LOCUS       NM_001278164            2038 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens NBL1, DAN family BMP antagonist (NBL1), transcript
            variant 6, mRNA.
ACCESSION   NM_001278164
VERSION     NM_001278164.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Kobayashi,H., Satake,E., Murata,Y., Otsuka,H., Tsunemi,A.,
            Azuma,M., Nakamura,Y., Saito,T. and Abe,M.
  TITLE     Neuroblastoma suppressor of tumorigenicity 1 is associated with the
            severity of interstitial fibrosis and kidney function decline in
            IgA nephropathy
  JOURNAL   J Nephrol 36 (8), 2245-2256 (2023)
   PUBMED   37436574
  REMARK    GeneRIF: Neuroblastoma suppressor of tumorigenicity 1 is associated
            with the severity of interstitial fibrosis and kidney function
            decline in IgA nephropathy.
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Kobayashi,H., Looker,H.C., Satake,E., D'Addio,F., Wilson,J.M.,
            Saulnier,P.J., Md Dom,Z.I., O'Neil,K., Ihara,K., Krolewski,B.,
            Badger,H.S., Petrazzuolo,A., Corradi,D., Galecki,A., Wilson,P.C.,
            Najafian,B., Mauer,M., Niewczas,M.A., Doria,A., Humphreys,B.D.,
            Duffin,K.L., Fiorina,P., Nelson,R.G. and Krolewski,A.S.
  TITLE     Neuroblastoma suppressor of tumorigenicity 1 is a circulating
            protein associated with progression to end-stage kidney disease in
            diabetes
  JOURNAL   Sci Transl Med 14 (657), eabj2109 (2022)
   PUBMED   35947673
  REMARK    GeneRIF: Neuroblastoma suppressor of tumorigenicity 1 is a
            circulating protein associated with progression to end-stage kidney
            disease in diabetes.
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2038)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2038)
  AUTHORS   Ahmed,A., Kandola,P., Ziada,G. and Parenteau,N.
  TITLE     Purification and partial amino acid sequence of proteins from human
            epidermal keratinocyte conditioned medium
  JOURNAL   J Protein Chem 20 (4), 273-278 (2001)
   PUBMED   11594460
REFERENCE   6  (bases 1 to 2038)
  AUTHORS   Ozaki,T., Enomoto,H., Nakamura,Y., Kondo,K., Seki,N., Ohira,M.,
            Nomura,N., Ohki,M., Nakagawara,A. and Sakiyama,S.
  TITLE     The genomic analysis of human DAN gene
  JOURNAL   DNA Cell Biol 16 (9), 1031-1039 (1997)
   PUBMED   9324305
REFERENCE   7  (bases 1 to 2038)
  AUTHORS   Ozaki,T., Ma,J., Takenaga,K. and Sakiyama,S.
  TITLE     Cloning of mouse DAN cDNA and its down-regulation in transformed
            cells
  JOURNAL   Jpn J Cancer Res 87 (1), 58-61 (1996)
   PUBMED   8609050
REFERENCE   8  (bases 1 to 2038)
  AUTHORS   White,P.S., Maris,J.M., Beltinger,C., Sulman,E., Marshall,H.N.,
            Fujimori,M., Kaufman,B.A., Biegel,J.A., Allen,C., Hilliard,C.,
            Valentine,M.B., Look,A.T., Enomoto,H., Sakiyama,S. and Brodeur,G.M.
  TITLE     A region of consistent deletion in neuroblastoma maps within human
            chromosome 1p36.2-36.3
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5520-5524 (1995)
   PUBMED   7777541
REFERENCE   9  (bases 1 to 2038)
  AUTHORS   Enomoto,H., Ozaki,T., Takahashi,E., Nomura,N., Tabata,S.,
            Takahashi,H., Ohnuma,N., Tanabe,M., Iwai,J., Yoshida,H. et al.
  TITLE     Identification of human DAN gene, mapping to the putative
            neuroblastoma tumor suppressor locus
  JOURNAL   Oncogene 9 (10), 2785-2791 (1994)
   PUBMED   8084583
REFERENCE   10 (bases 1 to 2038)
  AUTHORS   Ozaki,T. and Sakiyama,S.
  TITLE     Molecular cloning and characterization of a cDNA showing negative
            regulation in v-src-transformed 3Y1 rat fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 90 (7), 2593-2597 (1993)
   PUBMED   8385338
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK300872.1, DB016315.1,
            AL031727.43 and BM988954.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001278164.1.
            
            Summary: This gene product is the founding member of the
            evolutionarily conserved CAN (Cerberus and DAN) family of proteins,
            which contain a domain resembling the CTCK (C-terminal cystine
            knot-like) motif found in a number of signaling molecules. These
            proteins are secreted, and act as BMP (bone morphogenetic protein)
            antagonists by binding to BMPs and preventing them from interacting
            with their receptors. They may thus play an important role during
            growth and development. Alternatively spliced transcript variants
            have been identified for this gene. Read-through transcripts
            between this locus and the upstream mitochondrial inner membrane
            organizing system 1 gene (GeneID 440574) have been observed.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (6) uses an alternate splice site
            in the 5' exon, lacks a portion of the 5' coding region, and
            initiates translation at a downstream start codon, compared to
            variant 1. The encoded isoform (2) has a shorter N-terminus,
            compared to isoform 1. Variants 2, 3, 4, 6, 7, and 8 encode the
            same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB016315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK300872.1         1-2
            3-289               DB016315.1         1-287
            290-956             AK300872.1         309-975
            957-2009            AL031727.43        85774-86826
            2010-2038           BM988954.1         23-51               c
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..2038
                     /gene="NBL1"
                     /gene_synonym="D1S1733E; DAN; DAND1; NB; NO3"
                     /note="NBL1, DAN family BMP antagonist"
                     /db_xref="GeneID:4681"
                     /db_xref="HGNC:HGNC:7650"
                     /db_xref="MIM:600613"
     exon            1..150
                     /gene="NBL1"
                     /gene_synonym="D1S1733E; DAN; DAND1; NB; NO3"
                     /inference="alignment:Splign:2.1.0"
     exon            151..339
                     /gene="NBL1"
                     /gene_synonym="D1S1733E; DAN; DAND1; NB; NO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..715
                     /gene="NBL1"
                     /gene_synonym="D1S1733E; DAN; DAND1; NB; NO3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 6; neuroblastoma candidate region, suppression of
                     tumorigenicity 1; differential screening-selected gene
                     aberrant in neuroblastoma; DAN domain family member 1;
                     neuroblastoma suppressor of tumorigenicity 1;
                     neuroblastoma 1, DAN family BMP antagonist"
                     /codon_start=1
                     /product="neuroblastoma suppressor of tumorigenicity 1
                     isoform 2 precursor"
                     /protein_id="NP_001265093.1"
                     /db_xref="GeneID:4681"
                     /db_xref="HGNC:HGNC:7650"
                     /db_xref="MIM:600613"
                     /translation="MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIV
                     GHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGH
                     EEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGG
                     QTPEPEDPPGAPHTEEEGAED"
     exon            340..451
                     /gene="NBL1"
                     /gene_synonym="D1S1733E; DAN; DAND1; NB; NO3"
                     /inference="alignment:Splign:2.1.0"
     exon            452..2038
                     /gene="NBL1"
                     /gene_synonym="D1S1733E; DAN; DAND1; NB; NO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBL1"
                     /gene_synonym="D1S1733E; DAN; DAND1; NB; NO3"
                     /note="hexamer: AATAAA"
     polyA_site      2038
                     /gene="NBL1"
                     /gene_synonym="D1S1733E; DAN; DAND1; NB; NO3"
                     /note="major polyA site"
ORIGIN      
        1 gcagatgcag gctgggtgtg gagggtgcga gtaggctgga gtacaccagg gagttcccag
       61 caggccacta ggagccaccc aggatgcccg gcaacctcat gagtcagaca agcagggctg
      121 tgtctatctg gaagtttcca gccaagctag ggctctggag gccacgggca tgatgcttcg
      181 ggtcctggtg ggggctgtcc tccctgccat gctactggct gccccaccac ccatcaacaa
      241 gctggcactg ttcccagata agagtgcctg gtgcgaagcc aagaacatca cccagatcgt
      301 gggccacagc ggctgtgagg ccaagtccat ccagaacagg gcgtgcctag gacagtgctt
      361 cagctacagc gtccccaaca ccttcccaca gtccacagag tccctggttc actgtgactc
      421 ctgcatgcca gcccagtcca tgtgggagat tgtgacgctg gagtgcccgg gccacgagga
      481 ggtgcccagg gtggacaagc tggtggagaa gatcctgcac tgtagctgcc aggcctgcgg
      541 caaggagcct agtcacgagg ggctgagcgt ctatgtgcag ggcgaggacg ggccgggatc
      601 ccagcccggc acccaccctc acccccatcc ccacccccat cctggcgggc agacccctga
      661 gcccgaggac ccccctgggg ccccccacac agaggaagag ggggctgagg actgaggccc
      721 ccccaactct tcctcccctc tcatccccct gtggaatgtt gggtctcact ctctggggaa
      781 gtcaggggag aagctgaagc ccccctttgg cactggatgg acttggcttc agactcggac
      841 ttgaatgctg cccggttgcc atggagatct gaaggggcgg ggttagagcc aagctgcaca
      901 atttaatata ttcaagagtg gggggaggaa gcagaggtct tcagggctct ttttttgggg
      961 ggggtggtct cttcctgtct ggcttctaga gatgtgcctg tgggaggggg aggaagttgg
     1021 ctgagccatt gagtgctggg ggaggccatc caagatggca tgaatcgggc taaggtccct
     1081 gggggtgcag atggtactgc tgaggtcccg ggcttagtgt gagcatcttg ccagcctcag
     1141 gcttgaggga gggctgggct agaaagacca ctggcagaaa caggaggctc cggcccacag
     1201 gtttccccaa ggcctctcac cccacttccc atctccaggg aagcgtcgcc ccagtggcac
     1261 tgaagtggcc ctccctcagc ggaggggttt gggagtcagg cctgggcagg accctgctga
     1321 ctcgtggcgc gggagctggg agccaggctc tccgggcctt tctctggctt ccttggcttg
     1381 cctggtgggg gaaggggagg aggggaagaa ggaaagggaa gagtcttcca aggccagaag
     1441 gagggggaca accccccaag accatccctg aagacgagca tccccctcct ctccctgtta
     1501 gaaatgttag tgccccgcac tgtgccccaa gttctaggcc ccccagaaag ctgccagagc
     1561 cggccgcctt ctcccctctc ccagggatgc tctttgtaaa tatcggatgg gtgtgggagt
     1621 gaggggttac ctccctcgcc ccaaggttcc agaggcccta ggcgggatgg gctcgctgaa
     1681 cctcgaggaa ctccaggacg aggaggacat gggacttgcg tggacagtca gggttcactt
     1741 gggctctctc tagctcccca attctgcctg cctcctccct cccagctgca ctttaaccct
     1801 agaaggtggg gacctggggg gagggacagg gcaggcgggc ccatgaagaa agcccctcgt
     1861 tgcccagcac tgtctgcgtc tgctcttctg tgcccagggt ggctgccagc ccactgcctc
     1921 ctgcctgggg tggcctggcc ctcctggctg ttgcgacgcg ggcttctgga gcttgtcacc
     1981 attggacagt ctccctgatg gaccctcagt cttctcatga ataaattcct tcaacgcc
//
