LOCUS       NM_001385408            4862 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens NBPF member 15 (NBPF15), transcript variant 14, mRNA.
ACCESSION   NM_001385408
VERSION     NM_001385408.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4862)
  AUTHORS   Wu,H., Zhai,L.T., Guo,X.X., Rety,S. and Xi,X.G.
  TITLE     The N-terminal of NBPF15 causes multiple types of aggregates and
            mediates phase transition
  JOURNAL   Biochem J 477 (2), 445-458 (2020)
   PUBMED   31808794
  REMARK    GeneRIF: We suggest that the entanglements between the mosaic
            disorder-ordered segments in NBPF15 N terminus have triggered the
            multiple types of aggregates and phase transition of NBPF15
            proteins, which could be associated with Olduvai-related cognitive
            dysfunction diseases
REFERENCE   2  (bases 1 to 4862)
  AUTHORS   O'Bleness,M.S., Dickens,C.M., Dumas,L.J., Kehrer-Sawatzki,H.,
            Wyckoff,G.J. and Sikela,J.M.
  TITLE     Evolutionary history and genome organization of DUF1220 protein
            domains
  JOURNAL   G3 (Bethesda) 2 (9), 977-986 (2012)
   PUBMED   22973535
REFERENCE   3  (bases 1 to 4862)
  AUTHORS   Vandepoele,K., Van Roy,N., Staes,K., Speleman,F. and van Roy,F.
  TITLE     A novel gene family NBPF: intricate structure generated by gene
            duplications during primate evolution
  JOURNAL   Mol Biol Evol 22 (11), 2265-2274 (2005)
   PUBMED   16079250
REFERENCE   4  (bases 1 to 4862)
  AUTHORS   Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
            Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
            Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
            Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
            Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
  TITLE     Human ORFeome version 1.1: a platform for reverse proteomics
  JOURNAL   Genome Res 14 (10B), 2128-2135 (2004)
   PUBMED   15489335
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC246785.2.
            
            Summary: This gene is a member of the neuroblastoma breakpoint
            family (NBPF) which consists of dozens of recently duplicated genes
            primarily located in segmental duplications on human chromosome 1.
            This gene family has experienced its greatest expansion within the
            human lineage and has expanded, to a lesser extent, among primates
            in general. Members of this gene family are characterized by
            tandemly repeated copies of DUF1220 protein domains. Gene copy
            number variations in the human chromosomal region 1q21.1, where
            most DUF1220 domains are located, have been implicated in a number
            of developmental and neurogenetic diseases such as microcephaly,
            macrocephaly, autism, schizophrenia, cognitive disability,
            congenital heart disease, neuroblastoma, and congenital kidney and
            urinary tract anomalies. Altered expression of some gene family
            members is associated with several types of cancer. This gene
            family contains numerous pseudogenes. [provided by RefSeq, May
            2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.1606.1,
                                           SRR14038197.2427496.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000581897.7/ ENSP00000463178.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC246785.2         188544-188832       c
            290-408             AC246785.2         188006-188124       c
            409-526             AC246785.2         186529-186646       c
            527-795             AC246785.2         183700-183968       c
            796-894             AC246785.2         177935-178033       c
            895-1036            AC246785.2         175938-176079       c
            1037-1191           AC246785.2         167304-167458       c
            1192-1401           AC246785.2         166992-167201       c
            1402-1504           AC246785.2         165108-165210       c
            1505-1719           AC246785.2         164058-164272       c
            1720-1792           AC246785.2         162944-163016       c
            1793-1998           AC246785.2         162274-162479       c
            1999-2050           AC246785.2         160936-160987       c
            2051-2214           AC246785.2         156863-157026       c
            2215-2266           AC246785.2         155769-155820       c
            2267-2439           AC246785.2         154981-155153       c
            2440-2491           AC246785.2         154210-154261       c
            2492-2664           AC246785.2         153441-153613       c
            2665-2716           AC246785.2         152680-152731       c
            2717-2889           AC246785.2         151853-152025       c
            2890-2995           AC246785.2         151033-151138       c
            2996-4862           AC246785.2         148553-150419       c
FEATURES             Location/Qualifiers
     source          1..4862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..4862
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /note="NBPF member 15"
                     /db_xref="GeneID:284565"
                     /db_xref="HGNC:HGNC:28791"
                     /db_xref="MIM:610414"
     exon            1..289
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            290..408
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            409..526
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            527..795
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            796..894
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1036
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1191
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1401
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     CDS             1227..3239
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /note="isoform 1 is encoded by transcript variant 14;
                     neuroblastoma breakpoint family, member 16; neuroblastoma
                     breakpoint family member 15; NBPF family member NBPF15"
                     /codon_start=1
                     /product="NBPF family member NBPF15 isoform 1"
                     /protein_id="NP_001372337.1"
                     /db_xref="CCDS:CCDS72852.1"
                     /db_xref="GeneID:284565"
                     /db_xref="HGNC:HGNC:28791"
                     /db_xref="MIM:610414"
                     /translation="MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFL
                     TQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQ
                     ERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQ
                     KLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPY
                     DSNQPHKKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRN
                     LQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWD
                     QVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVL
                     EQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDY
                     LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEP
                     EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRR
                     GRRSKKKRRRGRKEGEDDNPPCPRLYGVLMEVEEPEVLQDSLDRCYSTPSMYFEQPDS
                     FQHYRSVFYSFEEEHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ"
     exon            1402..1504
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1719
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1792
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1998
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2050
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2214
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2266
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2439
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2491
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2664
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2716
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2889
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2995
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..4862
                     /gene="NBPF15"
                     /gene_synonym="AB14; AG3; NBPF16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctctcct gacgcgccgg gcgggaccct gaggagccag ctggcgcagg ctatgggctg
       61 ggcggcggtt gagacagcgg cggtatcggg aggggtaggt gagggtcgcg aggctgcgtg
      121 agcatctgag tgaacgcggt gcttttggga acgcgggacg ggcgacctgt ggcgccagga
      181 gcgggccgag gcgtggcgca cggatgccgt ctggatggga agttacggtt tacagcgaag
      241 tccacccagc gtttccgagg tgaaggcgcc gcgccaggcc gggcgggcgg ctggtgatgg
      301 gcaagccggg tgtaccaagt ccaggatgca catgaggagc gtttgtagca gtcactgaat
      361 cacctcatga ctagcggggc aggcctctaa ttcaccgcag gatttccgat ctcactctgt
      421 tgcccaggct ggagtgcagt ggcacaatca cagctgaccg caaccttgac ctcccaaggc
      481 tcaggtgatc ctcctgcctc agcccccaag tagctgggac ctacaggcaa tctgaaagca
      541 aatcctgttt agatgcaggc gaaggttcct ggtgacccag gctctcacct taccgtccct
      601 taccgtcctc ctgagggtgt cctggagctt cagtgctgtg tgttcttggc ctccacgctg
      661 gggctgccac caactcccac tgtccagggc ttccagtgga ctctccgagg tactgatgta
      721 gaaacttccc cattcggtgc accaagagca acctcacacg gtgtgggctg aatgaagagc
      781 tgccagatcc cacagaaatg tgattgataa cagtaaagcc acactactca agtgcctgaa
      841 atacccctca ttgtcttctt caggtggcaa gggctctgga acagccacat aaagcccttg
      901 aagataagga tggtcaaaca aaataatatc atacctggag aaactcagat cttggtaaga
      961 tttactggtt gggaatccaa agttaatgcc aagaagcagc cgccagttgg gatcaaatgt
     1021 gagcctatgg atcaagacgg ttacctggca cgctggccac aatctacctc actcttatca
     1081 gagtctgcgc tactgacagt gctttcagct ctgagttgag gcacctcgaa ccttgttttt
     1141 gtggtgaagg atcctaaagt gctgtgggga gtgatcacat ttttgacaac atccctgact
     1201 ccacctcttc tgccacaaac gtcagcatgg tggtatcagc cggccctttg tccagcgaga
     1261 aggcagagat gaacattcta gaaatcaatg agaaattgcg cccccagttg gcagagaaga
     1321 aacagcagtt cagaaacctc aaagagaaat gttttctaac tcaactggcc ggcttcctgg
     1381 ccaaccgaca gaagaaatac aaatatgaag agtgcaaaga tctcataaaa tttatgctga
     1441 ggaatgagcg acagttcaag gaggagaagc ttgcagagca gctcaagcaa gctgaggagc
     1501 tcaggcaata taaagtcctg gttcacgctc aggaacgaga gctgacccag ttaagggaga
     1561 agttacggga agggagagat gcctcccgct cattgaatga gcatctccag gccctcctca
     1621 ctccggatga gccggacaag tcccaggggc aggacctcca agaacagctg gctgaggggt
     1681 gtagactgac acagcacctt gtccaaaagc tcagcccaga aaatgacaac gatgacgatg
     1741 aagatgttca agttgaggtg gctgagaaag tgcagaaatc gtctgccccc agggagatgc
     1801 agaaggctga agaaaaggaa gtccctgagg actcactgga ggaatgtgcc atcacttgtt
     1861 caaatagcca tggcccttat gactccaacc agccacataa gaaaaccaaa atcacatttg
     1921 aggaagacaa agtcgactca actctcattg gctcatcctc tcatgttgaa tgggaggatg
     1981 ctgtacacat tattccagaa aatgaaagtg atgatgagga agaggaagaa aaagggccag
     2041 tgtctcccag gaatctgcag gagtctgaag aggaggaagt cccccaggag tcctgggatg
     2101 aaggttattc gactctctca attcctcctg aaatgttggc ctcgtaccag tcttacagca
     2161 gcacatttca ctcattagag gaacagcaag tctgcatggc tgttgacata ggcagacatc
     2221 ggtgggatca agtgaaaaag gaggaccaag aggcaacagg tcccaggctc agcagggagc
     2281 tgctggatga gaaagagcct gaagtcttgc aggactcact ggatagatgt tattcaactc
     2341 cttcaggttg tcttgaactg actgactcat gccagcccta cagaagtgcc ttttacgtat
     2401 tggagcaaca gcgtgttggc ttggctattg acatggatga aattgaaaag taccaagaag
     2461 tggaagaaga ccaagaccca tcatgcccca ggctcagcag ggagctgctg gatgagaaag
     2521 agcctgaagt cttgcaggac tcactggata gatgttattc gactccttca gattatcttg
     2581 aactgcctga cttaggccag ccctacagca gtgctgttta ctcattggag gaacagtacc
     2641 ttggcttggc tcttgacgtg gacagaatta aaaaggacca agaagaggaa gaagaccaag
     2701 gcccaccatg ccccaggctc agcagggagc tgctggaggt agtagagcct gaagtcttgc
     2761 aggactcact ggatagatgt tattcaactc cttccagttg tcttgaacag cctgactcct
     2821 gccagcccta tggaagttcc ttttatgcat tggaggaaaa acatgttggc ttttctcttg
     2881 acgtgggaga aattgaaaag aaggggaagg ggaagaaaag aaggggaaga agatcaaaga
     2941 agaaaagaag aaggggaaga aaagaagggg aagatgacaa cccaccatgc cccaggctct
     3001 acggcgtgct gatggaagtg gaagagcctg aagtcttaca ggactcactg gatagatgtt
     3061 attcgactcc gtcaatgtac tttgaacaac ctgactcatt ccagcactac agaagtgtgt
     3121 tttactcatt tgaggaagag catatcagct tcgcccttta cgtggacaat aggtttttta
     3181 ctttgacggt gacaagtctc cacctggtgt tccagatggg agtcatattc ccacaataag
     3241 cagctcttac taagccgaga gatgtcattc ctgcaggcag gacctatagg cacgagaaga
     3301 tttgaatgaa agtacagttc catttggaag cccagacata ggatgggtca gtgagcatgg
     3361 ctctattcct attctcaaac catgccattg gcaacctgtg ctcaatctga agacaatgga
     3421 cccatgttag gtgtgacacg ttcacataac tgtgcagaac atgccgggag tgatcagtca
     3481 gacattttaa tttgaaccac gtatctctgg gtagctacaa aattcctcag ggatttcatt
     3541 ttgcaggcat gtctctgagc ttctatacct gctcaaggtc attgtcatct ttgtgtttag
     3601 ctcatccaaa ggtgttaccc tggtttcaat gaacctaacc tcattctttg tgtcttcagt
     3661 gttggcttgt tttagctgat ccatctgtaa cacaggaggg atccttggct gaggattgta
     3721 tttcagaacc accaactgct cttgacaatt gttaacccgc taggctcctt tggttagaga
     3781 agccacagtc cttcagcctc caattggtgt cagtacttag gaagaccaca gctagatgga
     3841 caaacagcat tgggaggcct tagccctgct cctctcaatt ccatcctgta gagaacagga
     3901 gtcaggagcc gctggcagga gacagcatgt cacccaggac tctgccggtg cagaatatga
     3961 acaatgccat gttcttgcag aaaacactta gcctgagttt cataggaggt aatcaccaga
     4021 caactgcaga atgtagaaca ctgagcagga caactgacct gtctccttca catagtccat
     4081 atcaccacaa atcacacaac aaaaaggaga agagatattt tgggttcaaa aaaagtaaaa
     4141 agataatgta gctgcatttc tttagttatt ttgaacccca aatatttcct catctttttg
     4201 ttgttgtcat ggatggtggt gacatggact tgtttataga ggacaggtca gctgtctggc
     4261 tcaatgatct acattctgaa gttgtctgaa aatgtcttca tgattaaatt cagcctaaac
     4321 attttgccgg gaacactgca gagacaatgc tgtgagtttc caacctcagc ccatctgcgg
     4381 gcagagaagg tctagtttgt ccatcaccat tatgatatca ggactggtta cttggttaag
     4441 gaggggtcta ggagatctgt cccttttaga gacaccttac ttataatgaa gtacttggga
     4501 aagcggtttt caagagtata aatatcctgt attctaatga tcatcctcta aacattttat
     4561 catttattaa tcctccctgc ctgtgtctat tattatattc atatctctac actgcaaatt
     4621 ttgggtctca atttttactg tgcctttgtt tttactagtg tctgctgttg caaaaagaag
     4681 aaaacattct ctgcctgagt tttaattttt gtccaaagtt aattttaatc tatacaatta
     4741 aaaccttttg cctatcactc tggacttctg gattgttttt tacattcagt gttataatat
     4801 ttgattatgc tgattggttt tggtgggtac tgatgcgaat taataaaaac atttcatttc
     4861 ca
//
