LOCUS       NM_001278141            7435 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens NBPF member 12 (NBPF12), mRNA.
ACCESSION   NM_001278141 XM_003119146 XM_003846733 XM_003960049-XM_003960057
            XM_003960194 XM_003960219-XM_003960227
VERSION     NM_001278141.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7435)
  AUTHORS   O'Bleness,M.S., Dickens,C.M., Dumas,L.J., Kehrer-Sawatzki,H.,
            Wyckoff,G.J. and Sikela,J.M.
  TITLE     Evolutionary history and genome organization of DUF1220 protein
            domains
  JOURNAL   G3 (Bethesda) 2 (9), 977-986 (2012)
   PUBMED   22973535
REFERENCE   2  (bases 1 to 7435)
  AUTHORS   Vandepoele,K., Van Roy,N., Staes,K., Speleman,F. and van Roy,F.
  TITLE     A novel gene family NBPF: intricate structure generated by gene
            duplications during primate evolution
  JOURNAL   Mol Biol Evol 22 (11), 2265-2274 (2005)
   PUBMED   16079250
REFERENCE   3  (bases 1 to 7435)
  AUTHORS   Meza-Zepeda,L.A., Forus,A., Lygren,B., Dahlberg,A.B., Godager,L.H.,
            South,A.P., Marenholz,I., Lioumi,M., Florenes,V.A.,
            Maelandsmo,G.M., Serra,M., Mischke,D., Nizetic,D., Ragoussis,J.,
            Tarkkanen,M., Nesland,J.M., Knuutila,S. and Myklebost,O.
  TITLE     Positional cloning identifies a novel cyclophilin as a candidate
            amplified oncogene in 1q21
  JOURNAL   Oncogene 21 (14), 2261-2269 (2002)
   PUBMED   11948409
  REMARK    GeneRIF: Positional cloning identifies a novel cyclophilin as a
            candidate amplified oncogene in 1q21; (COAS1, COAS2, COAS3)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244394.3.
            
            On Jul 23, 2021 this sequence version replaced NM_001278141.2.
            
            Summary: This gene is a member of the neuroblastoma breakpoint
            family (NBPF) which consists of dozens of recently duplicated genes
            primarily located in segmental duplications on human chromosome 1.
            This gene family has experienced its greatest expansion within the
            human lineage and has expanded, to a lesser extent, among primates
            in general. Members of this gene family are characterized by
            tandemly repeated copies of DUF1220 protein domains. Gene copy
            number variations in the human chromosomal region 1q21.1, where
            most DUF1220 domains are located, have been implicated in a number
            of developmental and neurogenetic diseases such as microcephaly,
            macrocephaly, autism, schizophrenia, cognitive disability,
            congenital heart disease, neuroblastoma, and congenital kidney and
            urinary tract anomalies. Altered expression of some gene family
            members is associated with several types of cancer. This gene
            family contains numerous pseudogenes. [provided by RefSeq, May
            2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1902332.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000698835.1/ ENSP00000513971.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-689               AC244394.3         128456-129144       c
            690-961             AC244394.3         123906-124177       c
            962-1014            AC244394.3         120861-120913       c
            1015-1113           AC244394.3         118046-118144       c
            1114-1255           AC244394.3         115979-116120       c
            1256-1403           AC244394.3         107462-107609       c
            1404-1613           AC244394.3         107150-107359       c
            1614-1716           AC244394.3         105205-105307       c
            1717-1931           AC244394.3         104159-104373       c
            1932-2004           AC244394.3         103039-103111       c
            2005-2216           AC244394.3         102364-102575       c
            2217-2426           AC244394.3         100795-101004       c
            2427-2529           AC244394.3         98918-99020         c
            2530-2744           AC244394.3         97872-98086         c
            2745-2817           AC244394.3         96749-96821         c
            2818-3029           AC244394.3         96074-96285         c
            3030-3239           AC244394.3         94508-94717         c
            3240-3342           AC244394.3         92627-92729         c
            3343-3557           AC244394.3         91577-91791         c
            3558-3630           AC244394.3         90467-90539         c
            3631-3836           AC244394.3         89797-90002         c
            3837-3888           AC244394.3         88458-88509         c
            3889-4052           AC244394.3         84377-84540         c
            4053-4104           AC244394.3         83283-83334         c
            4105-4277           AC244394.3         82483-82655         c
            4278-4329           AC244394.3         81712-81763         c
            4330-4502           AC244394.3         80944-81116         c
            4503-4554           AC244394.3         80183-80234         c
            4555-4727           AC244394.3         79342-79514         c
            4728-4836           AC244394.3         78519-78627         c
            4837-5009           AC244394.3         77722-77894         c
            5010-5061           AC244394.3         76951-77002         c
            5062-5234           AC244394.3         76183-76355         c
            5235-5286           AC244394.3         75422-75473         c
            5287-5459           AC244394.3         74584-74756         c
            5460-5568           AC244394.3         73761-73869         c
            5569-7435           AC244394.3         71270-73136         c
FEATURES             Location/Qualifiers
     source          1..7435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..7435
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /note="NBPF member 12"
                     /db_xref="GeneID:149013"
                     /db_xref="HGNC:HGNC:24297"
                     /db_xref="MIM:608607"
     exon            1..689
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            690..961
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1014
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1113
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1255
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1403
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1613
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     CDS             1439..5812
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /note="chomosome one amplified sequence 1 cyclophilin;
                     chromosome 1 amplified sequence 1; neuroblastoma
                     breakpoint family member 12"
                     /codon_start=1
                     /product="NBPF family member NBPF12"
                     /protein_id="NP_001265070.1"
                     /db_xref="CCDS:CCDS72881.1"
                     /db_xref="GeneID:149013"
                     /db_xref="HGNC:HGNC:24297"
                     /db_xref="MIM:608607"
                     /translation="MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNLKERCFL
                     TQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQ
                     ERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLVQ
                     KLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC
                     DSIQPHKNIKITFEEDKVNSTVVVDRKSSHDECQDALNILPVPGPTSSATNVSMVVSA
                     GPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKYEEC
                     KDLIKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASR
                     SLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEED
                     EKVLESSSPREMQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDKVN
                     SSLVVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKL
                     RPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLLKSMLRNELQFKEEKL
                     AEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQ
                     GQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKE
                     VPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHII
                     PENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTF
                     HSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLAEKEPEVLQDSLDRCYSTP
                     SVYLGLTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAE
                     KEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEE
                     EDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKH
                     VGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRLSRELLAEKEPEV
                     LQDSLDRWYSTPSVYLGLTDPCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDP
                     SCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLAL
                     DVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP
                     YRSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRL
                     NSVLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHITFALDMDNS
                     FFTLTVTSLHLVFQMGVIFPQ"
     exon            1614..1716
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1931
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2004
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2216
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2426
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2529
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2744
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2817
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..3029
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3239
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3342
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3557
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3630
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3836
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3888
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4052
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4104
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4277
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            4278..4329
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4502
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            4503..4554
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            4555..4727
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..4836
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            4837..5009
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            5010..5061
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5234
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            5235..5286
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            5287..5459
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            5460..5568
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     exon            5569..7435
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7415..7420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /note="hexamer: AATAAA"
     polyA_site      7435
                     /gene="NBPF12"
                     /gene_synonym="COAS1; KIAA1245"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtcaga ctatggggcg gtgcggcagc gcgaagcctg cagtcctaaa ggcggggtcg
       61 ctccaggctt ccgagggggt gtgtctcccg cctctttaac ctggcagggg cggttcaagt
      121 ggccggggaa atcggcgaat tgcagggtca agggctggtg ctttgaaaga gaggcggagg
      181 ggagagaggg attttcccgt ccccgctgcg ctccgtcctc cattactcgt tttctccgcc
      241 cgcggcccga acccgttgtg cggtagaggc agccgggtcc ctttaaggcc cagctgcgct
      301 ccgtcctcca ttactccttt tctccgcccg cggcccgaac ccgttgtgcg gtagaggcag
      361 ccgggtccct ttaaggccca gctgcgcctg tgccttgggc tctcctgaca cggcccatcc
      421 ggaccctgag gagccagcgg gccgcaagca agttgctggg cggcggttga gatagcggcg
      481 gtgctgggag gggtaggtga gggtcgcgag gctgcctgag cttctgagtg agcctggtga
      541 ttttgggaac gcgggacggg cgacctgcgg cgccaggagc ggggccgagg tacggcggca
      601 cggctgcagc ctggatggga agttcaagtt tactgcgaag tccacccagc gttccggagg
      661 tgagggcgcc gcgccaggcc gggcggcagg cattctgaag gcaaatcctg tttagaccca
      721 ggcaaaggtt cctggtgacc caggctctca tgagcagatt gtcccttatc attctcctga
      781 ggatgtctgg agcttcagtg ctgtgtgctc ttggcctcca cactgggggt gccaccaact
      841 cccactgtcc agggcttctg gtggactctc cgaggcaccg atgtagaaac ttacccattc
      901 agtgcaccaa gagcagcctc acatggtgtg ggccgacatg aagagctgcc agatccaaca
      961 gttctcagaa ttcttcatat attttggaca gcagtttttc catcagatta ttttaaatgt
     1021 gattgataac agtaaagcca cactcctcaa gtgcctgaaa tacccctcat tgtcttcttc
     1081 aggtggcaag ggctctggaa cagccacata aagcccttga agataaggat ggtcaaacaa
     1141 aataatatca tacctggaga aactcagatc ttgctaagat ttactggttg ggaatccaaa
     1201 gttaatgcca agaagcagct gccagttggg atcaaatgtg agcctatgga tcaagacggt
     1261 tacctggcac gctggccaca atctacctca ctcttatcag agtctgagca gtgctttcag
     1321 ctctgagttg aggcacctcg aaccttgttt ttgtggtgaa ggatcctaaa gtgctgtggg
     1381 gagtgatcac atttttcaca acatccctga ctccacctct tctgccacaa acgtcagcat
     1441 ggtggtatca gccggccctt ggtccagcga gaaggcagag atgaacattc tagaaatcaa
     1501 cgagaaattg cgcccccagt tggcagagaa caaacagcag ttcagaaacc tcaaagagag
     1561 atgttttcta actcaactgg ccggcttcct ggccaaccga cagaagaaat acaagtatga
     1621 agagtgtaaa gacctcataa aatttatgct gaggaatgag cgacagttca aggaggagaa
     1681 gcttgcagag cagctgaaac aagctgagga gctcaggcaa tataaagtcc tggttcactc
     1741 tcaggaacga gagctgaccc agttaaggga gaagttacgg gaagggagag atgcctcccg
     1801 ctcattgaat gagcatctcc aggccctcct cactccggat gagccggaca agtcccaggg
     1861 gcaggacctc caagaacagc tggctgaggg gtgtagactg gcacagcaac ttgtccaaaa
     1921 gctcagccca gaaaatgatg aagatgagga tgaagatgtt caagttgagg aggatgagaa
     1981 agtactggaa tcatctgccc ccagggaggt gcagaaggct gaagagagca aagtccctga
     2041 ggactcactg gaggaatgtg ccatcacttg ttcaaatagc cacggccctt gtgactccat
     2101 ccagcctcac aagaacatca aaatcacatt tgaggaagac aaagtcaact caactgtggt
     2161 tgtagacaga aaatcctctc atgatgaatg tcaggatgct ctaaacattc tcccagtccc
     2221 tggccccacc tcttctgcca caaacgtcag catggtggta tcagccggcc ctttgtccag
     2281 cgagaaggca gagatgaaca ttctagaaat caatgagaag ttgcgccccc agctggcaga
     2341 gaagaaacag cagttcagaa gcctcaaaga gaaatgtttt gtaactcaac tggccggctt
     2401 cctggccaag cagcagaaca aatacaaata tgaagagtgc aaagacctca taaaatctat
     2461 gctgaggaat gagctacagt tcaaggagga gaagcttgca gagcagctga agcaagctga
     2521 ggagctcagg caatataaag tcctggttca ctctcaggaa cgagagctga cccagttaag
     2581 ggagaagtta cgggaaggga gagatgcctc ccgctcattg aatgagcatc tccaggccct
     2641 cctcactccg gatgagccgg acaagtccca ggggcaggac ctccaagaac agctggctga
     2701 ggggtgtaga ctggcacagc accttgtcca aaagctcagc ccagaaaatg atgaagatga
     2761 ggatgaagat gttcaagttg aggaggatga gaaagtgctg gaatcatctt cccccaggga
     2821 gatgcagaag gctgaagaaa gcaaagtccc tgaggactca ctggaggaat gtgccatcac
     2881 ttgttcaaat agccacggcc cttgtgactc caaccagcct cacaagaaca tcaaaatcac
     2941 atttgaggaa gacaaagtca actcatctct ggttgtagac agagaatcct ctcatgatga
     3001 atgtcaggat gctctaaaca ttctcccagt ccctggcccc acctcttctg ccacaaacgt
     3061 cagcatggtg gtatcagccg gccctttgtc cagcgagaag gcagagatga acattctaga
     3121 aatcaatgag aagttgcgcc cccagctggc agagaagaaa cagcagttca gaagcctcaa
     3181 agagaaatgt tttgtaactc aagtggcctg cttcctggcc aagcagcaga acaaatacaa
     3241 atatgaagag tgcaaagacc tcctaaaatc tatgctgagg aatgagctac agttcaagga
     3301 ggagaagctt gcagagcagc tgaagcaagc tgaggagctc aggcaatata aagtcctggt
     3361 tcactctcag gaacgagagc tgacccagtt aagggagaag ttacgggaag ggagagatgc
     3421 ctcccgctca ttgaatgagc atctccaggc cctcctcact ccggatgagc cggacaagtc
     3481 ccaggggcag gacctccaag aacagctggc tgaggggtgt agactggcac aacaccttgt
     3541 ccaaaagctc agcccagaaa atgataacga tgacgatgaa gatgttcaag ttgaggtggc
     3601 tgagaaagtg cagaaatcgt cttcccccag ggagatgcag aaggctgaag aaaaggaagt
     3661 ccctgaggac tcactggagg agtgtgccat cacttgttca aatagccatg gcccttatga
     3721 ctccaaccag ccacatagga aaaccaaaat cacatttgag gaagacaaag tcgactcaac
     3781 tctcattggc tcatcctctc atgttgaatg ggaggatgct gtacacatta tcccagaaaa
     3841 tgaaagtgat gatgaggaag aggaagaaaa agggccagtg tctcccagga atctgcagga
     3901 gtctgaagag gaggaagtcc cccaggagtc ctgggatgaa ggttattcga ctctctcaat
     3961 tcctcctgaa aggttggcct cataccagtc ttacagcagc acatttcact cattagagga
     4021 acagcaagtc tgcatggctg ttgacatagg cagacatcgg tgggatcaag tgaaaaagga
     4081 ggaccaagag gcaacaggtc ccaggctcag cagggagctg ctggctgaga aagagcctga
     4141 agtcttgcag gactcactgg atagatgtta ttcaactcct tcagtttatc ttggactgac
     4201 tgactcatgc cagccctaca gaagtgcctt ttacgtattg gagcaacagc gtgttggctt
     4261 ggctgttgac atggatgaaa ttgaaaagta ccaagaagtg gaagaagacc aagacccatc
     4321 atgccccagg ctcagcaggg agctgctggc tgagaaagag cctgaagtct tgcaggactc
     4381 actggataga tgttattcga ctccttcagg ttatcttgaa ctgcctgact taggccagcc
     4441 ctacagaagt gctgtttact cattggagga acagtacctt ggcttggctc ttgacgtgga
     4501 cagaattaaa aaggaccaag aagaggaaga agaccaaggc ccaccatgcc ccaggctcag
     4561 cagggagctg ctggaggtag tagagcctga agtcttgcag gactcactgg atagatgtta
     4621 ttcaactcct tccagttgtc ttgaacagcc tgactcctgc cagccctaca gaagttcctt
     4681 ttatgcattg gaggaaaaac atgttggctt ttctcttgac gtgggagaaa ttgaaaagaa
     4741 ggggaagggg aagaaaagaa ggggaagaag atcaaagaag aaaagaagaa ggggaagaaa
     4801 agaaggggaa gaagatcaaa acccaccatg ccccaggctc agcagggagc tgctggctga
     4861 gaaagagcct gaagtcttgc aggactcact ggatagatgg tattcgactc cttcagttta
     4921 tcttggactg actgacccat gccagcccta cagaagtgcc ttttacgtat tggagcaaca
     4981 gcgtgttggc ttggctgttg acatggatga aattgaaaag taccaagaag tggaagaaga
     5041 ccaagaccca tcatgcccca ggctcagcag ggagctgctg gctgagaaag agcctgaagt
     5101 cttgcaggac tcactggata gatgttattc gactccttca ggttatcttg aactgcctga
     5161 cttaggccag ccctacagaa gtgctgttta ctcattggag gaacagtacc ttggcttggc
     5221 tcttgacgtg gacagaatta aaaaggacca agaagaggaa gaagaccaag gcccaccatg
     5281 ccccaggctc agcagggagc tgctggaggt agtagagcct gaagtcttgc aggactcact
     5341 ggatagatgt tattcaactc cttccagttg tcttgaacag cctgactcct gccagcccta
     5401 cagaagttcc ttttatgcat tggaggaaaa acatgttggc ttttctcttg acgtgggaga
     5461 aattgaaaag aaggggaagg ggaagaaaag aaggggaaga agatcaaaga agaaaagaag
     5521 aaggggaaga aaagaagggg aagaagatca aaacccacca tgccccaggc tcaacagcgt
     5581 gctgatggaa gtggaagagc ctgaagtctt gcaggactca ctggatagat gttattcgac
     5641 tccatcaatg tactttgaac tacctgactc attccagcac tacagaagtg tgttttactc
     5701 atttgaggaa cagcacatca cctttgccct tgacatggac aatagctttt ttactttgac
     5761 ggtgacaagt ctccacctgg tcttccagat gggagtcata ttcccacaat aagcagccct
     5821 tactaagccg agaggtttca ttcctgcagg caggacctat aggcacctga agatttgaat
     5881 gaaactatag ttccatttgg aagcccagac ataggatggg tcagtgggca tggctctatt
     5941 cctattctca gagcatgcca gtggcaacct gtgctcagtc tgaagacaat ggacccacgt
     6001 taggtgtgac acgttcacat aactgtgcag cacatgccgg gagtgatcag ccggacattt
     6061 taatttgaac catgtatctc tgggtagcta caaaattcct cagggatttc attttgcagg
     6121 catgtctctg agcttctata cctactcaag gtcagtgtca tctttgtgtt tagttcatcc
     6181 aaaggtgtta ccctggtttc aatgaaccta acctcattat ttgtgtcttc agtgttggct
     6241 tgttttagct gatccatctg taacacagga gggatccttg gctgaggatt gtatttcaga
     6301 accaccaact gctcttgaca attgttaacc cactaggctc ctttggttag agaagccaca
     6361 gtccttcagc ctccaattgg tgtcagtact taggaagacc acagctagat ggacaaacag
     6421 cattgggagg ccttagccct gctcctctca attccatcct gtagagaaca ggagtcagga
     6481 gccgctggca ggagacagca tgtcacccag gactctgccg gtgcagaata tgagcaatgc
     6541 catgttcttg cagaaaacgc ttagcctgag tttcatagga ggtaatcacc agacaactgc
     6601 agaatgtaga acactgagca ggacaactga cctgtctcct tcacatagtc catatcacca
     6661 caaatcacac aacaaaaagg agaagagata ttttgggttg aaaaaaagta aaaagataat
     6721 gtagctgcat ttctttagtt attttgaacc ccaaatattt cctcatcttt ttgttgttgt
     6781 cattgatggt ggtgacatgg acttgtttat agaggacagg tcagctctct ggctcaatga
     6841 tctacattct gaagttgtct gaaaatgtct tcatgattaa attcagccta aactttttgc
     6901 tgggaacact gcagagacaa tgctgtgagt ttccaacctc agcccatctg cgggcagaga
     6961 aggtctagtt tgtccatcac cattatgata tcaggactgg ttacttggtt aaggaggggt
     7021 ctaggagatc tgtccctttt agagacacct tacttataat gaagtacttg ggaaagcggt
     7081 tttcaagagt ataaatatcc tgtattctaa tgatcatcct ctaaacattt tatcatttat
     7141 taatcctccc tgcctgtgtc tattattata tacatatctc tacgctgcaa attttgggtc
     7201 tcaattttta ctgtgccttt gtttttacta gtgtctgctg ttgcaaaaag aagaaaacat
     7261 tctctgcctg agttttaatt tttgtccaaa gttaatttta atctatacaa ttaaaacctt
     7321 ttgcctatca ctctggactt ttggattgtt ttttacattc agtgttataa tatttgatta
     7381 tgctgattgg ttttggtggg tactgatgtg aattaataaa aacatttcat ttcca
//
