LOCUS       NM_001024383           10219 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens neuron navigator 3 (NAV3), transcript variant 1, mRNA.
ACCESSION   NM_001024383 XM_005269214
VERSION     NM_001024383.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10219)
  AUTHORS   Ghaffar,A., Akhter,T., Stromme,P., Misceo,D., Khan,A., Frengen,E.,
            Umair,M., Isidor,B., Cogne,B., Khan,A.A., Bruel,A.L., Sorlin,A.,
            Kuentz,P., Chiaverini,C., Innes,A.M., Zech,M., Balaz,M.,
            Havrankova,P., Jech,R., Ahmed,Z.M., Riazuddin,S. and Riazuddin,S.
  TITLE     Variants of NAV3, a neuronal morphogenesis protein, cause
            intellectual disability, developmental delay, and microcephaly
  JOURNAL   Commun Biol 7 (1), 831 (2024)
   PUBMED   38977784
  REMARK    GeneRIF: Variants of NAV3, a neuronal morphogenesis protein, cause
            intellectual disability, developmental delay, and microcephaly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10219)
  AUTHORS   Umair,M., Alharbi,M., Aloyouni,E., Al Abdulrahman,A., Aldrees,M.,
            Al Tuwaijri,A., Bilal,M. and Alfadhel,M.
  TITLE     Mutated neuron navigator 3 as a candidate gene for a rare
            neurodevelopmental disorder
  JOURNAL   Mol Genet Genomic Med 12 (7), e2473 (2024)
   PUBMED   39038237
  REMARK    GeneRIF: Mutated neuron navigator 3 as a candidate gene for a rare
            neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 10219)
  AUTHORS   Bugaeva,O., Maliniemi,P., Prestvik,W.S., Leivo,E., Kluger,N.,
            Salava,A., Virtanen,S., Jantti,K., Saksela,O., Lehti,K., Kujala,P.,
            Krohn,K. and Ranki,A.
  TITLE     Tumour Suppressor Neuron Navigator 3 and Matrix Metalloproteinase
            14 are Co-expressed in Most Melanomas but Downregulated in Thick
            Tumours
  JOURNAL   Acta Derm Venereol 103, adv00883 (2023)
   PUBMED   36883877
  REMARK    GeneRIF: Tumour Suppressor Neuron Navigator 3 and Matrix
            Metalloproteinase 14 are Co-expressed in Most Melanomas but
            Downregulated in Thick Tumours.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10219)
  AUTHORS   Wang,Z., Yang,H. and Ren,L.
  TITLE     MiR-21 promoted proliferation and migration in hepatocellular
            carcinoma through negative regulation of Navigator-3
  JOURNAL   Biochem Biophys Res Commun 464 (4), 1228-1234 (2015)
   PUBMED   26210448
  REMARK    GeneRIF: Together, our findings suggest an important role for
            miR-21 in the progression of HCC, which negatively regulated
            Navigator-3 in the migration of HCC.
REFERENCE   5  (bases 1 to 10219)
  AUTHORS   Cohen-Dvashi,H., Ben-Chetrit,N., Russell,R., Carvalho,S.,
            Lauriola,M., Nisani,S., Mancini,M., Nataraj,N., Kedmi,M., Roth,L.,
            Kostler,W., Zeisel,A., Yitzhaky,A., Zylberg,J., Tarcic,G.,
            Eilam,R., Wigelman,Y., Will,R., Lavi,S., Porat,Z., Wiemann,S.,
            Ricardo,S., Schmitt,F., Caldas,C. and Yarden,Y.
  TITLE     Navigator-3, a modulator of cell migration, may act as a suppressor
            of breast cancer progression
  JOURNAL   EMBO Mol Med 7 (3), 299-314 (2015)
   PUBMED   25678558
  REMARK    GeneRIF: The authers propose that NAV3 inhibits breast cancer
            progression by regulating microtubule dynamics, biasing
            directionally persistent rather than random migration, and
            inhibiting locomotion of initiated cells.
REFERENCE   6  (bases 1 to 10219)
  AUTHORS   Hahtola,S., Burghart,E., Jeskanen,L., Karenko,L.,
            Abdel-Rahman,W.M., Polzer,B., Kajanti,M., Peltomaki,P.,
            Pettersson,T., Klein,C.A. and Ranki,A.
  TITLE     Clinicopathological characterization and genomic aberrations in
            subcutaneous panniculitis-like T-cell lymphoma
  JOURNAL   J Invest Dermatol 128 (9), 2304-2309 (2008)
   PUBMED   18337827
  REMARK    GeneRIF: Allelic NAV3 aberrations (LOH or deletion by FISH were
            identified in 44% of the subcutaneous panniculitis-like T-cell
            lymphoma samples.
REFERENCE   7  (bases 1 to 10219)
  AUTHORS   Karenko,L., Hahtola,S., Paivinen,S., Karhu,R., Syrja,S.,
            Kahkonen,M., Nedoszytko,B., Kytola,S., Zhou,Y., Blazevic,V.,
            Pesonen,M., Nevala,H., Nupponen,N., Sihto,H., Krebs,I., Poustka,A.,
            Roszkiewicz,J., Saksela,K., Peterson,P., Visakorpi,T. and Ranki,A.
  TITLE     Primary cutaneous T-cell lymphomas show a deletion or translocation
            affecting NAV3, the human UNC-53 homologue
  JOURNAL   Cancer Res 65 (18), 8101-8110 (2005)
   PUBMED   16166283
  REMARK    Erratum:[Cancer Res. 2008 Sep 15;68(18):7692]
REFERENCE   8  (bases 1 to 10219)
  AUTHORS   Peeters,P.J., Baker,A., Goris,I., Daneels,G., Verhasselt,P.,
            Luyten,W.H., Geysen,J.J., Kass,S.U. and Moechars,D.W.
  TITLE     Sensory deficits in mice hypomorphic for a mammalian homologue of
            unc-53
  JOURNAL   Brain Res Dev Brain Res 150 (2), 89-101 (2004)
   PUBMED   15158073
REFERENCE   9  (bases 1 to 10219)
  AUTHORS   Maes,T., Barcelo,A. and Buesa,C.
  TITLE     Neuron navigator: a human gene family with homology to unc-53, a
            cell guidance gene from Caenorhabditis elegans
  JOURNAL   Genomics 80 (1), 21-30 (2002)
   PUBMED   12079279
REFERENCE   10 (bases 1 to 10219)
  AUTHORS   Coy,J.F., Wiemann,S., Bechmann,I., Bachner,D., Nitsch,R., Kretz,O.,
            Christiansen,H. and Poustka,A.
  TITLE     Pore membrane and/or filament interacting like protein 1 (POMFIL1)
            is predominantly expressed in the nervous system and encodes
            different protein isoforms
  JOURNAL   Gene 290 (1-2), 73-94 (2002)
   PUBMED   12062803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138331.4, DR005268.1, AJ488201.1, AC073571.14, AB023155.2,
            AC073608.19 and AV728995.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001024383.1.
            
            Summary: This gene belongs to the neuron navigator family and is
            expressed predominantly in the nervous system. The encoded protein
            contains coiled-coil domains and a conserved AAA domain
            characteristic for ATPases associated with a variety of cellular
            activities. This gene is similar to unc-53, a Caenorhabditis
            elegans gene involved in axon guidance. Multiple alternatively
            spliced transcript variants for this gene have been described but
            only one has had its full-length nature determined. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ488201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397909.7/ ENSP00000381007.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AC138331.4         22347-22741         c
            396-700             DR005268.1         6-310
            701-701             AC138331.4         22041-22041         c
            702-2597            AJ488201.1         179-2074
            2598-2598           AC073571.14        26482-26482
            2599-5031           AJ488201.1         2076-4508
            5032-5032           AC073571.14        113682-113682
            5033-7578           AJ488201.1         4510-7055
            7579-8694           AB023155.2         3628-4743
            8695-9174           AC073608.19        45741-46220
            9175-10217          AB023155.2         5226-6268
            10218-10219         AV728995.1         692-693
FEATURES             Location/Qualifiers
     source          1..10219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..10219
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /note="neuron navigator 3"
                     /db_xref="GeneID:89795"
                     /db_xref="HGNC:HGNC:15998"
                     /db_xref="MIM:611629"
     exon            1..811
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..7726
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /note="isoform 1 is encoded by transcript variant 1; pore
                     membrane and/or filament interacting like protein 1;
                     unc-53 homolog 3"
                     /codon_start=1
                     /product="neuron navigator 3 isoform 1"
                     /protein_id="NP_001019554.1"
                     /db_xref="CCDS:CCDS66432.1"
                     /db_xref="GeneID:89795"
                     /db_xref="HGNC:HGNC:15998"
                     /db_xref="MIM:611629"
                     /translation="MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLEL
                     TETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKIYTDWANHYLAKSGHKRLIKD
                     LQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLS
                     AEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPPSEASQAKTQ
                     QDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGSSSKVQGASNLNRRSQSF
                     NSIDKNKPPNYANGNEKDSSKGPQSSSGVNGNVQPPSTAGQPPASAIPSPSASKPWRS
                     KSMNVKHSATSTMLTVKQSSTATSPTPSSDRLKPPVSEGVKTAPSGQKSMLEKFKLVN
                     ARTALRPPQPPSSGPSDGGKDDDAFSESGEMEGFNSGLNSGGSTNSSPKVSPKLAPPK
                     AGSKNLSNKKSLLQPKEKEEKNRDKNKVCTEKPVKEEKDQVTEMAPKKTSKIASLIPK
                     GSKTTAAKKESLIPSSSGIPKPGSKVPTVKQTISPGSTASKESEKFRTTKGSPSQSLS
                     KPITMEKASASSCPAPLEGREAGQASPSGSCTMTVAQSSGQSTGNGAVQLPQQQQHSH
                     PNTATVAPFIYRAHSENEGTALPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRR
                     MRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTSRPTPM
                     TWRLGQACPRLQAGDAPSLGAGYPRSGTSRFIHTDPSRFMYTTPLRRAAVSRLGNMSQ
                     IDMSEKASSDLDMSSEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLNRI
                     PDTATSRDIIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNI
                     TVPSRKNTQLRTDSEKRSTTDETWDSPEELKKPEEDFDSHGDAGGKWKTVSSGLPEDP
                     EKAGQKASLSVSQTGSWRRGMSAQGGAPSRQKAGTSALKTPGKTDDAKASEKGKAPLK
                     GSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATSSFGFKKPSGVGSSAMITSSGATITS
                     GSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPRPSKSST
                     SGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKV
                     AVSDSESVSLSGSPKSSPTSASACGAQGLRQPGSKYPDIASPTFRRLFGAKAGGKSAS
                     APNTEGVKSSSVMPSPSTTLARQGSLESPSSGTGSMGSAGGLSGSSSPLFNKPSDLTT
                     DVISLSHSLASSPASVHSFTSGGLVWAANMSSSSAGSKDTPSYQSMTSLHTSSESIDL
                     PLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQAN
                     QEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSAAGKYHFSNLVSPTNLSQFNLPGP
                     SMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLV
                     SSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMT
                     GRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQH
                     SSESVSSINSATSHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPP
                     SSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYK
                     HRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEI
                     EILKAENDRLKAETGNTAKPTRPPSESSSSTSSSSSRQSLGLSLNNLNITEAVSSDIL
                     LDDAGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIR
                     RLFKEYVFRIDTSTSLGLSSDCIASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVN
                     LKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLANKLAEYVI
                     TKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVG
                     SLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGR
                     YLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPM
                     DVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRTPWEDPSKWVLDTYPWSSATLPQ
                     ESPALLQLRPEDVGYESCTSTKEATTSKHIPQTDTEGDPLMNMLMKLQEAANYSSTQS
                     CDSESTSHHEDILDSSLESTL"
     exon            812..929
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            930..982
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1055
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1239
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1308
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1448
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..2475
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2591
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2700
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..3084
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3204
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3337
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3608
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..4317
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4806
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..4848
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..5009
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5010..5198
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5199..5251
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5252..5275
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5353
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5354..5437
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5438..5549
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5550..5671
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5672..5692
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5693..5865
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5866..5931
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            5932..6085
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            6086..6260
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            6261..6358
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            6359..6454
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            6455..6623
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            6624..6859
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            6860..7014
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            7015..7086
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            7087..7283
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            7284..7402
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            7403..7606
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     exon            7607..10219
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10194..10199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /note="hexamer: ATTAAA"
     polyA_site      10219
                     /gene="NAV3"
                     /gene_synonym="POMFIL1; STEERIN3; unc53H3"
                     /note="major polyA site"
ORIGIN      
        1 gaaatcagga agaacccctg tccttccact gttgtggtct tttggctgct ctgacagttg
       61 gactgaaggg cttttccttt tgattttttc ctctttttca atctcaaagt tcagactcag
      121 actgctttag tgagaaaaaa aaataagcaa aactaagagc tctttaatcc taagaaggag
      181 ctttgtagca gttaccttga agaagagttt actccccaaa ggagtattta gtattactta
      241 gatactgagt cactgaacag agagagagag agagacagag agagagagag agagagagag
      301 acagagagag agagagagag agagaaagag agagagagag agaatgagaa tgaatatgaa
      361 tcccagccag caagaaagaa aagatactta actaaagatg cagggaagtt ttgcctcttc
      421 ctgaaaatta tattattagc tttttaaaaa tcaggatgac tgctagtttt gtttaaagta
      481 tttgttctgg aaatactaaa gttggagtct accagactga ggttagaagc attttctttg
      541 gcagcaagaa gataatttta tagaagccat gcctgttctt ggggttgcct caaaactgag
      601 gcagccagct gttgggtcaa agcctgtgca tactgctctt ccgataccaa atcttggcac
      661 tactgggtca cagcactgtt cttcaagacc tttggaactt actgaaacag agagctccat
      721 gctttcttgt cagcttgcgt taaaatcaac ctgtgaattt ggagagaaga aacccctcca
      781 aggaaaagcc aaggagaaag aagacagcaa gatttacact gactgggcca accactacct
      841 agcaaaatca ggccacaagc ggctgatcaa ggacttgcaa caagacattg cagatggagt
      901 actcctagca gaaatcatcc agattattgc aaatgaaaaa gttgaagata tcaatggatg
      961 tcctagaagt cagtctcaga tgattgaaaa tgttgatgtc tgccttagtt ttctagcagc
     1021 cagaggggta aatgttcaag gtctatctgc tgaagaaata agaaatggaa acttaaaagc
     1081 cattctaggg ctgtttttca gtttatctcg ctacaagcag caacaacacc atcaacaaca
     1141 gtactatcag tccttggtgg aacttcagca gcgagttact cacgcttccc ctccatcgga
     1201 agccagccag gccaaaaccc agcaagatat gcagtccagt ctggcagcca gatatgcaac
     1261 tcagtctaat cacagtggaa ttgcaaccag tcaaaaaaag cctactaggc ttccagggcc
     1321 ctctagggtg cctgctgcag gaagcagcag caaggtccag ggagcctcta atttaaatag
     1381 gagaagtcag agctttaaca gcattgacaa aaacaagcct ccaaattatg caaatggaaa
     1441 cgaaaaagat tcctccaaag gacctcaatc gtcttcaggt gtaaatggta acgtgcagcc
     1501 tcccagtact gctgggcagc ctcctgcctc tgccatccct tctccaagtg ccagcaagcc
     1561 ctggcgcagc aagtccatga atgtcaaaca cagtgccacc tccaccatgt tgactgtaaa
     1621 gcagtcaagt acagccacct cccccacacc atcttcagac agactgaagc cacctgtctc
     1681 agaaggggtc aaaactgctc cctcaggaca gaaatccatg cttgagaaat tcaagctagt
     1741 caatgcccgg actgctttac gccccccgca gcctcccagt tcaggaccta gtgatggtgg
     1801 gaaggatgat gatgcctttt ctgaatctgg tgaaatggaa ggttttaaca gtggtctgaa
     1861 tagtggtggc tcaacaaata gcagtcccaa agtgtcacct aagttggccc ctccaaaagc
     1921 tggaagcaaa aatctcagca ataaaaagtc tttgctacag ccaaaggaaa aagaagaaaa
     1981 gaacagggac aaaaataaag tttgcactga aaaaccagtc aaagaagaga aggatcaggt
     2041 gacagagatg gctccaaaaa agacctccaa aattgcaagc ttgatcccta agggcagcaa
     2101 gacaacagca gctaagaagg aaagcttaat tccgtcttcc agtggtattc caaaaccagg
     2161 ctctaaagtt ccaacagtaa agcaaaccat ttcacctggc agcacagcaa gcaaagagtc
     2221 tgagaaattc aggactacca aggggagccc ttcccagtcc ttatctaagc ctataaccat
     2281 ggagaaagca agtgcttcta gttgtcctgc ccctttggaa ggaagggaag ctggccaagc
     2341 ttctccttct ggttcctgta ccatgacagt ggcacaaagc agtgggcaga gcacaggaaa
     2401 tggtgctgtc caactccctc aacagcagca acatagccac ccgaataccg cgacagtggc
     2461 accattcatt tacagggcac attcagaaaa tgaaggtacc gctttaccat cggctgactc
     2521 ctgtaccagt cctacaaaga tggacttatc atatagtaag actgctaagc agtgcctgga
     2581 ggagatatct ggtgaagacc ctgaaacaag aagaatgaga acagttaaaa acatagcaga
     2641 cttgaggcag aatttagaag agactatgtc cagtcttcgt gggactcaga taagccacag
     2701 caccctggag acaacatttg acagcactgt gacaacagaa gttaatggaa ggaccatacc
     2761 caacttgaca agtcgaccca cccccatgac ctggaggttg ggccaggcat gtccgcgact
     2821 tcaggcggga gatgctccct ccctgggtgc tggctatcct cgcagtggta ccagtcgatt
     2881 catccacaca gacccctcga ggttcatgta taccacgcct ctccgtcgag ctgctgtctc
     2941 taggctggga aacatgtcac agattgacat gagtgagaaa gcaagcagtg acctggacat
     3001 gtcttctgag gtcgatgtgg gtggatatat gagtgatggt gatatccttg ggaaaagtct
     3061 caggactgat gacatcaaca gtgggtacat gacagatgga ggacttaacc tatatactag
     3121 aagtctgaac cgaataccag acacagcaac ttcccgggac atcatccaga gaggggttca
     3181 cgatgtgaca gtggatgcag acagctggga tgacagcagt tcagtgagca gtggtctcag
     3241 tgacaccctt gataacatca gcactgatga cctgaacacc acatcctctg tcagctctta
     3301 ctccaacatc accgtcccct ctaggaagaa tactcagctg aggacagatt cagagaaacg
     3361 ctccaccaca gacgagacct gggatagtcc tgaggaactg aaaaaaccag aagaagattt
     3421 tgacagccat ggggatgctg gtggcaagtg gaagactgtg tcctctggac ttcctgaaga
     3481 ccccgagaag gcagggcaga aagcttccct gtctgtttca cagacaggtt cctggagaag
     3541 aggcatgtct gcccaaggag gggcgccatc taggcagaaa gctggaacaa gtgcactcaa
     3601 aacacccggg aaaaccgatg atgccaaagc ttctgagaaa ggaaaagctc ccctaaaagg
     3661 atcatctcta caaagatctc cttcagatgc aggaaaaagc agtggagatg aagggaaaaa
     3721 gcccccctca ggcattggaa gatcgactgc caccagctcc tttggcttta agaaaccaag
     3781 tggagtaggg tcatctgcca tgatcaccag cagtggagca accataacaa gtggctctgc
     3841 aacactgggt aaaattccaa aatctgctgc cattggcggg aagtcaaatg cagggagaaa
     3901 aaccagtttg gacggttcac agaatcagga tgatgttgtg ctgcatgtta gctcaaagac
     3961 taccctacaa tatcgcagct tgccccgccc ttcaaaatcc agcaccagtg gcattcctgg
     4021 ccgaggaggc cacagatcca gtaccagcag tattgattcc aacgtcagca gcaagtctgc
     4081 tggggccacc acctcgaaac tgagagaacc aactaaaatt gggtcagggc gctcgagtcc
     4141 tgtcaccgtc aaccaaacag acaaggaaaa ggaaaaagta gcagtctcag attcagaaag
     4201 tgtttctttg tcaggttccc ccaaatccag ccccacctct gccagcgcct gtggtgcaca
     4261 aggtctcagg cagccaggat ccaagtatcc agatattgcc tcacccacat ttcgaaggtt
     4321 gtttggtgcc aaggcaggtg gcaaatctgc ctctgcacct aatactgagg gtgtgaaatc
     4381 ttcctcagta atgcccagcc ctagtaccac attagcgcgg caaggcagtc tggagtcacc
     4441 gtcgtccggt acgggcagca tgggcagtgc tggtgggcta agcggcagca gcagccctct
     4501 cttcaataaa ccctcagact taactacaga tgttataagc ttaagtcact cgttggcctc
     4561 cagcccagca tcggttcact ctttcacatc aggtggtctc gtgtgggctg ccaatatgag
     4621 cagttcctct gcaggcagca aggatactcc gagctaccag tccatgacta gcctccacac
     4681 gagctctgag tccattgacc tccccctcag ccatcatggc tccttgtctg gactgaccac
     4741 aggcactcac gaggtccaga gcctgctcat gagaacgggt agtgtgagat ctactctctc
     4801 agaaagcatg cagcttgaca gaaatacact acccaaaaag ggactaagat ataccccatc
     4861 atctcggcag gccaaccaag aagagggcaa agagtggttg cgttctcatt ctactggagg
     4921 gcttcaggac actggcaacc agtcacctct ggtttcccct tctgccatgt catcttctgc
     4981 agctggaaaa taccactttt ctaacttggt gagcccaaca aatttgtctc agtttaacct
     5041 tcccgggccc agcatgatgc gctcaaacag catcccagcc caagactctt ccttcgatct
     5101 ctatgatgac tcccagcttt gtgggagtgc cacttctctg gaggaaagac ctcgtgccat
     5161 cagtcattcg ggctcattca gagacagcat ggaagaagtt catggctctt cattatcact
     5221 ggtgtccagc acttcttctc tttactctac agctgaagaa aaggctcatt cagagcaaat
     5281 ccataaactg cggagagagc tggttgcatc acaagaaaaa gttgctaccc tcacatctca
     5341 gctttcagca aatgctcacc ttgtagcagc ttttgaaaag agcttaggga atatgactgg
     5401 ccgattgcaa agtctaacta tgacagcgga acaaaaggaa tctgaactta tagaactaag
     5461 agaaaccatt gaaatgctga aggctcagaa ttctgctgcc caggcggcta ttcagggagc
     5521 actgaatggt ccagaccatc ctcccaaaga tcttcgcatc agaagacagc attcctctga
     5581 aagtgtttct agtatcaaca gtgccacaag ccattccagt attggcagtg gtaatgatgc
     5641 cgactccaag aagaagaaaa agaaaaactg ggtgaactct agaggaagtg agctgagaag
     5701 ttctttcaaa caagcctttg ggaagaaaaa gtccaccaag cctccttcat cacattctga
     5761 cattgaagag cttactgatt catcccttcc ggcatccccc aagttacccc ataatgctgg
     5821 tgactgtggc tcagcatcca tgaagccctc acaatctgct tcagcgtcac cccttgtctg
     5881 gccaccaaag aaacgacaaa atggccctgt gatctacaag catagatctc ggatctgtga
     5941 atgcacagaa gctgaggcag agataattct gcagctgaag agcgagctca gagaaaagga
     6001 attaaaatta acggatattc ggctggaggc cctcagctct gctcatcatc ttgatcagat
     6061 ccgggaagcc atgaaccgga tgcagaatga aattgaaata ctgaaagctg aaaatgaccg
     6121 gttgaaggca gaaactggta acacagctaa gcctactcgg ccaccgtcag aatcctcaag
     6181 cagcacctcc tcttcatctt ccaggcagtc attaggactt tctctaaaca atttgaacat
     6241 cacagaggct gttagctcag atattttgct agatgatgct ggtgatgcaa ctggacataa
     6301 agatggccgc agtgtgaaaa ttatagtctc cataagcaag ggctatggtc gagcaaagga
     6361 ccaaaaatct caggcatatt tgataggatc cattggtgtt agtggaaaaa ccaagtggga
     6421 tgtcttagat ggtgtaataa gacgtctctt taaggaatat gtattccgaa ttgatacatc
     6481 cactagcctt ggtctgagct ctgactgcat tgctagctac tgtataggag acttaattag
     6541 atcccataac ctagaagtgc ctgaattgct gccttgtgga taccttgttg gagataataa
     6601 catcatcact gtgaacctca aaggggtaga agaaaatagt ttggacagtt ttgtttttga
     6661 tacgctgatt cctaaaccaa ttacccaaag gtactttaac ttgttgatgg agcatcacag
     6721 aattatactc tcaggaccga gtggtactgg aaagacctat ttggcaaaca aacttgctga
     6781 atatgtaata accaaatctg gaaggaaaaa aacagaggat gcaattgcca cttttaatgt
     6841 ggaccacaag tcaagtaagg aattgcaaca atatctagct aacctggctg aacagtgcag
     6901 tgctgataat aatggagtgg agctcccagt tgtaataatt cttgataatc ttcatcatgt
     6961 gggctctctg agtgatatct tcaatggttt tctcaattgt aaatacaaca aatgtccata
     7021 tattattgga acaatgaatc agggagtttc ttcatcacca aatctagagc tgcatcacaa
     7081 tttcaggtgg gtattatgtg caaatcatac agaaccagtg aaaggctttt taggcagata
     7141 tcttcgaaga aaactcatag agatagaaat tgaaaggaac attcgcaata atgacctagt
     7201 caaaattata gattggattc cgaagacgtg gcatcatctc aacagttttt tggaaacaca
     7261 cagttcttct gacgttacca ttggtccccg actattcctt ccttgcccca tggatgtaga
     7321 aggttctaga gtatggttca tggatctctg gaactattct ttagtacctt atattctgga
     7381 ggcagtgaga gagggtcttc agatgtatgg gaaacgcaca ccatgggaag atccttcaaa
     7441 gtgggtgctt gacacatatc catggagctc agcaactctg cctcaggaga gcccagcctt
     7501 acttcagctg cgaccagaag atgttgggta tgaaagctgc acatccacta aggaagccac
     7561 aacctcaaag cacattccgc aaactgacac agaaggagat cccctgatga atatgctaat
     7621 gaaactccaa gaagcagcca attactcgag cacacaaagc tgcgacagcg aaagcaccag
     7681 ccaccatgaa gacattttgg attcatctct tgaatctacc ctctagaggg tgaaaaaagt
     7741 taagggaaaa gactttgctt ttaaaaaaat gtttcaaaag aaaggtattt tcactaaacc
     7801 actgccagta taaaagcacc ctgtcaaggg ccctgaccca gagttgtggt ctccaaggag
     7861 gcagcagaac taagtctgaa ccgccaagat gctaaattgc aatggaagct taactttagt
     7921 ttatttctaa gcatttttta tatctgtgga gtaatagaaa gctccattac tcaactggaa
     7981 aggaccctaa tgacagggca actgaacaga ttgcacatgg gatagccaaa ctggactttc
     8041 tttgtttcct ctttaaaagt ttacaatgca gaccattttt tgtcccttcc ttttgtttcc
     8101 tctgaggggc tgttcgcccc aggcagggtc catctttctg atctgtccaa cctcctttgt
     8161 gccacacggt gctggtcaca gggcttcagt agtgtttgtg ttgtgcgctc accccattcc
     8221 agaacaaatc caagaggcca gtcctccata agcacaaatg gaattgtgca accaccagaa
     8281 aaacactact gtggcaaact ggagaagtgc caatttaatt ctaactgcca cgttctcatg
     8341 atgtgctcca ccaacttttt agtatatgag tcactggttt tataaggttg tttttaccac
     8401 agtggtcttt ttaaaccacc tgcccactcc cttaacaaga gttttatacc aattattagt
     8461 caacactgat aaaaggcttt tttagggctt tatttgtttg agccttttca gtgaaagaag
     8521 gaacatttcc tatggtgctg tctcactgcc ttaaaacaga tttctatgac agtttaacag
     8581 ttggtttaaa tcctaaacca ttggtaattt ccactgtctt ttcatttaca accaagcaac
     8641 accagttaac atagtagcct catctctata tatctttctc tttttttttt ttttgaagaa
     8701 atggatagga gaaagatcag tatttttagc cttgtgaata gatcgctttg cctatcctcc
     8761 aaaatattaa aataacccag aaatgctctt tgaccgtcac ttaaaaccta agacatgtgg
     8821 cgaaattcca tccagttcta agtgaaagag tttcagaagg cagaagattt tgaattatta
     8881 tccagcaggg ctggaagcac tagatgcagc atgagcacaa ctattcggct ttccttccct
     8941 attgtttttg tttttttaat gagttttgac gcatgttgtt ttgattgcta ttgttgtaca
     9001 tgagaaattc agcattaaag aacactgaag cggtaaggtc actgtggaag aggaagcgtt
     9061 tatactgtaa aagaaggtta gatttgcaca gtctactggg taggtattgt aaataataat
     9121 ttttaaaact tgcacaaatc aaaacaaaca caaacaaaat tgtattttat cctgttggtg
     9181 ttaagaggtg tttcacttgc tgagatttcc tgtacattgc aaacaaatac agaatgcaaa
     9241 ccctcaaagc tgtattatct ggtgtgtttg tcctgtattt acagttgttt ttgactatgc
     9301 aggagctatc agtgctagag tgagcatgct tcaaaactgt acatgaagcc aatatatttt
     9361 tggataagta aaactgtctg aaagtacatc tgtcatggca ggctttaaag agagtgcatg
     9421 aaaactgatc agtcattgga gaagttacca ccacacacaa aggacaggtt ttaagtttat
     9481 gaaacccaag ggctaggcca tggtatagac ttcttctatg agtgtgtgaa aatgtgttac
     9541 ttttaggacg tgtatttggt gctactctct gtgaccacca atgggtcagt tgctatagaa
     9601 caacaacacc acgaaacatc tgtgcagttt tcagagtgtc acaaagtcaa taggtcctta
     9661 cacggtgcta ttgccctaag ggaaatccga actgaattta tgcacataga attgtcaccc
     9721 tgactttgaa gcctcaaaca tggatcaaat ctgttgtgaa acatcaatat atgtagctgg
     9781 atgagtgact agtttccctt gtataatatg tgatctaaga aaattgctaa tctttccctg
     9841 ccattttgag aaacacagtc caaacatgag cataaacaga atttcctgca atacatccca
     9901 gtaggtccac ctagtttaca acttaaacta gtttgtgaaa catttgtctg tatacatttt
     9961 atattttgta cattttgatg taacatatca tgtaaatagg cagaaacagt gaaataaatc
    10021 atctgaaaag ttttgtagtc tttgtaaagc cccaacaata agtacttggt gtcaatggac
    10081 ttaactggat gatgtatttt ctattggttt attgttcctc tagcttgtaa accagcttgc
    10141 atatattttt ttgcaaatgt gcaccctgta tctgtctaaa ttattacttt gccattaaag
    10201 tggaattatt tattgacaa
//
