LOCUS       NM_001348129            2344 bp    mRNA    linear   PRI 21-AUG-2024
DEFINITION  Homo sapiens negative regulator of P-body association (NBDY), mRNA.
ACCESSION   NM_001348129 NR_015367 XM_001718993 XM_001720195 XM_001721066
VERSION     NM_001348129.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Bloch,D.B., Sinow,C.O., Sauer,A.J. and Corman,B.H.P.
  TITLE     Assembly and regulation of the mammalian mRNA processing body
  JOURNAL   PLoS One 18 (3), e0282496 (2023)
   PUBMED   36877681
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2344)
  AUTHORS   Na,Z., Luo,Y., Schofield,J.A., Smelyansky,S., Khitun,A.,
            Muthukumar,S., Valkov,E., Simon,M.D. and Slavoff,S.A.
  TITLE     The NBDY Microprotein Regulates Cellular RNA Decapping
  JOURNAL   Biochemistry 59 (42), 4131-4142 (2020)
   PUBMED   33059440
REFERENCE   3  (bases 1 to 2344)
  AUTHORS   Zhai,H., Zhang,X., Sun,X., Zhang,D. and Ma,S.
  TITLE     Long Non-coding RNA LINC01420 Contributes to Pancreatic Cancer
            Progression Through Targeting KRAS Proto-oncogene
  JOURNAL   Dig Dis Sci 65 (4), 1042-1052 (2020)
   PUBMED   31562613
  REMARK    GeneRIF: Long Non-coding RNA LINC01420 Contributes to Pancreatic
            Cancer Progression Through Targeting KRAS Proto-oncogene.
REFERENCE   4  (bases 1 to 2344)
  AUTHORS   Konina,D.O., Filatova,A.Y. and Skoblov,M.Y.
  TITLE     LINC01420 RNA structure and influence on cell physiology
  JOURNAL   BMC Genomics 20 (Suppl 3), 298 (2019)
   PUBMED   32039714
  REMARK    GeneRIF: LINC01420 RNA structure and influence on cell physiology
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2344)
  AUTHORS   D'Lima,N.G., Ma,J., Winkler,L., Chu,Q., Loh,K.H., Corpuz,E.O.,
            Budnik,B.A., Lykke-Andersen,J., Saghatelian,A. and Slavoff,S.A.
  TITLE     A human microprotein that interacts with the mRNA decapping complex
  JOURNAL   Nat Chem Biol 13 (2), 174-180 (2017)
   PUBMED   27918561
  REMARK    GeneRIF: results implicate NoBody as a novel component of the mRNA
            decapping complex and demonstrate potential functionality of a
            newly discovered microprotein
REFERENCE   6  (bases 1 to 2344)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158200.17, BX537532.1, AA131515.1, BC048131.1, CA444043.1 and
            AL354865.9.
            
            On May 17, 2019 this sequence version replaced NM_001348129.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537532.1, SRR1660809.362555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374922.9/ ENSP00000489583.1
            NMD candidate          :: PMID: 27918561
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL158200.17        10088-10096
            10-502              BX537532.1         1-493
            503-844             AA131515.1         4-345               c
            845-1334            BC048131.1         829-1318
            1335-1541           CA444043.1         18-224              c
            1542-2116           BX537532.1         1534-2108
            2117-2161           AL354865.9         14259-14303
            2162-2344           BX537532.1         2154-2336
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..2344
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /note="negative regulator of P-body association"
                     /db_xref="GeneID:550643"
                     /db_xref="HGNC:HGNC:50713"
                     /db_xref="MIM:300992"
     exon            1..347
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..318
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /note="long intergenic non-protein coding RNA 1420;
                     non-annotated P-body dissociating polypeptide; protein
                     NoBody; P-body dissociating protein"
                     /codon_start=1
                     /product="negative regulator of P-body association"
                     /protein_id="NP_001335058.1"
                     /db_xref="CCDS:CCDS87751.1"
                     /db_xref="GeneID:550643"
                     /db_xref="HGNC:HGNC:50713"
                     /db_xref="MIM:300992"
                     /translation="MGDQPCASGRSTLPPGNAREAKPPKKRCLLAPRWDYPEGTPNGG
                     STTLPSAPPPASAGLKSHPPPPEK"
     exon            348..484
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /inference="alignment:Splign:2.1.0"
     exon            485..2344
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /inference="alignment:Splign:2.1.0"
     regulatory      719..724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /note="hexamer: AATAAA"
     polyA_site      736
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /note="major polyA site"
     regulatory      821..826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /note="hexamer: ACTAAA"
     polyA_site      844
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /note="hexamer: ATTAAA"
     polyA_site      1545
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /note="hexamer: ATTATA"
     polyA_site      1622
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
                     /note="hexamer: AATAAA"
     polyA_site      2297
                     /gene="NBDY"
                     /gene_synonym="LINC01420; NoBody"
ORIGIN      
        1 gaaacaggag gaagccagct ctgtgcctgg aggggactcg ccgccatctc aggtctcttg
       61 gctttgccag ggcccaccgg agaaaactga cgacccgttt ctgtaatcct tatgggagac
      121 caaccttgtg cctccgggag atccactctc ccacctggaa acgcacggga agccaagcct
      181 ccaaaaaagc gctgcctcct cgctccgcgt tgggattatc cggaaggaac tcccaacgga
      241 ggtagtacca ctctaccctc cgcacctcct cctgcatcag ccggcctgaa gtcgcaccct
      301 cctcctccgg agaagtagag aaataaattt ctcccaccct aaaccagtct ttgagtgatt
      361 gcagtatgac tccatttccc tggtgcattc atataatagt tcacctggtg aaaacaatga
      421 agattattta caatgctacc ctgctttttc tggtgtcctg aacctggaag ttgtgctttt
      481 taagtcttat gatgtaatca gcgcgatttc acttcctgaa tttcgatgaa ttctaagaca
      541 tgggcaagat cgggttgtaa gacctctgag atttaaggcc atgccctgga tcatggtgaa
      601 cttaccaaag caaacaatgc ctgtgagatg gtcctgcagc agccaaccag tgaactcttt
      661 tggtgacatc ctgttcttgt tgtataactt tatattccta taaatccatt aaggccccaa
      721 taaagtttgt ctctaagcgc tgtgttagat ctatatgact acatctagta aattgtgaat
      781 tttaagtaaa tattttataa gaactcctat gtaaagcatt actaaaatta gtgttgaaat
      841 atgaccttct tcctacattt attcatttat ttatgtctat ttattcattt attttagtga
      901 aaaatataag gaaagtagag gaaggttaaa tccaaaaaag aattgtttcc agtacacttt
      961 ctttaatttg ctgtcagttt ttgcatggaa tctacatctt tttatgctaa tcctcatcct
     1021 agtattttac atcttaacta tttttttctg actgaaatgg ttgatgtgct tgttttttgt
     1081 aattttctac tttccttcta aaatgcttag tattgaacaa atagaatatc ctaattaaaa
     1141 acagtaataa atattatggt gaaaaaatac aagtaaaatg ggaaaacatt agatagcagc
     1201 tttcaatatt tcatatagtt cataaatgtt tcaggaatta caaggttata gaaaaaaatt
     1261 tatagactat aataatttcc agggatataa aaaaataaag cttctacctt tgaattgtaa
     1321 taataaaaga taaacagact tgaaagcata tattatatct gaaaatgtca gataaacttg
     1381 gcttataaat taaaatataa aataataata caatttgttc aaataagtaa ttaaagctta
     1441 cattgtaaaa tgaatattta gagagattgt gaaacctgag tattttaccc aatcctctga
     1501 aattagtccc tagcatcaga attaaagaat ctgaaaaatc acaaatggag gtatggtgac
     1561 atttatgtat attctagagt tatgttatgc acacttaata aattatagac agttatttta
     1621 aagattgtat aatattacta atcacacatt agagttttaa aacttctgag ccaggctgaa
     1681 catcacaaac agtaaacaca gacttcttta aaaggacatc tggtgaaagg cattttatgc
     1741 atcagaaggc acagtattat aaagatgaca acactcttca aaataatcaa actattcaat
     1801 gcaaccctta tcaaaattaa ggttgcctac tttgaagaaa tttataacct gattctaaag
     1861 ttcatatgaa aatgtaatgg acccagaata gccaaaacaa tcttgaagta tacaaagttt
     1921 gaagagtcac atttccaaat tttaaaactt attacaaagc tacaataaac aagtctatgt
     1981 ggtactggca taggatataa atattgatca atgaaataga atccaaagtc cagacataag
     2041 ccctcacaaa agttaatttg cagccaatta acttctgaga aggaggcaag acaaaagggg
     2101 aaataactat tttcaataaa tggtactggg acaacttggt atctacatgc aaaaaaaaaa
     2161 caaaaaaaca aaaaacttcc acccctacct catgcaaaat acaaaaatta actcaaaata
     2221 ggccaaagac tcaaatataa gggttacact ataaaactct tgggaggaaa tatagaataa
     2281 atttttgtga ccttgaatta agtattagat ttttaattct tacaccaaag cacaagttaa
     2341 taaa
//
