LOCUS       NM_001098622             948 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens nanos C2HC-type zinc finger 3 (NANOS3), transcript
            variant 1, mRNA.
ACCESSION   NM_001098622 XR_017750 XR_017928
VERSION     NM_001098622.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 948)
  AUTHORS   Karimi,H., Boroujeni,P.B., Sabbaghian,M. and Meybodi,A.M.
  TITLE     Gene Alterations and Expression Spectrum of NANOS3 in
            Nonobstructive Azoospermia
  JOURNAL   Reprod Sci 29 (1), 92-99 (2022)
   PUBMED   34417763
  REMARK    GeneRIF: Gene Alterations and Expression Spectrum of NANOS3 in
            Nonobstructive Azoospermia.
REFERENCE   2  (bases 1 to 948)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 948)
  AUTHORS   Sousa,B.L., Nishi,M.Y., Santos,M.G., Brito,V.N., Domenice,S. and
            Mendonca,B.B.
  TITLE     Mutation analysis of NANOS3 in Brazilian women with primary ovarian
            failure
  JOURNAL   Clinics (Sao Paulo) 71 (12), 695-698 (2016)
   PUBMED   28076512
  REMARK    GeneRIF: despite the prominent role of NANOS3 in ovarian
            development, our findings suggest that NANOS3 mutations were not
            associated with POF in the present cohort of Brazilian women.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 948)
  AUTHORS   Panula,S., Reda,A., Stukenborg,J.B., Ramathal,C., Sukhwani,M.,
            Albalushi,H., Edsgard,D., Nakamura,M., Soder,O., Orwig,K.E.,
            Yamanaka,S., Reijo Pera,R.A. and Hovatta,O.
  TITLE     Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells
  JOURNAL   PLoS One 11 (10), e0165268 (2016)
   PUBMED   27768780
  REMARK    GeneRIF: data can be used to further elucidate the role of NANOS3
            and DAZL in germ cell development both in vitro and in vivo
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 948)
  AUTHORS   Grelet,S., Andries,V., Polette,M., Gilles,C., Staes,K.,
            Martin,A.P., Kileztky,C., Terryn,C., Dalstein,V., Cheng,C.W.,
            Shen,C.Y., Birembaut,P., Van Roy,F. and Nawrocki-Raby,B.
  TITLE     The human NANOS3 gene contributes to lung tumour invasion by
            inducing epithelial-mesenchymal transition
  JOURNAL   J Pathol 237 (1), 25-37 (2015)
   PUBMED   25904364
  REMARK    GeneRIF: NANOS3 has role in the acquisition of invasiveness by
            human lung tumour cells and propose a new mechanism of
            post-transcriptional regulation of epithelial-mesenchymal
            transition.
REFERENCE   6  (bases 1 to 948)
  AUTHORS   Julaton,V.T. and Reijo Pera,R.A.
  TITLE     NANOS3 function in human germ cell development
  JOURNAL   Hum Mol Genet 20 (11), 2238-2250 (2011)
   PUBMED   21421998
  REMARK    GeneRIF: NANOS3 modulates essential aspects of human germ cell
            development perhaps during the cell cycle.
REFERENCE   7  (bases 1 to 948)
  AUTHORS   Kusz,K., Tomczyk,L., Spik,A., Latos-Bielenska,A., Jedrzejczak,P.,
            Pawelczyk,L. and Jaruzelska,J.
  TITLE     NANOS3 gene mutations in men with isolated sterility phenotype
  JOURNAL   Mol Reprod Dev 76 (9), 804 (2009)
   PUBMED   19565640
  REMARK    GeneRIF: Report for the first time analysis of the NANOS3 gene in
            infertile males.
REFERENCE   8  (bases 1 to 948)
  AUTHORS   Qin,Y., Zhao,H., Kovanci,E., Simpson,J.L., Chen,Z.J. and
            Rajkovic,A.
  TITLE     Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women
            with premature ovarian failure
  JOURNAL   Fertil Steril 88 (5), 1465-1467 (2007)
   PUBMED   17418157
  REMARK    GeneRIF: Mutations in NANOS3 exons are rare in both Chinese and
            Caucasian women with premature ovarian failure.
            GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 948)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   10 (bases 1 to 948)
  AUTHORS   Tsuda,M., Sasaoka,Y., Kiso,M., Abe,K., Haraguchi,S., Kobayashi,S.
            and Saga,Y.
  TITLE     Conserved role of nanos proteins in germ cell development
  JOURNAL   Science 301 (5637), 1239-1241 (2003)
   PUBMED   12947200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020916.8 and KF511254.1.
            
            On Sep 24, 2020 this sequence version replaced NM_001098622.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI793167.1, CK821051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339133.6/ ENSP00000341992.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-632               AC020916.8         90275-90906
            633-757             AC020916.8         93583-93707
            758-948             KF511254.1         182-372             c
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..948
                     /gene="NANOS3"
                     /gene_synonym="NANOS1L; NOS3; ZC2HC12C"
                     /note="nanos C2HC-type zinc finger 3"
                     /db_xref="GeneID:342977"
                     /db_xref="HGNC:HGNC:22048"
                     /db_xref="MIM:608229"
     exon            1..632
                     /gene="NANOS3"
                     /gene_synonym="NANOS1L; NOS3; ZC2HC12C"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..694
                     /gene="NANOS3"
                     /gene_synonym="NANOS1L; NOS3; ZC2HC12C"
                     /codon_start=1
                     /product="nanos homolog 3"
                     /protein_id="NP_001092092.1"
                     /db_xref="CCDS:CCDS42511.1"
                     /db_xref="GeneID:342977"
                     /db_xref="HGNC:HGNC:22048"
                     /db_xref="MIM:608229"
                     /translation="MGTFDLWTDYLGLAHLVRALSGKEGPETRLSPQPEPEPMLEPVS
                     ALEPMPAPESVPVPGPKDQKRSLESSPAPERLCSFCKHNGESRAIYQSHVLKDEAGRV
                     LCPILRDYVCPQCGATRERAHTRRFCPLTGQGYTSVYSHTTRNSAGKKLVRPDKAKTQ
                     DTGHRRGGGGGAGFRGAGKSEPSPSCSPSMST"
     exon            633..948
                     /gene="NANOS3"
                     /gene_synonym="NANOS1L; NOS3; ZC2HC12C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      920..925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NANOS3"
                     /gene_synonym="NANOS1L; NOS3; ZC2HC12C"
                     /note="hexamer: AATAAA"
     polyA_site      948
                     /gene="NANOS3"
                     /gene_synonym="NANOS1L; NOS3; ZC2HC12C"
                     /note="major polyA site"
ORIGIN      
        1 aggctccaga gaggggaagg aaggggcagc agagaggggt cagaaggagg gagcttaagc
       61 caggcagggt tacttgtctc tgtgactcct tccgcctggc acatgctgcc cagctatggg
      121 gacctttgac ctgtggacag attacctggg tttggcacac ctggttaggg ctctgagtgg
      181 gaaagagggt cctgaaacca ggctgagccc ccagccagag ccagagccaa tgctggagcc
      241 ggtgtcagcc ctggagccga tgccagcgcc ggagtcggtg ccagtgccgg gacccaagga
      301 tcagaagcgc agcctggagt cctcgccagc tcccgaacgc ctgtgctctt tctgcaaaca
      361 caacggcgag tcccgggcca tctaccagtc ccacgtgctg aaggacgagg ctggcagggt
      421 gctgtgtccc atcctgcggg actacgtgtg tccccagtgc ggcgccacac gtgagcgcgc
      481 ccacacccga cgcttctgcc cacttactgg ccagggctac acctccgtct acagccacac
      541 cacccgaaac tcggcaggca agaagctggt ccggcctgac aaggcgaaga cacaggacac
      601 aggccaccgc cgaggaggag gaggaggagc aggtttcaga ggtgccggga agtctgagcc
      661 ttcgccctcc tgctctccct ccatgtccac ctaggaggct gcctacacct gggcaagggc
      721 acccgggctc ggctggattt ccaggaagac ccaccctatg acgactgccc ccactcccag
      781 accctccccc cagcctggga ttgagccctg gggatgaccc ggggttggca agggaagagc
      841 tgaaatcgcc ctgtccttgg ggaccccacc ctttgtgcca tctgccgttt ccctagtgct
      901 gggcatccag tcagccctca ataaatgctt atgaatggat caacaaca
//
