LOCUS       NM_004537              13159 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens nucleosome assembly protein 1 like 1 (NAP1L1),
            transcript variant 2, mRNA.
ACCESSION   NM_004537 NM_022348
VERSION     NM_004537.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13159)
  AUTHORS   Zhu,X., Li,Y., Shao,Z., Lu,X. and Chen,Y.
  TITLE     NAP1L1 Promotes Endometrial Cancer Progression via EP300-Mediated
            DDX5 Promoter Acetylation
  JOURNAL   Mol Cancer Res 22 (11), 1011-1021 (2024)
   PUBMED   38953887
  REMARK    GeneRIF: NAP1L1 Promotes Endometrial Cancer Progression via
            EP300-Mediated DDX5 Promoter Acetylation.
REFERENCE   2  (bases 1 to 13159)
  AUTHORS   Gul,G., Aydin,M.A., Algul,S., Kiziltan,R. and Kemik,O.
  TITLE     Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer
            patients: a potential biomarker with diagnostic and prognostic
            utility
  JOURNAL   Biomarkers 29 (1), 30-35 (2024)
   PUBMED   38258494
  REMARK    GeneRIF: Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric
            cancer patients: a potential biomarker with diagnostic and
            prognostic utility.
REFERENCE   3  (bases 1 to 13159)
  AUTHORS   Ohtomo,H., Yamane,T., Oda,T., Kodera,N., Kurita,J.I., Tsunaka,Y.,
            Amyot,R., Ikeguchi,M. and Nishimura,Y.
  TITLE     Dynamic Solution Structures of Whole Human NAP1 Dimer Bound to One
            and Two Histone H2A-H2B Heterodimers Obtained by Integrative
            Methods
  JOURNAL   J Mol Biol 435 (15), 168189 (2023)
   PUBMED   37380014
  REMARK    GeneRIF: Dynamic Solution Structures of Whole Human NAP1 Dimer
            Bound to One and Two Histone H2A-H2B Heterodimers Obtained by
            Integrative Methods.
REFERENCE   4  (bases 1 to 13159)
  AUTHORS   Freitag,M. and Schwertz,H.
  TITLE     A New Role of NAP1L1 in Megakaryocytes and Human Platelets
  JOURNAL   Int J Mol Sci 23 (23), 14694 (2022)
   PUBMED   36499021
  REMARK    GeneRIF: A New Role of NAP1L1 in Megakaryocytes and Human
            Platelets.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13159)
  AUTHORS   Xiaohua,Zhu., Xie,Y., Huang,W., Chen,Z. and Guo,S.
  TITLE     NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in
            ovarian cancer
  JOURNAL   BMC Cancer 22 (1), 339 (2022)
   PUBMED   35351053
  REMARK    GeneRIF: NAP1L1 promotes tumor proliferation through HDGF/C-JUN
            signaling in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13159)
  AUTHORS   Kho,Y., Kim,S.C., Jiang,C., Barma,D., Kwon,S.W., Cheng,J.,
            Jaunbergs,J., Weinbaum,C., Tamanoi,F., Falck,J. and Zhao,Y.
  TITLE     A tagging-via-substrate technology for detection and proteomics of
            farnesylated proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (34), 12479-12484 (2004)
   PUBMED   15308774
REFERENCE   7  (bases 1 to 13159)
  AUTHORS   Rehtanz,M., Schmidt,H.M., Warthorst,U. and Steger,G.
  TITLE     Direct interaction between nucleosome assembly protein 1 and the
            papillomavirus E2 proteins involved in activation of transcription
  JOURNAL   Mol Cell Biol 24 (5), 2153-2168 (2004)
   PUBMED   14966293
  REMARK    GeneRIF: These results suggest that the binding of
            sequence-specific DNA binding proteins to human nucleosome assembly
            protein 1 may be an important step contributing to the activation
            of transcription.
REFERENCE   8  (bases 1 to 13159)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   9  (bases 1 to 13159)
  AUTHORS   Asahara,H., Tartare-Deckert,S., Nakagawa,T., Ikehara,T., Hirose,F.,
            Hunter,T., Ito,T. and Montminy,M.
  TITLE     Dual roles of p300 in chromatin assembly and transcriptional
            activation in cooperation with nucleosome assembly protein 1 in
            vitro
  JOURNAL   Mol Cell Biol 22 (9), 2974-2983 (2002)
   PUBMED   11940655
REFERENCE   10 (bases 1 to 13159)
  AUTHORS   Simon,H.U., Mills,G.B., Kozlowski,M., Hogg,D., Branch,D., Ishimi,Y.
            and Siminovitch,K.A.
  TITLE     Molecular characterization of hNRP, a cDNA encoding a human
            nucleosome-assembly-protein-I-related gene product involved in the
            induction of cell proliferation
  JOURNAL   Biochem J 297 (Pt 2) (Pt 2), 389-397 (1994)
   PUBMED   8297347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU183927.1, AL162068.1,
            DA512918.1, AW950481.1, AF300335.2, DA137494.1, CD000987.1,
            CD678271.1, DB546929.1, AC011611.26 and AA057019.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004537.6.
            
            Summary: This gene encodes a member of the nucleosome assembly
            protein (NAP) family. This protein participates in DNA replication
            and may play a role in modulating chromatin formation and
            contribute to the regulation of cell proliferation. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms; however, not all have been fully described. [provided by
            RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2 and 4
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL162068.1, SRR11853565.7328.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618691.5/ ENSP00000477538.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               BU183927.1         348-466
            120-609             AL162068.1         105-594
            610-610             DA512918.1         431-431
            611-2316            AL162068.1         596-2301
            2317-2779           AW950481.1         125-587
            2780-3279           AF300335.2         280-779
            3280-3678           DA137494.1         159-557
            3679-3872           CD000987.1         3-196
            3873-4385           CD678271.1         1-513
            4386-4852           DB546929.1         1-467
            4853-4881           AC011611.26        133718-133746       c
            4882-4999           AA057019.1         32-149              c
            5000-13159          AC011611.26        125440-133599       c
FEATURES             Location/Qualifiers
     source          1..13159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..13159
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /note="nucleosome assembly protein 1 like 1"
                     /db_xref="GeneID:4673"
                     /db_xref="HGNC:HGNC:7637"
                     /db_xref="MIM:164060"
     exon            1..119
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            120..156
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1315
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /note="isoform 1 is encoded by transcript variant 2;
                     HSP22-like protein interacting protein; NAP-1-related
                     protein"
                     /codon_start=1
                     /product="nucleosome assembly protein 1-like 1 isoform 1"
                     /protein_id="NP_004528.1"
                     /db_xref="CCDS:CCDS9013.1"
                     /db_xref="GeneID:4673"
                     /db_xref="HGNC:HGNC:7637"
                     /db_xref="MIM:164060"
                     /translation="MADIDNKEQSELDQDLDDVEEVEEEETGEETKLKARQLTVQMMQ
                     NPQILAALQERLDGLVETPTGYIESLPRVVKRRVNALKNLQVKCAQIEAKFYEEVHDL
                     ERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEISEELKEKAKIEDEKKDEE
                     KEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFVLEFHF
                     EPNEYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKK
                     QKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPESGDLDDDAEAILAADFEIGHFLRERI
                     IPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ"
     exon            157..242
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            243..345
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            346..487
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            488..568
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            569..697
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            698..769
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            770..909
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1055
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1075
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1198
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1228
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1279
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..13159
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /note="hexamer: AATAAA"
     polyA_site      2148
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /note="major polyA site"
     regulatory      4831..4836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /note="hexamer: AATATA"
     polyA_site      4854
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
     regulatory      4982..4987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /note="hexamer: AATACA"
     polyA_site      4999
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
     regulatory      13136..13141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
                     /note="hexamer: ATTAAA"
     polyA_site      13159
                     /gene="NAP1L1"
                     /gene_synonym="NAP1; NAP1L; NRP"
ORIGIN      
        1 cttttttagc gccatctgct cgcggcgccg cctcctgctc ctcccgctgc tgctgccgct
       61 gccgccctga gtcactgcct gcgcagctcc ggccgcctgg ctccccatac tagtcgccga
      121 tatttggagt tcttacaaca tggcagacat tgacaacaaa gaacagtctg aacttgatca
      181 agatttggat gatgttgaag aagtagaaga agaggaaact ggtgaagaaa caaaactcaa
      241 agcacgtcag ctaactgttc agatgatgca aaatcctcag attcttgcag cccttcaaga
      301 aagacttgat ggtctggtag aaacaccaac aggatacatt gaaagcctgc ctagggtagt
      361 taaaagacga gtgaatgctc tcaaaaacct gcaagttaaa tgtgcacaga tagaagccaa
      421 attctatgag gaagttcacg atcttgaaag gaagtatgct gttctctatc agcctctatt
      481 tgataagcga tttgaaatta ttaatgcaat ttatgaacct acggaagaag aatgtgaatg
      541 gaaaccagat gaagaagatg agatttcgga ggaattgaaa gaaaaggcca agattgaaga
      601 tgagaaaaaa gatgaagaaa aagaagaccc caaaggaatt cctgaatttt ggttaactgt
      661 ttttaagaat gttgacttgc tcagtgatat ggttcaggaa cacgatgaac ctattctgaa
      721 gcacttgaaa gatattaaag tgaagttctc agatgctggc cagcctatga gttttgtctt
      781 agaatttcac tttgaaccca atgaatattt tacaaatgaa gtgctgacaa agacatacag
      841 gatgaggtca gaaccagatg attctgatcc cttttctttt gatggaccag aaattatggg
      901 ttgtacaggg tgccagatag attggaaaaa aggaaagaat gtcactttga aaactattaa
      961 gaagaagcag aaacacaagg gacgtgggac agttcgtact gtgactaaaa cagtttccaa
     1021 tgactctttc tttaactttt ttgcccctcc tgaagttcct gagagtggag atctggatga
     1081 tgatgctgaa gctatccttg ctgcagactt cgaaattggt cactttttac gtgagcgtat
     1141 aatcccaaga tcagtgttat attttactgg agaagctatt gaagatgatg atgatgatta
     1201 tgatgaagaa ggtgaagaag cggatgagga aggggaagaa gaaggagatg aggaaaatga
     1261 tccagactat gacccaaaga aggatcaaaa cccagcagag tgcaagcagc agtgaagcag
     1321 gatgtatgtg gccttgagga taacctgcac tgtaatagcc taaacacaac tcttatttac
     1381 ttacagcctt atgtttttgt attttcttgg tagactaggt aatttttttt taaaggacag
     1441 gaaactgata ttttaaagac caatttgttc tacctagcat tttaactagt ttttctgcca
     1501 gctatgttga atgcacaaat tctgtcacgc atgttcattc attgctacat aatttggttc
     1561 ttctggaata tttttatgta gctcttggag tacagctatg aaaattaaca actgttaaag
     1621 gaaatacctt tttttttttt ttgtaatttt ttccttgaag aaccaaagta ttttttcagc
     1681 tggttgttga atagggttaa gtccgcttgg attagctgtg cctttcatta ctttgttaca
     1741 gaaatgcagt gacttatact aagacaattt attgtttaaa aaaaaaattg gcaagacaac
     1801 tatatggtta agaatttcca gtatgaccac acccaataac tgttattaga gtgttaatgg
     1861 attattgtgt tttaggtgac atagttaact gtaaagtaac ctgactcagt atagttactg
     1921 gtaccacagt gaggtgaata aaacgggatt ttcagaagtt agcctgaatt taactgtatt
     1981 tttaaattta acctccatta actaagcatc ttttctttgt ggtagggtct accttctgct
     2041 tccctggaaa ggatgaattt acatcatttg acaagcctat tttcaagtta tttgttgttt
     2101 gtttgcttgt ttttgttttt gcagctaaaa taaaaatttc aaatacaatt ttagttctta
     2161 caagataatg tcttaatttt gtaccaattc aggtagaagt agaggcctac cttgaattaa
     2221 gggttatact cagtttttaa cacattgttg aagaaaaggt accagctttg gaacgagatg
     2281 ctatactaat aagcaagtgt aaaaaaaaaa aaaaaagagg aagaaaatct taagtgattg
     2341 atgctgtttt cttttaaaaa aaaaaaaaaa aattcatttt ctttgggtta gagctagaga
     2401 gaaggcccca agcttctatg gtttcttcta attcttattg cttaaagtat gagtatgtca
     2461 cttacccgtg cttctgttta ctgtgtaatt aaaatgggta gtactgttta cctaactacc
     2521 tcatggatgt gttaaggcat attgagttaa atctcatata atgtttctca atcttgttaa
     2581 aagctcaaaa ttttgggcct atttgtaatg ccagtgtgac actaagcatt ttgttcacac
     2641 cacgctttga taactaaact ggaaaacaaa ggtgttaagt acctctgttc tggatctggg
     2701 cagtcagcac tctttttaga tctttgtgtg gctcctattt ttatagaagt ggagggatgc
     2761 actatttcac aaggtccaag atttgttttc agatattttt gatgactgta ttgtaaatac
     2821 tacagggata gcactatagt attgtagtca tgagacttaa agtggaaata agactatttt
     2881 tgacaaaaga tgccattaaa tttcagactg tagagccaca tttacaatac ctcaggctaa
     2941 ttactgttaa ttttggggtt gaactttttt ttgacagtga gggtggatta ttggattgtc
     3001 attagaggaa ggtctagatt tcctgctctt aataaaatta cattgaattg atttttagag
     3061 gtaatgaaaa cttcctttct gagaagttag tgttaaggtc ttggaatgtg aacacattgt
     3121 ttgtagtgct atccattcct ctcctgagat tttaacttac tactggaaat ccttaaccaa
     3181 ttataatagc tttttttctt tattttcaaa atgatttcct ttgctttgat tagacactat
     3241 gtgctttttt tttttaacca tagttcatcg aaatgcagct ttttctgaac ttcaaagata
     3301 gaatcccatt tttaatgaac tgaagtagca aaatcatctt tttcattctt taggaaatag
     3361 ctattgccaa agtgaaggtg tagataatac ctagtcttgt tacataaagg ggatgtggtt
     3421 tgcagaagaa ttttctttat aaaattgaag ttttaaggga cgtcagtgtt tatgccattt
     3481 ttccagttcc aaaatgattc cattccattc tagaaatttg aagtatgtaa cctgaaatcc
     3541 ttaataaaat ttggatttaa ttttataaaa tgtactggtg atattttggg tgtttttttt
     3601 taaatgaatg tatatacttt ttttttgaag agtggagagt agtgatgtct agagggagct
     3661 attttgtgct gaggccacta tgttctgtaa atatataatt ttaagagcaa cctcacaatc
     3721 cctgctaagt ggagtttatt atttgaagac taaaatggaa ttccatagtt cctgataggt
     3781 tatattctgg gttattattc tgagttatct acaaacattt ttgagatttg tctttacact
     3841 ctgattgtag tttccagcag cccatgcaca ctgccaagta agtctcattt tttcctgtta
     3901 gaaatggtga aatatcatat aatcacttat aaagaaaact gatatgaaaa aattttagag
     3961 ttgtttgctt tatggtcact caagtagggt aagtgttcca caaattccac aagttgatag
     4021 tttaacatgg atgtctgaaa gccacatata taatttctta ggattcttaa attagtaaat
     4081 ctagcttact gaagcagtat tagcatcact attttagatt gcaaaaatac cttaattgtg
     4141 tggaactggc ttgtagagtg gtacttaaga aaaatgggat tctacctcta tttctgtttt
     4201 agcacactta atcaggaaag gatatattaa ctttcataaa aatatttttg ttgtgtgaat
     4261 aggttaatga tatggtaagg cccctaaaat aactgaatta attgtttatt gtaattgtag
     4321 gccattccca ttattaaaaa taaagacaaa acttgaagta actgaaaatc ttatcgtgct
     4381 atgtagaaat attgaactaa tattcaaata tttgaatgct ttggtttcag ggattggttt
     4441 aaaattggag tcctttttta tgggttagtc ttacaaaaat ttaagccttt atatttttga
     4501 ctttaaatca aaacaaatgt tattttaaat gtacagaata gattggtagt gcagaagagt
     4561 gtaagttctt cataggagct ttagaaaaga gaaatatgtg ctaattcagt ttttttttaa
     4621 tctgcactgt acatatatac ttggtaatta tgagcttgat tttgtttttg gaaatatgtg
     4681 ttcataattt aggtaatttg ctacttaaag cactaagtct ctgatacctg aaaagtacat
     4741 gtaaatggtg atggtgaaat aatactgcag ttaacttaat agatgtatac tggtgatttt
     4801 tgtatgctgg attaaaactc cagatattaa aatataacct ggataaaaag ccaagttctt
     4861 ggactgattg aggatcactt acatgacttt acagaaatgg aaacatcctt gttggtatat
     4921 gaaattattt tactcaagga taagtattca taagaaattt tgattgatgt atattttcaa
     4981 aaatacagta tgctttgtat cttgtgtttc ttccttttga catcatattg tcaggttttc
     5041 cagtttacaa aaattaagtt attcactaaa atcttagtac agacagtccc tgacttataa
     5101 tggtttgact taagacttca gctttatgag tttattggag tattaaacac atcttctact
     5161 tatgatattt ttgacttaca gtgggcttat tgaggcccga ccatgtcatc ctcaagccaa
     5221 gagtctgaat aaaagaagaa atggggtatt tagaaataat agattactgg cgggaaataa
     5281 gtcagtctgg ttgtttaatt ttcctatggg aaattgggca ttttaagttt tgtggatcct
     5341 agaacaaact gagttttatt attttgaaac ccaggataaa atattacata aaagcattgc
     5401 tttttagttt cttacatgtt ttatccattt atttttattt ttgagataga gtcttgctct
     5461 gttgcccagg ctggagtgca gtggcatgat ctcggctcac tacagctgtc atctcccggg
     5521 ttcaagcgat tctcgtgcct cagcattcca agtagtcggg attacaggcg tgtgccactg
     5581 agcccagctg atttttgtac ttttagtaga gatgggtttt caccatgttg gccaggctgg
     5641 tctcgacctc ctgacctcca gtgatcctcc cacctcagcc tctcaaagtg ctggcctctc
     5701 aaaagtgctg ggattacaag catgagccac cacgcccagc cagtttctta catgttttaa
     5761 acttaaagcc aaaaagaagg aactaggaat gtgtgattaa acgtgagtgc cagaagtcga
     5821 cagatctcat atccagagtt gaaggtctta ttcataattt tatcattcat aatgtattag
     5881 gcaattgcgg ctctggtaaa tttcatgagg ttgtaaaata gttgctacca gaaggctcaa
     5941 aatttgtatg agcttttagc tgagattttg agaatctgta ggaatttgtg aagtgagagg
     6001 aagaacctct gaacggtgag cagttcaggt ggaggaacag gaggaaatac aggcaaaggt
     6061 cccagaacag aacaattgag gctacattca aggaattgag atacctggaa atacaggtag
     6121 aaatacaagt ggccagtcca tagaaagttt agctgtggaa gtcctcttaa tgggtttaaa
     6181 acactggaac cacctgttac aagagtattt caagtgagga tgaggatgac cattccatgt
     6241 agaaattttt tttttttttt ttttttctga gacagggtct tacttcattt gcccaggttg
     6301 gagtgtactg ctgcaatcag cctctcgagt agctggtatc acaggcacgt gccaccacgc
     6361 ccagctaatt tttacatttg ttgagaggtg tttcaccatg ttggccaggc tggtttcgaa
     6421 ctcctggact caggtaatcc acccatcttg gtctcccaaa gtgctgggat tacagacgtt
     6481 agccactgca cctggctgaa agataatttt taaaggaaga catgattgat agaccaagtc
     6541 agccatttga aggtcagaac atttgaggta ggtgggcccc aggggccagt aaaggcttca
     6601 gggtcatata tatgcaactg aaaaagtaag ttaaatgacg tggcagcagc agtgaacaag
     6661 acgctgttag ctgttaagat aatttactta gccaagaaca aaagctttat ttaaaaaaat
     6721 tgctgaataa agttttatct gcagtgaatc cccttagtca aactccagat tggtgttttg
     6781 gggtaactta tcaatattac agctttcctt caactctgaa aatagttgaa agaattccgg
     6841 tatattcttt actctgatca acatactttt tggctcaaaa agttttctag tcttacaggc
     6901 gttttctatt tcagccctgg aatgggccat ttctccaagg attgctggct tcttagaata
     6961 gggagtatta cttagaaact taagtccagt tgctgaatat gctctttaca gggtatttct
     7021 agggcctttc aggtgaaaga aaatttgtac atgtatcata aaaactgaac gcacagtgga
     7081 tactttgaag ttgaatcaaa caatgttatt tttcctactg ctactgccgt ccgtatttgt
     7141 aattattttc aaataagtgg aatcagttga tccaactagg aaagtagatg aggttgctct
     7201 ataggaataa gaatccatga ataaaaatgg agatctaatt ttagactaaa acttttcagc
     7261 ccctaaacaa atgtctctgc taccaaattt taatggatat gtgtgagaat acaagtagtg
     7321 tctttgggta gtgtctttaa acacaggctt tagagtctgt ctaccacctg ttggttcagc
     7381 atcagtcttt tcatctgtat tgcgaaagat cgtggtgaac attaataagg aaacaaaagt
     7441 acttagagcc tatgagcact tcctaaacat aagaaaacct aaaatttgtg attgggatta
     7501 ctttttaaat tggttttaga actttatttc tgaactagtt ggggttttct tggttcaaag
     7561 gcaaaattcc tcctaggtgt aagggatgca ttactcagtg tacataagaa cactgagact
     7621 aagactggat aataaaatta aacatatgcc tcgttttgaa gattttatgt gtaaaaaaca
     7681 aaaaaaaaat tgaccttaac ctaaagtgag ctaggtttga aaatctcatc tcattccttt
     7741 cttgttttat tttaatacat gtgttttcat atgctgttta ctttctttgg cctttggcag
     7801 aacccagaaa tgatctaggg taaaacgaaa tgaggtatcg ctatatattt ggatttctca
     7861 tgcttcagaa tacccaaatt gtcattattc aggttatccc ttctatctcc caacatttac
     7921 ctggagcctt gacactggtg tggatgtgac atgggtgtct gtcttgagat cagatgtgat
     7981 tttagacttg gattaggcca gtcaacaaag ttttattttt attatctttg agatgattct
     8041 cactatgttg cctggactag tgtctaactc ctgggctcaa gtggttgtct cacctcaacc
     8101 tcctgaggtg ctatgcttac aagtgggagc tgccgcactt aactatggat ttcaaaactg
     8161 gaggctggaa ctgttgtctt tgctattcat ttggcttggt gagtggactt agccacttca
     8221 cggcaacttg gagatgaata gcccactgta tttaacctgc atttgcacta tttcagctct
     8281 gcttggctgc cttttctttt acttctgcca ctgggctttt gtgcatgtgt tttactagtt
     8341 caacatagga tctccttttc atcagtacct actctttggt tctataaatc tgaactggtt
     8401 ttgaaccagt tcaaaatact ctagaaacac ttgcttatta atgagtttcc taatttccag
     8461 cactgtgctt ggaacttggt aagtgtacag aaaagttttg gatgtatagg tcagttagga
     8521 tttatctaga cccattcaat gtaccaacca taatcctgtg tgggactgtg tagcaagtcg
     8581 aatgattgat tctcagtagt tcagtctcta aggtcttttg tagttgtcat attcctgtag
     8641 attgagaaaa ccaatgaaac aaagctggat tgtgtataca gttagctctt tcataatgca
     8701 ggggctaggg gccccagctt ccttcagtca aatctatgta taagctgatt cccccaaaac
     8761 ttgacagcct actgtggaaa ctttaccaat aagtcattta acacacactt tgtatgttat
     8821 gtgtattata tactgtaaaa agtaagctag agaaaatgtt aagcaatcgg aaatatatta
     8881 tggccaggtg tggtggctca tgcctgtaat cccaacactt tgggaggctg aggcgggcca
     8941 gtgacttgag gttacaagtt cgagaccagc ctggctaata tggagaaacc ctgcctctac
     9001 taaaaataca aaacttagct gtaggtggta gtggtgtgtg cctgtagtcc aagctactca
     9061 ggaggctgag gcacaagaat tgattgaact ctggaggtgg aggttgcagt gagcccacaa
     9121 gaattgactg aactcgggag gtggaggttg cagtgagccg agatagtgcc actgcactcc
     9181 aacctgagca acagaatgaa actgtctgtg tgtgtgtgtg tgtgtatgta tatgtatgtg
     9241 tatgtatatt tactctcagg tggaactgga ttataacagt ctcaatcctc actgccttca
     9301 tgaatagctg aggaggaggg gggtcttgct gtcacagggg tagtagagac agaagtaaac
     9361 ctgtaagtgg accctcttag ttcaaatttg atattcaaga gtcaacttag ttgtttttta
     9421 aagtcaaggg aaggcatatc aatagttgca gttacctagt actgcataac aaaacaacct
     9481 ccaaaactta atggcttaaa acaagcaaaa tttttctgac tgggcttagt ttgttgcagt
     9541 cgttttccaa aatgaccaaa gacatcaaag cttaaattac atattgtatg cctgttcagg
     9601 gagaaaaaca tatgcttttc cccatcattt tggaatcttt tacttgaatt atagctggac
     9661 aattgatttc cagctataat tcaagctata acgtagtgaa ctccctcaga caaaaatgtc
     9721 aagcttgatt agtaaaggaa cctcaagtgg tatgtataag gtgaccctta agtacacgtg
     9781 ttttcaaaag ttgggtataa tgtaactaga ctgagaggtt tcgagaaaaa cttcattgct
     9841 attccatgta tagttttaaa ctagtgggat ttcagtttac agtattaatc agcaatttgg
     9901 ggagaactaa gtgttcgttt aacattaaga taataaaaat aatgccttaa tcatacttga
     9961 ttgagaatat taattccctt tttatgcata aggatggaag ttaagtaact ttaacaatga
    10021 cacagttgag ttgtgttgga gccagcattt ggatggccct acactttgca ctgccttgta
    10081 gatatttctg tcacacaact agtggttaaa taagcatgtt ctttaggcta gagctttcag
    10141 agatgaaata ttttagagac cagagttaat ctagatttca ttttaaacaa tattcagata
    10201 atctttcctt tttctctccc ctgccctgaa gagtttgtat ttattataat gttgtataac
    10261 acagccccaa tacaatgtgg cttatatagg tttttctctt aggcttagac agactctggg
    10321 actgatatgg gagcttcatg gttctcaggc agactttcat tctacttttt gtctttggca
    10381 agttggttta ttatcaagtg gttgctgggg ctctatacat catgtccagg ttcaaggtac
    10441 aggatgggct gaaggaggct aaaggctact ggcatccaac ctctcctgta aaaagaagaa
    10501 cctatggttt atgctcacag tgctaaaagt aggatagtaa ataaaataga gctgggtgtg
    10561 aatgccaagg gaggttagga tgacagccac attggccaca tatgtcgaaa taagttgatt
    10621 tagaaaagga ttatttgatc aaggatatcc tggaacataa agcaaataac tacattttag
    10681 aaataagtga acagggctaa gaaaagtaat tttctttaaa tacggcccaa aaggattaat
    10741 tatgattgga gtcctgcttt gcccaaggct ttttatttca ttttgcatga taacctttct
    10801 cagaaccatg catgcacaaa ttaggttgag acaatgactt aaaagtgtaa atgaaatctc
    10861 attagaaaca aaaactttct ggtttctgac atgtttaagg ggtgctcatt gttactcaac
    10921 aatgatttac ttaggtagtt attgtgatgg gggcggttct aatgggattt ctttttctgg
    10981 taggtttagt ggcaacatac aagcttgcca taaacatttc ctgggtttta tcttcttgta
    11041 aaagtgttat tccacctttc tgagtctggc taccccacag aattctttta tcccttttac
    11101 tcttagatta ccttgtctgt aatgaaactt accctctctg aagcctgagt tgttcttcta
    11161 aagtaacacc actaccacct tctttattct catgtttttg ggaggaattg tctacactca
    11221 ctgctatatg tcctctatca cctaagaaag gtatttgccc attactggat ttttttttct
    11281 tacagagatc aatagtgatc aaattgaaca gcctatgtcc tcaggctgtg tgttttgtgg
    11341 caatggaaaa atgacagcaa aagagggaaa tatccttgga atttagttcc ttaaatggag
    11401 gtatttgccc aagtgactgt cagttacata tttgagttgc aaacaacggg ttgcatttac
    11461 cgggtttcag agtagaagca tacttaggaa aggtggtagg tgttcttggg ctcttcagtg
    11521 gggacagagg attgcttcca ctcttagtta ctggggtatc ttgtcacccc agagacccag
    11581 agccagaata tcaacacttt tgagtgattg cagttttgtg acaacataat actggttctc
    11641 tcagcctcct tcattggatt accttcctct ctgctccatt tcatccagtt ccatattttc
    11701 gtttgtcact tcaaagctaa tattaccata acaagtttac aaataatcag acttcctggt
    11761 tacttgttaa tactcaataa gatagcctgc ttgcccattt tgaataatat caatacattt
    11821 ccagacaaaa cattagtcat ttcccctcag tttaagtgct gtcaatcagc tctccgttag
    11881 gtacaatggc gaaaacactc atccaggatc ttggatattt agtgaagtag acgtgaaaat
    11941 tggataacta ctcatcagag tttgaagtga ttaggaagga attaactcag ccagaggaaa
    12001 tctgggattt gaatagggct ttgaagaatg aaaggtttac agaggatttg ggaaggtaaa
    12061 ttggaggctg cgaggacaag gagatgtatg actggcactc gctcaaggtt gagtggaacg
    12121 agtcaaaata agtaggaccc attctgtgga gggcttgtca tgcaagggta aggaattgga
    12181 atgtatacaa ttggaggcga atagaagttt tctgtcatgt tttaagagta aaactgaagg
    12241 ccatgtgtat gagtatggat caggtgattg ggccacccaa gaacttagat gagagaactg
    12301 aattaggctg ctggcagaac agaaaggacg gagacagctg atggacggtg cttggatcca
    12361 caattgtgtt tgtactacag ttaaaaaaaa gcgctaagca ctcattataa agcacttgct
    12421 ttaagctgtt acacagattg gtcactagga ggcatcagtt catcaactac taaggcgaaa
    12481 aggaaggcag ctctggacac ccacctaaga agtctggata gttctgtgtt aatacttaac
    12541 gttttcaact caaggacttt tggaaactag aatctagaat atttcttctg aatagtactt
    12601 caaagatgaa ataaggctaa gaagtctaaa ctgcactctg tgagactatt tgtttattta
    12661 tttaattatt tattttgaga cagattctcg ctctgttgcc caggctggag tgcagtggcg
    12721 tgatcttggc tcactgtaac cttcacctcc ctggctcaag caattctcct gcctcagcct
    12781 cccgagtagc tgggattaca ggcgctgtgg gttttttttt tttttgtatt tttagtagag
    12841 acggggtttc accatgttgg ccagacttgt gtcgagctcc tgacctcagg caatccgcct
    12901 gcctcagcct cccaaagtgt tgggattaca ggcgtgagcc accgcgccca gccttggtta
    12961 tcttttatac cctgatgagg gtaacgtgac atgttcataa tttactgggc tttaactttt
    13021 tcttgaaaga tgtttgacct ttggtctatc caaatcttta ataatgatca ttgtcatgag
    13081 tttctactgt atattgcaaa ttggtttaca gatcagaatt ttgtaatcat tatgaattaa
    13141 acacttaata actttccaa
//
