LOCUS       NM_001029861            1565 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nanos C2HC-type zinc finger 2 (NANOS2), mRNA.
ACCESSION   NM_001029861 XM_371181
VERSION     NM_001029861.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1565)
  AUTHORS   Hirano,T., Wright,D., Suzuki,A. and Saga,Y.
  TITLE     A cooperative mechanism of target RNA selection via
            germ-cell-specific RNA-binding proteins NANOS2 and DND1
  JOURNAL   Cell Rep 39 (11), 110894 (2022)
   PUBMED   35705038
  REMARK    GeneRIF: A cooperative mechanism of target RNA selection via
            germ-cell-specific RNA-binding proteins NANOS2 and DND1.
REFERENCE   2  (bases 1 to 1565)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1565)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1565)
  AUTHORS   Farshchian,M., Matin,M.M., Bahrami,M., Geerts,D., Dastpak,M.,
            Shahriyari,M., Tajeran,M., Mirahmadi,M. and Bahrami,A.R.
  TITLE     Pluripotency induction in HEK293T cells by concurrent expression of
            STELLA, OCT4 and NANOS2
  JOURNAL   Biochem Biophys Res Commun 480 (4), 635-640 (2016)
   PUBMED   27794480
  REMARK    GeneRIF: We conclude that heterogeneous population of the HEK293T
            cells might be easily shifted towards expression of the
            pluripotency markers by ectopic expression of the SON factors or by
            growth in serum depleted media.
REFERENCE   5  (bases 1 to 1565)
  AUTHORS   Bhandari,D., Raisch,T., Weichenrieder,O., Jonas,S. and
            Izaurralde,E.
  TITLE     Structural basis for the Nanos-mediated recruitment of the CCR4-NOT
            complex and translational repression
  JOURNAL   Genes Dev 28 (8), 888-901 (2014)
   PUBMED   24736845
REFERENCE   6  (bases 1 to 1565)
  AUTHORS   Jorgensen,A., Nielsen,J.E., Blomberg Jensen,M., Graem,N. and
            Rajpert-De Meyts,E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   7  (bases 1 to 1565)
  AUTHORS   Kusz,K.M., Tomczyk,L., Sajek,M., Spik,A., Latos-Bielenska,A.,
            Jedrzejczak,P., Pawelczyk,L. and Jaruzelska,J.
  TITLE     The highly conserved NANOS2 protein: testis-specific expression and
            significance for the human male reproduction
  JOURNAL   Mol Hum Reprod 15 (3), 165-171 (2009)
   PUBMED   19168545
  REMARK    GeneRIF: Data describe for the first time the expression pattern of
            the NANOS2 gene in human tissues and show that it is testis
            specific. We found that NANOS2 protein is present in prenatal germ
            cells and at later stages in spermatogenesis.
REFERENCE   8  (bases 1 to 1565)
  AUTHORS   Chang,H.R., Tsao,D.A., Wang,S.R. and Yu,H.S.
  TITLE     Expression of nitric oxide synthases in keratinocytes after UVB
            irradiation
  JOURNAL   Arch Dermatol Res 295 (7), 293-296 (2003)
   PUBMED   14615895
  REMARK    GeneRIF: The increased NO production with increased expression of
            iNOS and ncNOS may contribute to the pathological and physiological
            features of UVB-induced erythema and skin inflammation.
REFERENCE   9  (bases 1 to 1565)
  AUTHORS   Tsuda,M., Sasaoka,Y., Kiso,M., Abe,K., Haraguchi,S., Kobayashi,S.
            and Saga,Y.
  TITLE     Conserved role of nanos proteins in germ cell development
  JOURNAL   Science 301 (5637), 1239-1241 (2003)
   PUBMED   12947200
REFERENCE   10 (bases 1 to 1565)
  AUTHORS   Jaruzelska,J., Kotecki,M., Kusz,K., Spik,A., Firpo,M. and Reijo
            Pera,R.A.
  TITLE     Conservation of a Pumilio-Nanos complex from Drosophila germ plasm
            to human germ cells
  JOURNAL   Dev Genes Evol 213 (3), 120-126 (2003)
   PUBMED   12690449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042883.1, BC117484.1 and AC008623.4.
            
            On May 17, 2019 this sequence version replaced NM_001029861.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC042883.1, BI463423.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341294.4/ ENSP00000341021.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BC042883.1         3-5
            4-900               BC117484.1         96-992
            901-1068            BC042883.1         903-1070
            1069-1390           AC008623.4         42607-42928
            1391-1565           BC042883.1         1393-1567
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1565
                     /gene="NANOS2"
                     /gene_synonym="NOS2; ZC2HC12B"
                     /note="nanos C2HC-type zinc finger 2"
                     /db_xref="GeneID:339345"
                     /db_xref="HGNC:HGNC:23292"
                     /db_xref="MIM:608228"
     exon            1..1565
                     /gene="NANOS2"
                     /gene_synonym="NOS2; ZC2HC12B"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..502
                     /gene="NANOS2"
                     /gene_synonym="NOS2; ZC2HC12B"
                     /note="NOS-2"
                     /codon_start=1
                     /product="nanos homolog 2"
                     /protein_id="NP_001025032.1"
                     /db_xref="CCDS:CCDS33056.1"
                     /db_xref="GeneID:339345"
                     /db_xref="HGNC:HGNC:23292"
                     /db_xref="MIM:608228"
                     /translation="MQLPPFDMWKDYFNLSQVVWALIASRGQRLETQEIEEPSPGPPL
                     GQDQGLGAPGANGGLGTLCNFCKHNGESRHVYSSHQLKTPDGVVVCPILRHYVCPVCG
                     ATGDQAHTLKYCPLNGGQQSLYRRSGRNSAGRRVKR"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NANOS2"
                     /gene_synonym="NOS2; ZC2HC12B"
                     /note="hexamer: AATAAA"
     polyA_site      1565
                     /gene="NANOS2"
                     /gene_synonym="NOS2; ZC2HC12B"
                     /note="major polyA site"
ORIGIN      
        1 gggaaacgcc tgctgctctt gcccttgccc acgggccccc agccccagcc cctctcctgt
       61 ggcccaccac ccctgctttg gtgccatgca gctgccaccc ttcgacatgt ggaaggacta
      121 cttcaacctg agccaggtgg tgtgggcgct gatcgcaagt cggggtcaaa ggctggagac
      181 ccaagagatt gaggagccaa gtcccgggcc tccgctgggg caggatcagg ggctgggggc
      241 gccaggggcc aacgggggcc tggggaccct gtgcaacttc tgcaagcaca acggggagtc
      301 ccgccacgtc tactcctcac accagctgaa gacaccggat ggcgtggtgg tgtgtcccat
      361 cctgaggcac tacgtgtgtc ccgtgtgcgg ggccaccggt gaccaggccc atacgctcaa
      421 gtactgcccg cttaacggtg gccagcagtc cctctaccgc cgcagcgggc gcaactcggc
      481 cggacgcagg gtcaagcgct gagcatcgtg agatgctcac cacccgcacc cctgaccctc
      541 ctggtccatc ccacccaagt ccctaaactc tctcttccag tcacccagcc ctttggaatt
      601 tctggccccc agaactccac cctggctgga tcctgaaaca gtggaggctg ctgggagcca
      661 ggccagcccc gcccccttgg acctgtcagc cctcggagct ctggcctgtg ggcgttggcc
      721 tgagggtcct tggtgccgcg ggaacccttc ctgcacggcc ctgtagcgcc ctctgggccc
      781 cggttcatgg atcttttgtc ctcgtggggc ctgctggtga ctggagccct gccccttcga
      841 cttctctgtt ccttgtggag ttcttggatt tttgaacctc caggattcca cggtgctgtc
      901 ccaagccagc ccttaggaga tactgaacaa ggctggctga gaagtgccta ctcaagaact
      961 tcaagatggg atgtcgactt aagaccagcc ttctccatct tcagcctcct gcagaaccac
     1021 ggtgtcatcg tggaccacgc ctgttcattc cttccctgac ctcagtaccc atccgtcagg
     1081 agcggagtag gactctggag agcaccgtat cactggaggg caccgtgtct tcgcaggctc
     1141 acctgtggat ggagagccgt ggggtgagct gacacctttc aatgccccct ggttgttctt
     1201 ccccttgttc agcccattgc acccggtacc tgcccccatc cccaaatcac cgatgggtcc
     1261 tttcccccag cgagaagcat atctctcgac cacctcccgt ccgacccccc aaatcgtgat
     1321 agttgactaa aggacatttt tttttcctcc tgtgtttttc aacctccaac gttcaagtca
     1381 aggaaccgcc gataagaagg gggtttgagt acccggatgg gaatggcaat ggcctagctt
     1441 ttattttagg ggcaaagaga agaagggccc ccgtcagatt ttaagttgtt cagtttttgg
     1501 cacagggtcg ggaccctgag tattgagctc tggtgaataa aaaggttttc tagtcgtctt
     1561 tgaaa
//
