LOCUS       NM_002482               3225 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens nuclear autoantigenic sperm protein (NASP), transcript
            variant 2, mRNA.
ACCESSION   NM_002482
VERSION     NM_002482.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3225)
  AUTHORS   Zhang,S., Yang,J., Ji,D., Meng,X., Zhu,C., Zheng,G., Glessner,J.,
            Qu,H.Q., Cui,Y., Liu,Y., Wang,W., Li,X., Zhang,H., Xiu,Z., Sun,Y.,
            Sun,L., Li,J., Hakonarson,H., Li,J. and Xia,Q.
  TITLE     NASP gene contributes to autism by epigenetic dysregulation of
            neural and immune pathways
  JOURNAL   J Med Genet 61 (7), 677-688 (2024)
   PUBMED   38443156
  REMARK    GeneRIF: NASP gene contributes to autism by epigenetic
            dysregulation of neural and immune pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3225)
  AUTHORS   Qiu,Y., Pei,D., Wang,M., Wang,Q., Duan,W., Wang,L., Liu,K., Guo,Y.,
            Luo,L., Guo,Z., Guan,F., Wang,Z., Xing,A., Liu,Z., Ma,Z., Jiang,G.,
            Yan,D., Liu,X., Zhang,Z. and Wang,W.
  TITLE     Nuclear autoantigenic sperm protein facilitates glioblastoma
            progression and radioresistance by regulating the ANXA2/STAT3 axis
  JOURNAL   CNS Neurosci Ther 30 (4), e14709 (2024)
   PUBMED   38605477
  REMARK    GeneRIF: Nuclear autoantigenic sperm protein facilitates
            glioblastoma progression and radioresistance by regulating the
            ANXA2/STAT3 axis.
REFERENCE   3  (bases 1 to 3225)
  AUTHORS   Chen,M.Z., Wang,S.A., Hsu,S.C., Silva,K.A.S. and Yang,F.M.
  TITLE     Home Dust Mites Promote MUC5AC Hyper-Expression by Modulating the
            sNASP/TRAF6 Axis in the Airway Epithelium
  JOURNAL   Int J Mol Sci 23 (16), 9405 (2022)
   PUBMED   36012669
  REMARK    GeneRIF: Home Dust Mites Promote MUC5AC Hyper-Expression by
            Modulating the sNASP/TRAF6 Axis in the Airway Epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3225)
  AUTHORS   Hogan,A.K., Sathyan,K.M., Willis,A.B., Khurana,S., Srivastava,S.,
            Zasadzinska,E., Lee,A.S., Bailey,A.O., Gaynes,M.N., Huang,J.,
            Bodner,J., Rosencrance,C.D., Wong,K.A., Morgan,M.A., Eagen,K.P.,
            Shilatifard,A. and Foltz,D.R.
  TITLE     UBR7 acts as a histone chaperone for post-nucleosomal histone H3
  JOURNAL   EMBO J 40 (24), e108307 (2021)
   PUBMED   34786730
  REMARK    GeneRIF: UBR7 acts as a histone chaperone for post-nucleosomal
            histone H3.
REFERENCE   5  (bases 1 to 3225)
  AUTHORS   Zhu,Y., Li,B., Xu,G., Han,C. and Xing,G.
  TITLE     Knockdown of long noncoding RNA colorectal neoplasia differentially
            expressed inhibits hepatocellular carcinoma progression by
            mediating the expression of nuclear autoantigenic sperm protein
  JOURNAL   Oncol Rep 46 (6) (2021)
   PUBMED   34633056
  REMARK    GeneRIF: Knockdown of long noncoding RNA colorectal neoplasia
            differentially expressed inhibits hepatocellular carcinoma
            progression by mediating the expression of nuclear autoantigenic
            sperm protein.
REFERENCE   6  (bases 1 to 3225)
  AUTHORS   Alekseev,O.M., Bencic,D.C., Richardson,R.T., Widgren,E.E. and
            O'Rand,M.G.
  TITLE     Overexpression of the Linker histone-binding protein tNASP affects
            progression through the cell cycle
  JOURNAL   J Biol Chem 278 (10), 8846-8852 (2003)
   PUBMED   12509435
REFERENCE   7  (bases 1 to 3225)
  AUTHORS   Richardson,R.T., Bencic,D.C. and O'Rand,M.G.
  TITLE     Comparison of mouse and human NASP genes and expression in human
            transformed and tumor cell lines
  JOURNAL   Gene 274 (1-2), 67-75 (2001)
   PUBMED   11674998
REFERENCE   8  (bases 1 to 3225)
  AUTHORS   Richardson,R.T., Batova,I.N., Widgren,E.E., Zheng,L.X.,
            Whitfield,M., Marzluff,W.F. and O'Rand,M.G.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
REFERENCE   9  (bases 1 to 3225)
  AUTHORS   Batova,I. and O'Rand,M.G.
  TITLE     Histone-binding domains in a human nuclear autoantigenic sperm
            protein
  JOURNAL   Biol Reprod 54 (6), 1238-1244 (1996)
   PUBMED   8724350
REFERENCE   10 (bases 1 to 3225)
  AUTHORS   O'Rand,M.G., Richardson,R.T., Zimmerman,L.J. and Widgren,E.E.
  TITLE     Sequence and localization of human NASP: conservation of a Xenopus
            histone-binding protein
  JOURNAL   Dev Biol 154 (1), 37-44 (1992)
   PUBMED   1426632
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC361634.1, BC010105.2,
            AK291637.1 and CK300084.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002482.3.
            
            Summary: This gene encodes a H1 histone binding protein that is
            involved in transporting histones into the nucleus of dividing
            cells. Multiple isoforms are encoded by transcript variants of this
            gene. The somatic form is expressed in all mitotic cells, is
            localized to the nucleus, and is coupled to the cell cycle. The
            testicular form is expressed in embryonic tissues, tumor cells, and
            the testis. In male germ cells, this protein is localized to the
            cytoplasm of primary spermatocytes, the nucleus of spermatids, and
            the periacrosomal region of mature spermatozoa. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.2226.1, AK291637.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350030.8/ ENSP00000255120.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DC361634.1         54-72
            20-2579             BC010105.2         1-2560
            2580-2590           AK291637.1         2576-2586
            2591-3225           CK300084.1         19-653              c
FEATURES             Location/Qualifiers
     source          1..3225
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..3225
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /note="nuclear autoantigenic sperm protein"
                     /db_xref="GeneID:4678"
                     /db_xref="HGNC:HGNC:7644"
                     /db_xref="MIM:603185"
     exon            1..165
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2473
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /note="isoform 2 is encoded by transcript variant 2;
                     histone H1-binding protein; nuclear autoantigenic sperm
                     protein (histone-binding); NASP histone chaperone"
                     /codon_start=1
                     /product="nuclear autoantigenic sperm protein isoform 2"
                     /protein_id="NP_002473.2"
                     /db_xref="CCDS:CCDS524.1"
                     /db_xref="GeneID:4678"
                     /db_xref="HGNC:HGNC:7644"
                     /db_xref="MIM:603185"
                     /translation="MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAK
                     KLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARME
                     NGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKT
                     EDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAA
                     PEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKE
                     VSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLV
                     GQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI
                     EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK
                     SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENE
                     EEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQ
                     SCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQ
                     VKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGF
                     TPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE
                     VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC"
     exon            166..213
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            214..324
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            325..405
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            406..515
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            516..1532
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1612
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1698
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1772
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1961
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2128
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2185
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2263
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2392
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..3225
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3207..3212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /note="hexamer: AATAAA"
     polyA_site      3225
                     /gene="NASP"
                     /gene_synonym="FLB7527; HMDRA1; PRO1999"
                     /note="major polyA site"
ORIGIN      
        1 ctctaatctg ccattttctg tccctgagtg agtctctggc gtcccaaatt gcctgttttt
       61 ctcgcaggct ctattccgtt cgctggttcg ccacctcagg ggaacgatgg ccatggagtc
      121 cacagccact gccgccgtcg ccgcggagct ggtttctgcc gacaaaattg aagatgttcc
      181 tgctccttct acatctgcag ataaagtgga gagtctggat gtggatagtg aagctaagaa
      241 actattgggt ttaggacaga aacatctggt gatgggggat attccagcag ctgtcaatgc
      301 attccaggaa gcagctagtc ttttaggtaa gaagtatgga gagacagcta atgagtgtgg
      361 agaagccttc tttttctatg ggaaatcact tctggagttg gcaagaatgg agaatggtgt
      421 gttgggaaac gccttggaag gtgtgcatgt ggaagaggaa gaaggagaaa aaacagaaga
      481 tgaatctctg gtagaaaata atgataacat agatgaggaa gcaagggaag agttgagaga
      541 acaggtttat gacgccatgg gagaaaaaga agaagccaaa aaaacagaag acaagtcttt
      601 ggcaaagcct gaaactgata aagaacagga cagtgaaatg gagaagggtg gaagagaaga
      661 tatggatata agtaaatctg cagaggagcc acaggaaaaa gttgacttga ctctagattg
      721 gttaactgaa acctctgaag aggcaaaagg aggagcagca ccagaaggac cgaatgaagc
      781 tgaggtcact tctgggaagc cagaacagga agtaccagat gctgaggaag aaaaatcagt
      841 ttctggaact gatgtccaag aagagtgcag agaaaaagga ggtcaggaga agcagggaga
      901 ggtaattgtg agcatagagg agaagccaaa agaagtttca gaagagcagc ctgtggtgac
      961 tctagaaaag cagggcactg cagtggaggt agaagcagag tctttagacc cgacagtcaa
     1021 gccagtggat gtgggtgggg acgagccaga ggagaaggta gttacctctg aaaacgaggc
     1081 aggaaaggcg gttcttgaac aactggtagg tcaagaagta ccacctgctg aagagtcacc
     1141 agaggtgaca acagaggctg cagaggcctc agctgtagag gctggatcag aagtctctga
     1201 aaagcctggg caggaggctc cagttctccc taaggatggt gcagtcaatg gaccgtcagt
     1261 tgtaggagat cagactccta ttgaaccaca gacttctata gaaagactga cagaaacaaa
     1321 agatggctca ggactagagg agaaggtcag ggcaaagctg gttcctagtc aggaggagac
     1381 taagctgtct gtagaagagt ctgaggcagc tggagatggg gttgatacca aggtagccca
     1441 gggagctact gagaaatcac ctgaagacaa agttcagata gctgctaatg aagagacaca
     1501 agagagagaa gaacagatga aagagggtga agaaactgaa ggctcagaag aggatgataa
     1561 agaaaatgat aagaccgaag aaatgccaaa tgattcagtc cttgaaaaca agtctcttca
     1621 agaaaatgag gaggaggaga ttgggaacct agagcttgcc tgggatatgc tggatttagc
     1681 aaagatcatt tttaaaaggc aagaaacaaa agaagcacag ctttatgctg cccaggcaca
     1741 tcttaaactc ggagaagtta gtgttgaatc tgaaaactat gtgcaagctg tggaggagtt
     1801 ccagtcctgc cttaacctgc aggaacagta cctggaagcc cacgaccgtc tccttgcaga
     1861 gacccactac cagctgggct tggcttatgg gtacaactct cagtatgatg aggcagtggc
     1921 acagttcagc aaatctattg aagtcattga gaacagaatg gctgtactaa acgagcaggt
     1981 gaaggaggct gaaggatcgt ctgctgaata caagaaagaa attgaggaac taaaggaact
     2041 gctacccgaa attagagaga agatagaaga tgcaaaggag tctcagcgta gtgggaatgt
     2101 agctgaactg gctctgaaag ctactctggt ggagagttct acttcaggtt tcactcctgg
     2161 tggaggaggc tcttcagtct ccatgattgc cagtagaaag ccaacagacg gtgcttcctc
     2221 atcaaattgt gtgactgata tttcccacct tgtcagaaag aagaggaaac cagaggaaga
     2281 gagtccccgg aaagatgatg caaagaaagc caaacaagag ccggaggtga acggaggcag
     2341 tggggatgct gtccccagtg gaaatgaagt ttcggaaaac atggaggagg aggctgagaa
     2401 tcaggctgaa agccgggcag cagtggaggg gacagtggag gctggagcta cagttgaaag
     2461 cactgcatgt taagaggggg cacagccctc ctcccaaggg aaagtgtttt tgtatataat
     2521 gtattttttc acttttggag gattcttttt gtataacttc aataaagatt gtaagcaaag
     2581 gttgaggctt tgatggtttt tttcttaatt attggctgaa tctgccttgg agcactgctg
     2641 gttttatata ttagccaaag gttttgttct ggccttctgt actgatctgt gttcctgatc
     2701 ctaattccta tctgtctaac gtggaggtga tcaagtgtgg ctgtaggcct ttgttttcca
     2761 atggtgctat attctgtttt caaacacttc actgaaccca gctgtcttgc aaactttcag
     2821 tggtgctgtc cctggatggg ggctacaaaa acaagaattg gtgaagatct tgctcttcag
     2881 tgctgaaaat ggatgatgga ctttggctgt gagccaggcc taggatggtt cttgtcctat
     2941 atccacctag tcttcacctg gggctataat tctgtcctgg aaaaagaact ctgaaaacct
     3001 gggtcagggg aatgattcct aaggaaaacg gtctgcattt gagctctggt ttgaaagtag
     3061 ccaaggggac tgatggtgga cactccagat gtggttggaa gcatatgtgg ggaggctggc
     3121 tggttgagtt ttgttatttt ctgtatagaa aggttgagat atatcaacac ttggaattgt
     3181 tacccatctg cagaattgac ttctcaaata aagatgctaa aaatc
//
