LOCUS       NM_004538               2649 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nucleosome assembly protein 1 like 3 (NAP1L3), mRNA.
ACCESSION   NM_004538
VERSION     NM_004538.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2649)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2649)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2649)
  AUTHORS   Mo,X., Sun,J., Xu,L., Zhao,N., Yan,M., Li,H. and Qin,P.
  TITLE     Nucleosome Assembly Protein 1-Like 3 Enhances Cisplatin Resistance
            of Ovarian Cancer Cell by Activating Transforming Growth
            Factor-Beta Pathway
  JOURNAL   J Interferon Cytokine Res 40 (7), 333-340 (2020)
   PUBMED   32701410
  REMARK    GeneRIF: Nucleosome Assembly Protein 1-Like 3 Enhances Cisplatin
            Resistance of Ovarian Cancer Cell by Activating Transforming Growth
            Factor-Beta Pathway.
REFERENCE   4  (bases 1 to 2649)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2649)
  AUTHORS   Heshmati,Y., Kharazi,S., Turkoz,G., Chang,D., Kamali Dolatabadi,E.,
            Bostrom,J., Krstic,A., Boukoura,T., Wagner,E., Kadri,N.,
            Mansson,R., Altun,M., Qian,H. and Walfridsson,J.
  TITLE     The histone chaperone NAP1L3 is required for haematopoietic stem
            cell maintenance and differentiation
  JOURNAL   Sci Rep 8 (1), 11202 (2018)
   PUBMED   30046127
  REMARK    GeneRIF: we demonstrate that HOXA3 and HOXA5 genes are markedly
            upregulated when NAP1L3 is suppressed in umbilical cord blood (UCB)
            haematopoietic stem cells (HSCs). Taken together, our findings
            establish an important role for NAP1L3 in haematopoietic stem cells
            homeostasis and haematopoietic differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2649)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   7  (bases 1 to 2649)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
REFERENCE   8  (bases 1 to 2649)
  AUTHORS   Watanabe,T.K., Fujiwara,T., Nakamura,Y., Hirai,Y., Maekawa,H. and
            Takahashi,E.
  TITLE     Cloning, expression pattern and mapping to Xq of NAP1L3, a gene
            encoding a peptide homologous to human and yeast nucleosome
            assembly proteins
  JOURNAL   Cytogenet Cell Genet 74 (4), 281-285 (1996)
   PUBMED   8976385
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA294849.1, DA486883.1,
            AK315176.1, BC034954.2 and AA463251.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004538.5.
            
            Summary: This gene is intronless and encodes a member of the
            nucleosome assembly protein (NAP) family. This gene is linked
            closely to a region of genes responsible for several X-linked
            cognitive disability syndromes. [provided by RefSeq, Dec 2010].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660807.231118.1,
                                        SRR1803611.113743.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373079.4/ ENSP00000362171.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-447               DA294849.1         107-553
            448-944             DA486883.1         69-565
            945-1795            AK315176.1         943-1793
            1796-2643           BC034954.2         1789-2636
            2644-2649           AA463251.1         8-13                c
FEATURES             Location/Qualifiers
     source          1..2649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.32"
     gene            1..2649
                     /gene="NAP1L3"
                     /gene_synonym="MB20; NPL3"
                     /note="nucleosome assembly protein 1 like 3"
                     /db_xref="GeneID:4675"
                     /db_xref="HGNC:HGNC:7639"
                     /db_xref="MIM:300117"
     exon            1..2649
                     /gene="NAP1L3"
                     /gene_synonym="MB20; NPL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1795
                     /gene="NAP1L3"
                     /gene_synonym="MB20; NPL3"
                     /codon_start=1
                     /product="nucleosome assembly protein 1-like 3"
                     /protein_id="NP_004529.2"
                     /db_xref="CCDS:CCDS14465.1"
                     /db_xref="GeneID:4675"
                     /db_xref="HGNC:HGNC:7639"
                     /db_xref="MIM:300117"
                     /translation="MAEADFKMVSEPVAHGVAEEEMASSTSDSGEESDSSSSSSSTSD
                     SSSSSSTSGSSSGSGSSSSSSGSTSSRSRLYRKKRVPEPSRRARRAPLGTNFVDRLPQ
                     AVRNRVQALRNIQDECDKVDTLFLKAIHDLERKYAELNKPLYDRRFQIINAEYEPTEE
                     ECEWNSEDEEFSSDEEVQDNTPSEMPPLEGEEEENPKENPEVKAEEKEVPKEIPEVKD
                     EEKEVPKEIPEVKAEEKADSKDCMEATPEVKEDPKEVPQVKADDKEQPKATEAKARAA
                     VRETHKRVPEERLQDSVDLKRARKGKPKREDPKGIPDYWLIVLKNVDKLGPMIQKYDE
                     PILKFLSDVSLKFSKPGQPVSYTFEFHFLPNPYFRNEVLVKTYIIKAKPDHNDPFFSW
                     GWEIEDCKGCKIDWRRGKDVTVTTTQSRTTATGEIEIQPRVVPNASFFNFFSPPEIPM
                     IGKLEPREDAILDEDFEIGQILHDNVILKSIYYYTGEVNGTYYQFGKHYGNKKYRK"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAP1L3"
                     /gene_synonym="MB20; NPL3"
                     /note="hexamer: ATTAAA"
     polyA_site      2649
                     /gene="NAP1L3"
                     /gene_synonym="MB20; NPL3"
                     /note="major polyA site"
ORIGIN      
        1 atactgcgcc attcggctgc ggtacatctc ggcactctag ctgcagccgg gagaggcctt
       61 gccgccaccg ctgtcgccca agcctccact gccgctgcca cctcagcgcc ggcctctgca
      121 tccccagctc cagctccgct ctgcgccgct gctgccatcg ccgctgccac ctccgcagcc
      181 cgggcctccg ccgccgccac tcaagcatcc gtgagtcatt ttctgcccat ctctggtcgc
      241 gcggtctccc tggtagagtt tgtaggcttg caagatggca gaagcagatt ttaaaatggt
      301 ctcggaacct gtcgcccatg gggttgccga agaggagatg gctagctcga ctagtgattc
      361 tggggaagaa tctgacagca gtagctctag cagcagcact agtgacagca gcagcagcag
      421 cagcactagt ggcagcagca gcggcagcgg cagcagcagc agcagcagcg gcagcactag
      481 cagccgcagc cgcttgtata gaaagaagag ggtacctgag ccttccagaa gggcgcggcg
      541 ggccccgttg ggaacaaatt tcgtggatag gctgcctcag gcagttagaa atcgtgtgca
      601 agcgcttaga aacattcaag atgaatgtga caaggtagat accctgttct taaaagcaat
      661 tcatgatctt gaaagaaaat atgctgaact caacaagcct ctgtatgata ggcggtttca
      721 aatcatcaat gcagaatacg agcctacaga agaagaatgt gaatggaatt cagaggatga
      781 ggagttcagc agtgatgagg aggtgcagga taacacccct agtgaaatgc ctcccttaga
      841 gggtgaggaa gaagaaaacc ctaaagaaaa cccagaggtg aaagctgaag agaaggaagt
      901 tcctaaagaa attcctgagg tgaaggatga agaaaaggaa gttcctaaag aaattcctga
      961 ggtaaaggct gaagaaaaag cagattctaa agactgtatg gaggcaaccc ctgaagtaaa
     1021 agaagatcct aaagaagtcc cccaggtaaa ggcagatgat aaagaacagc ctaaagcaac
     1081 agaggctaag gcaagggctg cagtaagaga gactcataaa agagttcctg aggaaaggct
     1141 tcaggacagt gtagatctta aaagagctag gaagggaaag cctaaaagag aagaccctaa
     1201 aggcattcct gactattggc tgattgtttt aaagaatgtt gacaagctcg ggcctatgat
     1261 tcagaagtat gatgagccca ttctgaagtt cttgtcggat gttagcctga agttctcaaa
     1321 acctggccag cctgtaagtt acacctttga atttcatttt ctacccaacc catacttcag
     1381 aaatgaggtg ctggtgaaga catatataat aaaggcaaaa ccagatcaca atgatccctt
     1441 cttttcttgg ggatgggaaa ttgaagattg caaaggctgc aagatagact ggagaagagg
     1501 aaaagatgtt actgtgacaa ctacccagag tcgcacaact gctactggag aaattgaaat
     1561 ccagccaaga gtggttccta atgcatcatt cttcaacttc tttagtcctc ctgagattcc
     1621 tatgattggg aagctggaac cacgagaaga tgctatcctg gatgaggact ttgaaattgg
     1681 gcagatttta catgataatg tcatcctgaa atcaatctat tactatactg gagaagtcaa
     1741 tggtacctac tatcaatttg gcaaacatta tggaaacaag aaatacagaa aataagtcaa
     1801 tctgaaagat ttttcaagaa tcttaaaatc tcaagaagtg aagcagattc atacagcctt
     1861 gaaaaaagta aaaccctgac ctgtaacctg aacactatta ttccttatag tcaagttttt
     1921 gtggtttctt ggtagtctat attttaaaaa tagtcctaaa aagtgtctaa gtgccagttt
     1981 attctatcta ggctgttgta gtataatatt cttcaaaata tgtaagctgt tgtcaattat
     2041 ctaaagcatg ttagtttggt gctacacagt gttgattttt gtgatgtcct ttggtcatgt
     2101 ttctgttaga ctgtagctgt gaaactgtca gaattgttaa ctgaaacaaa tatttgcttg
     2161 aaaaaaaaag ttcatgaagt accaatgcaa gtgttttatt tttttctttt ttccagccca
     2221 taagactaag ggtttaaatc tgcttgcact agctgtgcct tcattagttt gctatagaaa
     2281 tccagtactt atagtaaata aaacagtgta ttttgaagtt tgactgcttg aaaaagatta
     2341 gcatacatct aatgtgaaaa gaccacattt gattcaactg agaccttgtg tatgtgacat
     2401 atagtggcct ataaatttaa tcataatgat gttattgttt accactgagg tgttaatata
     2461 acatagtatt tttgaaaaag tttcttcatc ttatattgtg taattgtaaa ctaaagatac
     2521 cgtgttttct ttgtattgtg ttctaccttc cctttcactg aaaatgatca cttcatttga
     2581 tactgttttt catgttcttg tattgcaacc taaaataaat aaatattaaa gtgtgttata
     2641 ctataaaaa
//
