LOCUS       NM_001385438            4288 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens NBPF member 15 (NBPF15), transcript variant 44, mRNA.
ACCESSION   NM_001385438
VERSION     NM_001385438.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4288)
  AUTHORS   Wu,H., Zhai,L.T., Guo,X.X., Rety,S. and Xi,X.G.
  TITLE     The N-terminal of NBPF15 causes multiple types of aggregates and
            mediates phase transition
  JOURNAL   Biochem J 477 (2), 445-458 (2020)
   PUBMED   31808794
  REMARK    GeneRIF: We suggest that the entanglements between the mosaic
            disorder-ordered segments in NBPF15 N terminus have triggered the
            multiple types of aggregates and phase transition of NBPF15
            proteins, which could be associated with Olduvai-related cognitive
            dysfunction diseases
REFERENCE   2  (bases 1 to 4288)
  AUTHORS   O'Bleness,M.S., Dickens,C.M., Dumas,L.J., Kehrer-Sawatzki,H.,
            Wyckoff,G.J. and Sikela,J.M.
  TITLE     Evolutionary history and genome organization of DUF1220 protein
            domains
  JOURNAL   G3 (Bethesda) 2 (9), 977-986 (2012)
   PUBMED   22973535
REFERENCE   3  (bases 1 to 4288)
  AUTHORS   Vandepoele,K., Van Roy,N., Staes,K., Speleman,F. and van Roy,F.
  TITLE     A novel gene family NBPF: intricate structure generated by gene
            duplications during primate evolution
  JOURNAL   Mol Biol Evol 22 (11), 2265-2274 (2005)
   PUBMED   16079250
REFERENCE   4  (bases 1 to 4288)
  AUTHORS   Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
            Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
            Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
            Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
            Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
  TITLE     Human ORFeome version 1.1: a platform for reverse proteomics
  JOURNAL   Genome Res 14 (10B), 2128-2135 (2004)
   PUBMED   15489335
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC246785.2.
            
            Summary: This gene is a member of the neuroblastoma breakpoint
            family (NBPF) which consists of dozens of recently duplicated genes
            primarily located in segmental duplications on human chromosome 1.
            This gene family has experienced its greatest expansion within the
            human lineage and has expanded, to a lesser extent, among primates
            in general. Members of this gene family are characterized by
            tandemly repeated copies of DUF1220 protein domains. Gene copy
            number variations in the human chromosomal region 1q21.1, where
            most DUF1220 domains are located, have been implicated in a number
            of developmental and neurogenetic diseases such as microcephaly,
            macrocephaly, autism, schizophrenia, cognitive disability,
            congenital heart disease, neuroblastoma, and congenital kidney and
            urinary tract anomalies. Altered expression of some gene family
            members is associated with several types of cancer. This gene
            family contains numerous pseudogenes. [provided by RefSeq, May
            2013].
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038194.2932899.1,
                                    SRR14038191.2384672.1 [ECO:0000331]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC246785.2         188544-188832       c
            290-320             AC246785.2         177935-177965       c
            321-462             AC246785.2         175938-176079       c
            463-617             AC246785.2         167304-167458       c
            618-827             AC246785.2         166992-167201       c
            828-930             AC246785.2         165108-165210       c
            931-1145            AC246785.2         164058-164272       c
            1146-1218           AC246785.2         162944-163016       c
            1219-1424           AC246785.2         162274-162479       c
            1425-1476           AC246785.2         160936-160987       c
            1477-1640           AC246785.2         156863-157026       c
            1641-1692           AC246785.2         155769-155820       c
            1693-1865           AC246785.2         154981-155153       c
            1866-1917           AC246785.2         154210-154261       c
            1918-2090           AC246785.2         153441-153613       c
            2091-2142           AC246785.2         152680-152731       c
            2143-2315           AC246785.2         151853-152025       c
            2316-2421           AC246785.2         151033-151138       c
            2422-4288           AC246785.2         148553-150419       c
FEATURES             Location/Qualifiers
     source          1..4288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..4288
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /note="NBPF member 15"
                     /db_xref="GeneID:284565"
                     /db_xref="HGNC:HGNC:28791"
                     /db_xref="MIM:610414"
     exon            1..289
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            290..320
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            321..462
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            463..617
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            618..827
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     CDS             653..2665
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /note="isoform 1 is encoded by transcript variant 44;
                     neuroblastoma breakpoint family, member 16; neuroblastoma
                     breakpoint family member 15; NBPF family member NBPF15"
                     /codon_start=1
                     /product="NBPF family member NBPF15 isoform 1"
                     /protein_id="NP_001372367.1"
                     /db_xref="CCDS:CCDS72852.1"
                     /db_xref="GeneID:284565"
                     /db_xref="HGNC:HGNC:28791"
                     /db_xref="MIM:610414"
                     /translation="MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFL
                     TQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQ
                     ERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQ
                     KLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPY
                     DSNQPHKKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRN
                     LQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWD
                     QVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVL
                     EQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDY
                     LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEP
                     EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRR
                     GRRSKKKRRRGRKEGEDDNPPCPRLYGVLMEVEEPEVLQDSLDRCYSTPSMYFEQPDS
                     FQHYRSVFYSFEEEHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ"
     exon            828..930
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1145
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1218
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1424
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1476
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1640
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1692
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1865
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1917
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2090
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2142
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2315
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2421
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..4288
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctctcct gacgcgccgg gcgggaccct gaggagccag ctggcgcagg ctatgggctg
       61 ggcggcggtt gagacagcgg cggtatcggg aggggtaggt gagggtcgcg aggctgcgtg
      121 agcatctgag tgaacgcggt gcttttggga acgcgggacg ggcgacctgt ggcgccagga
      181 gcgggccgag gcgtggcgca cggatgccgt ctggatggga agttacggtt tacagcgaag
      241 tccacccagc gtttccgagg tgaaggcgcc gcgccaggcc gggcgggcgg tggcaagggc
      301 tctggaacag ccacataaag cccttgaaga taaggatggt caaacaaaat aatatcatac
      361 ctggagaaac tcagatcttg gtaagattta ctggttggga atccaaagtt aatgccaaga
      421 agcagccgcc agttgggatc aaatgtgagc ctatggatca agacggttac ctggcacgct
      481 ggccacaatc tacctcactc ttatcagagt ctgcgctact gacagtgctt tcagctctga
      541 gttgaggcac ctcgaacctt gtttttgtgg tgaaggatcc taaagtgctg tggggagtga
      601 tcacattttt gacaacatcc ctgactccac ctcttctgcc acaaacgtca gcatggtggt
      661 atcagccggc cctttgtcca gcgagaaggc agagatgaac attctagaaa tcaatgagaa
      721 attgcgcccc cagttggcag agaagaaaca gcagttcaga aacctcaaag agaaatgttt
      781 tctaactcaa ctggccggct tcctggccaa ccgacagaag aaatacaaat atgaagagtg
      841 caaagatctc ataaaattta tgctgaggaa tgagcgacag ttcaaggagg agaagcttgc
      901 agagcagctc aagcaagctg aggagctcag gcaatataaa gtcctggttc acgctcagga
      961 acgagagctg acccagttaa gggagaagtt acgggaaggg agagatgcct cccgctcatt
     1021 gaatgagcat ctccaggccc tcctcactcc ggatgagccg gacaagtccc aggggcagga
     1081 cctccaagaa cagctggctg aggggtgtag actgacacag caccttgtcc aaaagctcag
     1141 cccagaaaat gacaacgatg acgatgaaga tgttcaagtt gaggtggctg agaaagtgca
     1201 gaaatcgtct gcccccaggg agatgcagaa ggctgaagaa aaggaagtcc ctgaggactc
     1261 actggaggaa tgtgccatca cttgttcaaa tagccatggc ccttatgact ccaaccagcc
     1321 acataagaaa accaaaatca catttgagga agacaaagtc gactcaactc tcattggctc
     1381 atcctctcat gttgaatggg aggatgctgt acacattatt ccagaaaatg aaagtgatga
     1441 tgaggaagag gaagaaaaag ggccagtgtc tcccaggaat ctgcaggagt ctgaagagga
     1501 ggaagtcccc caggagtcct gggatgaagg ttattcgact ctctcaattc ctcctgaaat
     1561 gttggcctcg taccagtctt acagcagcac atttcactca ttagaggaac agcaagtctg
     1621 catggctgtt gacataggca gacatcggtg ggatcaagtg aaaaaggagg accaagaggc
     1681 aacaggtccc aggctcagca gggagctgct ggatgagaaa gagcctgaag tcttgcagga
     1741 ctcactggat agatgttatt caactccttc aggttgtctt gaactgactg actcatgcca
     1801 gccctacaga agtgcctttt acgtattgga gcaacagcgt gttggcttgg ctattgacat
     1861 ggatgaaatt gaaaagtacc aagaagtgga agaagaccaa gacccatcat gccccaggct
     1921 cagcagggag ctgctggatg agaaagagcc tgaagtcttg caggactcac tggatagatg
     1981 ttattcgact ccttcagatt atcttgaact gcctgactta ggccagccct acagcagtgc
     2041 tgtttactca ttggaggaac agtaccttgg cttggctctt gacgtggaca gaattaaaaa
     2101 ggaccaagaa gaggaagaag accaaggccc accatgcccc aggctcagca gggagctgct
     2161 ggaggtagta gagcctgaag tcttgcagga ctcactggat agatgttatt caactccttc
     2221 cagttgtctt gaacagcctg actcctgcca gccctatgga agttcctttt atgcattgga
     2281 ggaaaaacat gttggctttt ctcttgacgt gggagaaatt gaaaagaagg ggaaggggaa
     2341 gaaaagaagg ggaagaagat caaagaagaa aagaagaagg ggaagaaaag aaggggaaga
     2401 tgacaaccca ccatgcccca ggctctacgg cgtgctgatg gaagtggaag agcctgaagt
     2461 cttacaggac tcactggata gatgttattc gactccgtca atgtactttg aacaacctga
     2521 ctcattccag cactacagaa gtgtgtttta ctcatttgag gaagagcata tcagcttcgc
     2581 cctttacgtg gacaataggt tttttacttt gacggtgaca agtctccacc tggtgttcca
     2641 gatgggagtc atattcccac aataagcagc tcttactaag ccgagagatg tcattcctgc
     2701 aggcaggacc tataggcacg agaagatttg aatgaaagta cagttccatt tggaagccca
     2761 gacataggat gggtcagtga gcatggctct attcctattc tcaaaccatg ccattggcaa
     2821 cctgtgctca atctgaagac aatggaccca tgttaggtgt gacacgttca cataactgtg
     2881 cagaacatgc cgggagtgat cagtcagaca ttttaatttg aaccacgtat ctctgggtag
     2941 ctacaaaatt cctcagggat ttcattttgc aggcatgtct ctgagcttct atacctgctc
     3001 aaggtcattg tcatctttgt gtttagctca tccaaaggtg ttaccctggt ttcaatgaac
     3061 ctaacctcat tctttgtgtc ttcagtgttg gcttgtttta gctgatccat ctgtaacaca
     3121 ggagggatcc ttggctgagg attgtatttc agaaccacca actgctcttg acaattgtta
     3181 acccgctagg ctcctttggt tagagaagcc acagtccttc agcctccaat tggtgtcagt
     3241 acttaggaag accacagcta gatggacaaa cagcattggg aggccttagc cctgctcctc
     3301 tcaattccat cctgtagaga acaggagtca ggagccgctg gcaggagaca gcatgtcacc
     3361 caggactctg ccggtgcaga atatgaacaa tgccatgttc ttgcagaaaa cacttagcct
     3421 gagtttcata ggaggtaatc accagacaac tgcagaatgt agaacactga gcaggacaac
     3481 tgacctgtct ccttcacata gtccatatca ccacaaatca cacaacaaaa aggagaagag
     3541 atattttggg ttcaaaaaaa gtaaaaagat aatgtagctg catttcttta gttattttga
     3601 accccaaata tttcctcatc tttttgttgt tgtcatggat ggtggtgaca tggacttgtt
     3661 tatagaggac aggtcagctg tctggctcaa tgatctacat tctgaagttg tctgaaaatg
     3721 tcttcatgat taaattcagc ctaaacattt tgccgggaac actgcagaga caatgctgtg
     3781 agtttccaac ctcagcccat ctgcgggcag agaaggtcta gtttgtccat caccattatg
     3841 atatcaggac tggttacttg gttaaggagg ggtctaggag atctgtccct tttagagaca
     3901 ccttacttat aatgaagtac ttgggaaagc ggttttcaag agtataaata tcctgtattc
     3961 taatgatcat cctctaaaca ttttatcatt tattaatcct ccctgcctgt gtctattatt
     4021 atattcatat ctctacactg caaattttgg gtctcaattt ttactgtgcc tttgttttta
     4081 ctagtgtctg ctgttgcaaa aagaagaaaa cattctctgc ctgagtttta atttttgtcc
     4141 aaagttaatt ttaatctata caattaaaac cttttgccta tcactctgga cttctggatt
     4201 gttttttaca ttcagtgtta taatatttga ttatgctgat tggttttggt gggtactgat
     4261 gcgaattaat aaaaacattt catttcca
//
