LOCUS       NM_178557               6056 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens N-acetyltransferase 8 like (NAT8L), mRNA.
ACCESSION   NM_178557 XM_003119921 XM_003403774
VERSION     NM_178557.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6056)
  AUTHORS   Kharel,P., Singhal,N.K., Mahendran,T., West,N., Croos,B., Rana,J.,
            Smith,L., Freeman,E., Chattopadhyay,A., McDonough,J. and Basu,S.
  TITLE     NAT8L mRNA oxidation is linked to neurodegeneration in multiple
            sclerosis
  JOURNAL   Cell Chem Biol 30 (3), 308-320 (2023)
   PUBMED   36882060
  REMARK    GeneRIF: NAT8L mRNA oxidation is linked to neurodegeneration in
            multiple sclerosis.
REFERENCE   2  (bases 1 to 6056)
  AUTHORS   De Falco,P., Lazzarino,G., Felice,F., Desideri,E., Castelli,S.,
            Salvatori,I., Ciccarone,F. and Ciriolo,M.R.
  TITLE     Hindering NAT8L expression in hepatocellular carcinoma increases
            cytosolic aspartate delivery that fosters pentose phosphate pathway
            and purine biosynthesis promoting cell proliferation
  JOURNAL   Redox Biol 59, 102585 (2023)
   PUBMED   36580805
  REMARK    GeneRIF: Hindering NAT8L expression in hepatocellular carcinoma
            increases cytosolic aspartate delivery that fosters pentose
            phosphate pathway and purine biosynthesis promoting cell
            proliferation.
REFERENCE   3  (bases 1 to 6056)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6056)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6056)
  AUTHORS   Miyanishi,H., Uno,K., Iwata,M., Kikuchi,Y., Yamamori,H., Yasuda,Y.,
            Ohi,K., Hashimoto,R., Hattori,K., Yoshida,S., Goto,Y.I.,
            Sumiyoshi,T. and Nitta,A.
  TITLE     Investigating DNA Methylation of SHATI/NAT8L Promoter Sites in
            Blood of Unmedicated Patients with Major Depressive Disorder
  JOURNAL   Biol Pharm Bull 43 (7), 1067-1072 (2020)
   PUBMED   32612069
  REMARK    GeneRIF: Investigating DNA Methylation of SHATI/NAT8L Promoter
            Sites in Blood of Unmedicated Patients with Major Depressive
            Disorder.
REFERENCE   6  (bases 1 to 6056)
  AUTHORS   Becker,I., Lodder,J., Gieselmann,V. and Eckhardt,M.
  TITLE     Molecular characterization of N-acetylaspartylglutamate synthetase
  JOURNAL   J Biol Chem 285 (38), 29156-29164 (2010)
   PUBMED   20643647
REFERENCE   7  (bases 1 to 6056)
  AUTHORS   Ariyannur,P.S., Moffett,J.R., Manickam,P., Pattabiraman,N.,
            Arun,P., Nitta,A., Nabeshima,T., Madhavarao,C.N. and
            Namboodiri,A.M.
  TITLE     Methamphetamine-induced neuronal protein NAT8L is the NAA
            biosynthetic enzyme: implications for specialized acetyl coenzyme A
            metabolism in the CNS
  JOURNAL   Brain Res 1335, 1-13 (2010)
   PUBMED   20385109
REFERENCE   8  (bases 1 to 6056)
  AUTHORS   Wiame,E., Tyteca,D., Pierrot,N., Collard,F., Amyere,M., Noel,G.,
            Desmedt,J., Nassogne,M.C., Vikkula,M., Octave,J.N., Vincent,M.F.,
            Courtoy,P.J., Boltshauser,E. and van Schaftingen,E.
  TITLE     Molecular identification of aspartate N-acetyltransferase and its
            mutation in hypoacetylaspartia
  JOURNAL   Biochem J 425 (1), 127-136 (2009)
   PUBMED   19807691
  REMARK    GeneRIF: Results indicated that NAT8L, but not NAT14, catalysed the
            synthesis of NAA from L-aspartate and acetyl-CoA.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6056)
  AUTHORS   Arun,P., Moffett,J.R. and Namboodiri,A.M.
  TITLE     Evidence for mitochondrial and cytoplasmic N-acetylaspartate
            synthesis in SH-SY5Y neuroblastoma cells
  JOURNAL   Neurochem Int 55 (4), 219-225 (2009)
   PUBMED   19524112
REFERENCE   10 (bases 1 to 6056)
  AUTHORS   Popsueva,A.E., Luchinskaya,N.N., Ludwig,A.V., Zinovjeva,O.Y.,
            Poteryaev,D.A., Feigelman,M.M., Ponomarev,M.B., Berekelya,L. and
            Belyavsky,A.V.
  TITLE     Overexpression of camello, a member of a novel protein family,
            reduces blastomere adhesion and inhibits gastrulation in Xenopus
            laevis
  JOURNAL   Dev Biol 234 (2), 483-496 (2001)
   PUBMED   11397015
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132868.24, BC103748.1 and
            BC010045.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 27, 2018 this sequence version replaced NM_178557.3.
            
            Summary: This gene encodes a single-pass membrane protein, which
            contains a conserved sequence of the GCN5 or NAT superfamily of
            N-acetyltransferases and is a member of the N-acyltransferase (NAT)
            superfamily. This protein is a neuron-specific protein and is the
            N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA
            synthesis from L-aspartate and acetyl-CoA. NAA is a major storage
            and transport form of acetyl coenzyme A specific to the nervous
            system. The gene mutation results in primary NAA deficiency
            (hypoacetylaspartia). [provided by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094797.1, BC103748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423729.3/ ENSP00000413064.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               AL132868.24        12100-12616         c
            518-1473            BC103748.1         1-956
            1474-5214           AL132868.24        3696-7436           c
            5215-6056           BC010045.2         78-919
FEATURES             Location/Qualifiers
     source          1..6056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..6056
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
                     /note="N-acetyltransferase 8 like"
                     /db_xref="GeneID:339983"
                     /db_xref="HGNC:HGNC:26742"
                     /db_xref="MIM:610647"
     exon            1..561
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1094
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
                     /EC_number="2.3.1.17"
                     /note="camello-like protein 3; NAA synthetase; Shati;
                     N-acetyltransferase 8-like (GCN5-related, putative)"
                     /codon_start=1
                     /product="N-acetylaspartate synthetase"
                     /protein_id="NP_848652.2"
                     /db_xref="CCDS:CCDS3359.2"
                     /db_xref="GeneID:339983"
                     /db_xref="HGNC:HGNC:26742"
                     /db_xref="MIM:610647"
                     /translation="MHCGPPDMVCETKIVAAEDHEALPGAKKDALLAAAGAMWPPLPA
                     APGPAAAPPAPPPAPVAQPHGGAGGAGPPGGRGVCIREFRAAEQEAARRIFYDGIMER
                     IPNTAFRGLRQHPRAQLLYALLAALCFAVSRSLLLTCLVPAALLGLRYYYSRKVIRAY
                     LECALHTDMADIEQYYMKPPGSCFWVAVLDGNVVGIVAARAHEEDNTVELLRMSVDSR
                     FRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKVAAHKLYESLGFRHMGASDHYVLP
                     GMTLSLAERLFFQVRYHRYRLQLREE"
     exon            562..726
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            727..6056
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
                     /note="hexamer: AATATA"
     polyA_site      2878
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
     regulatory      6035..6040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
                     /note="hexamer: AATAAA"
     polyA_site      6056
                     /gene="NAT8L"
                     /gene_synonym="CML3; NACED; NAT8-LIKE"
                     /note="major polyA site"
ORIGIN      
        1 ccctgcgcgc gccccggccg cccgccgcct ccgccccgcg cccctgagct gccgccgccg
       61 ccgccgccgc tgccgccgcc gccgccgccg ccgcgggtcc gagggcgccg cgcccttgcc
      121 ctgggcccgg ccgtgcccgc cgccgcccgg ccgcgtcccc gctgccgcgc cgcccggccg
      181 ggtgcatgca ttgtgggcct cccgacatgg tctgcgagac gaagatcgtg gccgccgagg
      241 accatgaggc gctgccgggg gccaagaagg acgcgctgct cgccgccgcc ggcgccatgt
      301 ggcccccgct gcccgccgcg cccgggccgg ccgccgcgcc ccccgcgccc ccacctgccc
      361 cggtggctca gcctcacggc ggggcggggg gcgcggggcc gccggggggg cgcggcgtgt
      421 gcatccgcga gttccgtgcg gccgagcagg aggcggcgcg ccgcatcttc tacgacggca
      481 tcatggagcg catccctaac acggccttcc gcggcctgcg gcagcacccg cgcgcgcagc
      541 tgctctacgc cctgctggcg gcgctgtgct tcgccgtgag ccgctcgctg ctgctgacgt
      601 gcctggtgcc ggccgcgctg ctgggcctgc gctactacta cagccgcaag gtgatccgcg
      661 cctacctgga gtgcgcgctg cacacggaca tggcggacat cgagcagtac tacatgaagc
      721 cgcccggctc ctgcttctgg gtggccgtgc tggatggcaa cgtggtgggc attgtggctg
      781 cacgggccca cgaggaggac aacacggtgg agctgctgcg gatgtctgtg gactcacgtt
      841 tccgaggcaa gggcatcgcc aaggcgctgg gccggaaggt gctggagttc gccgtggtgc
      901 acaactactc cgcggtggtg ctgggcacga cggccgtcaa ggtggccgcc cacaagctct
      961 acgagtcgct gggcttcaga cacatgggcg ccagtgacca ctacgtgctg ccgggcatga
     1021 ccctctcgct ggctgagcgc ctcttcttcc aggtccgcta ccaccgctac cgcctgcagc
     1081 tgcgcgagga gtgaccgccg ccgctcgccc gcccgccccc ccggccgccc tgtccgcctt
     1141 tgcccgcctg cccgccgccc ggcgcggcct gctttcagac gctcaattgg cgtttgtgtt
     1201 gggtttcccc ttttcaacat cctgcggttg tctggctggt tccggggggt gcggggctgt
     1261 tgttcttcgg cgacactttg gtgggggtgg gttgtttgtc gccatagccc ctcgcccttc
     1321 cccacctgcc tgggcggctt gccacctgaa gagtggcatc ttggaccacc gcggctgtcc
     1381 atgacgctgc cctgcccgcc gccactgggg aaggcccagc cttgctcacc aagcacagaa
     1441 cctctgcagc agatcccggg gccaggctcc ggccccgcct gcggccccag cgccactgcc
     1501 tgtggaggcc ccagctggcc acggcgctgc tttgctccgc gcatgccgag ggtgtggccc
     1561 ggctgagcat gccgcatgca cacagccccg ccctgccgcc ctgcccagac tggacccgga
     1621 gacccgggct ggtgagcgcc cctgtcccca gcccccagct ggctgtggga gggcctgccc
     1681 ctgcccccac ctcctggagg gcctggtctg ccccgcgccg cccggctctg tccacacctg
     1741 ctttgctctg acgccctcca tttctctggc tccggcccct cccctgcctg ggctgtgctg
     1801 actggtgtca tcacccaggt gactcccatg gcgtccgtgg cacagccagg gtgggggtcc
     1861 atgggacccc tctccccagt gcccactgga tcgtgctggc ctctcccaga tgtccccggg
     1921 gacctcctgc ctctggctga cggtccaccc tgtgaatctt atcagcccag gctgctgcca
     1981 acagcgccca gcccacagct tctcccagcc tgaaaccaac acattttcta ataagttatt
     2041 tagacagaat agcactctgc atgactttaa ttcttgggac aaaacggtag tttgtaccct
     2101 aagacacagt ttctggccca gtgtgatggg ggtgggtggc cgggtgggtg gagcgttttg
     2161 ctgttggaaa cctggaggga aaccctgatt ggatgtcatt tcctgccatg gagcacgcct
     2221 cccagccctg gcctgcagtg tgggcagggt ggggggcaag ggagtccgca gcctccggga
     2281 ggaggggcag ggcgctgcct tgggctgggt gggaagaggg gtggccgcct cggcttccgc
     2341 tggccatgct cctggtctct ccttcctgag gtcacaggca ggggctgccc tggacggggg
     2401 gcgggggggg tggcctggaa ggggagacag aggtggaggg tggcacaggc tgcacattca
     2461 gcttagaagt ggacctggct ttggtggcag gagaagaata aacacttgcc cagacccctt
     2521 tgtgtggggg aattggggag gggtcgtggc aggcagggtg ggccacggaa ctgggtccca
     2581 ggcatcaagg ccacgtgcag ggccatggag ggatgcttct cacgaggcgc ttcagaagcg
     2641 agcgaaggga cagagaagcc ctgcgtccaa gggccttttg tcctgttagc aattgaggtg
     2701 tgcagagcac tgtacagacc ccactcccct gtacattcct ccctggaggt gcccggtccc
     2761 cgcttgggga tgggagtttt gtagactgta cagaaatcgg caccctattt tcttgcagct
     2821 cagattttgt taatctggaa tatacagaca gacgtaaagt gttttagcaa aatggaaaca
     2881 aacagttgtg cctttttcct cttttggttt ggtttgggtt tggcctgggg ctggtcccag
     2941 ttggtgcggg gcatgctggg ggcaggaggg gcagggcggg ccaggtggag tcaggtcttg
     3001 ggggtgtcat gtcggggtgc tgccagcgtc ccttggtcct gtgcctttgg agcctcgggc
     3061 tcctggggtg cagggtgctt gggggtggct gttggagccc accgacgcca gggcagggcc
     3121 tggaggccca gggactgcca gtgtctcctt gatattgatc ctagcagatc cccctcctgg
     3181 gggttctgag agtcctgggc agtgtggcct tctctcattc tggtggcatc tgcgcccgtg
     3241 agtgacctct tccttggctg cactgccctg tgggtggtga gacgcttggc cttttttgtt
     3301 gctgccagga cttggtagag atggcaggaa gggtgtgcgg ggtggttgtg tgcagaaccc
     3361 tgccgcccct gaggtgagca gaggcactgg tgtgcctgcc aggctggggc ggagctgccc
     3421 ggaacccttg ccaggccaat gtgtagcttg gtggcgccct tgaaggccac tggggggtag
     3481 gtgtgtcctc ccccggggct ggaggccggg tgcctggtgg gtgggcctga cctggcccac
     3541 ctcatccctc cagcctggga tctcactgct ctgcacatgt gcactgacgt gaattttata
     3601 cgtttgtaga aactctgatg taacttcttc tacctctgaa gcgccctcct gggccctgct
     3661 gtcacgtggc tggtgcggct tccccgagtg ctggccccct gcccgctccc catgggcacc
     3721 caccactcaa actctgcgtg gtgaggcccg gggaaagcca ggccgggccc tagcactgct
     3781 caggggcctg gggctcctgg gatttctgtg tgtttggaag cctctgtttt tggagtgggg
     3841 ggcgtggaag gcgggagggg ctgacagtgc ctggggccag agctgggcga aggaggacat
     3901 cctcactgga cgagcactgc aggcctgacg agaggctccg ggcagctgag ggctgaagcg
     3961 cctcgggatg ccccacactg cccagagcca cgggtcttgc tgtgctgggg gtggggtggc
     4021 cccaggcagc tgccactgcc caggtgtgag tcgctgcaga cctggtccct gagggtggga
     4081 ggcctgcttg tgctgaagct gccatgtggt ctggccccca gaagggctcc tgagcgtagg
     4141 gagttgagcc ccgcagccgt ggcggcatct cctcctcctt cctccgcccc atgcccagcc
     4201 ttgcttccgg ctggtggcat gccttggggc cgggcagcag gtgagaagct gcccccggag
     4261 ggaggggcca agggctgggt cagtctggcc tgaggggtgg atggctggcc ctgggggaag
     4321 gctgggcctg ggaggccctg tggacagcag gcctgaggcc acgaggtcct ggggccaccc
     4381 ctctcctgct ctgggtgtcc ttctcagaga agatggcaga aggctgcagg ccctagaggg
     4441 gacgacgggc tggggacgcc ctgagcttcc tggctgtgtg gcaggtgctg gggaagctct
     4501 ctgggccata gggacctggc tcccctctga gaggcccgcc tgccctgggg cacccagggc
     4561 tgtgctggtg gcctgaggct gggaacttgg gttcctgggc tctgctggcg cctgggcttt
     4621 gtgggggccg aaggtggttg ccccgccggg cagggggctg tgtgggccct cgtggggcca
     4681 ccttcctgtc agtgcccgag ggacggtggg acagttgccc ctgcgccaag ggagcccact
     4741 gccatccccc gtgggctggc gctgcagtcg cgcaccctgt gttgcctgct gacttgctta
     4801 tgtctgtttg gaagctgctt ctgtttggcc acaggcctgt gttcctgggc tgatggccac
     4861 agagctgaca cttggggttt gagttccaga cttgcagacc ctgggatccg cttactcctc
     4921 cgcgccacgg ctgctgtgct tccagaggtg gcgtgatgcc tcccggggcc atggtggggt
     4981 gaaggatggc gagccggaca taccattgtt ggatgtattt tttttaaaac agcaataatt
     5041 agccatttta aaggagggat gtacctgtgt gtgtgcatgt gcacgtgttt gagcgtgtgt
     5101 gtgtgtgcaa gtgggttctt ggatatgtgt agtgtgagca tgtgtgcatg tgtgagcctg
     5161 tgcacgtgca tgttgtaggt gcataagcat gtacacgcgt gagcatgcat gtgtgtgtac
     5221 acgtgtatag gtgtacatgt gcatgagttg tgtacatgcg tgagcacgtg tatagatgta
     5281 cgtgtgtgtg cgcatgtgtg cgtgtacatg tgtttgtgtc ttgggtatgc ataagcatgc
     5341 acgtgtgtat gaatgtgcgt gtgtatgcat gagcacgtat gcatgtgtga tgcgcatgtt
     5401 cttgtgtact tctctgaggg ggcacatatg tatgagtgta tgagtgcata catatgcata
     5461 tggtgtacgt gtgtgtactt tgtgtgtggg catgtatgcg tatgagtact tgtgtgtggc
     5521 tggtgtatgg gtgagcatgc acatgtgtat ggatgcatat gtgagctgta catgtagagt
     5581 gtacatgtgt gttgcatgag catgcatgcg tgcgagtgcc tgtgtgtgta cttgcatata
     5641 tgtggctgtg caggtacccg gcggtggtgg gctggcagtg cccggggaag caggtcctgc
     5701 tcacggcttc cctgctgggc cccaggcccc gggctgagcc tccctggccc ctcttgcccc
     5761 tcagtggagc agggcctggg tggagggcct gggcagctcc agggcaggtc cggggaggcc
     5821 aggcttgggg agcacagggg gtggggttca cctgctgctg tttgttcccg aaactgtact
     5881 gtgagcccac ggcgggggca gattgttctg aggccccaga tgtgccaaaa cagcccccag
     5941 ggtgggggcg agcgagttct gaggagaggg gctgcggggg ccgggggtgg gtgtgtgccc
     6001 ctcccctgaa tggcccccaa tgctgctgtt tttcaataaa accagagttg aaggca
//
