LOCUS       NM_001143989            3371 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens NBPF member 4 (NBPF4), mRNA.
ACCESSION   NM_001143989 XR_040171
VERSION     NM_001143989.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3371)
  AUTHORS   Chen,W., Di,Z., Chen,Z., Nan,K., Gu,J., Ge,F., Liu,J., Zhang,H. and
            Miao,C.
  TITLE     NBPF4 mitigates progression in colorectal cancer through the
            regulation of EZH2-associated ETFA
  JOURNAL   J Cell Mol Med 25 (18), 9038-9050 (2021)
   PUBMED   34405537
  REMARK    GeneRIF: NBPF4 mitigates progression in colorectal cancer through
            the regulation of EZH2-associated ETFA.
REFERENCE   2  (bases 1 to 3371)
  AUTHORS   Vandepoele,K., Van Roy,N., Staes,K., Speleman,F. and van Roy,F.
  TITLE     A novel gene family NBPF: intricate structure generated by gene
            duplications during primate evolution
  JOURNAL   Mol Biol Evol 22 (11), 2265-2274 (2005)
   PUBMED   16079250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC402863.1, AK316438.1,
            AK057395.1 and AL359258.23.
            
            On Nov 20, 2020 this sequence version replaced NM_001143989.2.
            
            Summary: This gene is a member of the neuroblastoma breakpoint
            family (NBPF) which consists of dozens of recently duplicated genes
            primarily located in segmental duplications on human chromosome 1.
            This gene family has experienced its greatest expansion within the
            human lineage and has expanded, to a lesser extent, among primates
            in general. Members of this gene family are characterized by
            tandemly repeated copies of DUF1220 protein domains. Gene copy
            number variations in the human chromosomal region 1q21.1, where
            most DUF1220 domains are located, have been implicated in a number
            of developmental and neurogenetic diseases such as microcephaly,
            macrocephaly, autism, schizophrenia, cognitive disability,
            congenital heart disease, neuroblastoma, and congenital kidney and
            urinary tract anomalies. Altered expression of some gene family
            members is associated with several types of cancer. This gene
            family contains numerous pseudogenes. [provided by RefSeq, Mar
            2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302318.1, AK316438.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415641.8/ ENSP00000389237.2
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DC402863.1         6-14
            10-1037             AK316438.1         1-1028
            1038-2479           AK057395.1         652-2093
            2480-2494           AK316438.1         2471-2485
            2495-3371           AL359258.23        55603-56479         c
FEATURES             Location/Qualifiers
     source          1..3371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..3371
                     /gene="NBPF4"
                     /note="NBPF member 4"
                     /db_xref="GeneID:148545"
                     /db_xref="HGNC:HGNC:26550"
                     /db_xref="MIM:613994"
     exon            1..178
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            179..391
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..2130
                     /gene="NBPF4"
                     /note="neuroblastoma breakpoint family member 4"
                     /codon_start=1
                     /product="NBPF family member NBPF4"
                     /protein_id="NP_001137461.1"
                     /db_xref="CCDS:CCDS44182.1"
                     /db_xref="GeneID:148545"
                     /db_xref="HGNC:HGNC:26550"
                     /db_xref="MIM:613994"
                     /translation="MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLI
                     TQATAYSLANQLKKYKCEEYKDIIDSVLRDELQSMEKLAEKLRQAEELRQYKALVHSQ
                     AKELTQLREKLREGRDASRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVH
                     KLSPENDEDEDEDEDDKDEEVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHN
                     PSNSNQPHRSTKITFKEHEVDSALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPV
                     PPRHHDKSNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEV
                     KGQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQ
                     VSLALVDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSD
                     CHQPYSSTLSSLEDQLACSALDVASPTEAACPQGTWSGDLSHHQSEVQVSQAQLEPST
                     LVPSCLRLQLDQGFHCGNGLAQRGLSSTTCSFSANADSGNQWPFQELVLEPSLGMKNP
                     PQLEDDALEGSASNTQGRQVTGRIRASLVLILKTIRRRLPFSKWRLAFRFAGPHAESA
                     EIPNTAGRTQRMAG"
     exon            392..491
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            492..706
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..785
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            786..997
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1049
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1189
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1241
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1411
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1463
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1636
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1873
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2088
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..3371
                     /gene="NBPF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3349..3354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBPF4"
                     /note="hexamer: ATTAAA"
     polyA_site      3371
                     /gene="NBPF4"
                     /note="major polyA site"
ORIGIN      
        1 aattctgtta ttgcaactgc agaccgttac ctggtacgct ggctgctacc tccctcactc
       61 ttgtcagagt cggagctaca ggcagtgcct tcagctctga gctcaggcat cccggtccct
      121 gtttttgcgg ttaaggactc taaagtgttg tgtcgtgttc atcaactttt tctcaacttc
      181 cctggctcta cctcttctgc cacaaacgtc agcatggtgg tatctgccga ccctttgtcc
      241 agcgagaggg cagagatgaa catcctagaa atcaaccagg aattgcgctc gcagctggca
      301 gagagcaatc agcagttccg agacctcaaa gagaaattcc ttataactca agctactgcc
      361 tactccctgg ccaaccagct gaagaaatac aagtgtgaag agtacaaaga catcatagac
      421 tctgtgctga gggatgaact gcagtccatg gagaagctgg cagagaagct caggcaagct
      481 gaggagctca ggcagtataa agccctggtt cactctcagg caaaagagct gacccagtta
      541 cgggagaagt tacgggaagg gagagatgcc tcccgctggc tgaacaagca tctgaaaacc
      601 ctcctcactc ctgatgaccc tgacaagtcc cagggtcagg acctccgaga gcagctggct
      661 gaggggcaca ggctggcaga gcaccttgtt cacaagctga gcccagaaaa tgatgaagat
      721 gaagatgagg atgaagacga caaagacgag gaggttgaga aagtacagga atcacctgcc
      781 cccagagagg tgcagaagac tgaagaaaag gaagtccctc aggactcact ggaggaatgt
      841 gctgtcactt gttcaaatag tcacaaccct tctaactcca accagcctca caggagcacc
      901 aaaatcacat ttaaggaaca cgaagtcgac tctgctctgg ttgtagagag tgaacaccct
      961 catgatgaag aggaggaagc tctaaacatt cccccagaaa atcaaaatga ccatgaggag
     1021 gaggagggga aagcgccagt gccccccaga caccatgaca agtccaactc ttaccggcat
     1081 cgtgaagtct ctttcttggc attggatgaa cagaaagttt gctccgctca ggatgttgcc
     1141 agggattact ccaatcccaa atgggatgaa acctcacttg gcttcctcga aaagcaaagt
     1201 gatcttgaag aggtgaaagg acaagaaaca gttgctccca ggctcagcag gggaccgctg
     1261 agagtggaca agcatgaaat cccccaggag tcactggatg gatgttgctt gactccttcc
     1321 atccttcctg acctgactcc ctcctaccac ccttattgga gcactttgta ctcttttgaa
     1381 gacaagcaag tcagcttggc tcttgtagac aaaattaaaa aggatcaaga ggagatagaa
     1441 gaccaaagcc caccatgccc caggctcagc caggagctgc cagaggtgaa ggagcaggaa
     1501 gtcccagagg actctgtgaa tgaagtttac ttgactccct cagttcacca tgacgtgtct
     1561 gactgccacc agccttatag cagcaccttg tcctcattgg aggatcagct tgcctgctct
     1621 gctctggatg tagcctcccc caccgaggcg gcctgtcccc aagggacttg gagtggagac
     1681 ttgagccacc accagtcaga ggtgcaagtt tcacaggcac agctggaacc aagcaccctg
     1741 gtgcccagtt gtctgcgact acagctggat caagggttcc actgtgggaa cggcttggcc
     1801 cagcggggcc tttcctccac cacctgcagc ttctcagcca atgctgattc tgggaaccaa
     1861 tggcccttcc aagagctggt tttagagccc tctctgggga tgaagaaccc tccccagctg
     1921 gaagatgatg cacttgaagg ctcagcaagc aacacacaag ggcgtcaagt cactggccgg
     1981 attcgtgcct cccttgtcct gatactgaag accatcagaa gaagactccc gttcagcaag
     2041 tggagactgg cattcagatt cgctggcccg catgctgaga gcgcagagat accaaatact
     2101 gctggaagga cgcaaaggat ggcaggatga aagaatgtca caaaaagcag cttttccact
     2161 tgataaaaac aactaaaaca gcaaagcaag tttaagtcca aacacaatac tgcaggggtc
     2221 cttcactgag gattgaattt cagacacaga atactcttga tgacttcaag ccactatgct
     2281 cctttgattt gagaagccac attccatccc cctccaattg tgatcaatac ctagggagac
     2341 caatgcccag atggacaaat agcattgacc ggcgttagcc ctgtttctca attcccatcg
     2401 tgtagagaac aggagtccgc agctgctggc aggagacagc atgtcagccg ggactctgcc
     2461 agggcagagt atgagcaatg ccatgttctt gctgaaaacg cttagcctga gtttcatagg
     2521 cggtaaccct cagataactg cagaatgtag aacattgaac aggacaactg acctgtctcc
     2581 ttcaaacagt ccatgtcacc accaagaaca caacaaaaag gagaagagac attttgagtt
     2641 caaaaagagt aaaaagccta tgcagcttat gcttttttag tcattttgaa cccaaaacat
     2701 ctcctcatct ttttgttgtt gtcattgatg gtggtgacat ggacttgttt gtggaggaca
     2761 ggtcagctgt ctggctcaat ggtctacatt ctgaagttat ctgaaaatgt cgtcatgatt
     2821 aaattcagcc taaacatttt gccaggaact ctgcagagtc catgctgtga gcttcctacc
     2881 tcagcccatc tgcaggcaga gaaggcccag tgtgtccatc cccagtgcgg tgatactagg
     2941 atggtcactt ggttaaggag gggtctagga gctctgtccc ttgtaaagac atcttatttg
     3001 taagtaattt ggaaagtggt ttgaaatagt ataaatatcc tgtattctag tgatcttctt
     3061 cagaacattt tatcaccaat taatcacccc gtctgtgtca gttattatat ttaagtttgt
     3121 acattgaaaa ttgtctatct caaaatctta ccttatactt gcttttgctg gcattctttg
     3181 taaaaaagat cattccctgc ccaaatttta actttcatcc aaaattaatt ttaatttctt
     3241 tttgctggca ttctgttgtg aaaaagaata ttctctgccc caattataac tttcatccaa
     3301 aattaatttt agtccatcag ttaaaatttt aaattttaaa tctgtttaat taaaacattt
     3361 cttgcctctc a
//
