LOCUS       NM_005746               4360 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens nicotinamide phosphoribosyltransferase (NAMPT), mRNA.
ACCESSION   NM_005746
VERSION     NM_005746.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4360)
  AUTHORS   Li,Y., Xin,C., Xie,J. and Sun,X.
  TITLE     Association between visfatin and periodontitis: a systematic review
            and meta-analysis
  JOURNAL   PeerJ 12, e17187 (2024)
   PUBMED   38560458
  REMARK    GeneRIF: Association between visfatin and periodontitis: a
            systematic review and meta-analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4360)
  AUTHORS   Wang,Y.R. and Ma,Y.P.
  TITLE     [Mechanism and Clinical Significance of NAMPT in Multiple Myeloma]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (1), 138-145 (2024)
   PUBMED   38387912
  REMARK    GeneRIF: [Mechanism and Clinical Significance of NAMPT in Multiple
            Myeloma].
REFERENCE   3  (bases 1 to 4360)
  AUTHORS   He,X.L., Guo,H.J., Lei,Y.R., Li,J., Li,J.Y., Li,M.H., Li,N.,
            Wang,F. and Mo,C.F.
  TITLE     NAMPT promotes the malignant progression of HBV-associated
            hepatocellular carcinoma through activation of SREBP1-mediated
            lipogenesis
  JOURNAL   FASEB J 38 (2), e23444 (2024)
   PUBMED   38252081
  REMARK    GeneRIF: NAMPT promotes the malignant progression of HBV-associated
            hepatocellular carcinoma through activation of SREBP1-mediated
            lipogenesis.
REFERENCE   4  (bases 1 to 4360)
  AUTHORS   El-Masry,S.A., Farid,M.N., Hassan,N.E., Soliman,M.A., Mekkawy,L.H.,
            Elashry,G.I. and Abd El-Fattah,S.N.
  TITLE     Fibroblast growth factor-21 and Visfatin as potential predictors
            for metabolic risk factors in obese children
  JOURNAL   Sci Rep 14 (1), 1190 (2024)
   PUBMED   38216702
  REMARK    GeneRIF: Fibroblast growth factor-21 and Visfatin as potential
            predictors for metabolic risk factors in obese children.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4360)
  AUTHORS   Masood,S.H., Khan,T.A., Baloch,A.A., Hasan,S.M., Naqvi,A.M. and
            Iqbal,M.U.N.
  TITLE     Association of Visfatin gene polymorphism with obesity related
            metabolic disorders among Pakistani population: a case control
            study
  JOURNAL   Sci Rep 13 (1), 23002 (2023)
   PUBMED   38155161
  REMARK    GeneRIF: Association of Visfatin gene polymorphism with obesity
            related metabolic disorders among Pakistani population: a case
            control study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4360)
  AUTHORS   Kitani,T., Okuno,S. and Fujisawa,H.
  TITLE     Growth phase-dependent changes in the subcellular localization of
            pre-B-cell colony-enhancing factor
  JOURNAL   FEBS Lett 544 (1-3), 74-78 (2003)
   PUBMED   12782293
REFERENCE   7  (bases 1 to 4360)
  AUTHORS   Rongvaux,A., Shea,R.J., Mulks,M.H., Gigot,D., Urbain,J., Leo,O. and
            Andris,F.
  TITLE     Pre-B-cell colony-enhancing factor, whose expression is
            up-regulated in activated lymphocytes, is a nicotinamide
            phosphoribosyltransferase, a cytosolic enzyme involved in NAD
            biosynthesis
  JOURNAL   Eur J Immunol 32 (11), 3225-3234 (2002)
   PUBMED   12555668
REFERENCE   8  (bases 1 to 4360)
  AUTHORS   Ognjanovic,S., Bao,S., Yamamoto,S.Y., Garibay-Tupas,J., Samal,B.
            and Bryant-Greenwood,G.D.
  TITLE     Genomic organization of the gene coding for human pre-B-cell colony
            enhancing factor and expression in human fetal membranes
  JOURNAL   J Mol Endocrinol 26 (2), 107-117 (2001)
   PUBMED   11241162
REFERENCE   9  (bases 1 to 4360)
  AUTHORS   Samal,B., Sun,Y., Stearns,G., Xie,C., Suggs,S. and McNiece,I.
  TITLE     Cloning and characterization of the cDNA encoding a novel human
            pre-B-cell colony-enhancing factor
  JOURNAL   Mol Cell Biol 14 (2), 1431-1437 (1994)
   PUBMED   8289818
REFERENCE   10 (bases 1 to 4360)
  AUTHORS   Siderovski,D.P., Blum,S., Forsdyke,R.E. and Forsdyke,D.R.
  TITLE     A set of human putative lymphocyte G0/G1 switch genes includes
            genes homologous to rodent cytokine and zinc finger
            protein-encoding genes
  JOURNAL   DNA Cell Biol 9 (8), 579-587 (1990)
   PUBMED   1702972
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC106046.1, U02020.1,
            AC007032.2 and AI299587.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005746.2.
            
            Summary: This gene encodes a protein that catalyzes the
            condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate
            to yield nicotinamide mononucleotide, one step in the biosynthesis
            of nicotinamide adenine dinucleotide. The protein belongs to the
            nicotinic acid phosphoribosyltransferase (NAPRTase) family and is
            thought to be involved in many important biological processes,
            including metabolism, stress response and aging. This gene has a
            pseudogene on chromosome 10. [provided by RefSeq, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.127360.1,
                                           SRR1803614.179901.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222553.8/ ENSP00000222553.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2106              BC106046.1         6-2111
            2107-2448           U02020.1           2035-2376
            2449-4051           AC007032.2         54263-55865         c
            4052-4360           AI299587.1         25-333              c
FEATURES             Location/Qualifiers
     source          1..4360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..4360
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /note="nicotinamide phosphoribosyltransferase"
                     /db_xref="GeneID:10135"
                     /db_xref="HGNC:HGNC:30092"
                     /db_xref="MIM:608764"
     exon            1..156
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1575
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /EC_number="2.4.2.12"
                     /note="NAmPRTase; pre-B cell-enhancing factor; pre-B-cell
                     colony-enhancing factor 1"
                     /codon_start=1
                     /product="nicotinamide phosphoribosyltransferase
                     precursor"
                     /protein_id="NP_005737.1"
                     /db_xref="CCDS:CCDS5737.1"
                     /db_xref="GeneID:10135"
                     /db_xref="HGNC:HGNC:30092"
                     /db_xref="MIM:608764"
                     /translation="MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKT
                     ENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWN
                     YILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPIT
                     VATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGT
                     DTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSV
                     VSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPV
                     TENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTR
                     DLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDL
                     EEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH"
     exon            157..313
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            314..417
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            418..546
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            547..705
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            706..842
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1068
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1188
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1329
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1464
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..4360
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2593..2598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /note="hexamer: ATTAAA"
     polyA_site      2615
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /note="major polyA site"
     regulatory      4059..4064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /note="hexamer: ATTAAA"
     polyA_site      4085
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
     regulatory      4341..4346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /note="hexamer: AATAAA"
     polyA_site      4360
                     /gene="NAMPT"
                     /gene_synonym="1110035O14Rik; PBEF; PBEF1; VF; VISFATIN"
                     /note="major polyA site"
ORIGIN      
        1 agtgacttaa gcaacggagc gcggtgaagc tcatttttct ccttcctcgc agccgcgcca
       61 gggagctcgc ggcgcgcggc ccctgtcctc cggcccgaga tgaatcctgc ggcagaagcc
      121 gagttcaaca tcctcctggc caccgactcc tacaaggtta ctcactataa acaatatcca
      181 cccaacacaa gcaaagttta ttcctacttt gaatgccgtg aaaagaagac agaaaactcc
      241 aaattaagga aggtgaaata tgaggaaaca gtattttatg ggttgcagta cattcttaat
      301 aagtacttaa aaggtaaagt agtaaccaaa gagaaaatcc aggaagccaa agatgtctac
      361 aaagaacatt tccaagatga tgtctttaat gaaaagggat ggaactacat tcttgagaag
      421 tatgatgggc atcttccaat agaaataaaa gctgttcctg agggctttgt cattcccaga
      481 ggaaatgttc tcttcacggt ggaaaacaca gatccagagt gttactggct tacaaattgg
      541 attgagacta ttcttgttca gtcctggtat ccaatcacag tggccacaaa ttctagagag
      601 cagaagaaaa tattggccaa atatttgtta gaaacttctg gtaacttaga tggtctggaa
      661 tacaagttac atgattttgg ctacagagga gtctcttccc aagagactgc tggcatagga
      721 gcatctgctc acttggttaa cttcaaagga acagatacag tagcaggact tgctctaatt
      781 aaaaaatatt atggaacgaa agatcctgtt ccaggctatt ctgttccagc agcagaacac
      841 agtaccataa cagcttgggg gaaagaccat gaaaaagatg cttttgaaca tattgtaaca
      901 cagttttcat cagtgcctgt atctgtggtc agcgatagct atgacattta taatgcgtgt
      961 gagaaaatat ggggtgaaga tctaagacat ttaatagtat caagaagtac acaggcacca
     1021 ctaataatca gacctgattc tggaaaccct cttgacactg tgttaaaggt tttggagatt
     1081 ttaggtaaga agtttcctgt tactgagaac tcaaagggtt acaagttgct gccaccttat
     1141 cttagagtta ttcaagggga tggagtagat attaatacct tacaagagat tgtagaaggc
     1201 atgaaacaaa aaatgtggag tattgaaaat attgccttcg gttctggtgg aggtttgcta
     1261 cagaagttga caagagatct cttgaattgt tccttcaagt gtagctatgt tgtaactaat
     1321 ggccttggga ttaacgtctt caaggaccca gttgctgatc ccaacaaaag gtccaaaaag
     1381 ggccgattat ctttacatag gacgccagca gggaattttg ttacactgga ggaaggaaaa
     1441 ggagaccttg aggaatatgg tcaggatctt ctccatactg tcttcaagaa tggcaaggtg
     1501 acaaaaagct attcatttga tgaaataaga aaaaatgcac agctgaatat tgaactggaa
     1561 gcagcacatc attaggcttt atgactgggt gtgtgttgtg tgtatgtaat acataatgtt
     1621 tattgtacag atgtgtgggg tttgtgtttt atgatacatt acagccaaat tatttgttgg
     1681 tttatggaca tactgccctt tcattttttt tcttttccag tgtttaggtg atctcaaatt
     1741 aggaaatgca tttaaccatg taaaagatga gtgctaaagt aagcttttta gggccctttg
     1801 ccaataggta gtcattcaat ctggtattga tcttttcaca aataacagaa ctgagaaact
     1861 tttatatata actgatgatc acataaaaca gatttgcata aaattaccat gattgcttta
     1921 tgtttatatt taacttgtat ttttgtacaa acaagattgt gtaagatata tttgaagttt
     1981 cagtgattta acagtctttc caacttttca tgatttttat gagcacagac tttcaagaaa
     2041 atacttgaaa ataaattaca ttgccttttg tccattaatc agcaaataaa acatggcctt
     2101 aacaaagttg tttgtgttat tgtacaattt gaaaattatg tcgggacata ccctatagaa
     2161 ttactaacct tactgcccct tgtagaatat gtattaatca ttctacatta aagaaaataa
     2221 tggttcttac tggaatgtct aggcactgta cagttattat atatcttggt tgttgtattg
     2281 taccagtgaa atgccaaatt tgaaaggcct gtactgcaat tttatatgtc agagattgcc
     2341 tgtggctcta atatgcacct caagatttta aggagataat gtttttagag agaatttctg
     2401 cttccactat agaatatata cataaatgta aaatacttac aaaagtggaa gtagtgtatt
     2461 ttaaagtaat tacacttctg aatttatttt tcatattcta tagttggtat gacttaaatg
     2521 aattactgga gtgggtagtg agtgtactta aatgtttcaa ttctgttata ttttttatta
     2581 agtttttaaa aaattaaatt ggatattaaa ttgtatggac atcatttatt aattttaaac
     2641 tgaatgccct caataagtaa tactgaagca cattcttaaa tgaagataaa ttatctccaa
     2701 tgaaaagcat gacatgtgtt tcaatagaag aatcttaagt tggctaaatt caaagtgctt
     2761 gacatcaaaa tgttctagag tgattagcta ctagattctg aatcatacat cacatctgac
     2821 tagagaccag tttctttcga atgattcttt tatgtatgta gatctgttct tctgaggcag
     2881 cggttggcca actatagccc aaaggccaaa tttggacttc tttttataaa tgcagattgt
     2941 ctatggctgc tttcccacta ctccagccta aggtaaacag ctgcaataga agccaaatga
     3001 gaatcgcaaa gcccaaaatg tttattaacc tgccctttac acaaaattac acaaaaagtt
     3061 tcctgatctc tgttctaaga aaaggagtgt gccttgcatt taaaaggaaa tgttggtttc
     3121 tagggaaggg aggaggctaa ataattgata cggaattttc ctcttttgtc ttcttttttc
     3181 tcacttaaga atccgatact ggaagactga tttagaaaag tttttaacat gacattaaat
     3241 gtgaaatttt aaaaattgaa aagccataaa tcatctgttt taaatagtta catgagaaaa
     3301 tgatcactag aataacctaa ttagaagtgt tatcttcatt aaatgttttt tgtaagtggt
     3361 attagaaaga atatgttttt cagatggttc tttaaacatg tagtgagaac aataagcatt
     3421 attcactttt agtaagtctt ctgtaatcca tgatataaaa taattttaaa atgatttttt
     3481 aatgtatttg agtaaagatg agtagtatta agaaaaacac acatttcttc acaaaatgtg
     3541 ctaaggggcg tgtaaagaat caaaagaaac tattaccaat aatagttttg ataatcaccc
     3601 ataattttgt gtttaaacat tgaaattata gtacagacag tattctctgt gttctgtgaa
     3661 tttcagcagc ttcagaatag agtttaattt agaaatttgc agtgaaaaaa gctatctctt
     3721 tgttcacaac cataaatcag gagatggaga ttaattctat tggctcttag tcacttggaa
     3781 ctgattaatt ctgactttct gtcactaagc acttggtatt tggccatctc cattctgagc
     3841 accaaacggt taacacgaat gtccactaga actctgctgt gtgtcaccct taaatcagtc
     3901 taaatcttcc agacaaaagc aaatggcatt tatggattta agtcattaga ttttcaactg
     3961 acattaatta atccctcttg attgattata tcatcaagta tttatatctt aaataggagg
     4021 taggatttct gtgttaagac tcttatttgt accctataat taaagtaaaa tgttttttat
     4081 gagtatccct tgttttccct tcttaaattg ttatcaaaca atttttataa tgaaatctat
     4141 cttggaaaat tagaaagaaa aatggcaagg tatttattgt tctgtttgcc ataatttaga
     4201 actcacactt aagtattttg tagttttaca ttccttttta acccattcag tggagaatgt
     4261 cagcttttct cccaagttgt atgttaagtc tattctaata tgtactcaac atcaagttat
     4321 aaacatgtaa taaacatgga aataaagttt agctctatta
//
