LOCUS       NM_003826               3559 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens NSF attachment protein gamma (NAPG), mRNA.
ACCESSION   NM_003826
VERSION     NM_003826.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3559)
  AUTHORS   Xu,Y., Zhang,Y.B., Liang,L.J., Tian,J.L., Lin,J.M., Wang,P.P.,
            Li,R.H., Gu,M.L. and Gao,Z.C.
  TITLE     NAPG mutation in family members with hereditary hemorrhagic
            telangiectasia in China
  JOURNAL   BMC Pulm Med 21 (1), 197 (2021)
   PUBMED   34112136
  REMARK    GeneRIF: NAPG mutation in family members with hereditary
            hemorrhagic telangiectasia in China.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3559)
  AUTHORS   Li,X.W., Liu,B.C., Wang,Y., Zhao,Q.Z., Shen,Q., Chen,S.Q., Ji,J.,
            Yang,F.P., Gao,L.H., Xu,Y., Feng,G.Y., He,L. and He,G.
  TITLE     NAPG may not be a common risk gene shared by bipolar disorder and
            schizophrenia in Chinese population
  JOURNAL   Psychiatr Genet 22 (2), 107-108 (2012)
   PUBMED   22113424
  REMARK    GeneRIF: study did not support NAPG as a susceptible gene for
            schizophrenia in the Chinese Han population
REFERENCE   3  (bases 1 to 3559)
  AUTHORS   Ahn,M.J., Won,H.H., Lee,J., Lee,S.T., Sun,J.M., Park,Y.H.,
            Ahn,J.S., Kwon,O.J., Kim,H., Shim,Y.M., Kim,J., Kim,K., Kim,Y.H.,
            Park,J.Y., Kim,J.W. and Park,K.
  TITLE     The 18p11.22 locus is associated with never smoker non-small cell
            lung cancer susceptibility in Korean populations
  JOURNAL   Hum Genet 131 (3), 365-372 (2012)
   PUBMED   21866343
REFERENCE   4  (bases 1 to 3559)
  AUTHORS   Yosifova,A., Mushiroda,T., Stoianov,D., Vazharova,R., Dimova,I.,
            Karachanak,S., Zaharieva,I., Milanova,V., Madjirova,N.,
            Gerdjikov,I., Tolev,T., Velkova,S., Kirov,G., Owen,M.J.,
            O'Donovan,M.C., Toncheva,D. and Nakamura,Y.
  TITLE     Case-control association study of 65 candidate genes revealed a
            possible association of a SNP of HTR5A to be a factor susceptible
            to bipolar disease in Bulgarian population
  JOURNAL   J Affect Disord 117 (1-2), 87-97 (2009)
   PUBMED   19328558
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3559)
  AUTHORS   Li,X., Zhang,J., Wang,Y., Ji,J., Yang,F., Wan,C., Wang,P., Feng,G.,
            Lindpaintner,K., He,L. and He,G.
  TITLE     Association study on the NAPG gene and bipolar disorder in the
            Chinese Han population
  JOURNAL   Neurosci Lett 457 (3), 159-162 (2009)
   PUBMED   19429185
  REMARK    GeneRIF: Our study supports NAPG as a candidate for susceptibility
            to bipolar disorder as several combinations of haplotype were found
            to be associated with bipolar disorder.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3559)
  AUTHORS   Lemons,P.P., Chen,D., Bernstein,A.M., Bennett,M.K. and
            Whiteheart,S.W.
  TITLE     Regulated secretion in platelets: identification of elements of the
            platelet exocytosis machinery
  JOURNAL   Blood 90 (4), 1490-1500 (1997)
   PUBMED   9269766
REFERENCE   7  (bases 1 to 3559)
  AUTHORS   Mastick,C.C. and Falick,A.L.
  TITLE     Association of N-ethylmaleimide sensitive fusion (NSF) protein and
            soluble NSF attachment proteins-alpha and -gamma with glucose
            transporter-4-containing vesicles in primary rat adipocytes
  JOURNAL   Endocrinology 138 (6), 2391-2397 (1997)
   PUBMED   9165027
REFERENCE   8  (bases 1 to 3559)
  AUTHORS   Whiteheart,S.W., Griff,I.C., Brunner,M., Clary,D.O., Mayer,T.,
            Buhrow,S.A. and Rothman,J.E.
  TITLE     SNAP family of NSF attachment proteins includes a brain-specific
            isoform
  JOURNAL   Nature 362 (6418), 353-355 (1993)
   PUBMED   8455721
REFERENCE   9  (bases 1 to 3559)
  AUTHORS   Whiteheart,S.W., Brunner,M., Wilson,D.W., Wiedmann,M. and
            Rothman,J.E.
  TITLE     Soluble N-ethylmaleimide-sensitive fusion attachment proteins
            (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes
  JOURNAL   J Biol Chem 267 (17), 12239-12243 (1992)
   PUBMED   1601890
REFERENCE   10 (bases 1 to 3559)
  AUTHORS   Wilson,D.W., Whiteheart,S.W., Wiedmann,M., Brunner,M. and
            Rothman,J.E.
  TITLE     A multisubunit particle implicated in membrane fusion
  JOURNAL   J Cell Biol 117 (3), 531-538 (1992)
   PUBMED   1315316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA296597.1, AK314495.1,
            BC001889.1, CK005676.1, AK126942.1, AK023725.1 and CA312045.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003826.2.
            
            Summary: This gene encodes soluble NSF attachment protein gamma.
            The soluble NSF attachment proteins (SNAPs) enable
            N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target
            membranes. NSF and SNAPs appear to be general components of the
            intracellular membrane fusion apparatus, and their action at
            specific sites of fusion must be controlled by SNAP receptors
            particular to the membranes being fused. The product of this gene
            mediates platelet exocytosis and controls the membrane fusion
            events of this process.[provided by RefSeq, Dec 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.101342.1,
                                           SRR1803617.195191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322897.11/ ENSP00000324628.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DA296597.1         171-180
            11-1015             AK314495.1         1-1005
            1016-1154           BC001889.1         1003-1141
            1155-1674           CK005676.1         41-560
            1675-2579           AK126942.1         1979-2883
            2580-2580           AK023725.1         953-953
            2581-3556           AK126942.1         2885-3860
            3557-3559           CA312045.1         20-22               c
FEATURES             Location/Qualifiers
     source          1..3559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.22"
     gene            1..3559
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /note="NSF attachment protein gamma"
                     /db_xref="GeneID:8774"
                     /db_xref="HGNC:HGNC:7642"
                     /db_xref="MIM:603216"
     exon            1..132
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1015
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /note="soluble NSF attachment protein; SNAP-gamma;
                     N-ethylmaleimide-sensitive factor attachment protein,
                     gamma"
                     /codon_start=1
                     /product="gamma-soluble NSF attachment protein"
                     /protein_id="NP_003817.1"
                     /db_xref="CCDS:CCDS45827.1"
                     /db_xref="GeneID:8774"
                     /db_xref="HGNC:HGNC:7642"
                     /db_xref="MIM:603216"
                     /translation="MAAQKINEGLEHLAKAEKYLKTGFLKWKPDYDSAASEYGKAAVA
                     FKNAKQFEQAKDACLREAVAHENNRALFHAAKAYEQAGMMLKEMQKLPEAVQLIEKAS
                     MMYLENGTPDTAAMALERAGKLIENVDPEKAVQLYQQTANVFENEERLRQAVELLGKA
                     SRLLVRGRRFDEAALSIQKEKNIYKEIENYPTCYKKTIAQVLVHLHRNDYVAAERCVR
                     ESYSIPGFNGSEDCAALEQLLEGYDQQDQDQVSDVCNSPLFKYMDNDYAKLGLSLVVP
                     GGGIKKKSPATPQAKPDGVTATAADEEEDEYSGGLC"
     exon            133..200
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            201..285
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            286..303
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            304..334
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            335..444
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            445..511
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            512..582
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            583..661
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            662..741
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            742..871
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            872..3559
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3537..3542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /note="hexamer: AATAAA"
     polyA_site      3559
                     /gene="NAPG"
                     /gene_synonym="GAMMASNAP"
                     /note="major polyA site"
ORIGIN      
        1 ctatttgggc ggattcttgg cgccggagga agaggcaggg tcaccctctc tccacgtcag
       61 agacctgact gtggagatgg cggctcagaa gataaacgag gggctggaac acctcgccaa
      121 agcagagaaa tacctgaaaa ctggtttttt aaaatggaag ccagattatg acagtgccgc
      181 ttctgaatat ggaaaagcag ctgttgcttt taaaaatgcc aaacagtttg agcaagcaaa
      241 agatgcctgc ctgagggaag ctgttgccca tgaaaataat agggctcttt ttcatgctgc
      301 caaagcttat gagcaagctg gaatgatgtt gaaggagatg cagaaactac cagaggccgt
      361 tcagctaatt gagaaggcca gcatgatgta tctagaaaac ggcaccccag acacagcagc
      421 catggctttg gagcgagctg gaaagcttat agaaaatgtt gatccagaga aggctgtaca
      481 gttatatcaa cagacagcta atgtgtttga aaatgaagaa cgcttacgac aggcagttga
      541 attactagga aaagcctcca gactactagt acgaggacgt aggtttgatg aggcggcact
      601 ctctattcag aaagaaaaaa atatttataa ggaaattgag aattatccaa cttgttataa
      661 gaaaacaatt gctcaagtct tagttcatct acacagaaat gactatgtag ctgcagaaag
      721 atgtgtccgg gagagctata gcatccctgg gttcaatggc agtgaagact gtgctgccct
      781 ggaacagctt cttgaaggtt atgaccagca agaccaagat caggtgtcag atgtctgcaa
      841 ctcaccgctt ttcaagtaca tggacaatga ttatgctaag ctgggcctga gtttggtggt
      901 tccaggaggg ggaatcaaga agaaatcacc tgcaacacca caggccaagc ctgatggtgt
      961 cactgccacg gctgctgatg aagaggaaga tgaatactca ggaggactat gctagtattt
     1021 tgcttgctga aaagaaaagg gaaacaaagg taaaatcctg acatgccatt tcaaggactt
     1081 gggaatagat tagggatatc cgtacttcat tacagtcatg attttggatc ctaataaaga
     1141 ctagttttta gttaccatct tcccaaatca ctcattgtat ccattacctg tgaagcatat
     1201 ctttttcttt ccataagagc ttttctaaga caccagcagg aattaacaga aaatgtactg
     1261 tcatgtttta atacattgat taaaaaattt gcaagccaaa ttatacataa attatgttct
     1321 aaacaaaagg ggtaataagc ataggtattc tctcttggac acttgtaagt tactgttagt
     1381 gaattgtttt ttacgtttca tttaataatt gctgctaaag gtgatgttta ctgataaatc
     1441 attttaaaat ttttttgttt tgaaaagtaa atttatcccc catgatgtta gatacattta
     1501 aattattaag tcttttcaga gatgagatgg ggacaggaag ttattttgag ccttacaata
     1561 ttatttagcc caataaaaga tgcattgaag ctcttatata ttatgagttt gaaaaatttt
     1621 gaaggtagca tattgaagtg atctataaat atcttcagtc ctctctgaag tgtgggtatt
     1681 tcttctatct aaaaaataca tacagtgact gtcttcaaat ctacttggtt cttgaccaaa
     1741 taggagctaa tgggtaatga ataccttttt gtttgtttgt ttgtttgttt tgttttttgt
     1801 tttttttttt aagggtctca ctcttttgcc caggctggag tgcagtggca caatcacggc
     1861 tcccaggcta atgtttttat ttttaatttg taattttttt tttatttttt ttgttgagat
     1921 ggagttgctc catgttgcac aggctgttct caaactccta agctcaagcc atctgcctgc
     1981 cttggcctcc caaagtgctg ggattgtaga cataagccac ctcacccagc ctatgaatat
     2041 ctttctaaca ttgtaagaat gaggtaatgt ttccatcagt ctaatacaga tatatttctt
     2101 ccctccaaaa cagtttattt tgattgttta ttttattttg attgtaactc cgtcataact
     2161 tgacatggaa aatgctatat actatgaaaa cttagctgaa agggaagaat tgttttagaa
     2221 agacaatatt taaaacaccg cactgccaat atattgatcc tttatagtta tttcctaaaa
     2281 tgctgttttc gaaacattcc tttttcaccc tgttgtgtgg cttagaccca tctcgtaatc
     2341 tgttaattgg aaagaggcta cagacaccag cagtgtgcgt tctgcaggta cacgctgcca
     2401 aagtaattcc tgctcatcca tgccctgtct ctgtctcttt tagagtcata ccttatttga
     2461 gtataggttg cttaattttg ctagacttcc tgaaaacact aaggtggagt atcagaagtg
     2521 attttagtca cagttctgcg ggagagctta gaataacatc ctcctttggg aggtggtctc
     2581 gggtgcgtgg atgttggtat acagtcttta ttgtaagtct gatacaaaat gctaataaat
     2641 ttaatgtttt tcttccttaa tttattggca tagttcttca ggtagcacct catttttatt
     2701 aatgatattg ggattaacta tgaacaagct atatgtagac atttgcattt aaggacattg
     2761 cagtgtttca aagatcccat cattgcagct tgtatccttt agatccaatc ggaaacttct
     2821 ggagtcttac attaatgctc atttgagcta attagtaatc tgtttaaaca gatttggcaa
     2881 tactttaaag atactgtaga ctatttatgt atagatagat catattaccc attaaagtct
     2941 gggggaaaaa attttttaat tttactcttc ttatgtactg aaaacttttt ttaaaaaagg
     3001 tgatgatgaa gtgcattctg tagcagcagc gcagctatgc tttaaaccac acaaaaggct
     3061 gtgtccaggt gcagcctcct tcacccttcc tgcccacggt gaggattgaa taaccaggac
     3121 ttggggatat tgtttgttgt cagggttatt ctgtgtggta aggaatattt gtttcacatt
     3181 tatacatttt ctttttccac tcacgtaagt ttctatcttg agagcatagt ccaaagtgca
     3241 aaacttggtg tttacaagga aaattgtctt ccagaactcc actgtcatca ctttcaccaa
     3301 agtggaagtt tgcatgaata tgctcagaat ctaatattca atgttctgtt acattgtaag
     3361 tgaagtccag ctacaaaata gatttaatat attgaattta tttgtacata tgcagagtac
     3421 ggtatttctg tatggaatct gctttattcc tatttttccc aactctgatg agtagaatat
     3481 taaatgtgtt gttatggaaa tacagattat tgcttctata ggaagataat tatgaaaata
     3541 aaacctgaaa ctatataaa
//
