LOCUS       NM_001083608            3670 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens nuclear prelamin A recognition factor (NARF),
            transcript variant 4, mRNA.
ACCESSION   NM_001083608
VERSION     NM_001083608.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Yang,Y., Chen,C., Zuo,Q., Lu,H., Salman,S., Lyu,Y., Huang,T.Y.,
            Wicks,E.E., Jackson,W. 3rd, Datan,E., Wang,R., Wang,Y., Le,N.,
            Zhu,Y., Qin,W. and Semenza,G.L.
  TITLE     NARF is a hypoxia-induced coactivator for OCT4-mediated breast
            cancer stem cell specification
  JOURNAL   Sci Adv 8 (49), eabo5000 (2022)
   PUBMED   36490339
  REMARK    GeneRIF: NARF is a hypoxia-induced coactivator for OCT4-mediated
            breast cancer stem cell specification.
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Ding,D., Valdivia,A.O. and Bhattacharya,S.K.
  TITLE     Nuclear prelamin a recognition factor and iron dysregulation in
            multiple sclerosis
  JOURNAL   Metab Brain Dis 35 (2), 275-282 (2020)
   PUBMED   31823109
  REMARK    GeneRIF: Nuclear prelamin a recognition factor and iron
            dysregulation in multiple sclerosis.
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Malki,K., Uher,R., Paya-Cano,J., Binder,E., Rietschel,M., Zobel,A.,
            Mors,O., Hauser,J., Henigsberg,N., Jerman,B., Souery,D.,
            Placentino,A., Ng,M.Y., Cohen-Woods,S., Sluyter,F., Farmer,A.,
            Aitchison,K.J., Craig,I.W., Lewis,C.M., McGuffin,P. and
            Schalkwyk,L.C.
  TITLE     Convergent animal and human evidence suggests a role of PPM1A gene
            in response to antidepressants
  JOURNAL   Biol Psychiatry 69 (4), 360-365 (2011)
   PUBMED   20970119
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Moller-Krull,M., Zemann,A., Roos,C., Brosius,J. and Schmitz,J.
  TITLE     Beyond DNA: RNA editing and steps toward Alu exonization in
            primates
  JOURNAL   J Mol Biol 382 (3), 601-609 (2008)
   PUBMED   18680752
  REMARK    GeneRIF: Data suggest that gorilla, chimpanzee, and human nuclear
            prelamin A recognition factor genes exemplify the versatile
            interplay of pre- and posttranscriptional modifications leading to
            novel genetic potential.
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Lattanzi,G., Columbaro,M., Mattioli,E., Cenni,V., Camozzi,D.,
            Wehnert,M., Santi,S., Riccio,M., Del Coco,R., Maraldi,N.M.,
            Squarzoni,S., Foisner,R. and Capanni,C.
  TITLE     Pre-Lamin A processing is linked to heterochromatin organization
  JOURNAL   J Cell Biochem 102 (5), 1149-1159 (2007)
   PUBMED   17654502
  REMARK    GeneRIF: Prelamin A processing is linked to heterochromatin
            organization.
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   Lev-Maor,G., Sorek,R., Levanon,E.Y., Paz,N., Eisenberg,E. and
            Ast,G.
  TITLE     RNA-editing-mediated exon evolution
  JOURNAL   Genome Biol 8 (2), R29 (2007)
   PUBMED   17326827
  REMARK    GeneRIF: RNA editing enables exonization of a nuclear prelamin A
            recognition factor Alu-exon.
            GeneRIF: Creation of a novel Alu-exon and elimination of a
            premature stop codon by RNA editing.
REFERENCE   7  (bases 1 to 3670)
  AUTHORS   Hackstein,J.H.
  TITLE     Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive
            acquisitions?
  JOURNAL   Biochem Soc Trans 33 (Pt 1), 47-50 (2005)
   PUBMED   15667261
REFERENCE   8  (bases 1 to 3670)
  AUTHORS   Barton,R.M. and Worman,H.J.
  TITLE     Prenylated prelamin A interacts with Narf, a novel nuclear protein
  JOURNAL   J Biol Chem 274 (42), 30008-30018 (1999)
   PUBMED   10514485
REFERENCE   9  (bases 1 to 3670)
  AUTHORS   Maltese,W.A.
  TITLE     Posttranslational modification of proteins by isoprenoids in
            mammalian cells
  JOURNAL   FASEB J 4 (15), 3319-3328 (1990)
   PUBMED   2123808
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB123829.1, BC016440.1,
            AF128406.1 and AC124287.10.
            
            On Jun 1, 2019 this sequence version replaced NM_001083608.1.
            
            Summary: Several proteins have been found to be prenylated and
            methylated at their carboxyl-terminal ends. Prenylation was
            initially believed to be important only for membrane attachment.
            However, another role for prenylation appears to be its importance
            in protein-protein interactions. The only nuclear proteins known to
            be prenylated in mammalian cells are prelamin A- and B-type lamins.
            Prelamin A is farnesylated and carboxymethylated on the cysteine
            residue of a carboxyl-terminal CaaX motif. This
            post-translationally modified cysteine residue is removed from
            prelamin A when it is endoproteolytically processed into mature
            lamin A. The protein encoded by this gene binds to the prenylated
            prelamin A carboxyl-terminal tail domain. It may be a component of
            a prelamin A endoprotease complex. The encoded protein is located
            in the nucleus, where it partially colocalizes with the nuclear
            lamina. It shares limited sequence similarity with iron-only
            bacterial hydrogenases. Alternatively spliced transcript variants
            encoding different isoforms have been identified for this gene,
            including one with a novel exon that is generated by RNA editing.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) is missing an in-frame coding
            exon compared to transcript variant 1, resulting in an isoform (d)
            that is lacking a 48 aa protein segment compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.224849.1, BC016440.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            undergoes RNA editing :: PMID: 17326827
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DB123829.1         105-140
            37-1395             BC016440.1         1-1359
            1396-1400           AF128406.1         1568-1572
            1401-3670           AC124287.10        110845-113114
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3670
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="nuclear prelamin A recognition factor"
                     /db_xref="GeneID:26502"
                     /db_xref="HGNC:HGNC:29916"
                     /db_xref="MIM:605349"
     exon            1..90
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1290
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="isoform d is encoded by transcript variant 4;
                     iron-only hydrogenase-like protein 2; prenyl-dependent
                     prelamin A binding protein"
                     /codon_start=1
                     /product="nuclear prelamin A recognition factor isoform d"
                     /protein_id="NP_001077077.1"
                     /db_xref="CCDS:CCDS42403.1"
                     /db_xref="GeneID:26502"
                     /db_xref="HGNC:HGNC:29916"
                     /db_xref="MIM:605349"
                     /translation="MKCEHCTRKECSKKTKTDDQENVSADAPSPAQENGEKCDTSKHK
                     VLVVSVCPQSLPYFAAKFNLSVTDASRRLCGFLKSLGVHYVFDTTIAADFSILESQKE
                     FVRRYRQHSEEERTLPMLTSACPGWVRYAERVLGRPITAHLCTAKSPQQVMGSLVKDY
                     FARQQNLSPEKIFHVIVAPCYDKKLEALQESLPPALHGSRGADCVLTSGEIAQIMEQG
                     DLSVRDAAVDTLFGDLKEDKVTRHDGASSDGHLAHIFRHAAKELFNEDVEEVTYRALR
                     NKDFQEVTLEKNGEVVLRFAAAYGFRNIQNMILKLKKGKFPFHFVEVLACAGGCLNGR
                     GQAQTPDGHADKALLRQMEGIYADIPVRRPESSAHVQELYQEWLEGINSPKAREVLHT
                     TYQSQERGTHSLDIKW"
     exon            91..171
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..304
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..439
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..558
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..688
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..752
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..890
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1048
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..3670
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1373..1378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="hexamer: ATTAAA"
     polyA_site      1392
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="major polyA site"
     regulatory      3652..3657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NARF"
                     /gene_synonym="IOP2"
                     /note="hexamer: AATAAA"
     polyA_site      3670
                     /gene="NARF"
                     /gene_synonym="IOP2"
ORIGIN      
        1 gtcccagtct cccggtgctt ccctgaggct gaggcgcccg gcctcccgcc cgccgcgctc
       61 cagatgaagt gtgagcactg cacgcgcaag gaatgtagta agaaaacaaa aactgatgac
      121 caagagaatg tgtcagccga tgcaccgagt ccagcccagg aaaatggaga gaaatgtgat
      181 acctcaaagc acaaagtgct ggtagtgtct gtgtgtcctc aatctttgcc ttattttgct
      241 gctaaattca acctcagtgt aactgatgca tccagaagac tctgtggttt cctcaaaagt
      301 cttggggtgc actatgtatt tgatacgacg atagctgcgg attttagtat cctggagagt
      361 caaaaagaat tcgtgcgtcg ctatcgccag cacagtgagg aggaacgcac cctgcccatg
      421 ctgacctctg cctgtcctgg ctgggtccga tacgccgagc gggtgctggg tcgccccatc
      481 actgcccacc tctgcaccgc caagtccccc cagcaggtca tgggctcttt ggtgaaggat
      541 tatttcgcca gacagcagaa cctgtctcca gagaagattt tccacgtcat tgtggcccct
      601 tgttatgaca agaagctgga ggctcttcag gaaagccttc cccctgcttt gcatggctcc
      661 cggggcgctg actgcgtgtt aacatcaggt gaaattgctc aaataatgga gcaaggtgac
      721 ctctcagtga gagatgctgc cgtcgacact ctgtttggag acttgaagga ggacaaagtg
      781 acgcgtcatg atggagccag ctcagacggg cacctggcac acatcttcag acatgcggcc
      841 aaggagctgt tcaacgagga tgtggaggag gtcacttacc gagccctgag aaacaaagac
      901 ttccaagagg tcacccttga gaagaacgga gaggtggtgt tacgctttgc tgcagcctat
      961 ggctttcgaa acatccagaa catgatcctg aagcttaaga agggcaagtt cccattccac
     1021 tttgtggagg tcctcgcctg tgctggagga tgcttaaatg gcagaggcca agcccagact
     1081 ccagacggac atgcggataa ggccctgctg cggcagatgg aaggcattta cgctgacatc
     1141 cctgtgcggc gtccggagtc cagtgcacac gtgcaggagc tgtaccagga gtggctggag
     1201 gggatcaact cccccaaggc ccgagaggtg ctgcatacca cgtaccagag ccaggagcgt
     1261 ggcacacaca gcctggacat caagtggtga agtcaggcca gggccttcca gctgctcttg
     1321 gggccagagc caagagcctc tcagtagagg gaggggctgc cctgagtgga gtattaaaga
     1381 cacttaagaa aaccgctcaa tggattactt tggtttctcc gagttccctg ctaccccgtt
     1441 tattggaggc ccctcaggca gtttcatgtg gtgctatctt cataataggt gtgggattgg
     1501 aacttttttt ttcttttttt ttttttgaga cggagtctca ctctgtcacc caggctggag
     1561 tgcaatggcg caatctcagc tcactgcaac ctctgcctcc cgggttcaag cgattctctt
     1621 gccccagcct cccgagtagc tgggactaac gcgcacacca ccatgcccag ctaatttttg
     1681 tatttttagt agagatgggg tttcactatg ttggccaggc tggtattgaa ttcctgacct
     1741 cctgatccac ccgccttggc ctcccaaagt gccaggactg caggcatgag ccaccgtgcc
     1801 tggcagattg gaacgtttta acatgagagg agcacttccc caatttatcc cttcatccta
     1861 agattgtgaa aaagtcccaa agagtgggaa tggagacaga ctactgtatt ttaggtttaa
     1921 aaagaaaaat ccagaaagtg tcctgtgaag agctaggacc cccagaggtt ctaatgcaca
     1981 tgacttgaag gtgatttgat gtgggagtga gggcagaggg tggggtggct gtgcctgtgg
     2041 actcctgtgg ccctggggtt gttagggcag gcagtccaca gtcccagatc cctgcccatt
     2101 ttggctcttt cttttaccca ctcatatttt ccttgaaaat gtttttgcca gaacattaat
     2161 aactgtcagc cttttagaat caggagactt acgtacaaat ctggattttc agcttttctt
     2221 agaaaaactg tagtttctga caacagtagg ccccattcct cacagccagt caccaccctc
     2281 ctcccattcc tcacagccag tcaccaccct cctggaccat actcggccct gggccattcc
     2341 tcacagccag tcaccaccct cctcccattc ctcacagcca gtcaccaccc tcctggacca
     2401 cactcggccc tgggccattc ctcacagcca gtcaccaccc tcctggacca tactcagggc
     2461 cctggaggcc tggcaaccca ggccccaact caaacttgta cattcagtct ttcagtcgga
     2521 ctcgcactgg ggcaagggtg acagacacga gaatggaaaa ttgagaaggc tgcccgcacc
     2581 agctgggtgg gtgcaggggg ccccagctca tcatcagcac tgtcgtgggg tgggagtcgg
     2641 gggtaaaggt tccgtctgac cctgaggggt tgaggatatt caggtggtcc agcctcccgc
     2701 agaagacttc cctgtcaccc ttggcagaca ggtttcttct cacacggccc tggcccatcc
     2761 actcgccatg aagccctctg tgctcagggt gatggagccc cctccattct ggcactgcac
     2821 tgtgggcatg agcttgcctt aaaaagaaag gagaggccag gcacggtggc tcgtgcccta
     2881 taatcccagc acactgggag gccaaggtgg gaggattgct ggagtccagg agtttctaca
     2941 tgggagactc tgtctctaca aatttttttt ttttttttga gacagagtct cactttgtca
     3001 cccaggctgg agttcagtgg cgtgatctcg gctcacagca acctccgcct cctgggttca
     3061 agcgattctc ctgcctcagc ctctggagta gctgggatta caggcgcgcg ccaccgcgcc
     3121 tggctaattg tattcttagt tgagacgggt ttcgccatgt tgatcgggcc ggtcaggctg
     3181 gaatttctga cctcaggtga tccaaccacc tcagcctccc aaaatgctgg gattacaggc
     3241 gtgagccact gcacctggca aaaaattttt ttttaaaaag gagaaagcag tttaaccaca
     3301 aacagtgaaa cagagctggc agacgcctga aactccatgg aaccatgcag ctgtacccta
     3361 gggctcctcc caggaaaaga gagatgtcaa cgtggcccaa ggtgtcctga agcactggga
     3421 ttggattaac tcgagcgatg gccttcccag ccctccgtgc tgcagagcct ctgctcgcta
     3481 ggctgccttc atctcactct gtgtgctgtg cctgtgcacc tgtcttgtca ataactgcat
     3541 atattgtgtt gcgttgcctg tcttgctgga taactgcata tattgtgttc agttgtgtat
     3601 ttgttttgct ttcagtctat atacagttgg gtttccaacc tctgattctg gaataaacag
     3661 ttgcagcgtg
//
