LOCUS       NM_152667               3803 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens N-acetylneuraminic acid phosphatase (NANP), mRNA.
ACCESSION   NM_152667
VERSION     NM_152667.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3803)
  AUTHORS   Willems,A.P., Sun,L., Schulz,M.A., Tian,W., Ashikov,A., van
            Scherpenzeel,M., Hermans,E., Clausen,H., Yang,Z. and Lefeber,D.J.
  TITLE     Activity of N-acylneuraminate-9-phosphatase (NANP) is not essential
            for de novo sialic acid biosynthesis
  JOURNAL   Biochim Biophys Acta Gen Subj 1863 (10), 1471-1479 (2019)
   PUBMED   31121216
REFERENCE   2  (bases 1 to 3803)
  AUTHORS   Kim,S.H., Constantine,K.L., Duke,G.J., Goldfarb,V., Hunt,J.T.,
            Johnson,S., Kish,K., Klei,H.E., McDonnell,P.A., Metzler,W.J.,
            Mueller,L., Poss,M.A., Fairchild,C.R. and Bhide,R.S.
  TITLE     Design, synthesis, functional and structural characterization of an
            inhibitor of N-acetylneuraminate-9-phosphate phosphatase:
            observation of extensive dynamics in an enzyme/inhibitor complex
  JOURNAL   Bioorg Med Chem Lett 23 (14), 4107-4111 (2013)
   PUBMED   23747226
REFERENCE   3  (bases 1 to 3803)
  AUTHORS   Maliekal,P., Vertommen,D., Delpierre,G. and Van Schaftingen,E.
  TITLE     Identification of the sequence encoding
            N-acetylneuraminate-9-phosphate phosphatase
  JOURNAL   Glycobiology 16 (2), 165-172 (2006)
   PUBMED   16237198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031673.19, DA858639.1, BC022552.1, AL833116.1, CF126993.1 and
            AI693731.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152667.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833116.1, SRR1803616.119896.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304788.4/ ENSP00000302441.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL031673.19        30425-30426         c
            3-36                DA858639.1         1-34
            37-1505             BC022552.1         1-1469
            1506-2250           AL833116.1         1477-2221
            2251-2920           CF126993.1         72-741
            2921-3353           AL833116.1         2892-3324
            3354-3661           AI693731.1         38-345              c
            3662-3803           AL833116.1         3633-3774
FEATURES             Location/Qualifiers
     source          1..3803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..3803
                     /gene="NANP"
                     /gene_synonym="C20orf147; dJ694B14.3; HDHD4"
                     /note="N-acetylneuraminic acid phosphatase"
                     /db_xref="GeneID:140838"
                     /db_xref="HGNC:HGNC:16140"
                     /db_xref="MIM:610763"
     exon            1..156
                     /gene="NANP"
                     /gene_synonym="C20orf147; dJ694B14.3; HDHD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..813
                     /gene="NANP"
                     /gene_synonym="C20orf147; dJ694B14.3; HDHD4"
                     /EC_number="3.1.3.29"
                     /note="haloacid dehalogenase-like hydrolase domain
                     containing 4; Neu5Ac-9-Pase; haloacid dehalogenase-like
                     hydrolase domain-containing protein 4"
                     /codon_start=1
                     /product="N-acylneuraminate-9-phosphatase"
                     /protein_id="NP_689880.1"
                     /db_xref="CCDS:CCDS13173.1"
                     /db_xref="GeneID:140838"
                     /db_xref="HGNC:HGNC:16140"
                     /db_xref="MIM:610763"
                     /translation="MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEE
                     AEIICDKVQVKLSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKS
                     TRLQHMTLAEDVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQ
                     REEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLK
                     SSPVPHYMVSSVLELPALLQSIDCKVSMST"
     exon            157..3803
                     /gene="NANP"
                     /gene_synonym="C20orf147; dJ694B14.3; HDHD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3142..3147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NANP"
                     /gene_synonym="C20orf147; dJ694B14.3; HDHD4"
                     /note="hexamer: AATAAA"
     polyA_site      3165
                     /gene="NANP"
                     /gene_synonym="C20orf147; dJ694B14.3; HDHD4"
                     /note="major polyA site"
     regulatory      3781..3786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NANP"
                     /gene_synonym="C20orf147; dJ694B14.3; HDHD4"
                     /note="hexamer: AATAAA"
     polyA_site      3803
                     /gene="NANP"
                     /gene_synonym="C20orf147; dJ694B14.3; HDHD4"
ORIGIN      
        1 gcagtccgcc ttgcgcatgc gcaggcggcg gtggcaaggc tacggttcgc gccagcggcc
       61 ggcgctatgg ggctgagccg cgtgcgggcg gttttctttg acttggacaa cactctcatc
      121 gacacggccg gggcgagcag gagaggcatg ttggaggtga taaaactctt acaatcaaaa
      181 taccattata aagaagaggc tgaaatcatc tgtgataaag ttcaagttaa actcagcaag
      241 gaatgttttc atccttacaa tacatgcatt actgatttaa ggacttcaca ttgggaagaa
      301 gcaatccagg aaacaaaagg tggtgcagcc aatagaaaat tggctgaaga atgttatttc
      361 ctttggaaat ctacacgttt acagcatatg acactagcag aagacgtcaa agccatgctt
      421 actgaacttc gaaaggaggt ccgcctactt ctattaacga atggggacag acagacccag
      481 agggagaaga ttgaggcttg tgcctgtcag tcctattttg acgctgttgt tgtaggtgga
      541 gagcagagag aggagaaacc agcaccgtcc atattttatt actgctgcaa tcttctcgga
      601 gtacaacctg gggactgtgt gatggtcggt gacacattag aaaccgacat ccaaggaggc
      661 ctcaatgcag gattgaaagc aacagtctgg atcaataaaa atggaatagt gccactgaag
      721 tcctccccag ttccgcatta catggtttct tctgtgctag agttacctgc tctcttacaa
      781 agtatagact gcaaagtcag tatgtccact taaagcacat aaaagggcat gattatgaat
      841 gttagaatca atttgctgag tatgaaataa gaaaagttag ggcactccac ttatgataat
      901 ccagctctaa gaataatttt acttatgatt taatggccaa tattttgaag gtcttcccaa
      961 ccctattgct tctaagttgt aacaaccaac cattgagtgg tacttatatc tgaaaattca
     1021 gattgcatga attcaggtca gtagtatagc ccagaaaatt taaggaaata tattatttgt
     1081 tagtctgtat ctggagcttt ttaaaattat gttattaatc ttttagtatc ttggctgcat
     1141 aatgccaagc aggattgctt tacacatgga tgcacaaatg taaggtttat cttctggctt
     1201 aaaaatagat atttttaaaa aatagatttt ctaaaacaca gatttatgaa agcaagtgaa
     1261 tctggttaat atgaaataag tactaagtca catgcaaatc aaggtattat atagtgaaat
     1321 tattttgcat attttgaaaa cataaaccat agtttttgcc tactttggat gtatactttc
     1381 ttttatgaac ctgatttttc tgtatgacat tttttttttt ttcagagggc agggagcaat
     1441 ttttctatgg catgtgacag attcctccag ttagaaaaag ctgttaaaat caacacatgg
     1501 tgctccttta ccgtgacatt ttctcacctg tgcacagtga gccggtagct tccttttagt
     1561 cttcacctct caaggaaatg tttttactgt cttttcccag acacacagtg gggttgaggg
     1621 agctaggctg ttttgctaga gataattgca aggcacgtgg cactaaaagt catttttctt
     1681 ctgtggatcc ataagaggaa catttcctca gtgtagccta acaatgcagc ccccaatctg
     1741 ttcctttttt tttttgaaat gggatctctg tcgcccaggt tggagtgcca tggcaccatc
     1801 tcggctcact gcaacctctg cctcctgagc tcaagtgatc ctcccacctc agcctcccaa
     1861 gggtgtgtgt gactacaagt acacactacc acgcccagct aatgtgtgtt tttgtagaga
     1921 tgggattttg ccatgttgcc caggctggtc tcgaattcct ggattcaagt gatcctccca
     1981 cctcagcctc ctaaagtcct aggattatag gcatgagcca ctgtgcctgg ccccctcatc
     2041 tgatagaaaa ttagattttg ctatgagcca tttcctgagg gccaatttaa tactcgtgtg
     2101 actcttctta gagttaccat ctgccttaaa tttcctctgt ttttcacatt cttggaaata
     2161 tatcattgtt ttgcaaattt ctatatctaa ttcagggttt accaggagct taataattaa
     2221 tggctacata gcaaggcatc gtcttggaac cggagaattt tctctagact attaggctag
     2281 acagtctcat gattatacta accaaacctg gagtaaagtg gttgaaaaaa aagaaagtat
     2341 aaaggggctt attaaagtgg ttaataaata tgatttaggt tggtttttga tatgtttttc
     2401 ttccaactgt tatataagaa actactaatg taaaatagta ggctatatgt tgggatgtgt
     2461 atagctatgt cttcaagact aatactcaga gaatcaaatt gtagattgta cctatctgtg
     2521 agcctatttc tttagccagt tttctgtcta ctgccaagaa acagaattct ctgcctcatg
     2581 caaatgccct ttcgtgttta cttttcgctc tagattttta aaaatgtgat tgtgcccttg
     2641 actgtaccaa agtgctgttg ctataacagt gaacatttgt gaacagagga tgtttgtagt
     2701 ttcaaatgca gtacccatat gaccttgatc atattttagc tatttaaaaa ttaagttgga
     2761 ggattttggc agaagtagtc acatgcatga ttgctctgat agattggttg gcgtgtgctg
     2821 cagggggctt gtccttttaa ctctcccaca ggatggatgt aggcagtgtc acattcatta
     2881 tgctgagagt gaaggttcat cactcctgta tcatggtagc aaatctcaac aggatagctt
     2941 ctaggatgtt aagtgagcag ttctccagca gaaatgatgt agaaggaaaa aattgaataa
     3001 ttaaatttcc ttgtcttcac agtttgtatt ctacagagta cagtaatgta ttacattcca
     3061 tttgcaccct tccttaggga agaactttgt ggttatctac cttctgagtg gaatgttaca
     3121 gaaaatattt taaaatattg gaataaacct atgattttat taatattttt tgttttagaa
     3181 taatattcct taaaattatg ggtgatgttt tgtcatcttt attttttttc aaagtttccc
     3241 tgtagtggcc ttctcacaca aagccagagg ccctccctaa cactgcttac agaggtgggc
     3301 ctagaacaga catgaatgga cactgcacct ggaataccag cacctggtgg ggaggtttgg
     3361 ttccatgtgc acctccacat acaaggcacg aacatctcag atctgggagt gcccaggacc
     3421 cagtggatgc tcagtattgt aggaaagcag gtctttacca aagttcttgg tttattgctt
     3481 tcaaacttct ttgcaacctt cagtaagaaa cattttctat cataacctct ttaacacatt
     3541 tatagtgtta gataacactg taactatata taaatataaa tataacacat gtatataaat
     3601 aaatataaat ataacatttt atagtataac attaatatgt gtatgggatc cagttttata
     3661 tgtttaattt tcataaaaca ttcttgttac gtgtgatgat atttttcatt ccattctttt
     3721 ttgaattagg gaatatattc attgttgaac aagtactact tgtagtacac aagtcaaaaa
     3781 aataaaaggg tgaatggtga aaa
//
