LOCUS       NM_020378               1350 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens N-acetyltransferase 14 (putative) (NAT14), mRNA.
ACCESSION   NM_020378
VERSION     NM_020378.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1350)
  AUTHORS   Wiame,E., Tyteca,D., Pierrot,N., Collard,F., Amyere,M., Noel,G.,
            Desmedt,J., Nassogne,M.C., Vikkula,M., Octave,J.N., Vincent,M.F.,
            Courtoy,P.J., Boltshauser,E. and van Schaftingen,E.
  TITLE     Molecular identification of aspartate N-acetyltransferase and its
            mutation in hypoacetylaspartia
  JOURNAL   Biochem J 425 (1), 127-136 (2009)
   PUBMED   19807691
  REMARK    GeneRIF: Results indicated that NAT8L, but not NAT14, catalysed the
            synthesis of NAA from L-aspartate and acetyl-CoA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1350)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 1350)
  AUTHORS   Takahashi,S., Harigae,H., Yokoyama,H., Kaku,M. and Sasaki,T.
  TITLE     Genomic structure and regulation of a novel human gene, Klp1
  JOURNAL   Biochim Biophys Acta 1522 (3), 207-211 (2001)
   PUBMED   11779635
REFERENCE   7  (bases 1 to 1350)
  AUTHORS   Takahashi,S., Furuyama,K., Kobayashi,A., Taketani,S., Harigae,H.,
            Yamamoto,M., Igarashi,K., Sasaki,T. and Hayashi,N.
  TITLE     Cloning of a coproporphyrinogen oxidase promoter regulatory element
            binding protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 596-602 (2000)
   PUBMED   10873651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008735.9, BM785191.1, BC019079.2 and BU730663.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020378.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.437245.1,
                                           SRR3476690.160183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000205194.5/ ENSP00000205194.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC008735.9         191157-191158       c
            3-477               BM785191.1         3-477
            478-927             BC019079.2         439-888
            928-1350            BU730663.1         19-441              c
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1350
                     /gene="NAT14"
                     /gene_synonym="KLP1"
                     /note="N-acetyltransferase 14 (putative)"
                     /db_xref="GeneID:57106"
                     /db_xref="HGNC:HGNC:28918"
     exon            1..71
                     /gene="NAT14"
                     /gene_synonym="KLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            72..191
                     /gene="NAT14"
                     /gene_synonym="KLP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..740
                     /gene="NAT14"
                     /gene_synonym="KLP1"
                     /note="K562 cell-derived leucine-zipper-like protein 1;
                     K562 cells-derived leucine-zipper-like protein 1;
                     N-acetyltransferase 14 (GCN5-related, putative)"
                     /codon_start=1
                     /product="probable N-acetyltransferase 14"
                     /protein_id="NP_065111.1"
                     /db_xref="CCDS:CCDS12926.1"
                     /db_xref="GeneID:57106"
                     /db_xref="HGNC:HGNC:28918"
                     /translation="MAPSHLSVREMREDEKPLVLEMLKAGVKDTENRVALHALTRPPA
                     LLLLAAASSGLRFVLASFALALLLPVFLAVAAVKLGLRARWGSLPPPGGLGGPWVAVR
                     GSGDVCGVLALAPGTNAGDGARVTRLSVSRWHRRRGVGRRLLAFAEARARAWAGGMGE
                     PRARLVVPVAVAAWGVGGMLEGCGYQAEGGWGCLGYTLVREFSKDL"
     exon            192..1350
                     /gene="NAT14"
                     /gene_synonym="KLP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAT14"
                     /gene_synonym="KLP1"
                     /note="hexamer: AATAAA"
     polyA_site      1350
                     /gene="NAT14"
                     /gene_synonym="KLP1"
                     /note="major polyA site"
ORIGIN      
        1 acttccgccc gcgaccccct tccagacccg ctcccgaaac cttgtcgaag gaccaaaggc
       61 gaccggtgca ggtgcacgac gccagctccc ttctgggggg ccggggcctg ggggttgcca
      121 tggcccccag ccacctgtca gtgcgggaga tgagggaaga tgagaagccc ctggtgctgg
      181 agatgctgaa ggccggcgtg aaggacacgg aaaaccgcgt ggccctccat gccttgacac
      241 ggccgccggc cctgctcctc ctggcggcgg ccagcagcgg cctgcgcttt gtcctggctt
      301 ccttcgccct ggccctcctc ctgccggtgt tcctggctgt ggccgccgtg aagctgggcc
      361 tgcgggcccg atggggctcg ctgcctccgc cgggtggcct ggggggcccc tgggtggccg
      421 tgcggggctc cggtgacgtg tgtggggtcc tggctctggc ccctggcaca aatgcagggg
      481 acggggcccg ggtcacccgc ctgtctgtct ctcgctggca ccgccgccgg ggcgtgggca
      541 ggaggctgct ggccttcgcg gaggcccggg ctcgggcctg ggctgggggc atgggggagc
      601 cccgggcccg gctcgtggtc cccgtggctg tggccgcctg gggggtggga gggatgctgg
      661 agggctgtgg ctaccaggcc gaggggggct ggggctgcct gggctacacg ctggtgaggg
      721 aattcagcaa agacctgtga agctacagac tgacagccag ggcaggggag gagggagggg
      781 cgccagcacc tgatgatcgc ctactgtctg cgggttcttt tacctgctct ccctcagtga
      841 gtcctcaacc accctgggcc cagaaacaga ggcctgccga ggggaggagc ctggcctctg
      901 tccacccgtc agcagtgtga agtctgttgt gtttgagctt ctcagagtgg aatgactcct
      961 tttccttcct ggccctcggg ggcctctcga ggtcagcctc tccaacccct acctcagctc
     1021 ctgtctgcac tgagaaacct ccccgggtga tgtctgcaaa gtctgtgctg tccgtgcccc
     1081 aggctgggag agctatctgg ggagggggag aggaggccga gcagaataca ccccagagtt
     1141 agggtttgcg actccgcctc cctgggacct ggattgggtc agatgcctgt ccttggaggg
     1201 gacaaggttg actgcttagg aggcgcgacg cacagggctg ccaggcctgg cccctctctg
     1261 ggaaggttga gagctgagac gggcagccct gtcccttcct ccagatccgt ctggtttttt
     1321 acaccgtttg ttaataaagc ctgaaaccgc
//
