LOCUS       NM_001167738           11613 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens neuron navigator 1 (NAV1), transcript variant 2, mRNA.
ACCESSION   NM_001167738
VERSION     NM_001167738.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11613)
  AUTHORS   Witkowski,G., Szulczyk,B., Nurowska,E., Jurek,M., Pasierski,M.,
            Lipiec,A., Charzewska,A., Dawidziuk,M., Milewski,M., Owsiak,S.,
            Rola,R., Sienkiewicz Jarosz,H. and Hoffman-Zacharska,D.
  TITLE     Functional Characteristics of the Nav1.1 p.Arg1596Cys Mutation
            Associated with Varying Severity of Epilepsy Phenotypes
  JOURNAL   Int J Mol Sci 25 (3), 1745 (2024)
   PUBMED   38339022
  REMARK    GeneRIF: Functional Characteristics of the Nav1.1 p.Arg1596Cys
            Mutation Associated with Varying Severity of Epilepsy Phenotypes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11613)
  AUTHORS   Fu,W., Vasylyev,D., Bi,Y., Zhang,M., Sun,G., Khleborodova,A.,
            Huang,G., Zhao,L., Zhou,R., Li,Y., Liu,S., Cai,X., He,W., Cui,M.,
            Zhao,X., Hettinghouse,A., Good,J., Kim,E., Strauss,E., Leucht,P.,
            Schwarzkopf,R., Guo,E.X., Samuels,J., Hu,W., Attur,M., Waxman,S.G.
            and Liu,C.J.
  TITLE     Nav1.7 as a chondrocyte regulator and therapeutic target for
            osteoarthritis
  JOURNAL   Nature 625 (7995), 557-565 (2024)
   PUBMED   38172636
  REMARK    GeneRIF: Nav1.7 as a chondrocyte regulator and therapeutic target
            for osteoarthritis.
REFERENCE   3  (bases 1 to 11613)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 11613)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 11613)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 11613)
  AUTHORS   Ostensson,M., Monten,C., Bacelis,J., Gudjonsdottir,A.H.,
            Adamovic,S., Ek,J., Ascher,H., Pollak,E., Arnell,H., Browaldh,L.,
            Agardh,D., Wahlstrom,J., Nilsson,S. and Torinsson-Naluai,A.
  TITLE     A possible mechanism behind autoimmune disorders discovered by
            genome-wide linkage and association analysis in celiac disease
  JOURNAL   PLoS One 8 (8), e70174 (2013)
   PUBMED   23936387
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 11613)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 11613)
  AUTHORS   Peeters,P.J., Baker,A., Goris,I., Daneels,G., Verhasselt,P.,
            Luyten,W.H., Geysen,J.J., Kass,S.U. and Moechars,D.W.
  TITLE     Sensory deficits in mice hypomorphic for a mammalian homologue of
            unc-53
  JOURNAL   Brain Res Dev Brain Res 150 (2), 89-101 (2004)
   PUBMED   15158073
REFERENCE   9  (bases 1 to 11613)
  AUTHORS   Maes,T., Barcelo,A. and Buesa,C.
  TITLE     Neuron navigator: a human gene family with homology to unc-53, a
            cell guidance gene from Caenorhabditis elegans
  JOURNAL   Genomics 80 (1), 21-30 (2002)
   PUBMED   12079279
  REMARK    GeneRIF: cloning of the gene neuron navigator-1 (NAV1), a human
            homolog of unc-53, a gene involved in axon guidance in
            Caenorhabditis elegans
REFERENCE   10 (bases 1 to 11613)
  AUTHORS   Coy,J.F., Wiemann,S., Bechmann,I., Bachner,D., Nitsch,R., Kretz,O.,
            Christiansen,H. and Poustka,A.
  TITLE     Pore membrane and/or filament interacting like protein 1 (POMFIL1)
            is predominantly expressed in the nervous system and encodes
            different protein isoforms
  JOURNAL   Gene 290 (1-2), 73-94 (2002)
   PUBMED   12062803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645504.10.
            
            On Jun 2, 2019 this sequence version replaced NM_001167738.1.
            
            Summary: This gene belongs to the neuron navigator family and is
            expressed predominantly in the nervous system. The encoded protein
            contains coiled-coil domains and a conserved AAA domain
            characteristic for ATPases associated with a variety of cellular
            activities. This gene is similar to unc-53, a Caenorhabditis
            elegans gene involved in axon guidance. The exact function of this
            gene is not known, but it is thought to play a role in in neuronal
            development and regeneration. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, uses an alternate start codon, and lacks an
            alternate in-frame exon in the central coding region, compared to
            variant 1. The encoded isoform (2) has a distinct N-terminus and is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648460.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AL645504.10        58629-58805
            178-316             AL645504.10        99150-99288
            317-614             AL645504.10        99741-100038
            615-1308            AL645504.10        100905-101598
            1309-1755           AL645504.10        102135-102581
            1756-1797           AL645504.10        104039-104080
            1798-1946           AL645504.10        105158-105306
            1947-2117           AL645504.10        107197-107367
            2118-2170           AL645504.10        108469-108521
            2171-2194           AL645504.10        109283-109306
            2195-2272           AL645504.10        109418-109495
            2273-2356           AL645504.10        112521-112604
            2357-2468           AL645504.10        113195-113306
            2469-2590           AL645504.10        122322-122443
            2591-2787           AL645504.10        126682-126878
            2788-2980           AL645504.10        127147-127339
            2981-3149           AL645504.10        127432-127600
            3150-3247           AL645504.10        127893-127990
            3248-3343           AL645504.10        128171-128266
            3344-3503           AL645504.10        128675-128834
            3504-3739           AL645504.10        129252-129487
            3740-3894           AL645504.10        130332-130486
            3895-3966           AL645504.10        130632-130703
            3967-4163           AL645504.10        131194-131390
            4164-4282           AL645504.10        131869-131987
            4283-4480           AL645504.10        135817-136014
            4481-11613          AL645504.10        138566-145698
FEATURES             Location/Qualifiers
     source          1..11613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..11613
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /note="neuron navigator 1"
                     /db_xref="GeneID:89796"
                     /db_xref="HGNC:HGNC:15989"
                     /db_xref="MIM:611628"
     exon            1..177
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..4576
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /note="isoform 2 is encoded by transcript variant 2; pore
                     membrane and/or filament interacting like protein 3;
                     unc-53 homolog 1"
                     /codon_start=1
                     /product="neuron navigator 1 isoform 2"
                     /protein_id="NP_001161210.1"
                     /db_xref="CCDS:CCDS53456.1"
                     /db_xref="GeneID:89796"
                     /db_xref="HGNC:HGNC:15989"
                     /db_xref="MIM:611628"
                     /translation="MLHLPLPRSGRTVNFPRSWDESSSISSGLSDASDNLSSEEFNAS
                     SSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKM
                     EPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSAL
                     KVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKK
                     PPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSN
                     IQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGR
                     TTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPT
                     PLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCF
                     TPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFP
                     SSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEE
                     TKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRSNSI
                     PTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSS
                     AEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAET
                     AEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLN
                     SITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSA
                     PSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVS
                     ELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPS
                     SGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVV
                     VRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLS
                     TESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPM
                     MQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSC
                     KDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIG
                     TTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLR
                     VLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQ
                     EGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPED
                     RTVKDSTPSSLDSDPLMAMLLKLQEAANYIESPDRETILDPNLQATL"
     exon            178..316
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..614
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..1308
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1755
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1797
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1946
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2117
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2170
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2194
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2272
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2356
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2468
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2590
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2787
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2980
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3149
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3247
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3343
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3503
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3739
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3894
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..3966
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4163
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            4164..4282
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4480
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..11613
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7961..7966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /note="hexamer: AATAAA"
     polyA_site      7988
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
     regulatory      11590..11595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /note="hexamer: AATAAA"
     polyA_site      11613
                     /gene="NAV1"
                     /gene_synonym="POMFIL3; STEERIN1; UNC53H1"
                     /note="major polyA site"
ORIGIN      
        1 aggtttccga ccctccgcgt ggcccacagc tcataccttt tcgggtgtcc ccgggtgtca
       61 ggcgagagcg gtcctggggg gcgctgggtg cccacccggt gaatggccgc ctgagccggg
      121 gaagatgctt catctgcccc tgcccagatc cggaagaacg gtgaatttcc cccgcagctg
      181 ggatgaaagc agctccatca gtagtggact cagcgatgcc tcagacaatc tcagttcaga
      241 agaattcaat gccagctcct cactcaactc cctcccaagt actcccactg cttctcgcag
      301 gaactcaaca atagtgctac gcacagactc agagaagcgc tcactggcag aaagtgggct
      361 gagctggttt agtgaatcag aggagaaagc ccctaaaaaa ctggagtacg acagtggtag
      421 cctgaagatg gaacctggga cttctaagtg gcggagggag cggcctgaga gctgtgatga
      481 ttcatccaag ggtggagaac tgaaaaagcc catcagcctg ggccaccctg gttccctgaa
      541 gaagggcaag accccacctg tggctgtaac ttcccccatc actcacacag cccagagtgc
      601 cctcaaagtc gcaggcaaac ctgagggcaa agctacagac aagggtaagc ttgcagtgaa
      661 gaatactggg ctccaacgct cctcctctga tgctggtcgg gaccgcctga gtgatgctaa
      721 gaagcccccc tcgggcattg ctcgcccctc cacttcggga tcctttggct acaagaagcc
      781 tcctcctgcc acaggcacag ccactgtcat gcaaactggt ggttcagcca ctctcagcaa
      841 gatccagaag tcctcaggca tccctgtcaa gccagtaaat gggcgcaaga ctagcttaga
      901 tgtttccaac agtgcagagc caggattcct ggctcctgga gcccgttcta acatccagta
      961 ccgcagcctg ccccggccag ccaagtcaag ttctatgagc gtgaccggcg ggcggggtgg
     1021 acctcgccct gtgagcagca gcattgaccc cagtctcctc agcaccaagc agggaggcct
     1081 tacgccttcc agactgaagg agcctaccaa ggtagccagt gggcggacca ctccagcccc
     1141 tgtcaatcag acagatcggg aaaaggagaa ggccaaagcc aaggcagtgg ccttggactc
     1201 agacaacatc tccttgaaga gtattggctc cccagaaagt actcccaaga accaagcaag
     1261 ccaccccaca gccaccaagc tggcagagct gccaccaacc cctctcaggg ccacagcgaa
     1321 gagctttgtc aaaccaccct cactagccaa tcttgacaag gtcaactcca acagtctgga
     1381 tctaccatca tccagtgata ccacccatgc ttcaaaggtc ccagatctgc atgctacaag
     1441 ctcagcatct gggggccctc tcccttcctg cttcaccccc agtccggcac ccatcctcaa
     1501 tattaactca gccagcttct cccagggcct ggagctaatg agtggtttca gtgtgccaaa
     1561 agagacccgc atgtacccca aactctcagg cctgcacagg agcatggagt ccctccagat
     1621 gccaatgagc ctccccagtg ccttccccag cagtactccc gtccccaccc cacctgctcc
     1681 ccctgctgct cccacagaag aagagacgga agagctgact tggagtggaa gccccagagc
     1741 tgggcaactg gacagtaatc agcgggatcg gaacactctt cccaagaaag ggctcaggta
     1801 ccagcttcag tcccaggagg agaccaagga gaggcgacat tcccatacca ttggtgggct
     1861 gcctgaatcc gatgaccagt cagagctgcc ttctccccct gcacttccca tgtctctgag
     1921 tgcaaagggc caacttacca acatagtgag tcccactgcg gccaccacgc caagaatcac
     1981 ccgctccaac agcatcccca cccacgaggc ggccttcgag ctgtacagcg gctcccaaat
     2041 ggggagcacc ctgtccctgg ccgagagacc caagggaatg attcggtcag gatccttccg
     2101 agaccccacg gacgatgttc acggctcagt gctgtccctg gcctccagtg cctcctccac
     2161 ctactcctca gctgaggaga ggatgcaatc tgagcaaatc cggaagcttc gtagggaact
     2221 ggaatcatcc caggaaaaag tggccacctt gacgtctcag ctttctgcca atgctaatct
     2281 ggtggctgct tttgagcaga gcctggtgaa tatgacatcc cgcctgcgac acctggcaga
     2341 gacggccgag gagaaggaca ctgagctgct ggatttgcga gaaaccatag actttctgaa
     2401 gaaaaagaac tctgaggccc aggcagtcat tcagggagcc cttaatgcct cagaaaccac
     2461 acccaaagaa cttcggatca agagacaaaa ctcctcagat agcatctcaa gcctcaacag
     2521 catcactagc cattccagca tcggcagcag caaggatgct gatgcgaaaa agaagaaaaa
     2581 aaagagttgg cttcgaagtt ccttcaacaa agcgttcagt ataaaaaagg ggcccaagtc
     2641 agcttcctca tactcggata tagaggagat tgctacaccc gactcttcag ccccctcatc
     2701 ccccaaacta cagcatggtt ctacagagac tgcttcaccc tccatcaagt cctccacctc
     2761 gtcctccgtg ggcactgatg tcaccgaggg ccctgctcac ccagcccccc acactaggct
     2821 gttccatgca aatgaggagg aggagccaga gaagaaggag gtatcggagc tgcgctctga
     2881 gctatgggag aaggaaatga agcttacaga catccgcttg gaggccctca actctgccca
     2941 ccaactggat cagcttcggg agaccatgca caacatgcag ttggaggtgg acctgctgaa
     3001 agcagagaat gaccgactga aggtagcccc aggcccctca tcaggctcca ctccagggca
     3061 ggtccctgga tcatctgcat tatcttcccc acgccgctcc ctaggcctgg cactcaccca
     3121 ttccttcggc cccagtcttg cagacacaga cctgtcaccc atggatggca tcagtacttg
     3181 tggtccaaag gaggaagtga ccctccgggt ggtggtgagg atgcccccgc agcacatcat
     3241 caaaggggac ttgaagcagc aggaattctt cctgggctgt agcaaggtca gtggaaaagt
     3301 tgactggaag atgctggatg aagctgtttt ccaagtgttc aaggactata tttctaaaat
     3361 ggacccagcc tctaccctgg gactaagcac tgagtccatc catggctaca gcatcagcca
     3421 cgtgaaacga gtgttggatg cagagccccc cgagatgcct ccttgccgtc gaggtgtcaa
     3481 taacatatca gtctccctca aaggtctgaa ggagaaatgc gtcgacagcc tggtgttcga
     3541 gacgctgatc cccaagccga tgatgcagca ctacataagc ctcctgctga agcaccggcg
     3601 cctcgtcctc tcgggcccca gcggcacggg caagacctac ctgaccaatc gcttggccga
     3661 gtacctggtg gagcgctctg gccgtgaggt cacagagggc atcgtcagca ccttcaacat
     3721 gcaccagcag tcttgcaagg atctgcaact gtatctttcc aacctagcca accagataga
     3781 ccgggaaaca ggaattgggg atgtgcccct ggtgattcta ttggatgacc tgagtgaagc
     3841 aggctccatc agtgagttgg tcaatggggc cctcacctgc aagtatcata aatgtcccta
     3901 tattataggt accaccaatc agcctgtaaa aatgacaccc aaccatggct tgcacttgag
     3961 cttcaggatg ttgaccttct ccaacaacgt ggagccagcc aatggcttcc tggttcgtta
     4021 cctgaggagg aagctggtag agtcagacag cgacatcaat gccaacaagg aagagctgct
     4081 tcgggtgctc gactgggtac ccaagctgtg gtatcatctc cacaccttcc ttgagaagca
     4141 cagcacctca gacttcctca tcggcccttg cttctttctg tcgtgtccca ttggcattga
     4201 ggacttccgg acctggttca ttgacctgtg gaacaactct atcattccct atctacagga
     4261 aggagccaag gatgggataa aggtccatgg acagaaagct gcttgggagg acccagtgga
     4321 atgggtccgg gacacacttc cctggccatc agcccaacaa gaccaatcaa agctgtacca
     4381 cctgccccca cccaccgtgg gccctcacag cattgcctca cctcccgagg ataggacagt
     4441 caaagacagc accccaagtt ctctggactc agatcctctg atggccatgc tgctgaaact
     4501 tcaagaagct gccaactaca ttgagtctcc agatcgagaa accatcctgg accccaacct
     4561 tcaggcaaca ctttaagggt tcggcaatca ctgtcacccc cggacagcag aacgctggca
     4621 tcagctatct tagctcctcc tctcccctct cctctttcag agcactggct ctccagcccc
     4681 aggaggagaa caggagggag gaggagatga aagaggaggg acaggttctt ggtgctgtac
     4741 ctttgagaac ttcctaggaa ggaatggtgg ggtggcgttt gggaacttgt gccccctaaa
     4801 cacatttact ggcctcctct aatgactttg gggaaaagat gattctgggt ctttcccttg
     4861 acttcttgtt tcaattacaa actcctgggc tttctgggga ggggttcaga aaacatcaaa
     4921 acactgcagc agttcctaaa tgattctcac aagcaaccct gagagagaca gtcttgtgag
     4981 ggagatctgg gggaggcagg aagctcctca gattttctca cagacccttc ccaattccat
     5041 caccactgcc aacaactcct cccccagaga tctggctgga gcccagaaaa agaagcatgt
     5101 ggtttaaaaa atgtttaaat caatctgtaa aaggtaaaaa tgaaaaacaa aaacaagcaa
     5161 acaaacaaaa aacaatggaa aagatgaagc tggagagaga ggaaccagtt gccaaggtag
     5221 agagctgccc gctcctgccc tctggatgac ataggggaca tcaacaagac ggctgccaac
     5281 ctgagaagtc accaaaccac aaaaataacc ttacagcctt cagggaaaga ctaccagctc
     5341 tgtctttcta ccctctaatt taacaatgca taagagtcaa taaaccctac ttttttattt
     5401 ttggttttta ttttgttttc atttttttct cccatttgcc tatttatttt tttgtttccc
     5461 tttttttttt ctttttccgt ttttccattt cctcacatgt ccacgagatg cttgggttgc
     5521 ttttccaggg gctagtttgg cttttccaag tgggttttct ttggagaatc tgatgccatg
     5581 caattggcat gacacctgcc atgccactat ctttggcatc catggggctt atatgagaca
     5641 tgaagcattg gctcagaagt agagggagaa gaggaaccca gttcccttga cttccctttt
     5701 gagagcacac gttctgctgg gtagctcaat tgccagcctc tgtcatgaga aggtatagcc
     5761 ccatcttgat agaagagtta ctccgagctt tatcatggac cagaggaaaa ccagaaaact
     5821 gaaaacattc ctctgtcttg tggccagttt ggcctttcac tgcactattc tgatggtgcc
     5881 tgactgaatc caaatatcct agctggctct tactattttt cacaaatgag tattcacata
     5941 taagagatga acatccatgt gagatcatcc caatcagaat ataagactca aggagtttga
     6001 cttggtggcc aatacctgcc ttccaaagag atcctacctt tgcagatttg ctcctttccc
     6061 attgccttga aggtctggca atccctgttc tttcatttga caagtactta ctgagtactc
     6121 actatataca aatcattagg ttaaaacaga cacacacaca cacacacaca cacacacaca
     6181 cacacacaca cacacaagac ctgggccctt aagtttacag tccagcagga aatgttaacc
     6241 tccattcagc tacgccccct tgttatctag accttcggga tcatctaaga aatgtagctg
     6301 aaacccaagg agccagctag aaagaagctt ttgattagat gtacaataca ttgggggcag
     6361 aagatctggg atcaattaag atggagcctg aaggactatg gaatcttgct tgtcaggaat
     6421 gggcaagtct acttcctgcc atttctgaaa gccccgcggg accagcttct aggctgagct
     6481 gcctagtagg ctgaagcttc aggactctgc aggtcaagga tatgtgatga gcaccggcct
     6541 aagtgtttgc tcttcagatt cctaagtagc acaagacttt atcagaatct ataggcatac
     6601 caacctggat cactcttcca cccaaccgag gagtagatgc atctgaatct tcatatcggt
     6661 atattaagtc caaaagatgg tccgggctgc ccctcacaaa agcttctgca tccacgtggt
     6721 aagctcccat ggatgacagg gttctgtatg atggagacta ttattgctat tgctgctaat
     6781 tccatgagct gtgaagatcc ctaaccaact cagctgtaac atatgcaatt ctgtggtggg
     6841 aagaggctgt gtgtccaagg atggtgctga aatcactgcc ttaaggtctc tgctgtgcag
     6901 aatgaggagg cccccgagct ggctgttcta acttagaagg aagagaagac tggatgggcc
     6961 tgcttgggat ctaggcctct tctaaaccct atcctaagct ccagttccat ggcaaggctc
     7021 agacttttaa tgccatctta atctgatggt tgagcgcttc actctatttt ctggtgctgc
     7081 ccagccagtg ccttctgcca tggatgttac tggctacttg agaaaaagga gaggggagaa
     7141 ccccttcttt cattccaact gcctccgacc ccaaagggat tcttggctct ctggtaacca
     7201 tggataccac catgaatttt atttggatcc tcagcaggtt gattctggag gcctcatgct
     7261 atgacttttt atttctcttc ctgggatcca ccaccctcta ctctcagctg actgctgcat
     7321 ttaggccagg tctccaattg ctttcctcca gaaagtgtgt tcccgtctag tgaggtagta
     7381 ttgaagcctc ggctttccct ctggagcctg ggaccctgtt tacagttgca catctgggcc
     7441 cctcactgtg gggattgatc attctcatga aggaatcaca gttatatggc aactgcagaa
     7501 ggctgagcct cctcatggtg ctataacccc ttgggacact catccagact tctctgaagc
     7561 agaaaacctg agctccccac tcactgccct agaatttatg gcaaggagca aatctacagc
     7621 attctctccc acctacgtcc tgcttcttgg ttgagactac tgggatcctt cagaaaagaa
     7681 acactgggtc ccatagctaa attctcaacc gccaggcacc ttcagaagaa tccagcctaa
     7741 tactggaatt tgtgctatta tcttcctctc cagcccccca actccatccc tcaccacagt
     7801 tgtctaggaa atgacatgaa ttcaatatct aatgtcaacc aatggggaga gccacaactc
     7861 caggagaggt tcctgagctg agtcccttaa tttctggatg aagaagacca acaagttttg
     7921 tccaatgtat ttgtttctca gaccttgcct aggcactaaa aataaaatac taggtcattg
     7981 gaggctaatg tgggacctga tgtctgcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtctc
     8041 cctctctcac acacacaaga gcagtttgct gttgctgttt cctaccttct gaggcttcaa
     8101 agtatttttt aaaatctatg ctttgtggca gctctacggt gcttatctct gtctttgtgt
     8161 caatccttaa gtacccatgt ctttttcatg tctaaccatt gggaaggtag aggctggcag
     8221 ggaagacaaa tctgctacaa gtccatggga agaccctaca atgaaatgtt cattggttgg
     8281 tatactgttt tagtcttgaa ttgccaactt tccaactgat ctatccatat tccttaagta
     8341 ctaaagacaa aatagagggc ttctttttct ctcttaatgt cttgccttct ggttttcctg
     8401 gtttgcaaga ctaagtgtac ctaatctcac catctcttca cttctagctc tctgaaacaa
     8461 gggtcacact actcagaggg ataacccctt acagtggtct gaggagtaac tatttcctaa
     8521 agtattctaa aagagtagga agagagaaat ggtagcctgc tgcttctcac agacacctca
     8581 catcctcact tgggatggca tccacataga aaccctgcat ttaggtaaaa tttgcctgac
     8641 tgaaggggac tcagtcctcc aaatcaaggt caagaagata tctgcatgag accttaagaa
     8701 ctctttattg ccattatttg gagagggcgg gggaattgtc ctaatcacac atttaacaca
     8761 gggaataagt gctgaagtga cccagatcac caagcgcagt tcctcatcat actttatttt
     8821 tgctttcctt attccttggc actgactaag ctaaagttaa gaagccgact tcataagcca
     8881 acccctgtga tgggatggaa aaatgggctt ttgcagaggg tttattaata gagatggata
     8941 tactactcac aagttctggc tcatggctcc actgagaagg ccatagtaat aaaatgatct
     9001 tatgaacact gttccccaaa ggccaaagcc tgaagatatt gccccttata atccaatcag
     9061 ccttatattt taataagtcc tgaatcaacc tgactacgga tatatggggc caccagggtg
     9121 catgggtgca tgtctgctca gcctagccct ggaagtgagc actgccggcc acagatcctg
     9181 ggaaaggtgg tagtaaccca gaagatgtag ccttgaaggg aggataccta tcaaaatgcc
     9241 aaagctgcag ggacacgaag acggttgaaa attcaacctg tgtatactag atccttccag
     9301 tttgatggtt tggtcattct tcttcatgat tataccatgg agaattttct gtgacaaggg
     9361 tggtcatgga agtaagtgag tgatcccctg gtttctcatt ccttaaagca gtggttcgca
     9421 aagtatggca caagaccagc agcatcagca gcctttggga acttgttaga aacgaaaatt
     9481 ctcaatccca tcccagatct gctgaatcag aaactctaat gagaggaccc ggcaatccac
     9541 gttttaataa gccctcctgg tgattctgat gcacactaaa ttcaactgtt ttaaagggaa
     9601 agccctttat agtattggag ttcccacact gagaggcttt ggggcccaaa ataagaaggt
     9661 tctaggttgt cattcagact ttaacattaa tttcaaagtc acctttctca tgcttccttg
     9721 tgtttctgtt tttccattta tgattttaac aaagaaaggt atgtgtgctt ttgggtggaa
     9781 gttaggagaa tgtttgtgtc tttcctagtt gaatacaacc ttcagagaaa aaccttatgc
     9841 cttggaaatt actacctggc acacaaaggg gcttcaacaa ggaaaagcag ttggaggtct
     9901 cttccagatt gctcttctgc cgaattattt gtatctattc cgagctgatt atgtaatagg
     9961 atggaaaaag taaaaaaaaa aaaaaaaatc taatttgtat ttccatgaca acgtgttctc
    10021 ccagcaacat ccctctcctt tatttgagtt ataaagggca ctgctgggcc tgagaaccag
    10081 gccagaacct ccttctgtat ggcagctaac agtgtagggc tccagtatcc caggaaggcc
    10141 ccttatccac actccactca gctcatagga gagtcttgca taatgaagac acagacctgg
    10201 gcacttcagt ccttgtgctc ctcctctctt ttccccacag caggacctgg atacagaagt
    10261 actcagccaa ggtgacagaa taaaatcctt tttttgttgt tttctgtttg tttgtttgtt
    10321 ttggagaagg agtctcgctt tgtcacccag gctggtgtgc agtggcacga tctcggctca
    10381 ctgcaacctc cgcctcccag gttcaagcga ttctcctgtc tcagcctcct gagtagctgg
    10441 gattacagac gtgcgccatc acgcccagct aatttttgta tttttagtag atacggagtt
    10501 ttgccttgtt ggccaggctg tgctggagct cctgacctca ggtgattcac ctgccacagc
    10561 ctcccaaagt gctgggatta caggcgtgag ccacagcacc ctgccaaata agatcctttt
    10621 taaaaaatat ctgaaaaaag cttcatatct ttacaaactc ataaaatagc tgattgggcc
    10681 atggaggaga tgaggctgtt tagaactggt tttgtttcaa gtttgtcaat tttccctgta
    10741 tgagaacttg ggtaaagcac aaagaaacat acagtgctag taacaggtct cctgcgccct
    10801 ggaactaagt gtttggagga aggactaaac cccgggggag gtgagtataa aataattcca
    10861 ctaagatcac ctcctcagtc cccagaaggc tgatggtgga tcctctggcc atctcctgtg
    10921 gggtcttact gctcctctgc catttctcta tgcctgaaga cacgaagatg atatcaaggc
    10981 agagctacca tatcgcagcc agtctctagg ctactgctgt gcagtggctc ccactttcta
    11041 atgctttttt gtttttgctt tttctaacaa aacaatcttt tttcaaaatg aattccaacc
    11101 cctgctagct tccttccccg cctccatact gttttaggca gcaccgttta tgtgacagag
    11161 tccgtgtttc tcaaatgcat ggtgttcctc aggtggagag tgggcagaag tttttgcaac
    11221 actttttttt taagttattg ggtgcaaaat cccaaaccag gatatgtgta tgtctgtgtg
    11281 tttatgtttt ttatttgacc ctcccctctt tcaacctacc cccttttata tctaatgtag
    11341 aaaaagcgaa attgaatctg gaaagcaaac tgttgtatat agttgcggta acaatcatga
    11401 agagagagcc gggctgtccc ctcagtaatt cattttaaat aacaaattat ttaaaaataa
    11461 aattcatgcc agagccagct gaagaggcct tccttcatca ccactgaggc cacccccaat
    11521 ctgggccctc tgtccatctg gcatgtctcc tcccagcaag attcatctgt tcaatgccat
    11581 ttgcgtttca ataaagttat ctcctgtact gtc
//
