LOCUS       NM_005969               2463 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleosome assembly protein 1 like 4 (NAP1L4),
            transcript variant 1, mRNA.
ACCESSION   NM_005969
VERSION     NM_005969.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2463)
  AUTHORS   Tan,L., Cheng,W., Liu,F., Wang,D.O., Wu,L., Cao,N. and Wang,J.
  TITLE     Positive natural selection of N6-methyladenosine on the RNAs of
            processed pseudogenes
  JOURNAL   Genome Biol 22 (1), 180 (2021)
   PUBMED   34120636
  REMARK    GeneRIF: Positive natural selection of N6-methyladenosine on the
            RNAs of processed pseudogenes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2463)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2463)
  AUTHORS   Mizuhashi,S., Fukushima,S., Ishibashi,T., Kuriyama,H., Kimura,T.,
            Kanemaru,H., Kajihara,I., Makino,K., Miyashita,A., Aoi,J., Kita,K.
            and Ihn,H.
  TITLE     Nucleosome assembly protein 1-like 4, a new therapeutic target for
            proliferation and invasion of melanoma cells
  JOURNAL   J Dermatol Sci 102 (1), 16-24 (2021)
   PUBMED   33583643
  REMARK    GeneRIF: Nucleosome assembly protein 1-like 4, a new therapeutic
            target for proliferation and invasion of melanoma cells.
REFERENCE   4  (bases 1 to 2463)
  AUTHORS   Tanaka,T., Hozumi,Y., Martelli,A.M., Iino,M. and Goto,K.
  TITLE     Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53
            acetylation to regulate cell fate
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (12), 118560 (2019)
   PUBMED   31634504
  REMARK    GeneRIF: The NAP1L4 regulates cell fate by controlling the
            expression of p53-responsive proarrest and proapoptotic genes
            through selective modulation of p53 acetylation at specific sites
            during normal homeostasis and in stress-induced responses.
REFERENCE   5  (bases 1 to 2463)
  AUTHORS   Tanaka,T., Hozumi,Y., Iino,M. and Goto,K.
  TITLE     NAP1L1 regulates NF-kappaB signaling pathway acting on
            anti-apoptotic Mcl-1 gene expression
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (10), 1759-1768 (2017)
   PUBMED   28687276
  REMARK    GeneRIF: knockdown of NAP1L1 suppresses IkappaBalpha degradation
            and nuclear transport of p65 subunit after treatment with TNF-a
            stimulation, leading to attenuation of the NF-kappaB
            transcriptional activity, whereas NAP1L4 knockdown remains
            silent.results of this study suggest that NAP1L1 downregulation
            renders the cell vulnerable to apoptotic cell death through
            attenuation of NF-kappaB transcriptional activity on the
            anti-apop...
REFERENCE   6  (bases 1 to 2463)
  AUTHORS   Rodriguez,P., Ruiz,M.T., Price,G.B. and Zannis-Hadjopoulos,M.
  TITLE     NAP-2 is part of multi-protein complexes in HeLa cells
  JOURNAL   J Cell Biochem 93 (2), 398-408 (2004)
   PUBMED   15368365
  REMARK    GeneRIF: NAP-2 is in complex(es) with other proteins, which are
            distinct from histones
REFERENCE   7  (bases 1 to 2463)
  AUTHORS   Shikama,N., Chan,H.M., Krstic-Demonacos,M., Smith,L., Lee,C.W.,
            Cairns,W. and La Thangue,N.B.
  TITLE     Functional interaction between nucleosome assembly proteins and
            p300/CREB-binding protein family coactivators
  JOURNAL   Mol Cell Biol 20 (23), 8933-8943 (2000)
   PUBMED   11073993
REFERENCE   8  (bases 1 to 2463)
  AUTHORS   Rodriguez,P., Pelletier,J., Price,G.B. and Zannis-Hadjopoulos,M.
  TITLE     NAP-2: histone chaperone function and phosphorylation state through
            the cell cycle
  JOURNAL   J Mol Biol 298 (2), 225-238 (2000)
   PUBMED   10764593
REFERENCE   9  (bases 1 to 2463)
  AUTHORS   Rodriguez,P., Munroe,D., Prawitt,D., Chu,L.L., Bric,E., Kim,J.,
            Reid,L.H., Davies,C., Nakagama,H., Loebbert,R., Winterpacht,A.,
            Petruzzi,M.J., Higgins,M.J., Nowak,N., Evans,G., Shows,T.,
            Weissman,B.E., Zabel,B., Housman,D.E. and Pelletier,J.
  TITLE     Functional characterization of human nucleosome assembly protein-2
            (NAP1L4) suggests a role as a histone chaperone
  JOURNAL   Genomics 44 (3), 253-265 (1997)
   PUBMED   9325046
REFERENCE   10 (bases 1 to 2463)
  AUTHORS   Hu,R.J., Lee,M.P., Johnson,L.A. and Feinberg,A.P.
  TITLE     A novel human homologue of yeast nucleosome assembly protein, 65 kb
            centromeric to the p57KIP2 gene, is biallelically expressed in
            fetal and adult tissues
  JOURNAL   Hum Mol Genet 5 (11), 1743-1748 (1996)
   PUBMED   8923002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U77456.1, BC022090.2 and
            AA573896.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005969.3.
            
            Summary: This gene encodes a member of the nucleosome assembly
            protein (NAP) family which can interact with both core and linker
            histones. It can shuttle between the cytoplasm and nucleus,
            suggesting a role as a histone chaperone. This gene is one of
            several located near the imprinted gene domain of 11p15.5, an
            important tumor-suppressor gene region. Alterations in this region
            have been associated with the Beckwith-Wiedemann syndrome, Wilms
            tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung,
            ovarian, and breast cancer. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77456.1, SRR3476690.659547.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380542.9/ ENSP00000369915.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                U77456.1           57-132
            77-2462             BC022090.2         35-2420
            2463-2463           AA573896.1         54-54               c
FEATURES             Location/Qualifiers
     source          1..2463
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2463
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /note="nucleosome assembly protein 1 like 4"
                     /db_xref="GeneID:4676"
                     /db_xref="HGNC:HGNC:7640"
                     /db_xref="MIM:601651"
     exon            1..76
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            77..107
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1221
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleosome assembly protein 2; nucleosome assembly protein
                     1-like 4b; NAP-2"
                     /codon_start=1
                     /product="nucleosome assembly protein 1-like 4 isoform 1"
                     /protein_id="NP_005960.1"
                     /db_xref="CCDS:CCDS41599.1"
                     /db_xref="GeneID:4676"
                     /db_xref="HGNC:HGNC:7640"
                     /db_xref="MIM:601651"
                     /translation="MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQER
                     LDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHDLERKYAALYQPL
                     FDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIP
                     EFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTN
                     SVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGT
                     VRTITKQVPNESFFNFFNPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLY
                     FTGEAIEDDDNFEEGEEGEEEELEGDEEGEDEDDAEINPKV"
     exon            108..166
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            167..266
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            267..408
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            409..495
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            496..627
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            628..699
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            700..839
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            840..985
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1008
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1128
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1158
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1215
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1253
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..2463
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2443..2448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /note="hexamer: ATTAAA"
     polyA_site      2463
                     /gene="NAP1L4"
                     /gene_synonym="hNAP2; NAP1L4b; NAP2; NAP2L"
                     /note="major polyA site"
ORIGIN      
        1 gttgttggag gccacggcgg cgcagcccca aagcgagcga agctagggtc gccgccactg
       61 ccgcaggagg cgtgagggga taaaaacatt cagatggcag atcacagttt ttcagatggg
      121 gttccttcag attccgtgga agctgctaaa aatgcaagta acacagaaaa gctcacagat
      181 caggtgatgc agaatcctcg agttctggca gctttacagg agcgacttga caatgtccct
      241 cacacccctt ccagctacat cgaaacttta cctaaagcag taaaaagaag aattaatgca
      301 ttgaaacaac ttcaggtgag atgtgctcac atagaagcca agttctatga agaggtacat
      361 gacttggaaa gaaagtatgc agcgctatac cagcctctct ttgacaagag aagagaattt
      421 atcaccggcg atgttgaacc aacagatgcg gaatcggaat ggcacagtga aaatgaagag
      481 gaagagaaat tggctggaga catgaaaagt aaagtagtcg tcacagaaaa agcagcggca
      541 acggctgaag agccagatcc caaaggaatt ccagagttct ggtttaccat cttcagaaat
      601 gtggacatgc tgagtgaatt agtccaggaa tatgatgaac caatcttgaa acacctgcag
      661 gatattaaag tgaaattttc tgaccctgga cagcctatgt cttttgtgtt agagttccac
      721 tttgaaccca acgactactt taccaactca gtcctgacaa aaacctacaa gatgaaatca
      781 gaaccagata aggctgatcc cttttccttt gaaggtcctg agattgtgga ctgtgacggg
      841 tgtactattg actggaagaa aggaaagaat gttactgtca aaaccatcaa gaaaaagcag
      901 aagcataagg gtcgaggcac tgttagaaca attacgaaac aagtacccaa tgagtccttt
      961 ttcaacttct tcaatccatt gaaagcatcc ggggatggag aatcactgga tgaagattct
     1021 gaattcacat tagcctctga ttttgaaatt ggacactttt tccgtgagcg gatagtcccg
     1081 cgggctgtgc tgtacttcac tggggaggcc atagaagatg atgacaattt tgaagaaggt
     1141 gaagaaggag aagaggagga attagaaggt gacgaggagg gagaagacga ggatgatgcg
     1201 gaaattaacc ccaaggtgta atttttgtct gttaatcatt catacgtttc tagaaggaac
     1261 ccagccagcc ggcggaatgc aagcagcagt aggaagcgga ggcgggtgcc tggcagaccg
     1321 gctgtcggga ctccaggcct gtgggcgggg cctcggtcct tgccgcagca caatcccgtg
     1381 gacagagctt actccatcta actcgttttc aagtgcatga ttttcacttt cacttttcct
     1441 ttttccttat tattttgctt aacttgtaca gtggcaactg aaatgcattt cagaaatagg
     1501 aggtttcgtc cagcaccctc tgcagccttg gtgcctgtag ctctggactt ccctgggcct
     1561 ttccctgtgg gagggccctg tagaccacat cagggtgggg tgggggtcac ttggcaaaaa
     1621 gggccgaggt ctggtgatgt ggttcccagg atctggaacc tctcccaccc ctcctgcagt
     1681 tggactgaat tcttcccttt catccgaaga aacccacttg ctgtttccag ccgctgaatc
     1741 tgctgagtgt gcagcctgca tcacctgctg tatgccgatc atctcagaaa gggctgtgta
     1801 gagtagggcc ctgttctcct taggatgttg cttcttgatt tttttttttt tttaggggtg
     1861 ggtcagggtt gtgacacacc agcccaggtg agagctgctg cgggtcacct catatttatt
     1921 tatcccttct tgcctgtgag gactgcggct tttcgctgtg gctcgtcctt aacgtttctg
     1981 aaccaccttg gtgccctgag caggaagatg tgccacttcc tagcaggcgc aaggcctgtg
     2041 cggaagaaac gccgctccct gccaccaggg ctgaagatgc gagcccgtcc tcatgacgca
     2101 ggcgccaccc tgctgccgga gccgggcttc ggcagtcttc tccactgagg gactgggctg
     2161 ggaagtcctg cgtttcagtg gagcgtatga gcgtcaagtc ctgctttctc agtagcccca
     2221 ttgcggggcc ccaccattca tcctgtctga aggtcctggg tttggtgtga ccgcttggcg
     2281 gctggtgggt ggggttttca agtgggtgac ggcgctctcc ggcagccggg gatggccgtg
     2341 tccgcactga ccaggcctgt ggagagtgct cggcctaacc ttagaacaca tttgtaactg
     2401 aatacagtgt tttcaatttg tacagaatag ttagaatatt ctattaaagt ggtgaaacat
     2461 tga
//
