LOCUS       NM_021963               2553 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nucleosome assembly protein 1 like 2 (NAP1L2), mRNA.
ACCESSION   NM_021963
VERSION     NM_021963.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Ding,Y., Shao,X., Li,X., Zhai,Y., Zhang,Y., Wang,S. and Fang,H.
  TITLE     Identification of candidate genes in atopic dermatitis based on
            bioinformatic methods
  JOURNAL   Int J Dermatol 55 (7), 791-800 (2016)
   PUBMED   26967585
  REMARK    GeneRIF: NAP1L2 may play an important role in the development and
            progression of atopic dermatitis.
REFERENCE   5  (bases 1 to 2553)
  AUTHORS   Attia,M., Forster,A., Rachez,C., Freemont,P., Avner,P. and
            Rogner,U.C.
  TITLE     Interaction between nucleosome assembly protein 1-like family
            members
  JOURNAL   J Mol Biol 407 (5), 647-660 (2011)
   PUBMED   21333655
  REMARK    GeneRIF: Results identified several proteins interacting with
            NAP1L2, including the ubiquitously expressed members of the
            nucleosome assembly protein family, NAP1L1 and NAP1L4.
REFERENCE   6  (bases 1 to 2553)
  AUTHORS   de Chassey,B., Navratil,V., Tafforeau,L., Hiet,M.S., Aublin-Gex,A.,
            Agaugue,S., Meiffren,G., Pradezynski,F., Faria,B.F., Chantier,T.,
            Le Breton,M., Pellet,J., Davoust,N., Mangeot,P.E., Chaboud,A.,
            Penin,F., Jacob,Y., Vidalain,P.O., Vidal,M., Andre,P.,
            Rabourdin-Combe,C. and Lotteau,V.
  TITLE     Hepatitis C virus infection protein network
  JOURNAL   Mol Syst Biol 4, 230 (2008)
   PUBMED   18985028
REFERENCE   7  (bases 1 to 2553)
  AUTHORS   Rogner,U.C., Danoy,P., Matsuda,F., Moore,G.E., Stanier,P. and
            Avner,P.
  TITLE     SNPs in the CpG island of NAP1L2: a possible link between DNA
            methylation and neural tube defects?
  JOURNAL   Am J Med Genet 110 (3), 208-214 (2002)
   PUBMED   12116227
REFERENCE   8  (bases 1 to 2553)
  AUTHORS   Rogner,U.C., Spyropoulos,D.D., Le Novere,N., Changeux,J.P. and
            Avner,P.
  TITLE     Control of neurulation by the nucleosome assembly protein-1-like 2
  JOURNAL   Nat Genet 25 (4), 431-435 (2000)
   PUBMED   10932189
REFERENCE   9  (bases 1 to 2553)
  AUTHORS   Rougeulle,C. and Avner,P.
  TITLE     Cloning and characterization of a murine brain specific gene Bpx
            and its human homologue lying within the Xic candidate region
  JOURNAL   Hum Mol Genet 5 (1), 41-49 (1996)
   PUBMED   8789438
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK316569.1, AB027013.1 and
            CB242638.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_021963.3.
            
            Summary: The protein encoded by this intronless gene is a member of
            the nucleosome assembly protein (NAP) family. The encoded protein
            represents a class of tissue-specific factors that interact with
            chromatin to regulate neuronal cell proliferation. [provided by
            RefSeq, Jan 2011].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660803.17575.1, SRR1803615.116834.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373517.4/ ENSP00000362616.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1742              AK316569.1         24-1765
            1743-2518           AB027013.1         1740-2515
            2519-2553           CB242638.1         15-49               c
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.2"
     gene            1..2553
                     /gene="NAP1L2"
                     /gene_synonym="BPX"
                     /note="nucleosome assembly protein 1 like 2"
                     /db_xref="GeneID:4674"
                     /db_xref="HGNC:HGNC:7638"
                     /db_xref="MIM:300026"
     exon            1..2553
                     /gene="NAP1L2"
                     /gene_synonym="BPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..1742
                     /gene="NAP1L2"
                     /gene_synonym="BPX"
                     /note="brain specific gene BPX; brain-specific protein,
                     X-linked"
                     /codon_start=1
                     /product="nucleosome assembly protein 1-like 2"
                     /protein_id="NP_068798.1"
                     /db_xref="CCDS:CCDS14423.1"
                     /db_xref="GeneID:4674"
                     /db_xref="HGNC:HGNC:7638"
                     /db_xref="MIM:300026"
                     /translation="MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDD
                     GKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVE
                     SLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYE
                     PTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEE
                     EEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKL
                     SDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEID
                     WNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLL
                     GHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKN
                     LEALVEDIDR"
     regulatory      2513..2518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAP1L2"
                     /gene_synonym="BPX"
                     /note="hexamer: AATAAA"
     regulatory      2522..2527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAP1L2"
                     /gene_synonym="BPX"
                     /note="hexamer: AATAAA"
     polyA_site      2534
                     /gene="NAP1L2"
                     /gene_synonym="BPX"
                     /note="major polyA site"
     polyA_site      2553
                     /gene="NAP1L2"
                     /gene_synonym="BPX"
ORIGIN      
        1 aagtgatagc tgcgtaatca tactgcggca ccgttttttt cttgcagcag tagctgcttg
       61 cggaggaggt ctgcccactg cagctctctg cagtctccgg ctctctcctg caggatcggt
      121 caacgcagcc gtcgccgccc tctgcaccca gcccaggtcg ccactgcttc agtccggttc
      181 tcaaagcctc agcaccatct tttatccccg agcagcctgg atcgtcgttc cctcagtccg
      241 gacgccactg ctaggtccga ccaccgccgc ttctgatatt tcggtgagtc ttttcctgtg
      301 gaggtttggt ctcccgatct ctgtggtagc caccttaggc gtgtacggtc ctttgaaaaa
      361 tggccgagtc agagaaccgc aaggagctgt cagaatccag tcaagaagag gctggtaatc
      421 agataatggt ggaagggctc ggggaacatc tggagcgcgg tgaagatgcc gctgctgggc
      481 ttggagacga tgggaagtgc ggtgaagaag ctgccgctgg gcttggggaa gaaggggaaa
      541 acggtgaaga tactgctgct gggtccgggg aagatgggaa aaaaggtggc gatactgatg
      601 aggactcaga ggcagaccgt ccaaaaggac ttatcggtta tgttttagat acagactttg
      661 ttgaaagtct acctgtgaaa gttaagtacc gtgtgttagc ccttaaaaag cttcaaacta
      721 gagcggccaa tttagaatcc aaattcctga gggaatttca tgacattgaa agaaagtttg
      781 ctgaaatgta ccaaccctta ctggaaaaaa gacgtcagat catcaatgca atctatgaac
      841 ctacagaaga ggaatgtgaa tataaatcag actctgagga ctgtgatgat gaggaaatgt
      901 gtcatgaaga gatgtatggt aatgaggagg gtatggtaca tgaatatgtg gatgaggacg
      961 atggttatga ggactattat tatgattatg ctgtggaaga ggaggaggag gaggaggagg
     1021 aggacgacat tgaggctact ggagaagaga ataaagaaga ggaggatcct aagggaattc
     1081 ctgatttttg gctaactgtt ttaaaaaacg ttgatacact cactcctttg attaagaaat
     1141 atgatgagcc tattctgaag ctcctgacag atattaaagt taagctttca gatcctggcg
     1201 agcccctcag tttcacacta gaatttcact tcaaacccaa tgaatatttc aaaaatgagt
     1261 tgttgacaaa gacctatgtg ctgaagtcaa agctagcata ttatgatccc catccctata
     1321 ggggaactgc gattgagtat tccacaggct gtgagataga ttggaatgaa ggaaagaatg
     1381 tcactttgaa aaccatcaag aagaaacaga aacatcggat ctggggaaca atccgaactg
     1441 taactgaaga ttttcccaag gattcatttt tcaatttttt ctctcctcat ggaatcacct
     1501 caaatggaag ggatggaaat gatgattttt tacttggtca caatttacgt acttacataa
     1561 ttccaagatc agtattattt ttctcaggtg atgcactgga atctcagcag gagggggtag
     1621 ttagagaagt taatgatgca atttatgaca aaattattta tgataattgg atggctgcaa
     1681 ttgaggaagt taaagcttgt tgcaaaaacc ttgaggcatt agtagaagac attgatcgtt
     1741 agagcagagt atacatggcc ctgaaattaa ctgccctaga tatagttact caaggtataa
     1801 gaagccttgt gttctgtatt tttcttgtag tgttagttaa aacatatgtt tcaaaaatat
     1861 aagaaaagtt caaaaactaa ttaatttgac cttgagtttt agtagtagaa tgttttcaag
     1921 aaatgtacac tgtggtaaat gatttaaaac actagtatag tgttgtgtag cttaatcctt
     1981 ctgaagtctt tttgtcatgt agctattaat ctgtggctat gaaatgatca gaaatgctaa
     2041 gtgagatcaa tatttgtttg gaaaaaaaat cttgggaaac aacccaaggg ttttcgctgt
     2101 tgttgttttt ctttttctat ttttgtttac ttagtccttt agctagtgga tttaattttg
     2161 ttgtgcctgc ttcattttgc aataacaatg cagtagaatt taaaacttgg atgcttaaga
     2221 ggcctgcata tagataagaa tttcaggcaa aactacattt attgttaata acagcttgtt
     2281 cataggctct tgtattttat gtaactgtga taaataatga aacttagtta tattgaggtt
     2341 attgtttgtc ggtgaagtgt tagtcacagt attttcaaaa gtttgcacat attgttctgt
     2401 gtaattgtgt aagccataat tacagtgttt aattctcttt tcctattaca tcattcattg
     2461 aaagtgatca ctttaccatt ttgaaaagat atttcgtgtt ctttcactgc aaaataaaaa
     2521 gaataaaaat ttcagagtgt ctcatgttta aaa
//
