LOCUS       NM_001405520            6891 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens NBPF member 26 (NBPF26), transcript variant 1, mRNA.
ACCESSION   NM_001405520
VERSION     NM_001405520.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6891)
  AUTHORS   Wang,K., Li,Y., Wang,J., Chen,R. and Li,J.
  TITLE     A novel 12-gene signature as independent prognostic model in stage
            IA and IB lung squamous cell carcinoma patients
  JOURNAL   Clin Transl Oncol 23 (11), 2368-2381 (2021)
   PUBMED   34028782
REFERENCE   2  (bases 1 to 6891)
  AUTHORS   Sikela,J.M. and van Roy,F.
  TITLE     Changing the name of the NBPF/DUF1220 domain to the Olduvai domain
  JOURNAL   F1000Res 6, 2185 (2017)
   PUBMED   29399325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6891)
  AUTHORS   Astling,D.P., Heft,I.E., Jones,K.L. and Sikela,J.M.
  TITLE     High resolution measurement of DUF1220 domain copy number from
            whole genome sequence data
  JOURNAL   BMC Genomics 18 (1), 614 (2017)
   PUBMED   28807002
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6891)
  AUTHORS   O'Bleness,M., Searles,V.B., Dickens,C.M., Astling,D., Albracht,D.,
            Mak,A.C., Lai,Y.Y., Lin,C., Chu,C., Graves,T., Kwok,P.Y.,
            Wilson,R.K. and Sikela,J.M.
  TITLE     Finished sequence and assembly of the DUF1220-rich 1q21 region
            using a haploid human genome
  JOURNAL   BMC Genomics 15 (1), 387 (2014)
   PUBMED   24885025
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6891)
  AUTHORS   Zhou,F., Xing,Y., Xu,X., Yang,Y., Zhang,J., Ma,Z. and Wang,J.
  TITLE     NBPF is a potential DNA-binding transcription factor that is
            directly regulated by NF-kappaB
  JOURNAL   Int J Biochem Cell Biol 45 (11), 2479-2490 (2013)
   PUBMED   23939288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC247039.2 and AC253572.3.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC247039.2         5940-6245           c
            307-388             AC253572.3         63963-64044
            389-648             AC253572.3         85309-85568
            649-984             AC253572.3         93496-93831
            985-1194            AC253572.3         105891-106100
            1195-1297           AC253572.3         107942-108044
            1298-1512           AC253572.3         108880-109094
            1513-1585           AC253572.3         110146-110218
            1586-1797           AC253572.3         110682-110893
            1798-2007           AC253572.3         112221-112430
            2008-2110           AC253572.3         114226-114328
            2111-2325           AC253572.3         115164-115378
            2326-2398           AC253572.3         116420-116492
            2399-2604           AC253572.3         116957-117162
            2605-2656           AC253572.3         118458-118509
            2657-2820           AC253572.3         122439-122602
            2821-2872           AC253572.3         123644-123695
            2873-3045           AC253572.3         124309-124481
            3046-3097           AC253572.3         125201-125252
            3098-3270           AC253572.3         125849-126021
            3271-3322           AC253572.3         126741-126792
            3323-3495           AC253572.3         127389-127561
            3496-3547           AC253572.3         128281-128332
            3548-3720           AC253572.3         130751-130923
            3721-3772           AC253572.3         131633-131684
            3773-3945           AC253572.3         132323-132495
            3946-4054           AC253572.3         133210-133318
            4055-4227           AC253572.3         133938-134110
            4228-4279           AC253572.3         134830-134881
            4280-4452           AC253572.3         134965-135137
            4453-4504           AC253572.3         136852-136903
            4505-4677           AC253572.3         137504-137676
            4678-4729           AC253572.3         138386-138437
            4730-4902           AC253572.3         139080-139252
            4903-5011           AC253572.3         139967-140075
            5012-6891           AC253572.3         140685-142564
FEATURES             Location/Qualifiers
     source          1..6891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p11.2"
     gene            1..6891
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /note="NBPF member 26"
                     /db_xref="GeneID:101060684"
                     /db_xref="HGNC:HGNC:49571"
     exon            1..306
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..5255
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neuroblastoma breakpoint family member 26;
                     NOTCH2NL-related"
                     /codon_start=1
                     /product="neuroblastoma breakpoint family member 26
                     isoform 1 precursor"
                     /protein_id="NP_001392449.1"
                     /db_xref="GeneID:101060684"
                     /db_xref="HGNC:HGNC:49571"
                     /translation="MPALRPALLWALLALWLCWAAPAHALQCRDGYEPCVNKGMCVTY
                     HSGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ
                     YSTPHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHLCANGSTCT
                     TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC
                     DRLYVPCAHSPCVNGGTCRQTGDFTFECNCLPVPDSTSSATNVSMVVSAGHWSSEKAE
                     MNILEINETLRPQLPENKQQLRNLKEKCFLTQLAGFLANRQKKYKYEECKDLIKFMLR
                     NERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLREGRDASRSLNEHLQAL
                     LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAP
                     REVQKTEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRES
                     SHDECQDALNILPVPGPTSSATNVSMVVSAGPLSGEKAAINILEINEKLRPQLAEKKQ
                     QFRNLKEKCFLTQLAGFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEE
                     LRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
                     EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEEC
                     AITCSNSHGPYDCNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEE
                     EEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYKSYSSTFHSLEEQQVC
                     MAVDIGRHRWDQVKKEDHEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDS
                     CQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSGELLDEKEPEVLQES
                     LDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPR
                     LSGELLDEKEPEVLQESLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDE
                     IEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSA
                     VYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYST
                     PSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK
                     EGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILE
                     QQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCL
                     EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKYQEVEEDQDPSCPRLSRELLDEKEPE
                     VLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQG
                     PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFS
                     LDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNSMLMEVEEPEVLQDS
                     LDICYSTPSMYFELPDSFQHYRSVFYSFEEEHISFALYVDNRFFTLTVTSLHLVFQMG
                     VIFPQ"
     exon            307..388
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            389..648
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            649..984
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1194
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1297
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1512
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1585
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1797
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..2007
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2110
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2325
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2398
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2604
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2656
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2820
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2872
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3045
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3097
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3270
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3322
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3495
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3547
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..3720
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3772
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3945
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4054
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4227
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4279
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            4280..4452
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            4453..4504
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4677
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            4678..4729
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            4730..4902
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            4903..5011
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..6891
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6753..6758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /note="hexamer: ATTAAA"
     polyA_site      6772
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /note="major polyA site"
     regulatory      6857..6862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
                     /note="hexamer: AATAAA"
     polyA_site      6891
                     /gene="NBPF26"
                     /gene_synonym="NOTCH2NLR"
ORIGIN      
        1 agccaaactt ccggcggcgg ctgaggcggc ggccgaggag cggcggactc ggggcgcggg
       61 gagtcgaggc atttgcacct gggcttcgga gcgtagcgcc agggcctgag cctttgaagc
      121 aggaggaggg gaggagagag tggggctcct ctatcgggac cccctcccca tgtggatctg
      181 cccaggcggc ggcggcggcg gcggcggagg aggaggagga ggcgaccgag aagatgcccg
      241 ccctgcgtcc cgctctgctg tgggcgctgc tggcgctctg gctgtgctgg gcggcccccg
      301 cgcatgcatt gcagtgtcga gatggctatg aaccctgtgt aaataaagga atgtgtgtta
      361 cctaccacag tggcacagga tactgcaaat gtccagaagg cttcttgggg gaatattgtc
      421 aacatcgaga cccctgtgag aagaaccgct gccagaatgg tgggacttgt gtggcccagg
      481 ccatgctggg gaaagccacg tgccggtgtg cctcagggtt tacaggagag gactgccagt
      541 actcgacacc tcatccatgc tttgtgtctc gaccttgcct gaatggcggc acatgccata
      601 tgctcagccg ggatacctat gagtgcacct gtcaagtcgg gtttacaggt aaggagtgcc
      661 aatggaccga tgcctgcctg tctcatctct gtgcaaatgg aagtacctgt accactgtgg
      721 ccaaccagtt ctcctgcaaa tgcctcacag gcttcacagg gcagaagtgt gagactgatg
      781 tcaatgagtg tgacattcca ggacactgcc agcatggtgg cacctgcctc aacctgcctg
      841 gttcctacca gtgccagtgc cttcagggct tcacaggcca gtactgtgac agactgtatg
      901 tgccctgtgc acactcgcct tgtgtcaatg gaggcacctg tcggcagact ggtgacttca
      961 cttttgagtg caactgcctt ccagtccctg actccacctc ttctgccaca aacgtcagca
     1021 tggtggtatc agccggccat tggtccagtg agaaggcaga gatgaacatt ctagaaatca
     1081 acgagacatt gcgcccccag ctgccagaga acaaacagca gttgagaaac ctcaaagaga
     1141 aatgttttct aactcaactg gccggcttcc tggccaaccg acagaagaaa tacaagtatg
     1201 aagagtgtaa agacctcata aaatttatgc tgaggaatga gcgacagttc aaggaggaga
     1261 agcttgcaga gcagctcaag caagctgagg agctcaggca atataaagtc ctggttcact
     1321 ctcaggaacg agagctgacg cagttaaagg agaagttacg ggaagggaga gatgcctccc
     1381 gctcattgaa tgagcatctc caggccctcc tcactccgga tgagccggac aagtcccagg
     1441 ggcaggacct ccaagaacag ctggctgagg ggtgtagact ggcacagcac cttgtccaaa
     1501 agctcagccc agaaaatgac gaagatgagg atgaagatgt tcaagttgag gaggatgaga
     1561 aagtactgga atcatctgcc cccagggagg tgcagaagac tgaagagagc aaagtccctg
     1621 aggactcact ggaggaatgt gccatcactt gttcaaatag ccacggccct tgtgactcca
     1681 accagcctca caagaacatc aaaatcacat ttgaggaaga cgaagtcaac tcaactctgg
     1741 ttgtagacag agaatcctct catgatgaat gtcaggatgc tctaaacatt ctcccagtcc
     1801 ctggccccac ctcttctgcc acaaacgtca gcatggtggt atcagccggc cctttgtccg
     1861 gcgagaaggc agcgataaac attctagaaa tcaatgagaa attgcgcccc cagctggcag
     1921 agaagaaaca gcagttcaga aacctcaaag agaaatgttt tctaactcaa ctggccggct
     1981 tcctggccaa ccagcagaac aaatacaaat atgaagagtg caaagatctc ataaaatcta
     2041 tgctgaggaa tgagcgacag ttcaaggagg agaagcttgc agagcagctc aagcaagctg
     2101 aggagctcag gcaatataaa gtcctggttc acgctcagga acgagagctg acccagttaa
     2161 gggagaagtt gcgggaaggg agagatgcct cccgctcatt gaatgagcat ctccaggccc
     2221 tcctcactcc ggatgagccg gacaagtccc aggggcagga cctccaagaa cagctggctg
     2281 aggggtgtag actggcacag caccttgtcc aaaagctcag cccagaaaat gacaacgatg
     2341 acgatgaaga tgttcaagtt gaggtggctg agaaagtgca gaaatcgtct gcccccaggg
     2401 agatgcagaa ggctgaagaa aaggaagtcc ctgaggactc actggaggaa tgtgccatca
     2461 cttgttcaaa tagccatggc ccttatgact gcaaccagcc acataggaaa accaaaatca
     2521 catttgagga agacaaagtc gactcaactc tcattggctc atcctctcat gttgaatggg
     2581 aggatgctgt acacattatt ccagaaaatg aaagtgatga tgaggaagag gaagaaaaag
     2641 gaccagtgtc tcccaggaat ctgcaggagt ctgaagagga ggaagtcccc caggagtcct
     2701 gggatgaagg ttattcgact ctctcaattc ctcctgaaat gttagcctcg tacaagtctt
     2761 acagcagcac atttcactca ttagaggaac agcaagtctg catggctgtt gacataggca
     2821 gacatcggtg ggatcaagtg aaaaaggagg accacgaggc aacaggtccc aggctcagca
     2881 gagagctgct ggatgagaaa gggcctgaag tcttgcagga ctcactggat agatgttatt
     2941 caactccttc aggttgtctt gaactgactg actcatgcca gccctacaga agtgcctttt
     3001 acgtattgga gcaacagcgt gttggcttgg ctgttgacat ggatgaaatt gaaaagtacc
     3061 aagaagtgga agaagaccaa gacccatcat gccccaggct cagcggggag ctgttggatg
     3121 agaaagagcc tgaagtcttg caggagtcac tggatagatg ctattcaact ccttcaggtt
     3181 gtcttgaact gactgactca tgccagccct acagaagtgc cttttacata ttggagcaac
     3241 agcgtgttgg cttggctgtt gacatggatg aaattgaaaa gtaccaagaa gtggaagaag
     3301 accaagaccc atcatgcccc aggctcagcg gggagctgtt ggatgagaaa gagcctgaag
     3361 tcttgcagga gtcactggat agatgctatt caactccttc aggttgtctt gaactgactg
     3421 actcatgcca gccctacaga agtgcctttt acatattgga gcaacagcgt gttggcttgg
     3481 ctgttgacat ggatgaaatt gaaaagtacc aagaagtgga agaagaccaa gacccatcat
     3541 gccccaggct cagcagggag ctgctggatg agaaagagcc tgaagtcttg caggactcac
     3601 tgggtagatg ttattcgact ccttcaggtt atcttgaact gcctgactta ggccagccct
     3661 acagcagtgc tgtttactca ttggaggaac agtaccttgg cttggctctt gacgtggaca
     3721 gaattaaaaa ggaccaagaa gaggaagaag accaaggccc accatgcccc aggctcagca
     3781 gggagctgct ggaggtagta gagcctgaag tcttgcagga ctcactggat agatgttatt
     3841 caactccttc cagttgtctt gaacagcctg actcctgcca gccctatgga agttcctttt
     3901 atgcattgga ggaaaaacat gttggctttt ctcttgacgt gggagaaatt gaaaagaagg
     3961 ggaaggggaa gaaaagaagg ggaagaagat caaagaagga aagaagaagg ggaagaaaag
     4021 aaggggaaga agatcaaaac ccaccatgcc ccaggctcag cagggagctg ctggatgaga
     4081 aagggcctga agtcttgcag gactcactgg atagatgtta ttcaactcct tcaggttgtc
     4141 ttgaactgac tgactcatgc cagccctaca gaagtgcctt ttacatattg gagcaacagc
     4201 gtgttggctt ggctgttgac atggatgaaa ttgaaaagta ccaagaagtg gaagaagacc
     4261 aagacccatc atgccccagg ctcagcaggg agctgctgga ggtagtagag cctgaagtct
     4321 tgcaggactc actggataga tgttattcaa ctccttccag ttgtcttgaa cagcctgact
     4381 cctgccagcc ctatggaagt tccttttatg cattggagga aaaacatgtt ggcttttctc
     4441 ttgacgtggg agaaattgaa aagtaccaag aagtggaaga agaccaagac ccatcatgcc
     4501 ccaggctcag cagggagctg ctggatgaga aagagcctga agtcttgcag gactcactgg
     4561 gtagatgtta ttcgactcct tcaggttatc ttgaactgcc tgacttaggc cagccctaca
     4621 gcagtgctgt ttactcattg gaggaacagt accttggctt ggctcttgac gtggacagaa
     4681 ttaaaaagga ccaagaagag gaagaagacc aaggcccacc atgccccagg ctcagcaggg
     4741 agctgctgga ggtagtagag cctgaagtct tgcaggactc actggataga tgttattcaa
     4801 ctccttccag ttgtcttgaa cagcctgact cctgccagcc ctatggaagt tccttttatg
     4861 cattggagga aaaacatgtt ggcttttctc ttgacgtggg agaaattgaa aagaagggga
     4921 aggggaagaa aagaagggga agaagatcaa agaaggaaag aagaagggga agaaaagaag
     4981 gggaagaaga tcaaaaccca ccatgcccca ggctcaacag catgctgatg gaagtggaag
     5041 agcctgaagt cttgcaggac tcactggata tatgttattc gactccgtca atgtactttg
     5101 aactacctga ctcattccag cactacagaa gtgtgtttta ctcatttgag gaagagcata
     5161 tcagcttcgc cctttacgtg gacaataggt tttttacttt gacggtgaca agtctccacc
     5221 tggtgttcca gatgggagtc atattcccac aataagcagc ccttactaag ccgagaggtg
     5281 tcattcctgc aggcaggacc tataggcacg tgaagatttg aatgaaagta cagttccatt
     5341 tggaagccca gacataggat ggttcagtgg gcatggctct attcctattc tcaaaccatg
     5401 ccagtggcaa cctgtgctca gtctgaagac aatggaccca cgttaggtgt gacacgttca
     5461 cataactgtg cagcacatgc cgggagtgat cagtcagaca ttttaatttg aaccacgtat
     5521 ctctgggtag ctacaaaatt cctcagggat gtcattttgc aggcatgtct ctgagcttct
     5581 atacctgctc aaggtcattg tcatctttgt gtttagctca tccaaaggtg ttaccctggt
     5641 ttcaatgaac ctaacctcat tctttgtgtc ttcagtgttg gcttgtttta gctgatccat
     5701 ctgtaacaca ggagggatcc ttggctgagg attgtatttc agaaccacca actgctcttg
     5761 acaattgtta acccgctagg ctcctttggt tagagaagcc acagtccttc agcctccaat
     5821 tggtgtcagt acttaggaag accacagcta gatggacaaa cagcattggg aggccttagc
     5881 cctgctcctc tcaattccat cctgtagaga acaggagtca ggagccgctg gcaggagaca
     5941 gcatgtcacc caggactctg ccggtgcaga atatgagcaa tgccatgttc ttgcagaaaa
     6001 cgcttaacct gagtttcata ggaggtaatc accagacaac tgcagaatgt agaacactga
     6061 gcaggacaac tgacctgtct ccttcacata gtccatatca ccacaaatca cacaacaaaa
     6121 aggagaagag atattttcgg ttgaaaaaaa gtaaaaagat aatgtagctg catttcttta
     6181 gttattttga accccaaata tttcctcatc tttttgttgt tgtcatggat ggtggtgaca
     6241 tggacttgtt tatagaggac aggtcagctg tctggctcaa tgatctacat tctgaagttg
     6301 tctgaaaatg tcttcatgat taaattcagc ctaaacgttt tgccgggaac actgcagaga
     6361 caatgctgtg agtttccaac ctcagcccat ctgcgggcag agaaggtcta gtttgtccat
     6421 caccattatg atatcaggac tggttacttg gttaaggagg ggtctaggag atctgtccct
     6481 tttagagaca ccttacttat aatgaagtac ttgggaaagc agttttcaag agtataaata
     6541 tcctgtattc taatgatcat cctctaaaca ttttatcatt tattaatcct ccctgcctgt
     6601 gtctattatt atattcatat ctctacactg caaattttgg gtctcaattt ttactgtgcc
     6661 tttgttttta ctagtgtctg ctgttgcaaa aagaagaaaa cattctctgc ctgagtttta
     6721 atttttgtcc aaagttaatt ttaatctata caattaaaac cttttgctat cactctggac
     6781 ttttggattg ttttttacat tcagtgttat aatatttgat tatgctgatt ggttttggtg
     6841 ggtactgatg cgaattaata aaaacatttc atttccatgt ttattttcta a
//
