LOCUS       NM_145117              11492 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens neuron navigator 2 (NAV2), transcript variant 2, mRNA.
ACCESSION   NM_145117
VERSION     NM_145117.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11492)
  AUTHORS   Weiss,B., Ott,T., Vick,P., Lui,J.C., Roeth,R., Vogel,S.,
            Waldmuller,S., Hoffmann,S., Baron,J., Wit,J.M. and Rappold,G.A.
  TITLE     Identification of novel genes including NAV2 associated with
            isolated tall stature
  JOURNAL   Front Endocrinol (Lausanne) 14, 1258313 (2023)
   PUBMED   38152138
  REMARK    GeneRIF: Identification of novel genes including NAV2 associated
            with isolated tall stature.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11492)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 11492)
  AUTHORS   Wang,R., Li,M., Wu,W., Qiu,Y., Hu,W., Li,Z., Wang,Z., Yu,Y.,
            Liao,J., Sun,W., Mao,J. and Zhu,Y.Z.
  TITLE     NAV2 positively modulates inflammatory response of fibroblast-like
            synoviocytes through activating Wnt/beta-catenin signaling pathway
            in rheumatoid arthritis
  JOURNAL   Clin Transl Med 11 (4), e376 (2021)
   PUBMED   33931978
  REMARK    GeneRIF: NAV2 positively modulates inflammatory response of
            fibroblast-like synoviocytes through activating Wnt/beta-catenin
            signaling pathway in rheumatoid arthritis.
REFERENCE   4  (bases 1 to 11492)
  AUTHORS   Koroknai,V., Szasz,I., Hernandez-Vargas,H., Fernandez-Jimenez,N.,
            Cuenin,C., Herceg,Z., Vizkeleti,L., Adany,R., Ecsedi,S. and
            Balazs,M.
  TITLE     DNA hypermethylation is associated with invasive phenotype of
            malignant melanoma
  JOURNAL   Exp Dermatol 29 (1), 39-50 (2020)
   PUBMED   31602702
  REMARK    GeneRIF: DNA hypermethylation is associated with invasive phenotype
            of malignant melanoma.
REFERENCE   5  (bases 1 to 11492)
  AUTHORS   Hu,W., Li,X., Cheng,R., Ke,J., Liu,Y., Ma,M., Cao,Y. and Liu,D.
  TITLE     NAV2 facilitates invasion of cutaneous melanoma cells by targeting
            SNAI2 through the GSK-3beta/beta-catenin pathway
  JOURNAL   Arch Dermatol Res 311 (5), 399-410 (2019)
   PUBMED   30997569
  REMARK    GeneRIF: Study found that melanoma tissues showed an upregulated
            expression of NAV2 which correlated with poor prognosis of
            cutaneous melanoma. NAV2-mediated invasion of melanoma cells was
            driven by enhanced epithelial-mesenchymal transition, which was
            resulted from SNAI2 upregulation via the GSK-3beta/beta-catenin
            pathway.
REFERENCE   6  (bases 1 to 11492)
  AUTHORS   Mitin,N.Y., Ramocki,M.B., Zullo,A.J., Der,C.J., Konieczny,S.F. and
            Taparowsky,E.J.
  TITLE     Identification and characterization of rain, a novel
            Ras-interacting protein with a unique subcellular localization
  JOURNAL   J Biol Chem 279 (21), 22353-22361 (2004)
   PUBMED   15031288
REFERENCE   7  (bases 1 to 11492)
  AUTHORS   Ishiguro,H., Shimokawa,T., Tsunoda,T., Tanaka,T., Fujii,Y.,
            Nakamura,Y. and Furukawa,Y.
  TITLE     Isolation of HELAD1, a novel human helicase gene up-regulated in
            colorectal carcinomas
  JOURNAL   Oncogene 21 (41), 6387-6394 (2002)
   PUBMED   12214280
  REMARK    GeneRIF: a novel gene, termed HELAD1 (helicase, APC down-regulated
            1) plays important role in colorectal carcinogenesis (HELAD1)
REFERENCE   8  (bases 1 to 11492)
  AUTHORS   Maes,T., Barcelo,A. and Buesa,C.
  TITLE     Neuron navigator: a human gene family with homology to unc-53, a
            cell guidance gene from Caenorhabditis elegans
  JOURNAL   Genomics 80 (1), 21-30 (2002)
   PUBMED   12079279
REFERENCE   9  (bases 1 to 11492)
  AUTHORS   Coy,J.F., Wiemann,S., Bechmann,I., Bachner,D., Nitsch,R., Kretz,O.,
            Christiansen,H. and Poustka,A.
  TITLE     Pore membrane and/or filament interacting like protein 1 (POMFIL1)
            is predominantly expressed in the nervous system and encodes
            different protein isoforms
  JOURNAL   Gene 290 (1-2), 73-94 (2002)
   PUBMED   12062803
REFERENCE   10 (bases 1 to 11492)
  AUTHORS   Merrill,R.A., Plum,L.A., Kaiser,M.E. and Clagett-Dame,M.
  TITLE     A mammalian homolog of unc-53 is regulated by all-trans retinoic
            acid in neuroblastoma cells and embryos
  JOURNAL   Proc Natl Acad Sci U S A 99 (6), 3422-3427 (2002)
   PUBMED   11904404
  REMARK    GeneRIF: regulated by all-trans retinoic acid in neuroblastoma
            cells
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009549.6, AC090662.9,
            AC111163.6 and AC015684.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_145117.4.
            
            Summary: This gene encodes a member of the neuron navigator gene
            family, which may play a role in cellular growth and migration.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2) lacks several alternate exons
            in the coding region, compared to variant 5. This results in a
            shorter protein (isoform 2), which maintains the reading frame and
            contains the same N- and C-termimi, compared to isoform 5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB063116.1, AF466143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349880.9/ ENSP00000309577.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1126              AC009549.6         72759-73884
            1127-1244           AC090662.9         52914-53031
            1245-1297           AC090662.9         63301-63353
            1298-1370           AC090662.9         89355-89427
            1371-1629           AC090662.9         100299-100557
            1630-1790           AC090662.9         112864-113024
            1791-2892           AC090662.9         153606-154707
            2893-3005           AC090662.9         160091-160203
            3006-3114           AC111163.6         673-781
            3115-3504           AC111163.6         2963-3352
            3505-3627           AC015684.11        173535-173657       c
            3628-3766           AC015684.11        121685-121823       c
            3767-4058           AC015684.11        113510-113801       c
            4059-4761           AC015684.11        112112-112814       c
            4762-5229           AC015684.11        108587-109054       c
            5230-5295           AC015684.11        107881-107946       c
            5296-5340           AC015684.11        106449-106493       c
            5341-5501           AC015684.11        103542-103702       c
            5502-5690           AC015684.11        101825-102013       c
            5691-5743           AC015684.11        95423-95475         c
            5744-5767           AC015684.11        89573-89596         c
            5768-5842           AC015684.11        89384-89458         c
            5843-5926           AC015684.11        80147-80230         c
            5927-6038           AC015684.11        79678-79789         c
            6039-6184           AC015684.11        77573-77718         c
            6185-6357           AC015684.11        74603-74775         c
            6358-6511           AC015684.11        66764-66917         c
            6512-6674           AC015684.11        65414-65576         c
            6675-6775           AC015684.11        64583-64683         c
            6776-6871           AC015684.11        62015-62110         c
            6872-7040           AC015684.11        60037-60205         c
            7041-7276           AC015684.11        56610-56845         c
            7277-7431           AC015684.11        54373-54527         c
            7432-7503           AC015684.11        54058-54129         c
            7504-7700           AC015684.11        52055-52251         c
            7701-7819           AC015684.11        50000-50118         c
            7820-8023           AC015684.11        42987-43190         c
            8024-11492          AC015684.11        36181-39649         c
FEATURES             Location/Qualifiers
     source          1..11492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..11492
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /note="neuron navigator 2"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
     exon            1..1126
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     CDS             860..8149
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /EC_number="3.6.4.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     retinoic acid inducible gene in neuroblastoma 1; helicase,
                     APC down-regulated 1; steerin-2; unc-53 homolog 2; pore
                     membrane and/or filament-interacting-like protein 2"
                     /codon_start=1
                     /product="neuron navigator 2 isoform 2"
                     /protein_id="NP_660093.2"
                     /db_xref="CCDS:CCDS7850.1"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
                     /translation="MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSK
                     VEVSKTTYPSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDTQIYTDWANHYLAKS
                     GHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDINGCPKNRSQMIENIDACLNFLAAK
                     GINIQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQPQKQHLSSPLPPAVSQVAGAPS
                     QCQAGTPQQQVPVTPQAPCQPHQPAPHQQSKAQAEMQSRLPGPTARVSAAGSEAKTRG
                     GSTTANNRRSQSFNNYDKSKPVTSPPPPPSSHEKEPLASSASSHPGMSDNAPASLESG
                     SSSTPTNCSTSSAIPQPGAATKPWRSKSLSVKHSATVSMLSVKPPGPEAPRPTPEAMK
                     PAPNNQKSMLEKLKLFNSKGGSKAGEGPGSRDTSCERLETLPSFEESEELEAASRMLT
                     TVGPASSSPKIALKGIAQRTFSRALTNKKSSLKGNEKEKEKQQREKDKEKSKDLAKRA
                     SVTERLDLKEEPKEDPSGAAVPEMPKKSSKIASFIPKGGKLNSAKKEPMAPSHSGIPK
                     PGMKSMPGKSPSAPAPSKEGERSRSGKLSSGLPQQKPQLDGRHSSSSSSLASSEGKGP
                     GGTTLNHSISSQTVSGSVGTTQTTGSNTVSVQLPQPQQQYNHPNTATVAPFLYRSQTD
                     TEGNVTAESSSTGVSVEPSHFTKTGQPALEELTGEDPEARRLRTVKNIADLRQNLEET
                     MSSLRGTQVTHSTLETTFDTNVTTEMSGRSILSLTGRPTPLSWRLGQSSPRLQAGDAP
                     SMGNGYPPRANASRFINTESGRYVYSAPLRRQLASRGSSVCHVDVSDKAGDEMDLEGI
                     SMDAPGYMSDGDVLSKNIRTDDITSGYMTDGGLGLYTRRLNRLPDGMAVVRETLQRNT
                     SLGLGDADSWDDSSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRKNLDVQTDA
                     EKHSQVERNSLWSGDDVKKSDGGSDSGIKMEPGSKWRRNPSDVSDESDKSTSGKKNPV
                     ISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPGTGKTDDAKVSEKGRLSPKASQVK
                     RSPSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGVTVTSRS
                     ATLGKIPKSSALVSRSAGRKSSMDGAQNQDDGYLALSSRTNLQYRSLPRPSKSNSRNG
                     AGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGISSDNESV
                     ASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATAENMK
                     NSVVISNPHATMTQQGNLDSPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSAP
                     SNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSSTGLIASS
                     KDDSLTPFVRTNSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLR
                     YTPTSQLRTQEDAKEWLRSHSAGGLQDTAANSPFSSGSSVTSPSGTRFNFSQLASPTT
                     VTQMSLSNPTMLRTHSLSNADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEE
                     VHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAF
                     EQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINTPELNCK
                     GNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWLRSSFKQAF
                     GKKKSPKSASSHSDIEEMTDSSLPSSPKLPHNGSTGSTPLLRNSHSNSLISECMDSEA
                     ETVMQLRNELRDKEMKLTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLKSE
                     SQGSGCSRAPSQVSISASPRQSMGLSQHSLNLTESTSLDMLLDDTGECSARKEGGRHV
                     KIVVSFQEEMKWKEDSRPHLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIIHVDPVSQL
                     GLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTTISVTVKGLAENSLDSLVFES
                     LIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFN
                     VDHKSSKELRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNCKYHK
                     CPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRFLRRKLMETEISGRVR
                     NMELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYS
                     IIPYLLEAVREGLQLYGRRAPWEDPAKWVMDTYPWAASPQQHEWPPLLQLRPEDVGFD
                     GYSMPREGSTSKQMPPSDAEGDPLMNMLMRLQEAANYSSPQSYDSDSNSNSHHDDILD
                     SSLESTL"
     exon            1127..1244
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1297
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1370
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1629
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1790
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2892
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3005
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3114
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3504
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3627
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3766
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..4058
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4761
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            4762..5229
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5230..5295
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5296..5340
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5341..5501
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5502..5690
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5691..5743
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5744..5767
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5768..5842
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5843..5926
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            5927..6038
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            6039..6184
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            6185..6357
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            6358..6511
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            6512..6674
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            6675..6775
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            6776..6871
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            6872..7040
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            7041..7276
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            7277..7431
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            7432..7503
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            7504..7700
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            7701..7819
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            7820..8023
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     exon            8024..11492
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8746..8751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /note="hexamer: AATAAA"
     polyA_site      8773
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /note="major polyA site"
     regulatory      11466..11471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /note="hexamer: AATAAA"
     polyA_site      11492
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /note="major polyA site"
ORIGIN      
        1 gtcctcccct gcgctgagcc ccgcagccag cgcagccttc ccgggaagcg cggcggccgc
       61 tcccgagcgc agccctgccc ggcccgccag ccgcgcgtcc cggcgcccgc gccccacggc
      121 cacagccttg cctctatcta gctcacggag catgtgcaga cccgcaggcg ctaaggtgct
      181 ctcagtccgg gggccttctg ggcagcggtg actgtcaccc caagagagac ctttcggggg
      241 ctcttgccgc acctctgctg cgtcgcgggt gacactgcgg tgctcgcgag cagggtggca
      301 gctgcctctc ggtggagacg tcttgggacc cttgcgccct tcttctctcc ttccttcgct
      361 gctgtctcct ttccttcctt ggctgctcgc tctttctctc gccggctcag acccgtagcc
      421 tccggaacgg gactcgtggg tcgccgccgc ctctgtctct tccaaagggg cctcctcact
      481 tcggagatgc agtgacaagt taatatgggc gtccaagcct ctgtttccca ggaggaaatt
      541 tgcaagaggc ggcagcccct gagcgcccag agctcttgaa aggccaccca ggagaggtgt
      601 gagacccggc ggcagcatcc gtccaggtgg gacccgctga gcgccgtggc cagtccccca
      661 ttcccatccc ggcaccccaa aggcgcgctc gcccgattgc ttcgagttcc ccgacctggg
      721 gatttttttt ttagccgctg gtggtgggcg cctcgtgggc taaggcccgg cgcctgctct
      781 gctacccgcg ctgcctttag cggtcgcccc cgccgccgct gccagggacg tgctgggaaa
      841 gcccaagccc cgggagaaga tgccggccat cctggtcgcc tccaaaatga agtcgggact
      901 gcccaaaccc gtgcacagcg ccgcgcccat cctgcacgtg cccccggccc gggcgggccc
      961 ccagccctgc tacctgaagt tgggaagcaa ggtggaggtg agcaagacca cctatcctag
     1021 ccagatcccc ctgaaatcgc aggtgctgca ggggctgcag gagccagcgg gggaggggct
     1081 cccgctgcgg aagagcggct cggtggaaaa cgggttcgat acccagatct acacagactg
     1141 ggccaatcat tacctagcca aatccggcca caagcgtctc atcagggatc tccagcaaga
     1201 tgtgacagat ggcgtcctcc tggcccagat tatccaggtt gtggcaaatg aaaagattga
     1261 agacatcaat ggctgtccga agaacagatc ccaaatgatt gaaaacatag atgcctgctt
     1321 gaatttcctg gcagctaagg gaataaacat ccaggggctg tctgcagaag agatcaggaa
     1381 tggaaacctc aaggccattc taggcctctt cttcagcctc tcccgataca agcagcagca
     1441 gcagcagccc cagaagcagc acctctcctc acctctgccg cccgccgtat cccaggtggc
     1501 cggggccccc tcccagtgcc aggctggcac ccctcagcag caggtgccag tcactcccca
     1561 agccccgtgc cagcctcacc agccagcgcc acatcagcag tcaaaagcac aagctgaaat
     1621 gcagtccaga cttccaggtc ctaccgcgag ggtatccgct gcaggcagcg aggccaaaac
     1681 acgcggaggg tcaactactg ctaacaaccg acgcagccag agctttaaca actatgataa
     1741 atccaaacca gtcacctccc cacccccacc gccaagcagc cacgagaaag agcctttggc
     1801 aagttcagcc tcctcccacc ccggaatgag tgacaatgca cctgcttcct tggagagcgg
     1861 cagcagctcc acccctacta attgcagtac ctcctcggcc atcccgcagc ccggtgcagc
     1921 caccaagcct tggcgcagca aatccctcag cgtgaagcac agtgccacgg tatccatgct
     1981 ctcggtcaag cctcctgggc ctgaggcccc caggcccaca cctgaagcca tgaagccggc
     2041 ccccaacaat cagaagtcca tgctggaaaa gctgaaactt ttcaacagta aagggggctc
     2101 aaaggcaggt gaggggccgg ggtcccggga cacaagctgt gagcggctgg agactctgcc
     2161 cagcttcgaa gagagcgagg agctggaggc cgccagtcgc atgctcacca ccgtgggccc
     2221 tgcttccagc agccccaaga ttgcactcaa gggcattgcc cagaggactt ttagccgggc
     2281 actgaccaac aagaagagtt ctctgaaagg caatgagaaa gagaaggaga aacaacagcg
     2341 ggagaaggat aaggagaaaa gcaaggacct tgccaagaga gcctctgtga cggagaggct
     2401 ggacctcaag gaggagccaa aagaagaccc cagtggagca gctgtgcccg agatgccaaa
     2461 aaagtcctcc aagattgcca gcttcatccc caaagggggg aagctcaaca gtgccaagaa
     2521 ggagcccatg gccccttccc acagtggaat accaaaacca ggaatgaaaa gcatgcccgg
     2581 gaaatcccca agtgccccag cgccttccaa ggaaggggag cggagccgga gtgggaagct
     2641 gagctcagga ctcccccagc agaagcccca gctggacggc agacactcca gttcctcttc
     2701 cagcctggcg tcctcagaag gaaaaggccc aggagggacc accctgaacc acagcatcag
     2761 cagccagact gtcagtgggt ctgtcgggac cacccagacc acaggaagca ataccgtcag
     2821 tgttcagcta cctcagcccc agcagcaata caaccatccc aacactgcca cggttgcacc
     2881 tttcctgtac aggtctcaga cggacactga agggaatgtt actgccgagt caagctcaac
     2941 aggtgtgagc gtggagccca gccacttcac caagactgga cagcctgctc tggaagaact
     3001 cactggggaa gatcctgagg ctcggcggct gcggacagtg aagaacatcg ctgatctgcg
     3061 gcagaatttg gaggaaacca tgtccagttt aaggggaact caggttacac acagcacatt
     3121 ggaaaccacg tttgacacca atgtcaccac ggagatgagt ggccgtagca tactcagctt
     3181 gacagggagg cccacacctc tgtcctggag actgggccag tccagccctc ggctccaagc
     3241 aggagacgcc ccctcaatgg gcaatgggta tccccctcga gccaacgcca gcaggttcat
     3301 caacactgag tcaggtcgct atgtgtactc cgcccctctg agaaggcagc tggcctcccg
     3361 gggcagtagt gtctgccatg tggacgtctc agacaaggca ggagatgaga tggacctgga
     3421 aggcatcagc atggatgccc ccggctacat gagcgacggg gatgttctga gcaagaacat
     3481 ccggaccgat gacattacaa gcggatacat gactgatggt ggacttggcc tctatacccg
     3541 tcgcctgaac cggctccctg atgggatggc tgtggtacgg gagaccctgc aacgaaatac
     3601 ctccctgggc ctcggagacg ctgacagctg ggacgacagc agctccgtca gcagcggcat
     3661 cagcgacacc atagacaacc tcagcactga tgacatcaac accagctcct ccatcagctc
     3721 ttatgccaac acacctgcct cctctcgaaa aaacctggat gtgcagactg atgctgagaa
     3781 gcactcacag gtggagagga attccctgtg gtctggtgat gatgtcaaga aatcagacgg
     3841 aggctcagac agcggcataa aaatggagcc aggttccaag tggaggcgga atccttctga
     3901 tgtgtctgac gagtccgaca aaagcacgtc gggcaagaag aatcctgtca tctcccagac
     3961 aggctcatgg cggcgaggca tgacagctca ggtgggcatc accatgccaa ggacgaagcc
     4021 ttcagccccg gcaggcgcac tgaagacccc aggaactgga aaaacagacg acgcaaaggt
     4081 gtctgagaaa ggaaggcttt ctcctaaagc ctcccaggtg aagcgctccc catcagatgc
     4141 aggccggagc agtggtgacg aatccaaaaa gcccctcccc agcagctcta ggacacctac
     4201 tgccaatgcc aacagctttg ggttcaagaa gcagagtggt tccgccgccg gcctggccat
     4261 gatcacagcc agcggggtga ctgtcaccag caggtcagcc acactgggca aaatcccaaa
     4321 gtcatctgca ctcgtcagtc ggtctgctgg tcggaagtca agtatggatg gggctcagaa
     4381 tcaggatgac gggtatctag ccctaagctc ccggacaaac cttcagtacc ggagtttgcc
     4441 gaggcccagt aagtccaaca gccggaacgg ggctgggaac aggtctagca ccagcagcat
     4501 agattccaac attagcagca agtccgcagg cctgccagtg cccaaactga gggagccttc
     4561 caaaacagcc ctaggcagct ctctaccagg tctggtcaac caaacagaca aggagaaagg
     4621 catctcatca gacaacgaga gtgtggcttc ctgtaactcg gtgaaagtga atccggcagc
     4681 ccagcctgtg tccagtccgg ctcagaccag tctccagcct ggagccaagt acccagatgt
     4741 ggcctctccc acactccgca gactctttgg tgggaagcct accaagcaag tgcccatcgc
     4801 cacagctgaa aacatgaaaa attcggtggt catctccaat cctcatgcca ccatgactca
     4861 gcaaggtaac ctagactccc cgtcaggcag tggcgtcctg agcagtggga gcagcagtcc
     4921 tctctacagc aagaatgtgg acctcaacca gtctccgcta gcctccagcc ccagctcagc
     4981 ccactcggcc ccttccaaca gcctcacctg gggcaccaac gccagcagct cctccgcagt
     5041 tagcaaggat ggcctgggct ttcagtctgt cagcagcctc cacaccagct gtgagtccat
     5101 cgacatctcc ctcagcagtg gaggggtccc cagccacaat tcttccactg gcctcatcgc
     5161 ctcctccaag gacgactcct tgactccctt tgtcagaact aacagtgtga agaccacact
     5221 gtcagaaagc cctctctctt cccctgctgc tagccctaag ttctgcagaa gtactctgcc
     5281 caggaaacag gacagtgacc cgcaccttga taggaacact ttgcctaaga aaggactcag
     5341 gtatactccc acctcccagc ttcgcacgca agaagatgca aaagaatggt tacggtccca
     5401 ttctgcagga ggccttcagg acaccgctgc caattccccc ttttcctctg gctccagcgt
     5461 gacttctccc tccggaacaa gattcaactt ttcccagctt gcgagtccca ccactgtcac
     5521 ccagatgagc ttgtccaacc cgaccatgct gaggactcac agcctctcca atgctgatgg
     5581 gcagtatgat ccatacactg acagccgctt ccggaatagc tccatgtccc tggatgagaa
     5641 gagcagaacc atgagccgtt caggctcatt ccgggatggg tttgaagaag ttcatggatc
     5701 ctcactctcc ttggtttcca gcacatcgtc agtttattct acaccagaag aaaaatgcca
     5761 gtcagagatt cgcaagctgc ggcgggaact ggatgcctcc caggagaaag tttcagcttt
     5821 gaccacccag ctgacagcaa atgctcacct tgtggcagcc tttgaacaga gtcttggtaa
     5881 catgacaatc aggctccaga gtctgaccat gacagctgag cagaaggact cagaactgaa
     5941 tgagttaaga aaaaccattg agctgctaaa gaaacagaac gcagctgccc aggctgccat
     6001 taatggagta attaacacac ctgagctcaa ctgcaaagga aacggcactg cccagtctgc
     6061 agacctccgc atccgcaggc agcactcctc agacagcgtc tccagcatca acagtgccac
     6121 cagccactcc agcgtgggca gcaacataga gagtgactca aagaagaaga agcggaagaa
     6181 ctggttacgc agctccttca agcaagcttt cgggaagaag aagtccccaa aatctgcgtc
     6241 ctctcattca gatattgagg agatgacgga ttcttctttg ccttcctcac caaagttacc
     6301 gcacaatggg tccacaggtt ccaccccact gctgaggaat tctcactcca actctctaat
     6361 ttcagaatgc atggatagtg aagctgagac cgtcatgcag ctccgaaatg agttaagaga
     6421 caaggagatg aagctgacgg atatccgctt agaagctctc agttctgccc accagctgga
     6481 ccagctccgg gaggccatga acaggatgca gagtgaaata gagaagctga aagctgagaa
     6541 tgatcggctg aagtcagagt ctcaaggcag tggctgcagc cgggctcctt cccaagtgtc
     6601 catctctgcc tccccgaggc agtccatggg cctctcccag cacagcttga acctcactga
     6661 gtcaaccagc ctggacatgt tgctggatga cactggtgaa tgctcggctc ggaaggaagg
     6721 aggcaggcat gttaagatag ttgtcagctt tcaggaggaa atgaagtgga aggaggattc
     6781 cagaccacat ctctttctta ttggctgcat tggagttagt ggcaagacga agtgggatgt
     6841 gctcgatggg gtggttagac ggctgttcaa agaatacatc attcatgtcg acccagtgag
     6901 tcagctaggg ctgaattcag acagcgttct tggctacagc attggagaaa tcaagcgcag
     6961 caacacttcc gaaacaccgg agctgcttcc ttgtggctat ctggttggag agaacacgac
     7021 catctcagtg actgtgaaag ggctcgcaga aaacagcctg gactcactgg tgtttgagtc
     7081 cttgattccc aagcccatcc tgcagcgcta cgtctccctc ctgatagagc accgtcggat
     7141 cattctctct ggccccagcg gcactgggaa aacctacctg gccaaccggc tgtctgagta
     7201 tatagtgctt cgagagggac gggagttgac agacggggtt atcgccacct ttaacgtgga
     7261 ccataagtcc agcaaggaat tgcgccagta cctgtccaac cttgctgacc agtgcaacag
     7321 tgagaacaat gctgtggaca tgcccctcgt catcatcctg gacaacctac accacgtgag
     7381 ctctctggga gagatcttca atgggctgct caactgcaag taccacaaat gcccttacat
     7441 aattggcaca atgaaccagg ctacctcttc gactcccaac ctgcagcttc accataactt
     7501 cagatgggtg ctttgtgcca accacacgga gcctgtgaag ggtttccttg gccgattcct
     7561 gaggaggaag ctcatggaaa cagagatcag tgggcgggtg cgcaatatgg agctggtaaa
     7621 aatcattgac tggattccca aggtctggca tcacctcaac cgcttcctgg aggctcacag
     7681 ttcctcggac gtcaccatcg gcccccggct cttcctgtca tgccccatcg atgtggacgg
     7741 ctcgagagtg tggttcaccg acttgtggaa ctattccatt atcccctatc tcctggaagc
     7801 cgtcagagaa ggactccagc tctatggaag gcgcgccccc tgggaggatc ctgccaagtg
     7861 ggtgatggac acatatccat gggcagccag cccacaacag cacgagtggc ctcccctgct
     7921 gcagttacgg cctgaggatg tcggcttcga cggctactcc atgcctcggg agggatcgac
     7981 aagcaagcag atgcccccca gtgatgctga aggtgacccg ctgatgaaca tgctgatgag
     8041 gctgcaggag gcagccaact actccagccc ccagagctat gacagcgact ccaacagcaa
     8101 cagccatcac gatgacatct tggactcctc tttggagtcc actctgtgac aggggcccgg
     8161 agcccagcgc cctcctcttc tcctcaccgc attccacctg catcccccac atcaccctga
     8221 agatgacttc ctgagccagc ccccagccac agccttagag ctgcgggaac accgagaccc
     8281 cccgtccttc agcctcgacc tgggtgcagg catcccgggc cagctgcctg cggaccgctt
     8341 ccttccacag cgagaactgc actaccttct gttgtacttt aattattgtt ttgccttgtt
     8401 gctgtgacct ccctaagaca ctgaagatac ttctcgggaa aggatcatcg ccgttgaaat
     8461 gaaaagagag acagagagaa aaaaaaaaag agaacccaca tgaagctctg aaaccaaaca
     8521 gcatcctgcc atgagcttcc cagagacaga agagactgga gcaaagtcgg aaacacagag
     8581 aagcacggct tcccctcagc acagaccctc cagactgggt ctcagagccg tgccacccac
     8641 cctcccacac agccggccac agggagaact ggtgctaacc agggtgcttg ctttggtcac
     8701 gttcaacgca ctacagagct acgacacagg gaaaccttag gagcaaataa accgtgcttt
     8761 catgtttttt aaatggtgct ttccttaccc gagaggtatt ttgcctgttc caatcaaacc
     8821 accccattca ggtccatcag cctctgatta atatccgtga gagtgagtga cggagtgaga
     8881 gtgtgagcga gtggatgtgg ctgtcagtgc agaacagcat gtgtctcttt ccttctgata
     8941 tatgaatgaa tcaggttttt tttttttttt ttctgcaaac actgtgtata gtgagacttg
     9001 ttctactttg gagaacaggt taccttttga aaatgaggtt gagtttcttc ctttctgatg
     9061 cattgatttt tgaagatttt tttttccccc ttcccctctt ggtcagaatc aatcctttgg
     9121 tgaaagtaag aaccgcagga gttgagtttt ggtttggtcc tgctcagttt tggtttttag
     9181 ttgtccatcc tcacagtcct acacactcgc ctcctcctgc tagggctggg ggtatctgtg
     9241 tcctttaaaa tggatgagga cctggtcctc gacatgtggg tgagccatgg accttgcctt
     9301 cccttctcgt ccttgagggt ttagaacaca caccaacacc tccagcgtcc ccgccccagc
     9361 ttccggtggg gtgatgcggt caccctgcaa aagacttgca ctttcctcag aaccaacatg
     9421 acgcagctca ataagggtga gggtcactcc ctcccagaag ccccgtctgg acgagccttg
     9481 cctgacctct tcggtgctga ccttcccaaa gtgatgcctt actggttttg tactaactgt
     9541 gttcatttta cataagtgtc gtgcctgcct ggggtttgtt ttttttgtca ttgttttccc
     9601 cattgaaaca aacagggcta aaaagtcatc tgttcattag gagaactcaa gttgctgtga
     9661 cttttctcat ccaaaagact catttgtgtg gatgcgtgac catgggaaaa agaaaaaaaa
     9721 aaagatccat tttttaggtt cttttcggtc tccagctgac aacccaactg gacaatgatc
     9781 tgtctggtgc aggagaaggc aaaagtttct acaagtctac atgaccttgc tgatacttgt
     9841 tctaatagaa acccagtctg ctgtgtcttc aacatactgg tattttcatt acaaagtatg
     9901 gtaaattttt gagttgtttg tttctgtttt gtaaagagaa tccttattgg acaccagtga
     9961 aggtgtctct gttttaatga tcagggtttt tattccatct tttgcatttc ttctatttct
    10021 gaaggtttgt ctcttggcat ctttttttag tttcttacca taagagtttg acccgaaact
    10081 gctcacttca cattggatga caccatgttc ttcctctttg aaaagaaaag gggaatgtgt
    10141 cccactagtg aaaggaaaac ttttcaacac tatccctgct ttagtctcag caaactcaga
    10201 ctattctgct tagccttcat tagtcatctg ggtgtgagtg tgtcttgttc tgtttttctt
    10261 tttaataaaa cttttaaacc atatatttag cctgtgacca ggggggccaa accctaagat
    10321 ttctggtaaa cctgaagggt ggccctcctc agacaattta tctcccagca atgaccctac
    10381 tacactcgcg tactgtgaat ttgggaggag gtaaagttga cttctcctcg tgggcagttt
    10441 tccaatcacc ttgtgagtag acacctgcca atattgtttg aaaccttttt ttaatatgac
    10501 atcctctctt gtcattctct tctccccttt cccacagact tccctcctgg gtccaggttc
    10561 agaaccaaga cttctgtacc tagtgctgcc tgattggtga acattgactt caagtagcat
    10621 agcccttgtg tgactcacaa ctccgtgtcc ttcctaaagt ttcgggaagc agggttgtct
    10681 aatatgcaca tttcttattt tggtcatatt tttactttag tgtcactcac cttttacaaa
    10741 gtgactttgt actcatttag ggctctatcg gaaatgcttc cattttgcct tttctacagt
    10801 taggccaatt ttgaaatata taaattctat gcaacattta tgttgagtta ccaatggaag
    10861 ccaaaagttc tcttcccaaa ctgccaagaa tgatacaggc cataattgaa atgggaatac
    10921 cttttaagtt tcattagggg tggggtggga gtgggacagg aacaagactt gcctagatct
    10981 ttgttgtatc ttggggactt ttactttgtt gtttgatgct taaacttcaa aattctctgt
    11041 attcaaattt gattgtggcg aatctacttc aaaaaggaaa aataatccaa ctttgtggat
    11101 attaaatgga aggtttgctg ttttgatcta gttgtttcca gtggagcagt tttatgaaat
    11161 atgttctata agatgtacat tttttcattg taacatagaa attgtaaata attgattaaa
    11221 gtgctgcatt ttgatgaatt ttttctagcc atttttaaag agaaaactag gaattgagta
    11281 ttttgtgtac ggtatgtttc catcctccct ccccttcctc ctcccctcct ctctctctct
    11341 tcctacctat ttaattttca tttgtcatga ggtttttgga tttgccaatg atctgctgga
    11401 catcatgccc catgtcatag agaataaagc tgatgattgt accagtctta aattattcat
    11461 gattcaataa aattgatgct tatttattca ga
//
