LOCUS       NM_005899               4613 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens NBR1 autophagy cargo receptor (NBR1), transcript
            variant 1, mRNA.
ACCESSION   NM_005899 XM_001127781
VERSION     NM_005899.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4613)
  AUTHORS   Hu,S., Wang,F., Mao,L., Jiang,X., Luo,Y., Qin,X., Zou,Z., Chen,C.,
            Yu,C. and Zhang,J.
  TITLE     NBR1-mediated autophagic degradation of caspase 8 protects vascular
            endothelial cells against arsenite-induced apoptotic cell death
  JOURNAL   Biochem Biophys Res Commun 715, 150006 (2024)
   PUBMED   38678786
  REMARK    GeneRIF: NBR1-mediated autophagic degradation of caspase 8 protects
            vascular endothelial cells against arsenite-induced apoptotic cell
            death.
REFERENCE   2  (bases 1 to 4613)
  AUTHORS   Cai,Y., Zhu,Y., Zheng,J., Zhang,Y. and Chen,W.
  TITLE     NBR1 mediates autophagic degradation of IRF3 to negatively regulate
            type I interferon production
  JOURNAL   Biochem Biophys Res Commun 623, 140-147 (2022)
   PUBMED   35914352
  REMARK    GeneRIF: NBR1 mediates autophagic degradation of IRF3 to negatively
            regulate type I interferon production.
REFERENCE   3  (bases 1 to 4613)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   4  (bases 1 to 4613)
  AUTHORS   Adolphe,F., Ferlicot,S., Verkarre,V., Posseme,K., Couve,S.,
            Garnier,P., Droin,N., Deloger,M., Job,B., Giraud,S.,
            Paillerets,B.B., Gardie,B., Richard,S., Renaud,F. and Gad,S.
  TITLE     Germline mutation in the NBR1 gene involved in autophagy detected
            in a family with renal tumors
  JOURNAL   Cancer Genet 258-259, 51-56 (2021)
   PUBMED   34488032
  REMARK    GeneRIF: Germline mutation in the NBR1 gene involved in autophagy
            detected in a family with renal tumors.
REFERENCE   5  (bases 1 to 4613)
  AUTHORS   Deosaran,E., Larsen,K.B., Hua,R., Sargent,G., Wang,Y., Kim,S.,
            Lamark,T., Jauregui,M., Law,K., Lippincott-Schwartz,J., Brech,A.,
            Johansen,T. and Kim,P.K.
  TITLE     NBR1 acts as an autophagy receptor for peroxisomes
  JOURNAL   J Cell Sci 126 (Pt 4), 939-952 (2013)
   PUBMED   23239026
  REMARK    GeneRIF: results suggest that NBR1 is the specific autophagy
            receptor for pexophagy.
REFERENCE   6  (bases 1 to 4613)
  AUTHORS   Brown,M.A., Xu,C.F., Nicolai,H., Griffiths,B., Chambers,J.A.,
            Black,D. and Solomon,E.
  TITLE     The 5' end of the BRCA1 gene lies within a duplicated region of
            human chromosome 17q21
  JOURNAL   Oncogene 12 (12), 2507-2513 (1996)
   PUBMED   8700509
REFERENCE   7  (bases 1 to 4613)
  AUTHORS   Harshman,K., Bell,R., Rosenthal,J., Katcher,H., Miki,Y.,
            Swenson,J., Gholami,Z., Frye,C., Ding,W., Dayananth,P. et al.
  TITLE     Comparison of the positional cloning methods used to isolate the
            BRCA1 gene
  JOURNAL   Hum Mol Genet 4 (8), 1259-1266 (1995)
   PUBMED   7581362
REFERENCE   8  (bases 1 to 4613)
  AUTHORS   Brown,M.A., Nicolai,H., Xu,C.F., Griffiths,B.L., Jones,K.A.,
            Solomon,E., Hosking,L., Trowsdale,J., Black,D.M. and McFarlane,R.
  TITLE     Regulation of BRCA1
  JOURNAL   Nature 372 (6508), 733 (1994)
   PUBMED   7997258
REFERENCE   9  (bases 1 to 4613)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
REFERENCE   10 (bases 1 to 4613)
  AUTHORS   Campbell,I.G., Nicolai,H.M., Foulkes,W.D., Senger,G., Stamp,G.W.,
            Allan,G., Boyer,C., Jones,K., Bast,R.C. Jr. and Solomon,E.
  TITLE     A novel gene encoding a B-box protein within the BRCA1 region at
            17q21.1
  JOURNAL   Hum Mol Genet 3 (4), 589-594 (1994)
   PUBMED   8069304
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY045337.1, AY450308.1 and
            AW874218.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005899.4.
            
            Summary: The protein encoded by this gene was originally identified
            as an ovarian tumor antigen monitored in ovarian cancer. The
            encoded protein contains a B-box/coiled-coil motif, which is
            present in many genes with transformation potential. It functions
            as a specific autophagy receptor for the selective autophagic
            degradation of peroxisomes by forming intracellular inclusions with
            ubiquitylated autophagic substrates. This gene is located on a
            region of chromosome 17q21.1 that is in close proximity to the
            BRCA1 tumor suppressor gene. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Apr
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Both variants 1 and
            3 encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.220892.1,
                                           SRR1803613.101771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590996.6/ ENSP00000466667.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                HY045337.1         248-281
            35-3873             AY450308.1         1-3839
            3874-4577           AY450308.1         3841-4544
            4578-4613           AW874218.1         18-53               c
FEATURES             Location/Qualifiers
     source          1..4613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4613
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /note="NBR1 autophagy cargo receptor"
                     /db_xref="GeneID:4077"
                     /db_xref="HGNC:HGNC:6746"
                     /db_xref="MIM:166945"
     exon            1..89
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            90..200
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2999
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /note="isoform a is encoded by transcript variant 1;
                     membrane component, chromosome 17, surface marker 2
                     (ovarian carcinoma antigen CA125); next to BRCA1 gene 1
                     protein; migration-inducing protein 19; cell
                     migration-inducing gene 19 protein; B-box protein;
                     neighbor of BRCA1 gene 1"
                     /codon_start=1
                     /product="next to BRCA1 gene 1 protein isoform a"
                     /protein_id="NP_005890.2"
                     /db_xref="CCDS:CCDS45694.1"
                     /db_xref="GeneID:4077"
                     /db_xref="HGNC:HGNC:6746"
                     /db_xref="MIM:166945"
                     /translation="MEPQVTLNVTFKNEIQSFLVSDPENTTWADIEAMVKVSFDLNTI
                     QIKYLDEENEEVSINSQGEYEEALKMAVKQGNQLQMQVHEGHHVVDEAPPPVVGAKRL
                     AARAGKKPLAHYSSLVRVLGSDMKTPEDPAVQSFPLVPCDTDQPQDKPPDWFTSYLET
                     FREQVVNETVEKLEQKLHEKLVLQNPSLGSCPSEVSMPTSEETLFLPENQFSWHIACN
                     NCQRRIVGVRYQCSLCPSYNICEDCEAGPYGHDTNHVLLKLRRPVVGSSEPFCHSKYS
                     TPRLPAALEQVRLQKQVDKNFLKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNS
                     IHGLQSPKSPLGRPESLLQSNTLMLPLQPCTSVMPMLSAAFVDENLPDGTHLQPGTKF
                     IKHWRMKNTGNVKWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHVGVVSVEFIAPA
                     LEGTYTSHWRLSHKGQQFGPRVWCSIIVDPFPSEESPDNIEKGMISSSKTDDLTCQQE
                     ETFLLAKEERQLGEVTEQTEGTAACIPQKAKNVASERELYIPSVDLLTAQDLLSFELL
                     DINIVQELERVPHNTPVDVTPCMSPLPHDSPLIEKPGLGQIEEENEGAGFKALPDSMV
                     SVKRKAENIASVEEAEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQKSLQMTFALPE
                     GPLGNEKEEIIHIAEEEAVMEEEEDEEDEEEEDELKDEVQSQSSASSEDYIIILPECF
                     DTSRPLGDSMYSSALSQPGLERGAEGKPGVEAGQEPAEAGERLPGGENQPQEHSISDI
                     LTTSQTLETVPLIPEVVELPPSLPRSSPCVHHHGSPGVDLPVTIPEVSSVPDQIRGEP
                     RGSSGLVNSRQKSYDHSRHHHGSSIAGGLVKGALSVAASAYKALFAGPPVTAQPIISE
                     DQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTELLQLNNNDWYSQRY"
     exon            201..263
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            264..282
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            283..305
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            306..500
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            501..578
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            579..793
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            794..961
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1171
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1331
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1622
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1772
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1848
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1959
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2124
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2566
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2661
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2719
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2825
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..4613
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4373..4378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /note="hexamer: AATAAA"
     polyA_site      4396
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /note="major polyA site"
     regulatory      4590..4595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
                     /note="hexamer: AATAAA"
     polyA_site      4613
                     /gene="NBR1"
                     /gene_synonym="1A1-3B; IAI3B; M17S2; MIG19"
ORIGIN      
        1 agattcaccc cacagggata gcggcagagc cggtagcgga cggtccttgc attggcctcc
       61 ggcaggcgcc ccccgggggc gggaagctgc ctcacagcat ggaaccacag gttactctaa
      121 atgtgacttt taaaaatgaa attcaaagct ttctggtttc tgatccagaa aatacaactt
      181 gggctgatat cgaagctatg gtaaaagttt catttgatct gaatactatt caaataaaat
      241 acctggatga ggaaaatgaa gaggtatcca tcaacagtca aggagaatat gaagaagcgc
      301 ttaagatggc agttaaacag ggaaaccaac tgcagatgca agtccacgaa gggcaccatg
      361 tcgttgatga agccccaccc ccagttgtag gagcaaaacg actagctgcc agggcaggga
      421 agaagccact tgcacattac tcttcactgg tgagagtctt gggatcagac atgaagaccc
      481 cagaggatcc tgcagtgcag tcgtttccac ttgttccatg tgacacagac cagcctcaag
      541 acaagccccc agactggttc acaagctacc tggagacgtt cagagaacaa gtggttaacg
      601 aaacggttga gaagcttgaa cagaaattac atgaaaagct tgtcctccag aacccatcct
      661 tgggttcttg tccctcagaa gtctcaatgc ctacttcaga agaaacattg tttttgccag
      721 aaaaccagtt cagctggcat attgcttgca acaactgcca aagaaggatt gttggtgtcc
      781 gctaccagtg tagcctatgc ccatcctaca atatctgtga agattgtgaa gcagggccat
      841 atggccatga cactaaccac gtcctgctga agttgcggag acctgttgtg ggctcctctg
      901 aaccgttctg tcactcaaag tactctactc ctcgtcttcc tgctgctctg gaacaagtca
      961 ggctccagaa acaggttgat aagaactttc ttaaagcaga aaagcaaagg ttgcgagctg
     1021 agaagaaaca acgtaaagca gaggtcaagg aacttaaaaa gcagcttaaa ctccatagga
     1081 aaattcacct gtggaattca atccatggac tccagagccc caagtctcct ttaggccgac
     1141 ctgagagctt gctccagtct aataccctga tgctcccttt gcagccctgt acctccgtta
     1201 tgccaatgct cagtgcagca tttgtggatg agaatttgcc tgatgggact caccttcagc
     1261 caggaaccaa gtttatcaaa cactggagga tgaaaaatac aggaaatgta aagtggagtg
     1321 cagacacaaa gctcaagttc atgtggggaa acctgacttt ggcttccaca gaaaagaagg
     1381 atgttttggt tccctgcctc aaggccggcc atgtgggagt tgtatctgtg gagttcattg
     1441 ccccagcctt ggagggaacg tatacttccc attggcgtct ttctcacaaa ggccagcaat
     1501 ttgggcctcg ggtctggtgc agtatcatag tagatccttt cccctccgaa gagagccctg
     1561 ataacattga aaagggcatg atcagctcaa gcaaaactga tgatctcacc tgccagcaag
     1621 aggaaacttt tcttctggct aaagaagaaa gacagcttgg tgaagtgact gagcagacag
     1681 aagggacagc agcctgcatc ccacagaagg caaaaaatgt tgccagtgag agggagctct
     1741 acatcccatc tgtggatctt ctgactgccc aggacctgct gtcctttgag ctgttggata
     1801 taaacattgt tcaagagttg gagagagtgc cccacaacac ccctgtggat gtgactccct
     1861 gcatgtctcc tctgccacat gacagtcctt taatagagaa gccaggcttg gggcagatag
     1921 aggaagagaa tgaaggggca ggatttaaag cacttcctga ttctatggtg tcagtaaaga
     1981 ggaaggctga gaacattgct tctgtggagg aagcagaaga agacctgagt gggacccagt
     2041 ttgtgtgtga gacagtaatc cgatccctta ccttggatgc tgccccagac cacaaccctc
     2101 cttgcagaca gaagtccttg cagatgacat ttgccttgcc tgaaggacca cttggaaatg
     2161 agaaggagga gattatccat atcgctgagg aagaagctgt catggaggag gaggaggatg
     2221 aggaggatga ggaggaggag gatgagctca aagatgaagt tcaaagtcag tcctctgctt
     2281 cctcagagga ttacatcatc atcctgcctg agtgctttga taccagccgc cccctggggg
     2341 attctatgta cagctctgcg ctctcacagc caggcctgga gcgaggtgct gaaggcaagc
     2401 ctggggttga ggctgggcag gaaccagctg aggctgggga aagactccct ggaggggaga
     2461 accagccaca ggagcacagc ataagtgaca tcctcacgac ctcacagact ctggaaacag
     2521 tgcccctaat cccagaggta gtggagcttc caccgtcact gcccaggagc tctccttgtg
     2581 tacatcatca tggttcccca ggagtggatt taccagttac cataccagaa gtttcttcag
     2641 tccctgatca gatcagagga gagcccagag gctcatcagg acttgtaaac agcagacaga
     2701 agagctatga ccactcaagg caccatcatg ggagcagcat tgctggagga ctggtgaagg
     2761 gggctttgtc tgttgctgcc tctgcataca aggccctgtt tgctgggcca ccagtcactg
     2821 cacagccaat aatttctgaa gatcagacag cagccctgat ggcccatctc tttgaaatgg
     2881 gattctgtga caggcagctg aacctacggc tgctgaagaa acacaattac aatatcctgc
     2941 aggttgtgac agaacttctt cagttaaaca acaacgactg gtacagccaa cgctattgag
     3001 gagtgacctt gtattaaata actgcctgct gctcagagat gatctttatt ctgtcattgg
     3061 ggtatgggat agaagccctt gcttattttt aatctgatga atctgtatag agcccatcgt
     3121 tgagttacca agacaatacc tgctacagta ttttggggag caaactaaag accagaactt
     3181 aaattttcac tttagacatt ggatgaatag tatgaagaca gtttttcagt tgatttggat
     3241 aaaactattt tagtgcattg acaagtgtaa cttcaacttc atatagaacc atttttcttt
     3301 ctgcttttat tgaaactgag tatttttctt tggctaatgt ggatttttta tggggatatc
     3361 tgttaatttt caggttttga aagacattaa cctcggaagt tgtttttaag aattattctc
     3421 ataattctta ttctcataat ttctgtaatc cacctcaagc ttcatagtta tttggcattg
     3481 aaataacacc cagagcatga tagaaatgtt gttactcttc ctctctcaag gagaaagtaa
     3541 ttttcctgca atacttaata attggcaccg ttgctttcta aagactccat ggtgcattca
     3601 agagtatcca acttcaaggg aatctccgca tttcaatgaa aggaggaaga gtgtgctgat
     3661 aaacctacca gcacctattg agcaatgtct attatagtaa ttttgcatac atttttattt
     3721 aagggaaaaa atataggtat tgtgaaatat tttgctaatc ttatagaaaa ggaaaaaatc
     3781 ccgttattta aagggaaaag taaatttaac agttgccttt tttcttaatg tcagggcaga
     3841 tcttatttta cagtacagtg ggggaaatag aaacatgtga aaggcaaaag gcaggctcct
     3901 aaattaatgt cagtgaagtt cagggtgggc aaatgagtgt gtgtgaggta taggaaatgc
     3961 tgatgacttc tttaatgctt gaagtccgtt cacaggtatc tagccctaga atgcctagaa
     4021 caggaagagg cagctggtgt tctgcaaaac ttggacaggg gcaaagttgc tgaaaaagtt
     4081 ttggtttaac ccgaagataa gtggaaaaga gcttgtccat gaacccaggt tctcactctg
     4141 tttacagaag tgtgttgagt acagttggtg aaggaagagg taacaaaaaa tgctaaatat
     4201 tttatccatg aaaatgactt ccagaaaagg aagaatatga accccagacc gaaggggaaa
     4261 agatagttaa tagtattatc taacctggtt ggtatttgta atgaatggtg attttaatta
     4321 gtcattagcc ataatgatgt ttatttacag tataactcct gaatgctact taaataaacc
     4381 aggattcaaa ctgcaagcca gccaggccgt tcattattta aaacgtttta atcggggctt
     4441 ccgggtagaa ggtggagcgg cagggtgtaa ttgggttgat gggtgggacc tgtcttgacc
     4501 atcggagttt tataatcgag ggccaggagg gcccgggttg ctctcctggt tatgtatgta
     4561 cttgtacata accacctaaa gaatggtgaa ataaatgttc ttggaaattc cta
//
