LOCUS       NM_015175               8842 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens neurobeachin like 2 (NBEAL2), transcript variant 1,
            mRNA.
ACCESSION   NM_015175 XM_291064 XM_941211
VERSION     NM_015175.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8842)
  AUTHORS   Wegner,P., Drube,J., Ziegler,L., Strotmann,B., Marquardt,R.,
            Kuchler,C., Groth,M., Nieswandt,B., Andreas,N. and Drube,S.
  TITLE     The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic
            level of the ribosomal protein RPS6 in mast cells
  JOURNAL   Immunology 172 (1), 61-76 (2024)
   PUBMED   38272677
  REMARK    GeneRIF: The Neurobeachin-like 2 protein (NBEAL2) controls the
            homeostatic level of the ribosomal protein RPS6 in mast cells.
REFERENCE   2  (bases 1 to 8842)
  AUTHORS   Delage,L., Carbone,F., Riller,Q., Zachayus,J.L., Kerbellec,E.,
            Buzy,A., Stolzenberg,M.C., Luka,M., de Cevins,C., Kalouche,G.,
            Favier,R., Michel,A., Meynier,S., Corneau,A., Evrard,C., Neveux,N.,
            Roudieres,S., Perot,B.P., Fusaro,M., Lenoir,C., Pelle,O.,
            Parisot,M., Bras,M., Heritier,S., Leverger,G., Korganow,A.S.,
            Picard,C., Latour,S., Collet,B., Fischer,A., Neven,B., Magerus,A.,
            Menager,M., Pasquier,B. and Rieux-Laucat,F.
  TITLE     NBEAL2 deficiency in humans leads to low CTLA-4 expression in
            activated conventional T cells
  JOURNAL   Nat Commun 14 (1), 3728 (2023)
   PUBMED   37349339
  REMARK    GeneRIF: NBEAL2 deficiency in humans leads to low CTLA-4 expression
            in activated conventional T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8842)
  AUTHORS   Pluthero,F.G. and Kahr,W.H.A.
  TITLE     Gray platelet syndrome: NBEAL2 mutations are associated with
            pathology beyond megakaryocyte and platelet function defects
  JOURNAL   J Thromb Haemost 19 (2), 318-322 (2021)
   PUBMED   33300270
  REMARK    GeneRIF: Gray platelet syndrome: NBEAL2 mutations are associated
            with pathology beyond megakaryocyte and platelet function defects.
REFERENCE   4  (bases 1 to 8842)
  AUTHORS   Lo,R.W., Li,L., Pluthero,F.G., Leung,R., Eto,K. and Kahr,W.H.A.
  TITLE     The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and
            is required for megakaryocyte alpha-granule biogenesis
  JOURNAL   Blood 136 (6), 715-725 (2020)
   PUBMED   32384141
  REMARK    GeneRIF: The endoplasmic reticulum protein SEC22B interacts with
            NBEAL2 and is required for megakaryocyte alpha-granule biogenesis.
REFERENCE   5  (bases 1 to 8842)
  AUTHORS   Wijgaerts,A., Wittevrongel,C., Thys,C., Devos,T., Peerlinck,K.,
            Tijssen,M.R., Van Geet,C. and Freson,K.
  TITLE     The transcription factor GATA1 regulates NBEAL2 expression through
            a long-distance enhancer
  JOURNAL   Haematologica 102 (4), 695-706 (2017)
   PUBMED   28082341
  REMARK    GeneRIF: we herein show a long-distance regulatory region with
            GATA1 binding sites as being a strong enhancer for NBEAL2
            expression.
REFERENCE   6  (bases 1 to 8842)
  AUTHORS   Kahr,W.H., Hinckley,J., Li,L., Schwertz,H., Christensen,H.,
            Rowley,J.W., Pluthero,F.G., Urban,D., Fabbro,S., Nixon,B.,
            Gadzinski,R., Storck,M., Wang,K., Ryu,G.Y., Jobe,S.M.,
            Schutte,B.C., Moseley,J., Loughran,N.B., Parkinson,J., Weyrich,A.S.
            and Di Paola,J.
  TITLE     Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet
            syndrome
  JOURNAL   Nat Genet 43 (8), 738-740 (2011)
   PUBMED   21765413
  REMARK    GeneRIF: Mutations in NBEAL2, encoding a BEACH protein is
            associated with gray platelet syndrome.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8842)
  AUTHORS   Gunay-Aygun,M., Falik-Zaccai,T.C., Vilboux,T., Zivony-Elboum,Y.,
            Gumruk,F., Cetin,M., Khayat,M., Boerkoel,C.F., Kfir,N., Huang,Y.,
            Maynard,D., Dorward,H., Berger,K., Kleta,R., Anikster,Y., Arat,M.,
            Freiberg,A.S., Kehrel,B.E., Jurk,K., Cruz,P., Mullikin,J.C.,
            White,J.G., Huizing,M. and Gahl,W.A.
  TITLE     NBEAL2 is mutated in gray platelet syndrome and is required for
            biogenesis of platelet alpha-granules
  JOURNAL   Nat Genet 43 (8), 732-734 (2011)
   PUBMED   21765412
  REMARK    GeneRIF: NBEAL2 mutation is associated with gray platelet syndrome.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 8842)
  AUTHORS   Albers,C.A., Cvejic,A., Favier,R., Bouwmans,E.E., Alessi,M.C.,
            Bertone,P., Jordan,G., Kettleborough,R.N., Kiddle,G., Kostadima,M.,
            Read,R.J., Sipos,B., Sivapalaratnam,S., Smethurst,P.A.,
            Stephens,J., Voss,K., Nurden,A., Rendon,A., Nurden,P. and
            Ouwehand,W.H.
  TITLE     Exome sequencing identifies NBEAL2 as the causative gene for gray
            platelet syndrome
  JOURNAL   Nat Genet 43 (8), 735-737 (2011)
   PUBMED   21765411
  REMARK    GeneRIF: NBEAL2 mutation is associated with gray platelet syndrome.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8842)
  AUTHORS   So,H.C., Fong,P.Y., Chen,R.Y., Hui,T.C., Ng,M.Y., Cherny,S.S.,
            Mak,W.W., Cheung,E.F., Chan,R.C., Chen,E.Y., Li,T. and Sham,P.C.
  TITLE     Identification of neuroglycan C and interacting partners as
            potential susceptibility genes for schizophrenia in a Southern
            Chinese population
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (1), 103-113 (2010)
   PUBMED   19367581
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   10 (bases 1 to 8842)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC094020.2, CR988681.1,
            AK131104.1, AB011112.3, BC029944.1 and BQ017286.1.
            
            On Aug 31, 2019 this sequence version replaced NM_015175.2.
            
            Summary: The protein encoded by this gene contains a beige and
            Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may
            play a role in megakaryocyte alpha-granule biogenesis. Mutations in
            this gene are a cause of gray platelet syndrome. [provided by
            RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131104.1, SRR14038193.1215017.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450053.8/ ENSP00000415034.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC094020.2         138297-138313
            18-177              CR988681.1         1-160
            178-5106            AK131104.1         1-4929
            5107-5107           AB011112.3         2774-2774
            5108-6249           AK131104.1         4931-6072
            6250-6250           AB011112.3         3917-3917
            6251-8564           AK131104.1         6074-8387
            8565-8697           BC029944.1         1969-2101
            8698-8842           BQ017286.1         22-166              c
FEATURES             Location/Qualifiers
     source          1..8842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..8842
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /note="neurobeachin like 2"
                     /db_xref="GeneID:23218"
                     /db_xref="HGNC:HGNC:31928"
                     /db_xref="MIM:614169"
     exon            1..247
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..8461
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neurobeachin-like protein 2"
                     /codon_start=1
                     /product="neurobeachin-like protein 2 isoform 1"
                     /protein_id="NP_055990.1"
                     /db_xref="CCDS:CCDS46817.1"
                     /db_xref="GeneID:23218"
                     /db_xref="HGNC:HGNC:31928"
                     /db_xref="MIM:614169"
                     /translation="MAASERLYELWLLYYAQKDLGYLQQWLKAFVGAFKKSISLSSLE
                     PRRPEEAGAEVPLLPLDELHVLAEQLHQADLEQALLLLKLFIILCRNLENIEAGRGQV
                     LVPRVLALLTKLVAELKGCPPPQGRGTQLENVALHALLLCEGLFDPYQTWRRQRSGEV
                     ISSKEKSKYKFPPAALPQEFSAFFQESLQNADHLPPILLLRLIHLFCAVLAGGKENGQ
                     MAVSDGSVKGLLSVVRGWSRGPAPDPCLVPLALEALVGAVHVLHASRAPPRGPELRAL
                     LESYFHVLNADWPAGLSSGPEEALVTLRVSMLDAIPMMLACEDRPVLQATFLSNNCFE
                     HLTRLIQNSKLYLQSRAPPEGDSDLATRLLTEPDVQKVLDQDTDAIAVHVVRVLTCIM
                     SDSPSAKEVFKERIGYPHLQEVLQSHGPPTHRLLQELLNMAVEGDHSMCPPPPIRNEQ
                     PVLVLAQWLPSLPTAELRLFLAQRLRWLCDSCPASRATCVQAGLVGCLLETLSTGLAL
                     EARCQEQLLALLQALGRVSIRPMELRHLLRPRPGLDSEPGGAEAGKARHAGAVIRTLS
                     GMARHQGPARALRYFDLTPSMAGIMVPPVQRWPGPGFTFHAWLCLHPMDTAPTPAPTR
                     PLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTMSLPEVSFADSAWHCVAI
                     VHVPGRRPFSQNLVHVYKDGHLVKTAPLRCPSLSEPFSSCCIGSAGYRTTTTTTGLPT
                     PPVPATLAYTHPALTRSQSVPASTGLGWGSGLVAPLQEGSIDSTLAGTQDTRWGSPTS
                     LEGELGAVAIFHEALQATALRTLCTLGPNETAPFKPEGELHELSTRLLLHYSPQACKN
                     NICLDLSPSHGLDGRLTGHRVETWDVKDVVNCVGGMGALLPLLERVAAQPKEAEAGPA
                     ETHDLVGPELTSGHNTQGLVLPLGKSSEERMERNAVAAFLLMLRNFLQGHMVNQESLV
                     QCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMEQVAAEGSGPLLYLLYQHLLFNFHLW
                     TLSDFAVRLGHIQYMSSIVREHRQKLRKKYGVQFILDALRTHYSPQRERPLAADDLRT
                     VQTSLLGLAREFLVRSLSADDVQVTQTMLSFLAATGDDGQAVGALDLLLALLHGSLVQ
                     ESLAVFLLEPGNLEVLLALLVRPGSLPLLPDRVCKILRRLQQNERLPERSRQRLRLRE
                     CGLQGLVACLPEGTVSPQLCQGLYKLFLGADCLNLSDLLAVVQLSLQADLSVRLDICR
                     QLFHLIYGQPDVVRLLARQAGWQDVLTRLYVLEAATAGSPPPSSPESPTSPKPAPPKP
                     PTESPAEPSDVFLPSEAPCPDPDGFYHALSPFCTPFDLGLERSSVGSGNTAGGGGSSG
                     TLTPASQPGTPSPLDGPRPFPAAPGRHSSSLSNVLEDGSLPEPTISGDDTSNTSNPQQ
                     TSEEELCNLLTNVLFSVTWRGVEGSDEAAWRERGQVFSVLTQLGASATLVRPPDCIKR
                     SLLEMMLESALTDIKEAPVGVLASLTQQALWLLRLLQDFLCAEGHGNQELWSEKLFEG
                     VCSLLDRLGAWPHLANGTADLREMAQIGLRLVLGYILLEDPQLHAQAYVRLHMLLQTA
                     VPARREEACYVLSKLEAALGRVLNTSSLESATDEAGSPLAAAAAAAAAERCSWLVPLV
                     RTLLDRAYEPLGLQWGLPSLPPTNGSPTFFEDFQAFCATPEWRHFIDKQVQPTMSQFE
                     MDTYAKSHDLMSGFWNACYDMLMSSGQRRQWERAQSRRAFQELVLEPAQRRARLEGLR
                     YTAVLKQQATQHSMALLHWGALWRQLASPCGAWALRDTPIPRWKLSSAETYSRMRLKL
                     VPNHHFDPHLEASALRDNLGEVPLTPTEEASLPLAVTKEAKVSTPPELLQEDQLGEDE
                     LAELETPMEAAELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQNVYFYDGSTERVET
                     EEGIGYDFRRPLAQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQ
                     TPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSPQEMLRASGLTQKWVQREIS
                     NFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPK
                     HAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDC
                     SDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVV
                     LPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYE
                     GAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLSAEEAAHRLARLDTNSPS
                     IFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFITQGSPDLLVTVSASGLLGTHSW
                     LPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGVSGQALAVAPDGKLLFSGGHW
                     DGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLS
                     VGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPLGA
                     TFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKLRASLPLAEQPTALT
                     VTEDFVLLGTAQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERSHVLVGLEDGKLI
                     VVVAGQPSEVRSSQFARKLWRSSRRISQVSSGETEYNPTEAR"
     exon            248..336
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            337..465
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            466..547
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            548..669
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            670..752
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            753..838
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1121
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1228
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1309
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1393
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1492
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..2094
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2227
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2347
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2669
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2752
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2845
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3020
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3154
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3314
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3417
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3580
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3739
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3899
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..3985
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            3986..4501
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..4680
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            4681..4840
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            4841..4978
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            4979..5347
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            5348..5497
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            5498..5655
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            5656..5780
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            5781..5916
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            5917..6077
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            6078..6394
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            6395..6490
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            6491..6615
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            6616..6756
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            6757..6887
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            6888..6997
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            6998..7115
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            7116..7213
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            7214..7330
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            7331..7420
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            7421..7530
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            7531..7703
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            7704..7798
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            7799..7915
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            7916..8074
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            8075..8223
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            8224..8359
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     exon            8360..8842
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8820..8825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /note="hexamer: AATAAA"
     polyA_site      8842
                     /gene="NBEAL2"
                     /gene_synonym="BDPLT4; GPS"
                     /note="major polyA site"
ORIGIN      
        1 agtgaggagg aggagcgagc agacttgggt ggctctgcgc cgcggaggcc acagccgcag
       61 acttccccag tagtaccgcg ccgctccgcc ccggagtgac gccctccgcc catgggcctg
      121 gccgagggca accggcgggc ggcgcggagg aggcggcgac aggtggcgcg cagcagggcc
      181 ggagccgggc cgggccatgg ccgcctcgga gcggctgtac gagttgtggc tgctctacta
      241 cgcgcagaag gacctgggtt acctgcagca gtggctgaag gcctttgtag gtgccttcaa
      301 gaagagcatc tcactgtcct ctctggagcc acgaaggcca gaggaggcag gtgcagaggt
      361 cccgctgcta ccactggatg agctgcatgt gctggccgaa cagctgcacc aggctgacct
      421 ggagcaagcc ctcctgctgc tcaagctctt catcattctc tgcaggaacc tggagaacat
      481 agaggcaggc cggggccaag tgctagtgcc ccgagtgctg gcactgttga ccaagttggt
      541 ggcggagctg aaaggatgcc caccacccca gggccgaggc acgcagttgg agaatgtggc
      601 cctacatgct ctgcttctct gcgagggcct ctttgaccct taccaaacct ggcggcgcca
      661 gcgcagtggg gaagtcatca gctccaagga gaagagcaaa tacaagttcc ctcctgctgc
      721 tttgccccag gaattcagcg ccttcttcca agagagccta cagaatgcag accacttgcc
      781 tcccatactg ctgttacgtc tcatccacct cttctgcgcc gtcctcgctg gaggaaagga
      841 gaacgggcag atggctgtaa gtgatggctc tgtgaagggc ctgctgagtg tggtgcgggg
      901 ctggagccgt gggccagccc cggacccgtg cctagtgcca ctggctctag aggcactggt
      961 aggtgcagtc catgtcttgc atgccagccg cgcacctcct cgtggcccag agcttcgtgc
     1021 cctgcttgag agctacttcc atgtccttaa tgctgactgg ccagctggtc tgagctcagg
     1081 ccccgaagag gcccttgtca ccctccgggt cagcatgctc gacgccatcc ccatgatgct
     1141 ggcatgtgaa gaccggccag tgctgcaagc caccttcctc agcaacaatt gctttgaaca
     1201 cctcactcgg ctcattcaga acagcaagct gtacctgcag tcccgggcgc cccccgaggg
     1261 ggacagtgac ctggctaccc ggttactgac tgagcccgat gtccaaaagg tcctggacca
     1321 agacacagac gccattgcag tccatgtagt cagagtgctg acctgcatca tgagtgactc
     1381 cccctcggcc aaggaggtgt ttaaggagcg catcggctac cctcacctgc aggaggttct
     1441 gcagagccat ggtcccccca cccatcggct gttgcaagag ctgctcaaca tggctgtgga
     1501 gggtgaccac agcatgtgcc cacctccacc aatccgcaac gagcagccgg tactggtgct
     1561 ggcgcagtgg ctgccgtcat tgcccaccgc tgagctgcgg ctcttcctag cgcaacgcct
     1621 caggtggctc tgtgacagct gccctgccag ccgtgccacc tgtgtgcagg caggcctggt
     1681 gggctgcctg ttggagacac tcagcacagg gctagccctg gaggcccgct gccaagagca
     1741 gctgctggca ctgctacaag cactgggccg tgtatcaata aggcccatgg agctgcgtca
     1801 cctgctgcgc ccccggccag gattggactc ggaaccaggc ggagctgagg ctggaaaggc
     1861 ccgacacgca ggtgctgtca tccgcacatt atcaggcatg gccaggcacc agggtcctgc
     1921 acgtgctctg cgctactttg acctcacgcc cagcatggcg ggcatcatgg taccccctgt
     1981 acagcgatgg ccagggcctg gcttcacctt tcatgcctgg ctctgtctgc accctatgga
     2041 tacagcacct acccctgccc ccacccgacc actccagcga aagcagctgt acagcttctt
     2101 taccagcagc ggctcagggt ttgaggcctt cttcacggcg gccgggaccc tggtggtggc
     2161 tgtgtgcaca cggaaggagt atttgaccat gagtttgccc gaagtgtcct ttgccgactc
     2221 tgcctggcac tgcgtggcta tcgtccatgt gcctgggcgc cggcccttca gccagaacct
     2281 ggtccatgtc tacaaagacg gccatctggt caagacagca ccccttcgct gcccctccct
     2341 cagtgagcct ttctcctcct gctgtatcgg ctccgctgga taccgcacaa cgaccaccac
     2401 cacagggctg cccacaccac cagtccccgc caccctggcc tacactcacc ccgccctcac
     2461 ccgctcccag tcagtcccag cctccacagg gcttggctgg gggtccgggc tggtggcccc
     2521 cctgcaggag ggcagcatcg actctaccct cgcaggcacc caggacactc ggtggggcag
     2581 ccccacatcc ctggagggtg agctgggggc tgtggccatc tttcacgaag ccctgcaggc
     2641 gacggctctg aggaccctgt gcaccctggg gcccaatgag acggcaccct tcaagcctga
     2701 gggggagctg catgagctca gcaccaggct gctcctccat tactcacctc aggcttgtaa
     2761 gaacaacatc tgcctggacc tgtcccccag tcatgggctt gatgggcgcc tgacgggcca
     2821 cagagtggag acctgggatg tgaaggatgt ggtgaactgc gttgggggta tgggtgccct
     2881 gctgcccctg ctggagcgag tagctgcaca gcccaaagag gctgaagcag gtccagctga
     2941 aacgcatgac ctcgtgggtc ctgaactgac ctctggtcac aacacccagg gcctggttct
     3001 cccattgggt aaatcttcag aggaacggat ggagaggaac gcagtggctg cttttctgct
     3061 gatgctgcgg aacttccttc agggtcacat ggtgaaccaa gagagcctgg tgcagtgcca
     3121 ggggcctgcc atcatcgggg ccctcctgcg aaaggtccca agctgggcca tggacatgaa
     3181 cgtgctcatg tccgcccagc tgctgatgga gcaggtggca gctgagggca gcgggcccct
     3241 cctgtaccta ctctaccagc atttgctctt caactttcac ctctggaccc tcagtgactt
     3301 cgccgtgcgc ctcggtcaca tccagtacat gtccagcata gttcgggagc acagacagaa
     3361 gctgcggaag aagtacggcg tccagtttat cttggatgct ctgcgcaccc actacagccc
     3421 gcagcgggag cgccccctgg ctgctgacga cctacgcacc gtgcagacct ccctcctggg
     3481 cctggcgagg gagttcctgg tgcggagtct ctcagcagat gacgtgcagg tcacgcagac
     3541 catgctgagc tttttggcgg ccacaggcga tgacggtcag gcggtgggtg cgctggacct
     3601 gctgctggcc ctgctgcacg gttccctggt gcaggagtcc ttggctgtct ttctgttgga
     3661 gccagggaac ctcgaagtgc tactggccct gctagtgcgg ccagggtcac tgcccctgct
     3721 gcccgatcga gtctgcaaga tcctgcgcag actgcagcag aatgagcggc tacctgagcg
     3781 gagccgccag cgcctccggc tgcgggagtg tggtctccag ggtctggttg cctgcttgcc
     3841 tgaggggact gtttcccccc agctctgcca gggcctctac aagctgttcc tgggggcaga
     3901 ttgcctgaac ctctcagatc tgctggctgt ggtacagctg tccctccagg ctgacctcag
     3961 cgttcgccta gacatctgtc gccagctttt ccacctcatc tacggacagc cagatgtagt
     4021 gcggcttctg gcccgacagg ctggctggca agatgtgctg acccggctat atgtcctgga
     4081 ggctgccaca gccggcagcc cccctccgtc ttccccagag tcacctacct cccccaagcc
     4141 agccccaccc aagccaccca ctgagtcacc tgctgagcct tcagatgtct tcctgccctc
     4201 agaggccccc tgccctgacc ctgatggctt ttaccatgct ctctccccat tctgcacgcc
     4261 ctttgacctg ggcctggaac ggtctagtgt aggatcaggc aacactgctg gtggtggcgg
     4321 cagcagtggg actcttactc cagccagcca gcccggcact ccttcgccac tggatgggcc
     4381 gcggcccttt cctgctgctc ctggccgcca cagctccagt ctctccaatg tgctggagga
     4441 cggcagcctc ccggagccca ccattagcgg ggatgatacc tcgaacacca gcaacccaca
     4501 gcaaacctct gaggaagagt tgtgcaatct gctcaccaac gtgctgttct cggtgacgtg
     4561 gcgtggcgtg gaaggcagcg atgaggctgc ctggcgggag cgtggccagg ttttctcagt
     4621 gctcacccag ctgggggcct cagccacact tgtgcgccca ccagactgca tcaagcgcag
     4681 cctcctggag atgatgctgg agtcagccct gaccgacatc aaagaggccc ccgtgggggt
     4741 cctggccagc ctcacccagc aagcgctttg gctgctgcgt ctgctgcagg acttcctgtg
     4801 tgctgaaggc catggtaacc aggaactgtg gagtgagaag ctctttgaag gtgtatgcag
     4861 cctacttgat cgcctgggag cctggcccca cctggccaac ggcacagctg atctccgtga
     4921 gatggcgcag attggcctac ggcttgtact tggctacatc ctgctggaag acccacagct
     4981 gcatgcccag gcctacgtga gattgcacat gctgctacag actgcagtgc cagcccgccg
     5041 cgaggaggcc tgctatgtgc tctccaagct ggaggctgca ctggggcggg tgctgaacac
     5101 ctcttccttg gagtcagcca ctgatgaggc agggtcccca cttgcagctg cagcagctgc
     5161 agcagctgca gagcgctgct cctggctggt gccactggtg cgcacgctgc tagaccgtgc
     5221 ctatgagccg ctggggctgc agtggggact gccctccctg ccacccacca atggcagccc
     5281 caccttcttt gaagacttcc aggctttttg tgccacaccc gaatggcgcc acttcatcga
     5341 caaacaggta cagccaacca tgtcccagtt cgaaatggac acgtatgcta agagccacga
     5401 ccttatgtca ggtttctgga atgcctgcta tgacatgctt atgagcagtg ggcagcggcg
     5461 ccagtgggag cgcgcccaga gtcgtcgggc cttccaggag ctggtgctgg aacctgcgca
     5521 gaggcgggcg cgcctggagg ggctacgcta cacggcagtg ctgaagcagc aggcaacgca
     5581 gcactccatg gccctgctgc actggggggc gctgtggcgc cagctcgcca gcccatgtgg
     5641 ggcctgggcg ctgagggaca ctcccatccc ccgctggaaa ctgtccagcg ccgagacata
     5701 ttcacgcatg cgtctgaagc tggtgcccaa ccatcacttc gaccctcacc tggaagccag
     5761 cgctctccga gacaatctgg gtgaggttcc cctgacaccc accgaggagg cctcactgcc
     5821 tctggcagtg accaaagagg ccaaagtgag caccccaccc gagttgctgc aggaggacca
     5881 gctcggcgag gacgagctgg ctgagctgga gaccccgatg gaggcagcag aactggatga
     5941 gcagcgtgag aagctggtgc tgtcggccga gtgccagctg gtgacggtag tggccgtggt
     6001 cccagggctg ctggaggtca ccacacagaa tgtatacttc tacgatggca gcactgagcg
     6061 cgtggaaacc gaggagggca tcggctatga tttccggcgc ccactggccc agctgcgtga
     6121 ggtccacctg cggcgtttca acctgcgccg ttcagcactt gagctcttct ttatcgatca
     6181 ggccaactac ttcctcaact tcccatgcaa ggtgggcacg accccagtct catctcctag
     6241 ccagactccc agaccccagc ctggccccat cccaccccat acccaggtac ggaaccaggt
     6301 gtactcgtgg ctcctgcgcc tacggccccc ctctcaaggc tacctaagca gccgctcccc
     6361 ccaggagatg ctgcgtgcct caggccttac ccagaaatgg gtacagcgtg agatatccaa
     6421 cttcgagtac ttgatgcaac tcaacaccat tgcggggcgg acctacaatg acctgtctca
     6481 gtaccctgtg ttcccctggg tcctgcagga ctacgtgtcc ccaaccctgg acctcagcaa
     6541 cccagccgtc ttccgggacc tgtctaagcc catcggtgtg gtgaacccca agcatgccca
     6601 gctcgtgagg gagaagtatg aaagctttga ggacccagca gggaccattg acaagttcca
     6661 ctatggcacc cactactcca atgcagcagg cgtgatgcac tacctcatcc gcgtggagcc
     6721 cttcacctcc ctgcacgtcc agctgcaaag tggccgcttt gactgctccg accggcagtt
     6781 ccactcggtg gcggcagcct ggcaggcacg cctggagagc cctgccgatg tgaaggagct
     6841 catcccggaa ttcttctact ttcctgactt cctggagaac cagaacggtt ttgacctggg
     6901 ctgtctccag ctgaccaacg agaaggtagg cgatgtggtg ctacccccgt gggccagctc
     6961 tcctgaggac ttcatccagc agcaccgcca ggctctggag tcggagtatg tgtctgcaca
     7021 cctacacgag tggatcgacc tcatctttgg ctacaagcag cgggggccag ccgccgagga
     7081 ggccctcaat gtcttctatt actgcaccta tgagggggct gtagacctgg accatgtgac
     7141 agatgagcgg gaacggaagg ctctggaggg cattatcagc aactttgggc agactccctg
     7201 tcagctgctg aaggagccac atccaactcg gctctcagct gaggaagcag cccatcgcct
     7261 tgcacgcctg gacactaact cacctagcat cttccagcac ctggacgaac tcaaggcatt
     7321 cttcgcagag gttgtcagtg atggtgtacc cctggtgcta gccctggtcc cccaccggca
     7381 gccccactcc ttcatcaccc agggttcccc agacctgttg gtgactgtga gtgccagtgg
     7441 gctgctgggc acccacagct ggttgcccta tgaccgcaac ataagcaact acttcagctt
     7501 cagcaaagac cccaccatgg gcagccacaa gacgcagcga ctgctgagtg gcccgtgggt
     7561 gccaggcagt ggtgtgagtg gacaagcact ggcagtggcc ccggatggaa agctgctatt
     7621 cagcggtggc cactgggatg gcagcctgcg ggtgactgca ctaccccgtg gcaagctgtt
     7681 gagccagctc agctgccacc ttgatgtagt aacctgcctt gcactggaca cctgtggcat
     7741 ctacctcatc tcaggctccc gggacaccac gtgcatggtg tggcggctcc tgcatcaggg
     7801 tggtctgtca gtaggcctgg caccaaagcc tgtgcaggtc ctgtatgggc atggggctgc
     7861 agtgagctgt gtggccatca gcactgaact tgacatggct gtgtctggat ctgaggatgg
     7921 aactgtgatc atacacactg tacgccgcgg acagtttgta gcggcactac ggcctctggg
     7981 tgccacattc cctggaccta ttttccacct ggcattgggg tccgaaggcc agattgtggt
     8041 acagagctca gcgtgggaac gtcctggggc ccaggtcacc tactccttgc acctgtattc
     8101 agtcaatggg aagttgcggg cttcactgcc cctggcagag cagcctacag ccctgacggt
     8161 gacagaggac tttgtgttgc tgggcaccgc ccagtgcgcc ctgcacatcc tccaactaaa
     8221 cacactgctc ccggccgcgc ctcccttgcc catgaaggtg gccatccgca gcgtggccgt
     8281 gaccaaggag cgcagccacg tgctggtggg cctggaggat ggcaagctca tcgtggtggt
     8341 cgcggggcag ccctctgagg tgcgcagcag ccagttcgcg cggaagctgt ggcggtcctc
     8401 gcggcgcatc tcccaggtgt cctcgggaga gacggaatac aaccctactg aggcgcgctg
     8461 aacctggcca gtccggctgc tcgggccccg cccccggcag gcctggcccg ggaggccccg
     8521 cccagaagtc ggcgggaaca ccccggggtg ggcagcccag gggggtgagc ggggcccacc
     8581 ctgcccagct cagggattgg cgggcgatgt taccccctca gggattggcg ggcggaagtc
     8641 ccgcccctcg ccggctgagg ggccgccctg agggccagca ctggcgtctg cggccgcagc
     8701 agcacttttt gcacagtctg gggcggggtt ccccggcttc caagtcgctg tttcgtcaaa
     8761 gcacgagggc cgcctgtggc cttaattcct aacggcggcc ccggttctcc cttctcggca
     8821 ataaaccagg cctagttttg ta
//
