LOCUS       NM_015654               1907 bp    mRNA    linear   PRI 13-AUG-2024
DEFINITION  Homo sapiens N-acetyltransferase 9 (NAT9), transcript variant 1,
            mRNA.
ACCESSION   NM_015654
VERSION     NM_015654.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Deshpande,P., Chimata,A.V., Snider,E., Singh,A., Kango-Singh,M. and
            Singh,A.
  TITLE     N-Acetyltransferase 9 ameliorates Abeta42-mediated
            neurodegeneration in the Drosophila eye
  JOURNAL   Cell Death Dis 14 (7), 478 (2023)
   PUBMED   37507384
  REMARK    GeneRIF: N-Acetyltransferase 9 ameliorates Abeta42-mediated
            neurodegeneration in the Drosophila eye.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1907)
  AUTHORS   Mok,J.W. and Choi,K.W.
  TITLE     Novel function of N-acetyltransferase for microtubule stability and
            JNK signaling in Drosophila organ development
  JOURNAL   Proc Natl Acad Sci U S A 118 (4) (2021)
   PUBMED   33479178
REFERENCE   3  (bases 1 to 1907)
  AUTHORS   Jiugang,Z., Jing,L. and Yonggang,L.
  TITLE     Characterization, expression profile, polymorphism and association
            of porcine NAT9 gene
  JOURNAL   Mol Biol Rep 39 (3), 3137-3142 (2012)
   PUBMED   21688147
REFERENCE   4  (bases 1 to 1907)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   5  (bases 1 to 1907)
  AUTHORS   Danik,J.S., Pare,G., Chasman,D.I., Zee,R.Y., Kwiatkowski,D.J.,
            Parker,A., Miletich,J.P. and Ridker,P.M.
  TITLE     Novel loci, including those related to Crohn disease, psoriasis,
            and inflammation, identified in a genome-wide association study of
            fibrinogen in 17 686 women: the Women's Genome Health Study
  JOURNAL   Circ Cardiovasc Genet 2 (2), 134-141 (2009)
   PUBMED   20031577
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 1907)
  AUTHORS   Filer,C.E., Ho,P., Bruce,I.N., Worthington,J. and Barton,A.
  TITLE     Investigation of association of genes NAT9, SLC9A3R1 and RAPTOR on
            chromosome 17q25 with psoriatic arthritis
  JOURNAL   Ann Rheum Dis 68 (2), 292-293 (2009)
   PUBMED   19139211
  REMARK    GeneRIF: no evidence was found for association of SNPs mapping to
            the NAT9, SLC9A3R1 and RAPTOR loci with susceptibility to psoriatic
            arthritis
REFERENCE   7  (bases 1 to 1907)
  AUTHORS   Helms,C., Cao,L., Krueger,J.G., Wijsman,E.M., Chamian,F.,
            Gordon,D., Heffernan,M., Daw,J.A., Robarge,J., Ott,J., Kwok,P.Y.,
            Menter,A. and Bowcock,A.M.
  TITLE     A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is
            associated with susceptibility to psoriasis
  JOURNAL   Nat Genet 35 (4), 349-356 (2003)
   PUBMED   14608357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA259097.1, BC004195.2 and HY222854.1.
            
            On May 17, 2019 this sequence version replaced NM_015654.4.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004195.2, SRR1660805.211804.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357814.8/ ENSP00000350467.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA259097.1         81-94
            15-1889             BC004195.2         1-1875
            1890-1907           HY222854.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1907
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /note="N-acetyltransferase 9"
                     /db_xref="GeneID:26151"
                     /db_xref="HGNC:HGNC:23133"
                     /db_xref="MIM:620913"
     exon            1..79
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /inference="alignment:Splign:2.1.0"
     exon            80..165
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..712
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /EC_number="2.3.1.308"
                     /note="isoform 1 is encoded by transcript variant 1;
                     embryo brain specific protein; N-acetyltransferase 9
                     (GCN5-related, putative);
                     alpha/beta-tubulin-N-acetyltransferase 9;
                     N-acetyltransferase 9 (putative)"
                     /codon_start=1
                     /product="alpha/beta-tubulin-N-acetyltransferase 9 isoform
                     1"
                     /protein_id="NP_056469.2"
                     /db_xref="CCDS:CCDS11706.1"
                     /db_xref="GeneID:26151"
                     /db_xref="HGNC:HGNC:23133"
                     /db_xref="MIM:620913"
                     /translation="MRLNQNTLLLGKKVVLVPYTSEHVPSRYHEWMKSEELQRLTASE
                     PLTLEQEYAMQCSWQEDADKCTFIVLDAEKWQAQPGATEESCMVGDVNLFLTDLEDLT
                     LGEIEVMIAEPSCRGKGLGTEAVLAMLSYGVTTLGLTKFEAKIGQGNEPSIRMFQKLH
                     FEQVATSSVFQEVTLRLTVSESEHQWLLEQTSHVEEKPYRDGSAEPC"
     exon            166..278
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /inference="alignment:Splign:2.1.0"
     exon            279..422
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /inference="alignment:Splign:2.1.0"
     exon            423..482
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /inference="alignment:Splign:2.1.0"
     exon            483..577
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1907
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1865..1870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /note="hexamer: TATAAA"
     regulatory      1879..1884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /note="hexamer: TATAAA"
     polyA_site      1885
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
     polyA_site      1889
                     /gene="NAT9"
                     /gene_synonym="EBSP; hNATL"
                     /note="major polyA site"
ORIGIN      
        1 agccggccgg gcctgggaac gtggctggtt ggaggaggta gatcaccctt tctgcggggg
       61 acgatttcgt cggtggtagg ctgctaccat gaggttgaat cagaacacct tgctgctggg
      121 gaagaaggtg gtccttgtac cctacacctc ggagcatgtg cccagcaggt accacgagtg
      181 gatgaaatca gaggagctgc agcgtttgac agcctcggag ccgctgaccc tggagcagga
      241 gtatgccatg cagtgcagct ggcaggaaga tgcagacaag tgtaccttca ttgtgctgga
      301 tgccgagaag tggcaggccc agccaggcgc caccgaagag agctgcatgg tgggagatgt
      361 gaacctcttc ctcacagatc tagaagacct caccttgggg gagatcgagg tcatgattgc
      421 agagcccagc tgcaggggta agggccttgg cactgaggcc gttctcgcga tgctgtctta
      481 cggagtgacc acgctaggtc tgaccaagtt tgaggctaaa attgggcaag gaaatgaacc
      541 aagcatccgg atgttccaga aacttcactt tgagcaggtg gctacgagca gtgtttttca
      601 ggaggtgacc ctcagactga cagtgagtga gtccgagcat cagtggcttc tggagcagac
      661 cagccacgtg gaagagaagc cttacagaga tgggtcggca gagccctgct gatggctggg
      721 ccttgtgggc agccactctg tgtgagcagg gtgttgggcc catacacttc aaagaccaga
      781 gccctgcact gggagagtgc tcctggccca ggctgggaat cacctttcga ggcccttcag
      841 actctggcgg ggcttgctgt ggcctccctc cagctagtgg tgtggctgag cagactccag
      901 ggccagggcc agttcccttc tcccctcccg gccaaaccca gacccagact ctaggaagct
      961 ggaatggagg gcagggatcc atgggagatg tcgggatgaa ggtgggagct ggaggtgcag
     1021 ggggacctgg aacatggatg ggagtggaca ggcctttctc cttagaggcc agaggtgctg
     1081 ccctggctgg gagtgaagct ccaggcacta ccagctttcc tgattttccc gtttggtcca
     1141 tgtgaagagc taccacgagc cccagcctca cagtgtccac tcaagggcag cttggtcctc
     1201 ttgtcctgca gaggcaggct ggtgtgaccc tgggaacttg acccgggaac aacaggtggt
     1261 ccagagtgag tgtggcctgg cccctcaacc tagtgtccgt cctcctctct cctggagcca
     1321 gtcttgagtt taaaggcatt agtgttagat acagctcctt gtggctggaa aacacccctc
     1381 tgctgataaa gctcaggggg cactgaggaa gcagaggccc cttgggggtg ccctcctgaa
     1441 gagagcgtca ggccatcagc tctgtccctc tggtgctccc acgtctgttc ctcaccctcc
     1501 atctctggga gcagctgcac ctgactggcc acgcgggggc agtggaggca caggctcagg
     1561 gtggccgggc tacctggcac cctatggctt acaaagtaga gttggcccag tttccttcca
     1621 cctgagggga gcactctgac tcctaacagt cttccttgcc ctgccatcat ctggggtggc
     1681 tggctgtcaa gaaaggccgg gcatgctttc taaacacagc cacaggaggc ttgtagggca
     1741 tcttccaggt ggggaaacag tcttagataa gtaaggtgac ttgcctaagg cctcccagca
     1801 cccttgatct tggagtctca cagcagactg catgtgaaca actggaaccg aaaacatgcc
     1861 tcagtataaa acaaacatta taaaacgaac gcgttgcttg ccgtggc
//
