LOCUS       NM_003960               1085 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens N-acetyltransferase 8 (putative) (NAT8), mRNA.
ACCESSION   NM_003960
VERSION     NM_003960.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1085)
  AUTHORS   Zhao,X., Yuan,H., Yang,H., Liu,Y., Xun,M., Li,X., Fan,T., Wu,B.,
            Guo,S. and Wang,H.
  TITLE     N-Acetyltransferase 8 Promotes Viral Replication by Increasing the
            Stability of Enterovirus 71 Nonstructural Proteins
  JOURNAL   J Virol 96 (6), e0011922 (2022)
   PUBMED   35170979
  REMARK    GeneRIF: N-Acetyltransferase 8 Promotes Viral Replication by
            Increasing the Stability of Enterovirus 71 Nonstructural Proteins.
            Erratum:[J Virol. 2023 Mar 30;97(3):e0025723. doi:
            10.1128/jvi.00257-23.. PMID: 36916908]
REFERENCE   2  (bases 1 to 1085)
  AUTHORS   Luo,S., Surapaneni,A., Zheng,Z., Rhee,E.P., Coresh,J., Hung,A.M.,
            Nadkarni,G.N., Yu,B., Boerwinkle,E., Tin,A., Arking,D.E.,
            Steinbrenner,I., Schlosser,P., Kottgen,A. and Grams,M.E.
  TITLE     NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD
  JOURNAL   Clin J Am Soc Nephrol 16 (1), 37-47 (2020)
   PUBMED   33380473
  REMARK    GeneRIF: NAT8 Variants, N-Acetylated Amino Acids, and Progression
            of CKD.
REFERENCE   3  (bases 1 to 1085)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1085)
  AUTHORS   Zand,B., Previs,R.A., Zacharias,N.M., Rupaimoole,R., Mitamura,T.,
            Nagaraja,A.S., Guindani,M., Dalton,H.J., Yang,L., Baddour,J.,
            Achreja,A., Hu,W., Pecot,C.V., Ivan,C., Wu,S.Y., McCullough,C.R.,
            Gharpure,K.M., Shoshan,E., Pradeep,S., Mangala,L.S.,
            Rodriguez-Aguayo,C., Wang,Y., Nick,A.M., Davies,M.A.,
            Armaiz-Pena,G., Liu,J., Lutgendorf,S.K., Baggerly,K.A., Eli,M.B.,
            Lopez-Berestein,G., Nagrath,D., Bhattacharya,P.K. and Sood,A.K.
  TITLE     Role of Increased n-acetylaspartate Levels in Cancer
  JOURNAL   J Natl Cancer Inst 108 (6), djv426 (2016)
   PUBMED   26819345
  REMARK    GeneRIF: Findings indicate that the NAA pathway has a prominent
            role in promoting tumor growth and represents a valuable target for
            anticancer therapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1085)
  AUTHORS   Ding,Y., Dellisanti,C.D., Ko,M.H., Czajkowski,C. and Puglielli,L.
  TITLE     The endoplasmic reticulum-based acetyltransferases, ATase1 and
            ATase2, associate with the oligosaccharyltransferase to acetylate
            correctly folded polypeptides
  JOURNAL   J Biol Chem 289 (46), 32044-32055 (2014)
   PUBMED   25301944
  REMARK    GeneRIF: ATase1 and ATase2 are endoplasmic reticulum-based
            acetyltransferases that form homo- and heterodimers and associate
            with members of the oligosaccharyltransferase complex
REFERENCE   6  (bases 1 to 1085)
  AUTHORS   Juhanson,P., Kepp,K., Org,E., Veldre,G., Kelgo,P., Rosenberg,M.,
            Viigimaa,M. and Laan,M.
  TITLE     N-acetyltransferase 8, a positional candidate for blood pressure
            and renal regulation: resequencing, association and in silico study
  JOURNAL   BMC Med Genet 9, 25 (2008)
   PUBMED   18402670
  REMARK    GeneRIF: we raise the hypothesis that the alternative SNP alleles
            of the NAT8 upstream region may have differential effect on gene
            expression
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1085)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 1085)
  AUTHORS   Popsueva,A.E., Luchinskaya,N.N., Ludwig,A.V., Zinovjeva,O.Y.,
            Poteryaev,D.A., Feigelman,M.M., Ponomarev,M.B., Berekelya,L. and
            Belyavsky,A.V.
  TITLE     Overexpression of camello, a member of a novel protein family,
            reduces blastomere adhesion and inhibits gastrulation in Xenopus
            laevis
  JOURNAL   Dev Biol 234 (2), 483-496 (2001)
   PUBMED   11397015
REFERENCE   9  (bases 1 to 1085)
  AUTHORS   Ozaki,K., Fujiwara,T., Nakamura,Y. and Takahashi,E.
  TITLE     Isolation and mapping of a novel human kidney- and liver-specific
            gene homologous to the bacterial acetyltransferases
  JOURNAL   J Hum Genet 43 (4), 255-258 (1998)
   PUBMED   9852678
REFERENCE   10 (bases 1 to 1085)
  AUTHORS   Vereb,J., Demant,F., Pavkovcekova,O. and Tischler,V.
  TITLE     [Agenesis and aplasia of the kidney in children in the x-ray
            diagnostic picture]
  JOURNAL   Cesk Pediatr 30 (3), 94-97 (1975)
   PUBMED   1139715
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092653.3 and BG426653.1.
            
            On May 17, 2019 this sequence version replaced NM_003960.3.
            
            Summary: This gene, isolated using the differential display method
            to detect tissue-specific genes, is specifically expressed in
            kidney and liver. The encoded protein shows amino acid sequence
            similarity to N-acetyltransferases. A similar protein in Xenopus
            affects cell adhesion and gastrulation movements, and may be
            localized in the secretory pathway. A highly similar paralog is
            found in a cluster with this gene. [provided by RefSeq, Sep 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012626.1, AF187813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272425.4/ ENSP00000272425.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC092653.3         52544-52555         c
            13-607              BG426653.1         9-603
            608-1085            AC092653.3         50856-51333         c
FEATURES             Location/Qualifiers
     source          1..1085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..1085
                     /gene="NAT8"
                     /gene_synonym="ATase2; CCNAT; CML1; GLA; Hcml1; TSC501;
                     TSC510"
                     /note="N-acetyltransferase 8 (putative)"
                     /db_xref="GeneID:9027"
                     /db_xref="HGNC:HGNC:18069"
                     /db_xref="MIM:606716"
     exon            1..105
                     /gene="NAT8"
                     /gene_synonym="ATase2; CCNAT; CML1; GLA; Hcml1; TSC501;
                     TSC510"
                     /inference="alignment:Splign:2.1.0"
     exon            106..1085
                     /gene="NAT8"
                     /gene_synonym="ATase2; CCNAT; CML1; GLA; Hcml1; TSC501;
                     TSC510"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..863
                     /gene="NAT8"
                     /gene_synonym="ATase2; CCNAT; CML1; GLA; Hcml1; TSC501;
                     TSC510"
                     /EC_number="2.3.1.80"
                     /note="kidney- and liver-specific gene product;
                     N-acetyltransferase 8 (GCN5-related, putative);
                     N-acetyltransferase 8 (camello like); camello-like protein
                     1; probable N-acetyltransferase 8; acetyltransferase 2;
                     cysteinyl-conjugate N-acetyltransferase"
                     /codon_start=1
                     /product="N-acetyltransferase 8"
                     /protein_id="NP_003951.3"
                     /db_xref="CCDS:CCDS1926.1"
                     /db_xref="GeneID:9027"
                     /db_xref="HGNC:HGNC:18069"
                     /db_xref="MIM:606716"
                     /translation="MAPCHIRKYQESDRQWVVGLLSRGMAEHAPATFRQLLKLPRTLI
                     LLLGGPLALLLVSGSWLLALVFSISLFPALWFLAKKPWTEYVDMTLCTDMSDITKSYL
                     SERGSCFWVAESEEKVVGMVGALPVDDPTLREKRLQLFHLFVDSEHRRQGIAKALVRT
                     VLQFARDQGYSEVILDTGTIQLSAMALYQSMGFKKTGQSFFCVWARLVALHTVHFIYH
                     LPSSKVGSL"
     regulatory      954..959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAT8"
                     /gene_synonym="ATase2; CCNAT; CML1; GLA; Hcml1; TSC501;
                     TSC510"
                     /note="hexamer: AATAAA"
     polyA_site      976
                     /gene="NAT8"
                     /gene_synonym="ATase2; CCNAT; CML1; GLA; Hcml1; TSC501;
                     TSC510"
                     /note="major polyA site"
ORIGIN      
        1 agtctacttt ccaggggtga gcaagcccca gacggtatct cctggatgcc agtgagcggc
       61 tgagagctga agctccctgg acactcaagg ctcttgtggt gacagtctga cgtaaaggcg
      121 tgcagggagg cctagctctg tctcctggac ttagagattt cagacacaga agtctgtcca
      181 tggctccttg tcacatccgc aaataccagg agagcgaccg ccagtgggtt gtgggcttgc
      241 tctcccgggg gatggccgag catgccccag ccaccttccg gcaattgctg aagctgcctc
      301 gaaccctcat actcttactt ggggggcccc tcgccctact cctggtctct ggatcctggc
      361 ttctagccct cgtgttcagc atcagcctct tccctgccct gtggttcctt gccaaaaaac
      421 cctggacgga gtatgtggac atgacattgt gcacagacat gtctgacatt accaaatcct
      481 acctgagtga gcgtggctcc tgcttctggg tggctgagtc tgaagagaag gtggtgggca
      541 tggtaggagc tctgcctgtt gatgatccca ccttgaggga gaagcggttg cagctgtttc
      601 atctctttgt ggacagtgag caccgtcgtc aggggatagc aaaagccctg gtcaggactg
      661 tcctccagtt tgcccgggac cagggctaca gtgaagttat cctggacacc ggcaccatcc
      721 agctctctgc tatggccctc taccagagca tgggcttcaa gaagacgggc cagtccttct
      781 tctgtgtgtg ggccaggcta gtggctcttc atacagttca tttcatctac cacctccctt
      841 cttctaaggt agggagtctg tgatctcttt ctgtgtgtat tggtcagaat agaatccatt
      901 cagctgtagc agcaagcaat ccccaacctt tcactgcaat gacctttcaa tgcaataaaa
      961 gcttattgtc cattcacatc tgagtcccat gtgattgctt gtggggtagc ttctgggttt
     1021 ctgcttcatt cagtcttttt gattcccatc tgtttcattt ttctagtgcc agcataatgt
     1081 tgcat
//
