LOCUS       NM_199461               4017 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens nanos C2HC-type zinc finger 1 (NANOS1), mRNA.
ACCESSION   NM_199461 XM_370579
VERSION     NM_199461.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4017)
  AUTHORS   Miles,W.O., Korenjak,M., Griffiths,L.M., Dyer,M.A., Provero,P. and
            Dyson,N.J.
  TITLE     Post-transcriptional gene expression control by NANOS is
            up-regulated and functionally important in pRb-deficient cells
  JOURNAL   EMBO J 33 (19), 2201-2215 (2014)
   PUBMED   25100735
  REMARK    GeneRIF: High NANOS expression is associated with retinoblastoma.
REFERENCE   2  (bases 1 to 4017)
  AUTHORS   Bhandari,D., Raisch,T., Weichenrieder,O., Jonas,S. and
            Izaurralde,E.
  TITLE     Structural basis for the Nanos-mediated recruitment of the CCR4-NOT
            complex and translational repression
  JOURNAL   Genes Dev 28 (8), 888-901 (2014)
   PUBMED   24736845
REFERENCE   3  (bases 1 to 4017)
  AUTHORS   Kusz-Zamelczyk,K., Sajek,M., Spik,A., Glazar,R., Jedrzejczak,P.,
            Latos-Bielenska,A., Kotecki,M., Pawelczyk,L. and Jaruzelska,J.
  TITLE     Mutations of NANOS1, a human homologue of the Drosophila morphogen,
            are associated with a lack of germ cells in testes or severe
            oligo-astheno-teratozoospermia
  JOURNAL   J Med Genet 50 (3), 187-193 (2013)
   PUBMED   23315541
  REMARK    GeneRIF: A group of 195 patients manifesting non-obstructive
            azoospermia or oligozoospermia were tested for mutations of the
            NANOS1 gene.
REFERENCE   4  (bases 1 to 4017)
  AUTHORS   Lu,C., Xu,M., Wang,Y., Qin,Y., Du,G., Wu,W., Han,X., Ji,C.,
            Yang,Y., Gu,A., Xia,Y., Song,L., Wang,S. and Wang,X.
  TITLE     Genetic variants in meiotic program initiation pathway genes are
            associated with spermatogenic impairment in a Han Chinese
            population
  JOURNAL   PLoS One 8 (1), e53443 (2013)
   PUBMED   23320086
  REMARK    GeneRIF: Single nucleotide polymorphisms in CYP26B1, NANOS1 and
            STRA8 genes support involvement of meiotic program initiation in
            modifying azoospermia and oligozoospermia risk in a Han-Chinese
            population
REFERENCE   5  (bases 1 to 4017)
  AUTHORS   Ginter-Matuszewska,B., Kusz,K., Spik,A., Grzeszkowiak,D.,
            Rembiszewska,A., Kupryjanczyk,J. and Jaruzelska,J.
  TITLE     NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within
            chromatoid body in human germ cells
  JOURNAL   Histochem Cell Biol 136 (3), 279-287 (2011)
   PUBMED   21800163
  REMARK    GeneRIF: NANOS1-PUMILIO2 complex, together with GEMIN3 and small
            noncoding RNAs, possibly regulate mRNA translation within the
            chromatoid body of the human germ cells.
REFERENCE   6  (bases 1 to 4017)
  AUTHORS   Bonnomet,A., Polette,M., Strumane,K., Gilles,C., Dalstein,V.,
            Kileztky,C., Berx,G., van Roy,F., Birembaut,P. and Nawrocki-Raby,B.
  TITLE     The E-cadherin-repressed hNanos1 gene induces tumor cell invasion
            by upregulating MT1-MMP expression
  JOURNAL   Oncogene 27 (26), 3692-3699 (2008)
   PUBMED   18223680
  REMARK    GeneRIF: The E-cadherin-repressed hNanos1 gene induces tumor cell
            invasion by upregulating MT1-MMP expression.
REFERENCE   7  (bases 1 to 4017)
  AUTHORS   Strumane,K., Bonnomet,A., Stove,C., Vandenbroucke,R.,
            Nawrocki-Raby,B., Bruyneel,E., Mareel,M., Birembaut,P., Berx,G. and
            van Roy,F.
  TITLE     E-cadherin regulates human Nanos1, which interacts with p120ctn and
            induces tumor cell migration and invasion
  JOURNAL   Cancer Res 66 (20), 10007-10015 (2006)
   PUBMED   17047063
  REMARK    GeneRIF: Findings describe a new function for hNanos1 as a
            downstream effector of E-cadherin loss contributing to tumor
            progression.
REFERENCE   8  (bases 1 to 4017)
  AUTHORS   Kurokawa,H., Aoki,Y., Nakamura,S., Ebe,Y., Kobayashi,D. and
            Tanaka,M.
  TITLE     Time-lapse analysis reveals different modes of primordial germ cell
            migration in the medaka Oryzias latipes
  JOURNAL   Dev Growth Differ 48 (3), 209-221 (2006)
   PUBMED   16573738
REFERENCE   9  (bases 1 to 4017)
  AUTHORS   Jaruzelska,J., Kotecki,M., Kusz,K., Spik,A., Firpo,M. and Reijo
            Pera,R.A.
  TITLE     Conservation of a Pumilio-Nanos complex from Drosophila germ plasm
            to human germ cells
  JOURNAL   Dev Genes Evol 213 (3), 120-126 (2003)
   PUBMED   12690449
REFERENCE   10 (bases 1 to 4017)
  AUTHORS   Husi,H., Ward,M.A., Choudhary,J.S., Blackstock,W.P. and Grant,S.G.
  TITLE     Proteomic analysis of NMDA receptor-adhesion protein signaling
            complexes
  JOURNAL   Nat Neurosci 3 (7), 661-669 (2000)
   PUBMED   10862698
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157788.16 and AF458985.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_199461.3.
            
            Summary: This gene encodes a CCHC-type zinc finger protein that is
            a member of the nanos family. This protein co-localizes with the
            RNA-binding protein pumilio RNA-binding family member 2 and may be
            involved in regulating translation as a post-transcriptional
            repressor. Mutations in this gene are associated with spermatogenic
            impairment. [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF458985.1, AF275269.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425699.3/ ENSP00000393275.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL157788.16        113975-113976
            3-1834              AF458985.1         1-1832
            1835-3488           AL157788.16        115809-117462
            3489-4017           AF458985.1         3486-4014
FEATURES             Location/Qualifiers
     source          1..4017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..4017
                     /gene="NANOS1"
                     /gene_synonym="EC_Rep1a; NOS-1; NOS1; SPGF12; ZC2HC12A"
                     /note="nanos C2HC-type zinc finger 1"
                     /db_xref="GeneID:340719"
                     /db_xref="HGNC:HGNC:23044"
                     /db_xref="MIM:608226"
     exon            1..4017
                     /gene="NANOS1"
                     /gene_synonym="EC_Rep1a; NOS-1; NOS1; SPGF12; ZC2HC12A"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..967
                     /gene="NANOS1"
                     /gene_synonym="EC_Rep1a; NOS-1; NOS1; SPGF12; ZC2HC12A"
                     /codon_start=1
                     /product="nanos homolog 1"
                     /protein_id="NP_955631.1"
                     /db_xref="CCDS:CCDS7607.1"
                     /db_xref="GeneID:340719"
                     /db_xref="HGNC:HGNC:23044"
                     /db_xref="MIM:608226"
                     /translation="MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWN
                     DYLGLATLITKAVDGEPRFGCARGGNGGGGSPPSSSSSSCCSPHTGAGPGALGPALGP
                     PDYDEDDDDDSDEPGSRGRYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAA
                     VLLGCAPAAAAAATTTSEATPREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCR
                     NNKEAMALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPAR
                     PPPRSARDGPPGKKLR"
     polyA_site      1813
                     /gene="NANOS1"
                     /gene_synonym="EC_Rep1a; NOS-1; NOS1; SPGF12; ZC2HC12A"
                     /note="major polyA site"
     regulatory      1991..1996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NANOS1"
                     /gene_synonym="EC_Rep1a; NOS-1; NOS1; SPGF12; ZC2HC12A"
                     /note="hexamer: AACAAA"
     polyA_site      2013
                     /gene="NANOS1"
                     /gene_synonym="EC_Rep1a; NOS-1; NOS1; SPGF12; ZC2HC12A"
     regulatory      3997..4002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NANOS1"
                     /gene_synonym="EC_Rep1a; NOS-1; NOS1; SPGF12; ZC2HC12A"
                     /note="hexamer: ATTAAA"
     polyA_site      4017
                     /gene="NANOS1"
                     /gene_synonym="EC_Rep1a; NOS-1; NOS1; SPGF12; ZC2HC12A"
ORIGIN      
        1 gcggcaggcc ggcgggcagg ctcggcgtgt cccttccgtc cggcccgcgc cggcggcggg
       61 gaggcggcgc gcggcccgca gcccgcccat ggaggctttc ccctgggcgc cccgctcgcc
      121 ccgccgcggc cgcgcccccc cgcccatggc gctcgtgccc agcgcccgct acgtgagcgc
      181 cccgggcccg gcgcacccgc agcccttcag ctcctggaac gactacctgg ggctcgccac
      241 gctcatcacc aaagcggtgg acggcgagcc gcgcttcggc tgcgcccgcg gtgggaacgg
      301 cggcggcggc tccccgccct cctcctcctc gtcgtcctgc tgctcccccc acacgggggc
      361 cgggcctggg gcgctggggc cggcgctggg gccgcccgac tacgacgagg acgacgacga
      421 cgacagcgac gagccggggt cccggggccg ctacctgggg agcgcgctgg aattgcgcgc
      481 gctggagctg tgcgcgggcc ccgccgaggc cgggctgctg gaggagcgct tcgccgagct
      541 gagcccgttc gcgggtcgtg ccgccgccgt gctgctgggc tgcgcgcccg ccgccgccgc
      601 cgccgccacc accaccagcg aggcgacgcc gcgcgaggag cgggccccgg cgtgggcggc
      661 cgagccccgg ctgcacgcgg cctccggggc ggcggccgcc cggctgctga agcccgagct
      721 gcaggtgtgc gtgttctgcc ggaacaacaa ggaggcgatg gcgctctaca ccacccatat
      781 cctcaagggc cccgacgggc gagtgctgtg tcccgtgctg cgccgctaca cgtgtcccct
      841 gtgcggcgcc agcggcgaca acgcgcacac catcaagtac tgcccgctct ccaaagtgcc
      901 gccgccgccc gcccgcccgc cgccccgcag cgccagggac ggcccgcctg gcaagaagct
      961 gcgctgaagg cccgggctcc cggccgccca gggtcgccgc cgcccctcgc accgctaggt
     1021 ctgcgcacca tctcgccccc gccgtgggga ggcgtgcggc tcagcggtcg gctcgacatg
     1081 ggacgtcgtc ctggtggttt ttgaaaagca gccgaccgtg tggagtactt ccgtgctgaa
     1141 cgattgggac tagacgctga aatccccatt tgtcttcagt ttctagtttg cacatccaga
     1201 acggcgaagg ctgggtgtgt attccactaa ctgaaatatg gcaacttaga ggcgctgttt
     1261 atttactgta tacgtcgacc tattttagat gcgcatcagt atgaaattgt ctcaatcttg
     1321 gatgtttcat tttatgaatg gaggcacttt actaggtcta gaatattttt ttaaaagcct
     1381 ctgaactgag cttaaaactg gcgattttat gaaatgtcgg caaaatgact attttattgt
     1441 ttgaagcgag ttaatattct cagttgtctt taaaaatcag ttactctaat tccaggtgaa
     1501 gcaagccgct ggtagcatca cccttatgag aagtgaaggt tttgtaaact ttccagtatt
     1561 aatttgggcg ggtattcccc gcttgtggct tgtttctgtc ctagctggag gtgtaaaatg
     1621 cacaatgtgt agcaggtaga atacagctcc ttatcgttct atgtaccagg tattttatta
     1681 ctgaactagc aactagcctt ttccaccttt aaaagttgtg ccaagtcata atcatattgt
     1741 gtataacttg gaaatggtgc tgtttaaaaa aattgtgtat ttatacagta acagtatgaa
     1801 ttcattaatc tcacctgtaa ctttcctact tggcattttc tctacacact caccctcttc
     1861 cagttcttta aaaacgttta tgatattaag atcaaaggga ggaagggaag acagcagtat
     1921 taattcaccc tagattactc aatttcaggg ttcctagtgg aggaaagccc attccagctg
     1981 ttgcctgtca aacaaataga agatggatct ctagctctga gctattcgtg tattaactcg
     2041 tattcaagaa ggttccaccg tgggctgcgt ctgactttaa tacaggcagt gctcaaacta
     2101 gaataagcac taattaaagg aattgttggg ggtccttcat gtgttcccac tcctactgga
     2161 agacccatgt cggtttccgg aaccccacca gtttacccat aagcaagact aaacctgatc
     2221 cttgggcaaa agttcctaac ccctacttta ccctcccacc ctcactttta aatccaccat
     2281 actgaatgcc acactatgga atgcagctac ctgccaagca aggcaataga aggcaaaaaa
     2341 tggaagtgaa ttaagatgaa ctcatctgaa atacacaaat gcattactat ctgaagatac
     2401 cagcaagagt ttagtctacg tgtataaggc tcccagtagg atttagctag gctactagaa
     2461 gttagactgc tttcgcatta aacagctaac ttcatccaca gcaaattgac tcaatcagga
     2521 accttcattt gaaggtgtgt tagaggatgg ggtaaatacc cgatagctgt ctttttggtg
     2581 aaagaaaagg tgcatttcaa gaacttgggg ggcaggagga aagcacaatg tttcttagcc
     2641 aggaaagaca aataatccaa cgctgctagt cttaacccca gaccagagag aactgcagat
     2701 ctgactgggc ctaaattaag tagcttaatg aaaccatgta attacttgtt ctcctttctt
     2761 ttgctataga aaatctacca gtttaaatga gcttcacctt ctgggtgaag tttctaaggt
     2821 caacatgaat cctcttacct ctctcactgc tcgtgttctg ccttttcaaa aggaccacta
     2881 tgaacagatc agcgcattct ctaggccaaa agggctagcc aggtggcaag atcaatttag
     2941 ctactttgta ttttcagagt caaattacag acggtttcca aaggtcttga gcatggggct
     3001 ttggcatagc ctcaatatat gggagtcact gtgatgagat gtgcctaatg ttaatttgat
     3061 attctgacat tgctatttta ccagaactaa gaacatattg agctggagct tcttgagggc
     3121 aggagagtat tggaaaagga atccagaaga ccctctccac tactcaggca gccactattc
     3181 atctattttt aaagtacccc attttcaggc cgggtgtggt ggctcatgcc tgtaatccca
     3241 gcactttggg aggcgaggcg ggggtggatc acaaggtcag gagaccagcc tggccaacat
     3301 ggcgaagccc cgtctctact aaaaatacaa aaattagccg ggtggtgtgg tgggcgcctg
     3361 taatcccagc tcctcaggag gctgaggcag gagaattgct tgaaaccagg aggcggaggt
     3421 tgcagtgagc ccagatcacg ccactgcact ccagcctgag caacagagcg actctgtctc
     3481 caaaaaagaa aaaaagtacc ccatgttcag cccctgtgcc aaatttgcct aggttttcca
     3541 gctgacaatg aatactggga gttaaaacgc agagtattac tatagttaat tttctagggt
     3601 tctcttatga aaagtatatg taaacacatt catttaaaaa tccttggaac tcaatgtgga
     3661 actttaaaca ttttgcaaaa ttacatttag agaaacccaa tttttcaaag tttaagaaat
     3721 atacaaagta tgacaaaatt atcttcataa gaacatgctg catacttgcc tagtagcaaa
     3781 acaatacagg gaagagtcaa aagggcttct ccaactgtag aggtacagat tgtcttaacc
     3841 tgttcttttc tgtacagact taaaatttct agtggctttt atttttcttt gtattttaat
     3901 tttcctacaa agtccttttt ggaagttgca gaattattag ctttgatgag aacaactttt
     3961 gtcatagatt tgatttatta aaccaaaatt atacatatta aaattatatc acaaata
//
