LOCUS       NM_001405672            7833 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens NBPF member 1 (NBPF1), transcript variant 7, mRNA.
ACCESSION   NM_001405672
VERSION     NM_001405672.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7833)
  AUTHORS   Li,L., Chen,S., Tang,Y., Wu,J., He,Y. and Qiu,L.
  TITLE     Oncogene or tumor suppressor gene: An integrated pan-cancer
            analysis of NBPF1
  JOURNAL   Front Endocrinol (Lausanne) 13, 950326 (2022)
   PUBMED   36060966
  REMARK    GeneRIF: Oncogene or tumor suppressor gene: An integrated
            pan-cancer analysis of NBPF1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7833)
  AUTHORS   Zhang,J., Zhao,Y., Wang,J., Sneh,T., Yu,Q., Zhou,X. and Gong,C.
  TITLE     NBPF1 independently determine the risk stratification and prognosis
            of patients with neuroblastoma
  JOURNAL   Genomics 112 (6), 3951-3957 (2020)
   PUBMED   32619576
  REMARK    GeneRIF: NBPF1 independently determine the risk stratification and
            prognosis of patients with neuroblastoma.
REFERENCE   3  (bases 1 to 7833)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7833)
  AUTHORS   Gao,Y., Zhu,H. and Mao,Q.
  TITLE     Effects of neuroblastoma breakpoint family member 1 (NBPF1) gene on
            growth and Akt-p53-Cyclin D pathway in cutaneous squamous carcinoma
            cells
  JOURNAL   Neoplasma 66 (4), 584-592 (2019)
   PUBMED   31058534
  REMARK    GeneRIF: Upregulation of NBPF1 might promote apoptosis of A431
            squamous carcinoma cells and block cell cycle via inhibiting the
            activation of Akt-p53-Cyclin signaling pathway
REFERENCE   5  (bases 1 to 7833)
  AUTHORS   Qin,Y., Tang,X. and Liu,M.
  TITLE     Tumor-Suppressor Gene NBPF1 Inhibits Invasion and PI3K/mTOR
            Signaling in Cervical Cancer Cells
  JOURNAL   Oncol Res 23 (1-2), 13-20 (2016)
   PUBMED   26802646
  REMARK    GeneRIF: NBPF1 overexpression may be a suppressor for cervical
            cancer via affecting cell invasion and apoptosis through regulating
            PI3K/mTOR signaling pathway.
REFERENCE   6  (bases 1 to 7833)
  AUTHORS   Andries,V., Vandepoele,K., Staes,K., Berx,G., Bogaert,P., Van
            Isterdael,G., Ginneberge,D., Parthoens,E., Vandenbussche,J.,
            Gevaert,K. and van Roy,F.
  TITLE     NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth
            inhibitory effects by inducing a G1 cell cycle arrest
  JOURNAL   BMC Cancer 15, 391 (2015)
   PUBMED   25958384
  REMARK    GeneRIF: We demonstrated that NBPF1 exerts different tumor
            suppressive effects, depending on the cell line analyzed, and
            provide new clues into the molecular mechanism of the enigmatic
            NBPF proteins.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7833)
  AUTHORS   O'Bleness,M.S., Dickens,C.M., Dumas,L.J., Kehrer-Sawatzki,H.,
            Wyckoff,G.J. and Sikela,J.M.
  TITLE     Evolutionary history and genome organization of DUF1220 protein
            domains
  JOURNAL   G3 (Bethesda) 2 (9), 977-986 (2012)
   PUBMED   22973535
REFERENCE   8  (bases 1 to 7833)
  AUTHORS   Vandepoele,K., Staes,K., Andries,V. and van Roy,F.
  TITLE     Chibby interacts with NBPF1 and clusterin, two candidate tumor
            suppressors linked to neuroblastoma
  JOURNAL   Exp Cell Res 316 (7), 1225-1233 (2010)
   PUBMED   20096688
  REMARK    GeneRIF: Chibby and clusterin were co-immunoprecipitated with
            NBPF1.
REFERENCE   9  (bases 1 to 7833)
  AUTHORS   Vandepoele,K., Van Roy,N., Staes,K., Speleman,F. and van Roy,F.
  TITLE     A novel gene family NBPF: intricate structure generated by gene
            duplications during primate evolution
  JOURNAL   Mol Biol Evol 22 (11), 2265-2274 (2005)
   PUBMED   16079250
REFERENCE   10 (bases 1 to 7833)
  AUTHORS   Laureys,G., Speleman,F., Versteeg,R., van der Drift,P., Chan,A.,
            Leroy,J., Francke,U., Opdenakker,G. and Van Roy,N.
  TITLE     Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in
            a neuroblastoma patient. Establishment of somatic cell hybrids and
            identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on
            chromosome 17 as breakpoint flanking single copy markers
  JOURNAL   Oncogene 10 (6), 1087-1093 (1995)
   PUBMED   7700633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC277909.1 and AC254635.1.
            
            On May 3, 2022 this sequence version replaced NM_001405672.1.
            
            Summary: This gene is a member of the neuroblastoma breakpoint
            family (NBPF) which consists of dozens of recently duplicated genes
            primarily located in segmental duplications on human chromosome 1.
            This gene family has experienced its greatest expansion within the
            human lineage and has expanded, to a lesser extent, among primates
            in general. Members of this gene family are characterized by
            tandemly repeated copies of DUF1220 protein domains. Gene copy
            number variations in the human chromosomal region 1q21.1, where
            most DUF1220 domains are located, have been implicated in a number
            of developmental and neurogenetic diseases such as microcephaly,
            macrocephaly, autism, schizophrenia, cognitive disability,
            congenital heart disease, neuroblastoma, and congenital kidney and
            urinary tract anomalies. Altered expression of some gene family
            members is associated with several types of cancer. This gene
            family contains numerous pseudogenes. [provided by RefSeq, Apr
            2013].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC277909.1         185116-185342
            228-499             AC277909.1         189897-190168
            500-1463            AC277909.1         190985-191948
            1464-1546           AC277909.1         203684-203766
            1547-1616           AC277909.1         204036-204105
            1617-1743           AC277909.1         205128-205254
            1744-1898           AC277909.1         206382-206536
            1899-2108           AC277909.1         206639-206848
            2109-2211           AC277909.1         208694-208796
            2212-2426           AC277909.1         209632-209846
            2427-2499           AC277909.1         210898-210970
            2500-2711           AC277909.1         211434-211645
            2712-2921           AC277909.1         212992-213201
            2922-3024           AC254635.1         129707-129809
            3025-3239           AC254635.1         130645-130859
            3240-3312           AC254635.1         131910-131982
            3313-3524           AC254635.1         132446-132657
            3525-3734           AC254635.1         134007-134216
            3735-3837           AC254635.1         135990-136092
            3838-4052           AC254635.1         136928-137142
            4053-4125           AC254635.1         138180-138252
            4126-4331           AC254635.1         138717-138922
            4332-4383           AC254635.1         140214-140265
            4384-4547           AC254635.1         144172-144335
            4548-4599           AC254635.1         145378-145429
            4600-4772           AC254635.1         146069-146241
            4773-4824           AC254635.1         146961-147012
            4825-4997           AC254635.1         147615-147787
            4998-5049           AC254635.1         148497-148548
            5050-5222           AC254635.1         149171-149343
            5223-5334           AC254635.1         150058-150169
            5335-5507           AC254635.1         150776-150948
            5508-5559           AC254635.1         151668-151719
            5560-5732           AC254635.1         152322-152494
            5733-5784           AC254635.1         153204-153255
            5785-5957           AC254635.1         153872-154044
            5958-6069           AC254635.1         154759-154870
            6070-7833           AC254635.1         160198-161961
FEATURES             Location/Qualifiers
     source          1..7833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..7833
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /note="NBPF member 1"
                     /db_xref="GeneID:55672"
                     /db_xref="HGNC:HGNC:26088"
                     /db_xref="MIM:610501"
     exon            1..227
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            228..499
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1463
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1546
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1616
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1743
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1898
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2108
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     CDS             1934..6313
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /note="isoform 3 is encoded by transcript variant 7;
                     neuroblastoma breakpoint family member 1; NBPF family
                     member NBPF1"
                     /codon_start=1
                     /product="NBPF family member NBPF1 isoform 3"
                     /protein_id="NP_001392601.1"
                     /db_xref="GeneID:55672"
                     /db_xref="HGNC:HGNC:26088"
                     /db_xref="MIM:610501"
                     /translation="MVVSAGPWSSEKAETNILEINEKLRPQLAEKKQQFRNLKEKCFV
                     TQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQ
                     ERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQ
                     KLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC
                     DSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSA
                     GPLFSEKAEMNILEINEKLHPQLAEKNQQFRNLKEKCFVTQLACFLANQQNKYKYEEC
                     KDLIKSMLRKERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTHLREKLREGRDASR
                     SLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEA
                     EKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHSPCDSNQPHKNINITFEEDKVN
                     STLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKL
                     HPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKL
                     AEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQ
                     GQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQESSAPREMPKAEEKE
                     VPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHII
                     PENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTF
                     HSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTP
                     SGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDE
                     KEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEE
                     EDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKH
                     VGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSRELLDEKGPE
                     VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQD
                     PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLA
                     LDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCL
                     PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCP
                     RLSGVLMEVEEPEVLQDSLDRCYSTPSMFFELPDSFQHYRSVFYSFEEQHISFALDVD
                     NRFLTLMGTSLHLVFQMGVIFPQ"
     exon            2109..2211
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2426
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2499
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2711
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2921
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3024
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3239
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3312
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3524
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3734
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3837
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..4052
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4125
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4126..4331
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..4383
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4384..4547
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4548..4599
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..4772
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..4824
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4825..4997
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            4998..5049
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            5050..5222
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            5223..5334
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            5335..5507
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            5508..5559
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            5560..5732
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            5733..5784
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            5785..5957
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            5958..6069
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     exon            6070..7833
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7809..7814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /note="hexamer: ATTAAA"
     polyA_site      7829
                     /gene="NBPF1"
                     /gene_synonym="AB13; AB14; AB23; AD2; NBG; NBPF"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcgcag gcgcaggcga ggggctgggt ggcggttgag acagcggcgg tactgggagg
       61 cgtaggtgag ggtcgcgagg ctgcccgagc ttctgagcga gcgcggtgct tttgggaacg
      121 cgggacgggc gatctgcggc gccaggagct gggccgaggc gcggcggcgc ggctgccggc
      181 tgccctgtga atgggaagtt acgcgaagtc cacccagcgt ttctgaggca atctgaaggc
      241 aaatcctgtt tagacccagg cgaaggttcc cggtgacccg ggctctcacc agccaattgt
      301 cccttgccgt cctcctgagg gtgcctggag cttaagcact gtgtgctctt ggcctccaca
      361 ctggggatgc cgctgactcc cactgtccag ggcttccagt ggattctccg aggccctgat
      421 gtagaaactt ccccattggg tgcaccaaga gcagcctcac atggtgtggg ctgacatcaa
      481 gagctgccag atccaacagg tcctgggaga gtaggagcca gtgcaaggag agaagtccat
      541 tgagaaaggc aaatggatga catcagaccc aggggctgag gtccccaact gcagctgggt
      601 agcttctgga gtggacaagg agcaacaggg aagttcgtgg cctggtgttc tgggatccac
      661 tgtctcatct cattcttgtg ggcaccagaa cgtatccaaa gacaagactc agtgtctctg
      721 gcaacagtga gccagagata gaatgtgttt cagaggagga ggaaggggtt gttgtacccc
      781 atggaaacag tatattgttt tacagtagcg tgtctttctc taataactac ttagcgtgtt
      841 cctgttaatg gaaaatattg gtggtgtaag tttccccact gttctcatct tcatgtaaat
      901 ttgttcattt ccttccttcc ttccttcctt ccttccctac ttccctccaa ctctctttct
      961 ctctcttttt attctttccc tccttcccac ccgccctcca tccctccctt ccttcctcct
     1021 tccctccttc cctcccttct ttcctttctt cctttcttct tttcttcttc tttctctctc
     1081 atgctctctc tttttctttc cttttcattc tctctacttt tttgaagaga tcacactgta
     1141 ctgaaaccta cattattttc caaaatctct ggatctgctt ctgtcttgca ggcagagagc
     1201 tcatccagta gcccttagct cttcccagcc ccctcctttg atttgtgggt gccactgcgg
     1261 cagctgctga gtctcagtgg tttctagtct tcaccaagtt ctgcccaccc agatggtttt
     1321 tacctgtcct caccagaaac ctgcactgtc tagattgctg aggctgcttc tccttaaccg
     1381 atctgctatc tgtattccag gggcacccca gggttagagg taaatggcac aggccttgaa
     1441 atctccaact gctctgactc caggaagatg gccaatcttt cctaagctgc tcaccttaca
     1501 agaaaacgaa tcgtactgct aagaattcaa acttcagcag tcatggggag ccttggaagg
     1561 agcccgaatc actgatggaa ttggacagtg catggagatg gttcagcagg acaaggtgtc
     1621 attggaggac agtgtggagt gcagagagac atgctttgaa atgggattga tccagtcctc
     1681 cttccttcac taccacatga atgctgggca gcccagggtc aacccaccgc accctcaact
     1741 cagacggtta cctggcacgc tggccacagt ctacctcact cttatcagag tctgagctac
     1801 tggcagtgct ttcagctctg agttcaggca cctcgaacct tgtttttgtg gtgaaggatc
     1861 ctaaagtgct gtggggagtg atcacatttt tcacaacatc cctggctcca cctcttctgc
     1921 cacaaacgtc agcatggtgg tatcagctgg cccttggtcc agcgagaagg cagagacgaa
     1981 cattttagaa atcaacgaga aattgcgccc ccagctggca gagaagaaac agcagttcag
     2041 aaacctcaaa gagaaatgtt ttgtaactca actggccggc ttcctggcca accgacagaa
     2101 gaaatacaag tatgaagagt gtaaagacct cataaaattt atgctgagga atgagcgaca
     2161 gttcaaggag gagaagcttg cagagcagct caagcaagct gaggagctca ggcaatataa
     2221 agtcctggtt cactctcagg aacgggagct gacccagtta agggagaagt tacgggaagg
     2281 gagagatgcc tcccgctcat tgaatcagca tctccaggcc ctcctcactc cggataagcc
     2341 agacaagtcc caggggcagg acctccaaga acagctggct gaggggtgta gactggcaca
     2401 gcaacttttc caaaagctca gcccagaaaa tgacgaagat gaggatgaag atgttcaagt
     2461 tgaggaggct gagaaagtac tggaatcatc tgcccccagg gaggtgcaga aggctgaaga
     2521 aagcaaagtc cctgaggact cactggagga atgtgccatc acttgttcaa atagccacgg
     2581 cccttgtgac tccaaccagc ctcacaagaa catcaacatc acctttgagg aagacaaagt
     2641 caactcagct ctggttgtag acagagaatc ctctcatgat gaatgtcagg atgctgtaaa
     2701 cattctccca gtccctggcc ccacctcttc tgccacaaac gtcagcatgg tggtatcagc
     2761 cggccctttg ttcagcgaga aggcagagat gaacattcta gaaatcaacg agaaattgca
     2821 tccccagctg gcagagaaga atcagcagtt cagaaacctc aaagagaaat gttttgtaac
     2881 tcaactggcc tgcttcctgg ccaaccagca gaacaaatac aaatatgaag agtgcaaaga
     2941 cctcataaaa tctatgctga ggaaagagcg acagttcaag gaggagaagc ttgcagagca
     3001 gctcaagcaa gctgaggagc tcaggcaata taaagtcctg gttcactctc aggaacgaga
     3061 gctgacccac ttaagggaga agttacggga agggagagat gcctcccgct cattgaatca
     3121 gcatctccag gccctcctca ctccggataa gccagacaag tcccaggggc aggacctcca
     3181 agaacagctg gctgaggggt gtagactggc acagcaactt ttccagaagc tcagcccaga
     3241 aaatgacgaa gatgaggatg aagatgttca agttgaggag gctgagaaag tactggaatc
     3301 atctgccccc agggaggtgc agaaggctga agaaagcaaa gtccctgagg actcactgga
     3361 ggaatgtgcc atcacttgtt caaatagcca cagcccttgt gactccaacc agcctcacaa
     3421 gaacatcaac atcacctttg aggaagacaa agtcaactca actctggttg tagacagaga
     3481 atcctctcat gatgaatgtc aggatgctgt aaacattctc ccagtccctg gccccacctc
     3541 ttctgccaca aacgtcagca tggtggtatc agccggcccc ttgtccagcg agaaggcaga
     3601 gatgaacatt ctagaaatca acgagaaatt gcatccccag ctggcagaga agaaacagca
     3661 gttcagaaac ctcaaagaga aatgttttgt aactcaactg gcctgcttcc tggccaacca
     3721 gcagaacaaa tacaaatatg aagagtgcaa agacctcata aaatctatgc tgaggaatga
     3781 gcgacagttc aaggaggaga agcttgcaga gcagctcaag caagctgagg agctcaggca
     3841 atataaagtc ctggttcact ctcaggaacg ggagctgacc cagttaaggg agaagttacg
     3901 ggaagggaga gatgcctccc gctcattgaa tcagcatctc caggccctcc tcactccgga
     3961 tgagccagac aagtcccagg ggcaggacct ccaagaacag ctggctgagg ggtgtagact
     4021 ggcacagcac cttgtccaaa agctcagccc agaaaatgac aatgatgacg atgaagatgt
     4081 tcaagttgag gtggctgaga aagtgcagga atcgtctgcc cccagggaga tgccgaaggc
     4141 tgaagaaaag gaagtccctg aggactcact ggaggaatgt gccatcactt gttcaaatag
     4201 ccatggccct tatgactcca accagccaca taggaaaacc aaaatcacat ttgaggaaga
     4261 caaagtcgac tcaactctca ttggctcatc ctctcatgtt gaatgggagg atgctgtaca
     4321 cattatccca gaaaatgaaa gtgatgatga ggaagaggaa gaaaaagggc cagtgtctcc
     4381 caggaatctg caggagtctg aagaggagga agtcccccag gagtcctggg atgaaggtta
     4441 ttcgactctc tcaattcctc ctgaaatgtt ggcctcgtac cagtcttaca gcggcacatt
     4501 tcactcatta gaggaacagc aagtctgcat ggctgttgac ataggcggac atcggtggga
     4561 tcaagtgaaa aaggaggacc aagaggcaac aggtcccagg ctcagcaggg agctgctgga
     4621 tgagaaaggg cctgaagtct tgcaggactc actggataga tgttattcaa ctccttcagg
     4681 ttatcttgaa ctgactgact catgccagcc ctacagaagt gccttttaca tattggagca
     4741 acagcgtgtt ggctgggctc ttgacatgga tgaaattgaa aagtaccaag aagtggaaga
     4801 agaccaagac ccatcatgcc ccaggctcag cagggagctg ctggatgaga aagagcctga
     4861 agtcttgcag gactcactgg atagatgtta ttcgactcct tcaggttatc ttgaactgcc
     4921 tgacttaggc cagccctaca gaagtgctgt ttactcattg gaggaacagt accttggctt
     4981 ggctcttgac gtggacagaa ttaaaaagga ccaggaagag gaagaagacc aaggcccacc
     5041 atgccccagg ctcagcaggg agctgctgga ggcagtagag cctgaagtct tgcaggactc
     5101 actggataga tgttattcaa ctccttccag ttgtcttgaa cagcctgact cctgcctgcc
     5161 ctatggaagt tccttttatg cattggagga aaaacatgtt ggcttttctc ttgacgtggg
     5221 agaaattgaa aagaagggga aggggaagaa aagaagggga agaagatcaa cgaagaaaag
     5281 aaggagaagg ggaagaaaag aaggggaaga agatcaaaac ccaccatgcc ccaggctcag
     5341 cagggagctg ctggatgaga aagggcctga agtcttgcag gactcactgg atagatgtta
     5401 ttcaactcct tcaggttatc ttgaactgac tgactcatgc cagccctaca gaagtgcctt
     5461 ttacatattg gagcaacagc gtgttggctg ggctcttgac atggatgaaa ttgaaaagta
     5521 ccaagaagtg gaagaagacc aagacccatc atgccccagg ctcagcaggg agctgctgga
     5581 tgagaaagag cctgaagtct tgcaggactc actggataga tgttattcga ctccttcagg
     5641 ttatcttgaa ctgcctgact taggccagcc ctacagaagt gctgtttact cattggagga
     5701 acagtacctt ggcttggctc ttgacgtgga cagaattaaa aaggaccagg aagaggaaga
     5761 agaccaaggc ccaccatgcc ccaggctcag cagggagctg ctggaggcag tagagcctga
     5821 agtcttgcag gactcactgg atagatgtta ttcaactcct tccagttgtc ttgaacagcc
     5881 tgactcctgc ctgccctatg gaagttcctt ttatgcattg gaggaaaaac atgttggctt
     5941 ttctcttgac gtgggagaaa ttgaaaagaa ggggaagggg aagaaaagaa ggggaagaag
     6001 atcaacgaag aaaagaagga gaaggggaag aaaagaaggg gaagaagatc aaaacccacc
     6061 atgccccagg ctcagcggtg tgctgatgga agtggaagag cctgaagtct tacaggactc
     6121 actggataga tgttattcga ctccgtcaat gttctttgaa ctacctgact cattccagca
     6181 ctacagaagt gtgttttact catttgagga acagcacatc agcttcgccc ttgacgtgga
     6241 caataggttt cttactttga tgggaacaag tctccacctg gtcttccaga tgggagtcat
     6301 attcccacag taagcagccc ttactaagcc gagagatgtc attcctgcag gcaggaccta
     6361 taggcacgtg aagatttgaa tgaaactata gttccatttg gaagcccaga cataggatgg
     6421 gtcagtgggc atggctctat tcctattctc agaccatgcc agtggcaacc tgtgctcagt
     6481 ctgaagacaa tggacccaag ttaggtgtga cacgttcaca taactgtgca gcacatgccg
     6541 ggagtgatca gtcagacatt ttaatttgaa ccacgtatct ctgggtagct acaaagttcc
     6601 tcagggattt cattttgcag gcatgtctct gagcttctat acctgctcaa ggtcagtgtc
     6661 atctttgtgt ttagctcatc caaaggtgtt accctggttt caatgaacct aacctcattc
     6721 tttgtatctt cagtgttgaa ttgttttagc tgatccatct ttaacgcagg agggatcctt
     6781 ggctgaggat tgtatttcag aaccaccaac tgctcttgac aattgttaac ccgctaggct
     6841 cctttggtta gagaagccac agtccttcag cctccaattg gtgtcagtac ttaggaagac
     6901 cacagctaga tggacaaaca gcattgggag gccttagccc tgctcctctc gattccatcc
     6961 tgtagagaac aggagtcagg agccgctggc aggagacagc atgtcaccca ggactctgcc
     7021 ggtgcagaat atgaacaacg ccatgttctt gcagaaaacg cttagcctga gtttcatagg
     7081 aggtaatcac cagacaactg cagaatgtag aacactgagc aggacaactg acctgtctcc
     7141 ttcacatagt ccatatcacc acaaatcaca caacaaaaag gagaagagat attttgggtt
     7201 caaaaaaagt aaaaagataa tatagctgca tttctttagt tattttgaac cccaaatatt
     7261 tcctcatctt tttgttgttg tcattgatgg tggtgacatg gacttgttta tagaggacag
     7321 gtcagctgtc tggctcaatg atctacattc tgaagttgtc tgaaaatgtc ttcatgatta
     7381 aattcagcct aaacgttttg ccgggaacac tgcagagaca atgctgtgag tttccaacct
     7441 tagcccatct gcgggcagag aaggtctagt ttgtccatca gcattatcat gatatcagga
     7501 ctggttactt ggttaaggag gggtctagga gatctgtccc ttttagagac accttactta
     7561 taatgaagta tttgggaggg tggttttcaa aagtagaaat gtcctgtatt ccgatgatca
     7621 tcctgtaaac attttatcat ttattaatca tccctgcctg tgtctattat tatattcata
     7681 tctctacgct ggaaactttc tgcctcaata tttactgtgc ctttgttttt gctagtttgt
     7741 gttgttgaaa aaaaaaacat tctctgcctg agttttaatt tttgtccaaa gttattttaa
     7801 tctatacaat taaaagcttt tgcctatcac tct
//
