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: involved in immune response or antiviral
                                   activity
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               FP884230.1         13-257
            246-320             AP002853.4         147810-147884
            321-539             AP002853.4         149717-149935
            540-683             AP002853.4         150954-151097
            684-821             AP002853.4         151474-151611
            822-939             AP002853.4         152692-152809
            940-1109            AP002853.4         153264-153433
            1110-1252           AP000880.4         2844-2986
            1253-1403           AP000880.4         20120-20270
            1404-1588           AP000880.4         20645-20829
            1589-1685           AP000880.4         21193-21289
            1686-1856           AP000880.4         21622-21792
            1857-1988           AP000880.4         23508-23639
            1989-2113           AP000880.4         44352-44476
            2114-2291           AP000880.4         48621-48798
            2292-4643           AP000880.4         51321-53672
FEATURES             Location/Qualifiers
     source          1..4643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..4643
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /note="neural cell adhesion molecule 1"
                     /db_xref="GeneID:4684"
                     /db_xref="HGNC:HGNC:7656"
                     /db_xref="MIM:116930"
     exon            1..245
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..2371
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /EC_number="2.7.11.1"
                     /note="isoform 8 precursor is encoded by transcript
                     variant 8; antigen recognized by monoclonal antibody
                     5.1H11; neural cell adhesion molecule, NCAM"
                     /codon_start=1
                     /product="neural cell adhesion molecule 1 isoform 8
                     precursor"
                     /protein_id="NP_001373220.1"
                     /db_xref="CCDS:CCDS91595.1"
                     /db_xref="GeneID:4684"
                     /db_xref="HGNC:HGNC:7656"
                     /db_xref="MIM:116930"
                     /translation="MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVA
                     GDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGED
                     GSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL
                     KKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ
                     NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKK
                     VDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD
                     PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG
                     QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY
                     SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQV
                     EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGL
                     KPETTYAVRLAALNGKGLGEISAASEFKTQPVREPSAPKLEGQMGEDGNSIKVNLIKQ
                     DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS
                     KAAHFVFRTSAQPTAIPATLGGNSASYTFVSLLFSAVTLLLLC"
     exon            246..320
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            321..539
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            540..683
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            684..821
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            822..939
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1109
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1252
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1403
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1588
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1685
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1856
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1988
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2113
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2291
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..4643
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4617..4622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /note="hexamer: ATTAAA"
     polyA_site      4643
                     /gene="NCAM1"
                     /gene_synonym="CD56; MSK39; NCAM"
                     /note="major polyA site"
ORIGIN      
        1 actcattctc cgatcagcgc gtgaacgcag ctcggctgcc gctggcagga aacaattctg
       61 caaaaataat catactcagc ctggcaattg tctgccccta ggtctgtcgc tcagccgccg
      121 tccacactcg ctgcaggggg gggggcacag aatttaccgc ggcaagaaca tccctcccag
      181 ccagcagatt acaatgctgc aaactaagga tctcatctgg actttgtttt tcctgggaac
      241 tgcagtttct ctgcaggtgg atattgttcc cagccagggg gagatcagcg ttggagagtc
      301 caaattcttc ttatgccaag tggcaggaga tgccaaagat aaagacatct cctggttctc
      361 ccccaatgga gaaaagctca ccccaaacca gcagcggatc tcagtggtgt ggaatgatga
      421 ttcctcctcc accctcacca tctataacgc caacatcgac gacgccggca tttacaagtg
      481 tgtggttaca ggcgaggatg gcagtgagtc agaggccacc gtcaacgtga agatctttca
      541 gaagctcatg ttcaagaatg cgccaacccc acaggagttc cgggaggggg aagatgccgt
      601 gattgtgtgt gatgtggtca gctccctccc accaaccatc atctggaaac acaaaggccg
      661 agatgtcatc ctgaaaaaag atgtccgatt catagtcctg tccaacaact acctgcagat
      721 ccggggcatc aagaaaacag atgagggcac ttatcgctgt gagggcagaa tcctggcacg
      781 gggggagatc aacttcaagg acattcaggt cattgtgaat gtgccaccta ccatccaggc
      841 caggcagaat attgtgaatg ccaccgccaa cctcggccag tccgtcaccc tggtgtgcga
      901 tgccgaaggc ttcccagagc ccaccatgag ctggacaaag gatggggaac agatagagca
      961 agaggaagac gatgagaagt acatcttcag cgacgatagt tcccagctga ccatcaaaaa
     1021 ggtggataag aacgacgagg ctgagtacat ctgcattgct gagaacaagg ctggcgagca
     1081 ggatgcgacc atccacctca aagtctttgc aaaacccaaa atcacatatg tagagaacca
     1141 gactgccatg gaattagagg agcaggtcac tcttacctgt gaagcctccg gagaccccat
     1201 tccctccatc acctggagga cttctacccg gaacatcagc agcgaagaaa agactctgga
     1261 tgggcacatg gtggtgcgta gccatgcccg tgtgtcgtcg ctgaccctga agagcatcca
     1321 gtacactgat gccggagagt acatctgcac cgccagcaac accatcggcc aggactccca
     1381 gtccatgtac cttgaagtgc aatatgcccc aaagctacag ggccctgtgg ctgtgtacac
     1441 ttgggagggg aaccaggtga acatcacctg cgaggtattt gcctatccca gtgccacgat
     1501 ctcatggttt cgggatggcc agctgctgcc aagctccaat tacagcaata tcaagatcta
     1561 caacaccccc tctgccagct atctggaggt gaccccagac tctgagaatg attttgggaa
     1621 ctacaactgt actgcagtga accgcattgg gcaggagtcc ttggaattca tccttgttca
     1681 agcagacacc ccctcttcac catccatcga ccaggtggag ccatactcca gcacagccca
     1741 ggtgcagttt gatgaaccag aggccacagg tggggtgccc atcctcaaat acaaagctga
     1801 gtggagagca gttggtgaag aagtatggca ttccaagtgg tatgatgcca aggaagccag
     1861 catggagggc atcgtcacca tcgtgggcct gaagcccgaa acaacgtacg ccgtaaggct
     1921 ggcggcgctc aatggcaaag ggctgggtga gatcagcgcg gcctccgagt tcaagacgca
     1981 gccagtccgg gaacccagtg cacctaagct cgaagggcag atgggagagg atggaaactc
     2041 tattaaagtg aacctgatca agcaggatga cggcggctcc cccatcagac actatctggt
     2101 caggtaccga gcgctctcct ccgagtggaa accagagatc aggctcccgt ctggcagtga
     2161 ccacgtcatg ctgaagtccc tggactggaa tgctgagtat gaggtctacg tggtggctga
     2221 gaaccagcaa ggaaaatcca aggcggctca ttttgtgttc aggacctcgg cccagcccac
     2281 agccatccca gcaaccttgg gaggcaattc tgcatcctac acctttgtct cattgctttt
     2341 ctctgcagtg actcttcttt tgctctgtta ggaacttgaa cacaaaaatt aaatttgctt
     2401 aaaagcccag ttcctatgaa aaagatcagt gccccctttg gaagaacctg gcaggaccac
     2461 catggccaca gctgctgagc aaccattctg tgtggaagag aaggttttgt gattggaaaa
     2521 agctttacct ccagacatgt caccactcac agatactttt gtgccacttc ataaggagtt
     2581 tgcccccttt ttaatggcag taaaaagaat ttgagagctc tttctttaaa tgctattttt
     2641 aaaaaccatc atgctagatt tacagagaag tttctgcata tctgctactt gttgcatttt
     2701 gggttcaaac ctaaatatga tgtagcagag gaagaattct aagtaccttc taaagcttgt
     2761 gtcagattgt taaaatcacc acacattccc ctcattctaa ctctgtgctc cttgtcctcc
     2821 cttcaataat aattggcttt gcttgcaatt aagcatttaa gtgcccatgt taaaagagcc
     2881 agaccgcact gattcacatg agcgttttgc tgacatgatg ggcaactgaa gtcacccctg
     2941 ttgcccatgc actggaaaaa aagttgaatt tgttggatat tttctggggc tgatgaacgt
     3001 tctgggatgt gctttcagtc ctcgtattac ggccagcacc ttacactgtc tctgtgaacg
     3061 gggccaagcc atgatgtgcc aacaagtgtc agctttgaaa ggtgtttgtc tcccaatcgg
     3121 ggtgactccc ctgctgcctg gcagcatgtc gcagatcagc acagagtggg gccgtggttc
     3181 agcagtgacc cacagaatgg ctttgagcat cagtctacag gacaggttgg aagcatccac
     3241 tgtgaaccag gcattagtcc cctacctggc ctgtgtgtgc tcagtagaga aggagaggga
     3301 caggccactc ccagactgcc cagcccagga gggttaataa attggggccg agccaacctg
     3361 tcagtgcttc ctgaatgccc cagcctctgt attggtgcgt tggttcagtg acattttcta
     3421 aactctcctg aaaatccagc tgctcctccc tgctgcttgg gagttcaccc aggagaggaa
     3481 atgggtgtgt tttgttaagg tcccttgtgg agactcaggg ctgaatcctg cttggtaata
     3541 tcagtgtgtg tgcttgggga tggaccttct actgaataaa aactccctcc ctccccccat
     3601 tgtggtcaca tatcattcta catatctcat ctctgagcat ctccatggaa gcttgatttt
     3661 tgttcttttt ggtttcttta tgtatttttt tctgttgtta ttatttttta atgttcaaag
     3721 actagccttt ccctttggga ttccaaatga tcccatgctg tggtctgagg ggcaaagcca
     3781 cctatgttgg cgctcgccat taatccccag cgctcagttt agaggctcac gtgcagacat
     3841 cagaggctcc atgctgcaca gtagctcagg cagggtagtg cctctcaacc cagccacaaa
     3901 actctccccg ctggagtccc agatggcgct tcacaccagg gcagtggagg caggcatggt
     3961 ttttgggcac agggcagagc ataaggatcc caggtcagtg tgggagagct actggctctt
     4021 aggatcacct tgggcagaag tcacacggct tcatcctagg agggcccagc ttgggagtct
     4081 gcctccccct gatcccagga ccacccacag gagaggggca gtgtccatct ttctgaaggg
     4141 accctttgga gatctcgtcc taagtgtgga gaggactgac gtggccctgt catctcaaca
     4201 catcccaggg tcaggcaggc ctcagctgaa acaatgtcag ggtcctcaag ggtcccattt
     4261 agacagaccc acggcttgta acagtgcgct cctcaggagg cagcactagc gcatacccac
     4321 tccccacgga cactgagttc ctggtgacag ctgcagcccc agccccgcca ggagtcctgg
     4381 agacagcagc cctcagagac cctgcaggag tgagtgcacc ccaccttgct cagccacacc
     4441 ccactcccct gtgccctgta gttgtgctgc ccatgctcca cacaccatgg ggcccctttg
     4501 ctcatttttg gactatttat acagcaggtt tggatcatgt ttttctacta ataagaatgc
     4561 taacattgtt gtgtagataa tcagtgaggg ctttatgaag tttacacctt tgcattatta
     4621 aaggaaataa cagttcatgt gaa
//
