LOCUS       NM_012336               3814 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens nuclear prelamin A recognition factor (NARF),
            transcript variant 1, mRNA.
ACCESSION   NM_012336
VERSION     NM_012336.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3814)
  AUTHORS   Yang,Y., Chen,C., Zuo,Q., Lu,H., Salman,S., Lyu,Y., Huang,T.Y.,
            Wicks,E.E., Jackson,W. 3rd, Datan,E., Wang,R., Wang,Y., Le,N.,
            Zhu,Y., Qin,W. and Semenza,G.L.
  TITLE     NARF is a hypoxia-induced coactivator for OCT4-mediated breast
            cancer stem cell specification
  JOURNAL   Sci Adv 8 (49), eabo5000 (2022)
   PUBMED   36490339
  REMARK    GeneRIF: NARF is a hypoxia-induced coactivator for OCT4-mediated
            breast cancer stem cell specification.
REFERENCE   2  (bases 1 to 3814)
  AUTHORS   Ding,D., Valdivia,A.O. and Bhattacharya,S.K.
  TITLE     Nuclear prelamin a recognition factor and iron dysregulation in
            multiple sclerosis
  JOURNAL   Metab Brain Dis 35 (2), 275-282 (2020)
   PUBMED   31823109
  REMARK    GeneRIF: Nuclear prelamin a recognition factor and iron
            dysregulation in multiple sclerosis.
REFERENCE   3  (bases 1 to 3814)
  AUTHORS   Malki,K., Uher,R., Paya-Cano,J., Binder,E., Rietschel,M., Zobel,A.,
            Mors,O., Hauser,J., Henigsberg,N., Jerman,B., Souery,D.,
            Placentino,A., Ng,M.Y., Cohen-Woods,S., Sluyter,F., Farmer,A.,
            Aitchison,K.J., Craig,I.W., Lewis,C.M., McGuffin,P. and
            Schalkwyk,L.C.
  TITLE     Convergent animal and human evidence suggests a role of PPM1A gene
            in response to antidepressants
  JOURNAL   Biol Psychiatry 69 (4), 360-365 (2011)
   PUBMED   20970119
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 3814)
  AUTHORS   Moller-Krull,M., Zemann,A., Roos,C., Brosius,J. and Schmitz,J.
  TITLE     Beyond DNA: RNA editing and steps toward Alu exonization in
            primates
  JOURNAL   J Mol Biol 382 (3), 601-609 (2008)
   PUBMED   18680752
  REMARK    GeneRIF: Data suggest that gorilla, chimpanzee, and human nuclear
            prelamin A recognition factor genes exemplify the versatile
            interplay of pre- and posttranscriptional modifications leading to
            novel genetic potential.
REFERENCE   5  (bases 1 to 3814)
  AUTHORS   Lattanzi,G., Columbaro,M., Mattioli,E., Cenni,V., Camozzi,D.,
            Wehnert,M., Santi,S., Riccio,M., Del Coco,R., Maraldi,N.M.,
            Squarzoni,S., Foisner,R. and Capanni,C.
  TITLE     Pre-Lamin A processing is linked to heterochromatin organization
  JOURNAL   J Cell Biochem 102 (5), 1149-1159 (2007)
   PUBMED   17654502
  REMARK    GeneRIF: Prelamin A processing is linked to heterochromatin
            organization.
REFERENCE   6  (bases 1 to 3814)
  AUTHORS   Lev-Maor,G., Sorek,R., Levanon,E.Y., Paz,N., Eisenberg,E. and
            Ast,G.
  TITLE     RNA-editing-mediated exon evolution
  JOURNAL   Genome Biol 8 (2), R29 (2007)
   PUBMED   17326827
  REMARK    GeneRIF: RNA editing enables exonization of a nuclear prelamin A
            recognition factor Alu-exon.
            GeneRIF: Creation of a novel Alu-exon and elimination of a
            premature stop codon by RNA editing.
REFERENCE   7  (bases 1 to 3814)
  AUTHORS   Hackstein,J.H.
  TITLE     Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive
            acquisitions?
  JOURNAL   Biochem Soc Trans 33 (Pt 1), 47-50 (2005)
   PUBMED   15667261
REFERENCE   8  (bases 1 to 3814)
  AUTHORS   Barton,R.M. and Worman,H.J.
  TITLE     Prenylated prelamin A interacts with Narf, a novel nuclear protein
  JOURNAL   J Biol Chem 274 (42), 30008-30018 (1999)
   PUBMED   10514485
REFERENCE   9  (bases 1 to 3814)
  AUTHORS   Maltese,W.A.
  TITLE     Posttranslational modification of proteins by isoprenoids in
            mammalian cells
  JOURNAL   FASEB J 4 (15), 3319-3328 (1990)
   PUBMED   2123808
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB123829.1, AF128406.1 and
            AC124287.10.
            
            On Nov 22, 2018 this sequence version replaced NM_012336.3.
            
            Summary: Several proteins have been found to be prenylated and
            methylated at their carboxyl-terminal ends. Prenylation was
            initially believed to be important only for membrane attachment.
            However, another role for prenylation appears to be its importance
            in protein-protein interactions. The only nuclear proteins known to
            be prenylated in mammalian cells are prelamin A- and B-type lamins.
            Prelamin A is farnesylated and carboxymethylated on the cysteine
            residue of a carboxyl-terminal CaaX motif. This
            post-translationally modified cysteine residue is removed from
            prelamin A when it is endoproteolytically processed into mature
            lamin A. The protein encoded by this gene binds to the prenylated
            prelamin A carboxyl-terminal tail domain. It may be a component of
            a prelamin A endoprotease complex. The encoded protein is located
            in the nucleus, where it partially colocalizes with the nuclear
            lamina. It shares limited sequence similarity with iron-only
            bacterial hydrogenases. Alternatively spliced transcript variants
            encoding different isoforms have been identified for this gene,
            including one with a novel exon that is generated by RNA editing.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.132017.1,
                                           SRR1803613.21246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309794.16/ ENSP00000309899.10
            RefSeq Select criteria :: based on expression
            undergoes RNA editing  :: PMID: 17326827
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB123829.1         105-106
            3-1544              AF128406.1         31-1572
            1545-3814           AC124287.10        110845-113114
FEATURES             Location/Qualifiers
     source          1..3814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3814
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="nuclear prelamin A recognition factor"
                     /db_xref="GeneID:26502"
                     /db_xref="HGNC:HGNC:29916"
                     /db_xref="MIM:605349"
     exon            1..90
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1434
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="isoform a is encoded by transcript variant 1;
                     iron-only hydrogenase-like protein 2; prenyl-dependent
                     prelamin A binding protein"
                     /codon_start=1
                     /product="nuclear prelamin A recognition factor isoform a"
                     /protein_id="NP_036468.1"
                     /db_xref="CCDS:CCDS32777.1"
                     /db_xref="GeneID:26502"
                     /db_xref="HGNC:HGNC:29916"
                     /db_xref="MIM:605349"
                     /translation="MKCEHCTRKECSKKTKTDDQENVSADAPSPAQENGEKGEFHKLA
                     DAKIFLSDCLACDSCMTAEEGVQLSQQNAKDFFRVLNLNKKCDTSKHKVLVVSVCPQS
                     LPYFAAKFNLSVTDASRRLCGFLKSLGVHYVFDTTIAADFSILESQKEFVRRYRQHSE
                     EERTLPMLTSACPGWVRYAERVLGRPITAHLCTAKSPQQVMGSLVKDYFARQQNLSPE
                     KIFHVIVAPCYDKKLEALQESLPPALHGSRGADCVLTSGEIAQIMEQGDLSVRDAAVD
                     TLFGDLKEDKVTRHDGASSDGHLAHIFRHAAKELFNEDVEEVTYRALRNKDFQEVTLE
                     KNGEVVLRFAAAYGFRNIQNMILKLKKGKFPFHFVEVLACAGGCLNGRGQAQTPDGHA
                     DKALLRQMEGIYADIPVRRPESSAHVQELYQEWLEGINSPKAREVLHTTYQSQERGTH
                     SLDIKW"
     exon            91..171
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..315
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..448
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..583
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..702
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..832
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..896
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1034
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1192
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..3814
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1517..1522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="hexamer: ATTAAA"
     polyA_site      1536
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="major polyA site"
     regulatory      3796..3801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="hexamer: AATAAA"
     polyA_site      3814
                     /gene="NARF"
                     /gene_synonym="IOP2"
ORIGIN      
        1 gtcccagtct cccggtgctt ccctgaggct gaggcgcccg gcctcccgcc cgccgcgctc
       61 cagatgaagt gtgagcactg cacgcgcaag gaatgtagta agaaaacaaa aactgatgac
      121 caagagaatg tgtcagccga tgcaccgagt ccagcccagg aaaatggaga gaagggagaa
      181 ttccacaagt tggctgatgc caagatattt ttgagcgact gcctggcatg tgacagctgt
      241 atgactgcag aggaaggagt ccaactttcc cagcaaaatg ccaaggactt cttccgcgtt
      301 ctgaacctta acaagaaatg tgatacctca aagcacaaag tgctggtagt gtctgtgtgt
      361 cctcaatctt tgccttattt tgctgctaaa ttcaacctca gtgtaactga tgcatccaga
      421 agactctgtg gtttcctcaa aagtcttggg gtgcactatg tatttgatac gacgatagct
      481 gcggatttta gtatcctgga gagtcaaaaa gaattcgtgc gtcgctatcg ccagcacagt
      541 gaggaggaac gcaccctgcc catgctgacc tctgcctgtc ctggctgggt ccgatacgcc
      601 gagcgggtgc tgggtcgccc catcactgcc cacctctgca ccgccaagtc cccccagcag
      661 gtcatgggct ctttggtgaa ggattatttc gccagacagc agaacctgtc tccagagaag
      721 attttccacg tcattgtggc cccttgttat gacaagaagc tggaggctct tcaggaaagc
      781 cttccccctg ctttgcatgg ctcccggggc gctgactgcg tgttaacatc aggtgaaatt
      841 gctcaaataa tggagcaagg tgacctctca gtgagagatg ctgccgtcga cactctgttt
      901 ggagacttga aggaggacaa agtgacgcgt catgatggag ccagctcaga cgggcacctg
      961 gcacacatct tcagacatgc ggccaaggag ctgttcaacg aggatgtgga ggaggtcact
     1021 taccgagccc tgagaaacaa agacttccaa gaggtcaccc ttgagaagaa cggagaggtg
     1081 gtgttacgct ttgctgcagc ctatggcttt cgaaacatcc agaacatgat cctgaagctt
     1141 aagaagggca agttcccatt ccactttgtg gaggtcctcg cctgtgctgg aggatgctta
     1201 aatggcagag gccaagccca gactccagac ggacatgcgg ataaggccct gctgcggcag
     1261 atggaaggca tttacgctga catccctgtg cggcgtccgg agtccagtgc acacgtgcag
     1321 gagctgtacc aggagtggct ggaggggatc aactccccca aggcccgaga ggtgctgcat
     1381 accacgtacc agagccagga gcgtggcaca cacagcctgg acatcaagtg gtgaagtcag
     1441 gccagggcct tccagctgct cttggggcca gagccaagag cctctcagta gagggagggg
     1501 ctgccctgag tggagtatta aagacactta agaaaaccgc tcaatggatt actttggttt
     1561 ctccgagttc cctgctaccc cgtttattgg aggcccctca ggcagtttca tgtggtgcta
     1621 tcttcataat aggtgtggga ttggaacttt ttttttcttt tttttttttt gagacggagt
     1681 ctcactctgt cacccaggct ggagtgcaat ggcgcaatct cagctcactg caacctctgc
     1741 ctcccgggtt caagcgattc tcttgcccca gcctcccgag tagctgggac taacgcgcac
     1801 accaccatgc ccagctaatt tttgtatttt tagtagagat ggggtttcac tatgttggcc
     1861 aggctggtat tgaattcctg acctcctgat ccacccgcct tggcctccca aagtgccagg
     1921 actgcaggca tgagccaccg tgcctggcag attggaacgt tttaacatga gaggagcact
     1981 tccccaattt atcccttcat cctaagattg tgaaaaagtc ccaaagagtg ggaatggaga
     2041 cagactactg tattttaggt ttaaaaagaa aaatccagaa agtgtcctgt gaagagctag
     2101 gacccccaga ggttctaatg cacatgactt gaaggtgatt tgatgtggga gtgagggcag
     2161 agggtggggt ggctgtgcct gtggactcct gtggccctgg ggttgttagg gcaggcagtc
     2221 cacagtccca gatccctgcc cattttggct ctttctttta cccactcata ttttccttga
     2281 aaatgttttt gccagaacat taataactgt cagcctttta gaatcaggag acttacgtac
     2341 aaatctggat tttcagcttt tcttagaaaa actgtagttt ctgacaacag taggccccat
     2401 tcctcacagc cagtcaccac cctcctccca ttcctcacag ccagtcacca ccctcctgga
     2461 ccatactcgg ccctgggcca ttcctcacag ccagtcacca ccctcctccc attcctcaca
     2521 gccagtcacc accctcctgg accacactcg gccctgggcc attcctcaca gccagtcacc
     2581 accctcctgg accatactca gggccctgga ggcctggcaa cccaggcccc aactcaaact
     2641 tgtacattca gtctttcagt cggactcgca ctggggcaag ggtgacagac acgagaatgg
     2701 aaaattgaga aggctgcccg caccagctgg gtgggtgcag ggggccccag ctcatcatca
     2761 gcactgtcgt ggggtgggag tcgggggtaa aggttccgtc tgaccctgag gggttgagga
     2821 tattcaggtg gtccagcctc ccgcagaaga cttccctgtc acccttggca gacaggtttc
     2881 ttctcacacg gccctggccc atccactcgc catgaagccc tctgtgctca gggtgatgga
     2941 gccccctcca ttctggcact gcactgtggg catgagcttg ccttaaaaag aaaggagagg
     3001 ccaggcacgg tggctcgtgc cctataatcc cagcacactg ggaggccaag gtgggaggat
     3061 tgctggagtc caggagtttc tacatgggag actctgtctc tacaaatttt tttttttttt
     3121 ttgagacaga gtctcacttt gtcacccagg ctggagttca gtggcgtgat ctcggctcac
     3181 agcaacctcc gcctcctggg ttcaagcgat tctcctgcct cagcctctgg agtagctggg
     3241 attacaggcg cgcgccaccg cgcctggcta attgtattct tagttgagac gggtttcgcc
     3301 atgttgatcg ggccggtcag gctggaattt ctgacctcag gtgatccaac cacctcagcc
     3361 tcccaaaatg ctgggattac aggcgtgagc cactgcacct ggcaaaaaat ttttttttaa
     3421 aaaggagaaa gcagtttaac cacaaacagt gaaacagagc tggcagacgc ctgaaactcc
     3481 atggaaccat gcagctgtac cctagggctc ctcccaggaa aagagagatg tcaacgtggc
     3541 ccaaggtgtc ctgaagcact gggattggat taactcgagc gatggccttc ccagccctcc
     3601 gtgctgcaga gcctctgctc gctaggctgc cttcatctca ctctgtgtgc tgtgcctgtg
     3661 cacctgtctt gtcaataact gcatatattg tgttgcgttg cctgtcttgc tggataactg
     3721 catatattgt gttcagttgt gtatttgttt tgctttcagt ctatatacag ttgggtttcc
     3781 aacctctgat tctggaataa acagttgcag cgtg
//
