LOCUS       NM_015686               4928 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens NALCN channel auxiliary factor 2 (NALF2), mRNA.
ACCESSION   NM_015686
VERSION     NM_015686.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4928)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158069.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 4, 2019 this sequence version replaced NM_015686.2.
            
            Summary: This gene encodes a product belonging to a family of
            proteins with unknown function. The presence of two transmembrane
            domains suggests that this protein is a multi-pass membrane
            protein. [provided by RefSeq, Sep 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087142.1, BC136518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252338.5/ ENSP00000252338.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1818              AL158069.16        6843-8660
            1819-1990           AL158069.16        31510-31681
            1991-4928           AL158069.16        32088-35025
FEATURES             Location/Qualifiers
     source          1..4928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..4928
                     /gene="NALF2"
                     /gene_synonym="bB57D9.1; CXorf63; FAM155B; TED; TMEM28"
                     /note="NALCN channel auxiliary factor 2"
                     /db_xref="GeneID:27112"
                     /db_xref="HGNC:HGNC:30701"
     exon            1..1818
                     /gene="NALF2"
                     /gene_synonym="bB57D9.1; CXorf63; FAM155B; TED; TMEM28"
                     /inference="alignment:Splign:2.1.0"
     CDS             958..2376
                     /gene="NALF2"
                     /gene_synonym="bB57D9.1; CXorf63; FAM155B; TED; TMEM28"
                     /note="transmembrane protein 28; transmembrane protein
                     FAM155B; bB57D9.1 (TED protein); family with sequence
                     similarity 155 member B"
                     /codon_start=1
                     /product="NALCN channel auxiliary factor 2"
                     /protein_id="NP_056501.2"
                     /db_xref="CCDS:CCDS35317.1"
                     /db_xref="GeneID:27112"
                     /db_xref="HGNC:HGNC:30701"
                     /translation="MFRGAWMWPGKDAAALTICCCCCCWAPRPSDKPCADSERAQRWR
                     LSLASLLFFTVLLADHLWLCAGARPRARELSSAMRPPWGAGRERQPVPPRAVLPLPPP
                     PPGEPSAPPGTCGPRYSNLTKAAPAAGSRPVCGGVPEPTGLDAACTKLQSLQRLFEPT
                     TPAPPLRPPDSLSRAPAEFPSAKKNLLKGHFRNFTLSFCDTYTVWDLLLGMDRPDSLD
                     CSLDTLMGDLLAVVASPGSGAWEACSNCIEAYQRLDRHAQEKYDEFDLVLHKYLQAEE
                     YSIRSCTKGCKAVYKAWLCSEYFSVTQQECQRWVPCKQYCLEVQTRCPFILPDNEEMV
                     YGGLPGFICTGLLDTSPKRLETKCCDVQWVSCEAKKKKFKESEAPKTHQQQFHHSYFH
                     HYHQQYHHYHPHHDPPGRVSNKPALLPVSGGSRLSPSRIRLCVLVLMLLHTVVSFSSN
                     QGGGGLGLETLPALEEGLTREE"
     exon            1819..1990
                     /gene="NALF2"
                     /gene_synonym="bB57D9.1; CXorf63; FAM155B; TED; TMEM28"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..4928
                     /gene="NALF2"
                     /gene_synonym="bB57D9.1; CXorf63; FAM155B; TED; TMEM28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4904..4909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NALF2"
                     /gene_synonym="bB57D9.1; CXorf63; FAM155B; TED; TMEM28"
                     /note="hexamer: AATAAA"
     polyA_site      4928
                     /gene="NALF2"
                     /gene_synonym="bB57D9.1; CXorf63; FAM155B; TED; TMEM28"
                     /note="major polyA site"
ORIGIN      
        1 ccagtcccgc tccctcctcc tctccgtgcc tctttctccg ccctgctccc cgccaaacac
       61 acttgcacag gggctctcaa ggtgttctcc gcacagcgga agatggcgac agactgaggg
      121 tgcatggcca gcgggagcca cggggccgtg ccgctgggct gcagccacag cggtgcgaac
      181 gagaggcgga agcgagaggc gcactaagta aagcccggtg tctgcgtccg gcgcctgtgg
      241 cgctgccggg agccaggtgg cccgcccgag ccggaactcc aggagcagcg ggtgcggagc
      301 cagagcggag cccgccaggg actggccccg gcgaacaccc ggagcgcgaa cgaagcccga
      361 agggcccggc aacggaccgg ccggccggcc taggagggcg cgagcgaggc agggagcggc
      421 gtggagcggg cagcgggcgg acgggcggga gcggagcggc gcggggcgag gggagcggag
      481 cggagcgcgg cggcggggcc cgcacggcgg cgctgagggg cgcagagctg cgccgaaccg
      541 agacggccgg tttggagtgc gagccgggcg gccgccggcg cggagtgaag tggcacggag
      601 ccgagggcag ctgaggggcc cgacactatg aggagtgcgg cgccgccgcc gcagccgcca
      661 ccgccccagt gccccgcacc gcccccagcc gggacgccgg gcagcgccta gcgggccggg
      721 cggcggcgcc cgggctgaga gcgacggagc gcgggagcgg cgcggagacg gcaccagagc
      781 gccccgcgac tccggcctga gcggggcatc gcgccggccg gcctgcctca ccatgcagcc
      841 cccgaggtag agcctggacg gcgccgagga gcgcagagcg gcgcgcagcc cgcccgcccc
      901 agacggccgt ctggcctcgc gcctgcctgt tccctccagc ccggaccccc ctgaaatatg
      961 ttcaggggcg cttggatgtg gcccgggaaa gacgccgccg cgctgactat ctgctgctgc
     1021 tgctgctgct gggctcccag gccgagcgac aaaccttgcg ccgactccga gcgggcgcag
     1081 cgatggcgac tgtccctggc gtccctgctc ttcttcaccg tgctgctcgc tgaccatctg
     1141 tggctgtgcg cgggggcccg gccccgggcc agggagctga gcagcgccat gcggccccca
     1201 tggggggccg gccgggagcg gcagccggtg cctcctcgcg cggtgctgcc gctgccgccg
     1261 ccgccgcccg gcgagcccag cgcgccccca ggcacctgcg gccccagata cagcaacctg
     1321 accaaagccg cccccgccgc cggctctcgg ccggtctgcg gcggcgtccc agagcccacg
     1381 gggctggacg cagcttgcac caaattgcaa tctttgcaga gacttttcga accgactact
     1441 ccggcccccc ctctgcggcc ccctgactcc ctttcccgtg ccccggccga gttcccctcc
     1501 gccaaaaaaa acttgctcaa aggccacttt cggaacttca ctctctcctt ttgcgacacc
     1561 tacacggtct gggacttgct gctgggcatg gaccgccccg acagcctgga ctgtagcctg
     1621 gacaccctga tgggggacct gctggccgtg gtggccagcc cgggctccgg ggcctgggag
     1681 gcgtgtagca actgtatcga ggcgtaccag cggctggacc gacacgctca ggaaaaatat
     1741 gacgagttcg acctcgtgct gcataaatac ttacaggcgg aagagtactc aatccggtcc
     1801 tgcacgaaag gctgtaaggc tgtctacaag gcctggctgt gctcagaata cttcagcgtg
     1861 acccagcagg aatgccagcg ctgggtgccc tgcaagcaat actgcctgga ggtgcagacc
     1921 cggtgcccct ttatactccc cgacaatgag gaaatggtgt acggagggct ccctggcttt
     1981 atctgtacag ggttgctgga tacttcacca aagcgtctgg aaaccaagtg ctgtgacgtg
     2041 cagtgggtct cctgtgaggc gaagaagaag aagttcaagg agtctgaggc ccccaaaacc
     2101 caccagcagc aattccacca ctcctatttc caccactacc accaacagta ccatcactac
     2161 cacccccatc atgatccccc aggccgtgtc agcaacaagc ccgccctgct gccggtctct
     2221 gggggctccc gcctcagccc tagcaggatc cggctctgcg tccttgttct catgctcctc
     2281 cataccgtgg tgtccttctc cagcaaccag ggtggtgggg gattggggct ggagacactg
     2341 cctgccctag aggagggcct gacacgggaa gagtgacagt agggagggag gacagacctc
     2401 caccacactg acatcagctc cagctccccc aggttggggg ggagggggct cctcccatgg
     2461 gaggtgtagg ataaggtggg ggcgggggaa atgggggaat gacacatccc ccccaaccta
     2521 cccccacccc aaaagcagct ccaacagaat ggccagaggg cctcagggag ctgcaaaact
     2581 catccaggag aaaaaggcag gagcagcaag tgacccctcc caagctccca tctatggggc
     2641 ttagcaaaaa aagggaggaa gtgggggctg gatatgccca cccctgccaa aagccctgac
     2701 cccagggaag gaggctgctc acccagcctt ggccctgcag ggaatgttgg ggggcacaga
     2761 ggggagaagc tctttccccc actccacatt ccttttgttg ccaagatcct taattccctc
     2821 ctgcccatat ccctacaggc gacggcagac agtgcaatgg ccctcctgcc acttcagcac
     2881 accttgcccc acctgggacc atcacacgtg aagcaccagg ctgggagatg aggtgcacac
     2941 agttgcagct aggtcggggc cccagttaag ctgtgcccca ccaccctagg caatgagggg
     3001 caggaaaggg gtacagaatg aatggtgaaa gagagtggag atacggaagg gggagaggag
     3061 aggagaaatg tggacagagg gcttgaagac atggccgaat aggctactgc cacccggctt
     3121 tggggagatg ggcgataagt gttgaggtag gctcgagaac tgctccccaa atcagtgaga
     3181 attgcattag gagccctctg gggaaagagc acaggaactg agttgctggg cctcaaaaca
     3241 aaaggctgca ggcacatggt tagactgccg ctgtctgaag gaccatatct tacagaaggt
     3301 gcacatactc ccaagggcca ctcttgccct ggagatcttg gccttggggc caaagacatt
     3361 tccatttccg atctccatgg ggaggaggga cttaagccca agtgggtcag gcctggccca
     3421 ggtccttata ctcccctatc ttgtcctagc ccaggcctcc atgaaggaga acctggtggc
     3481 attgccccag agctctccag agatgagcct cccctatccc caccctgtcc ccgtccccag
     3541 cctaccaaag agtattcaca cctttccatc cctgactcta tgggttactg tcccaattgc
     3601 gaaacaccca tactcctctt caccctgtag cagggtcttc tgctccagtc accccggcct
     3661 cttgcaagag aaagtccagg gactggcaag aagacccttt gactaaagat aatgtgctgt
     3721 catatcttgg ctgagaaact gttgagtcag gctagaggac tggacaagag aagaggcatt
     3781 gagagccccc ttgggagcca ttagccttgc tctggtctgc tgtgtggggt tggggagtag
     3841 gggggatccc acattgcctg ggacatctga atgctgatac gaatggacag gaaagggagc
     3901 cagagctgta tacctgggac aggccaggga gcctttagtg ccagcagggc ctgtgtcctg
     3961 ggatgtgatg ctagtgagtg aatgggaggg cgggcctgga gctgcgtgag agtgaaacca
     4021 agaagcggat ggggaaggga gagctggcct tggtcagctt agggatgaat ggagaaggaa
     4081 tcattcatgg gcctcggcta ggtcccagac tgattacatg agactgggga gtccttccct
     4141 gccagttttc tcatttatta cagcctatcc cccaacccta cccctgtgcc ctgcctacac
     4201 actcccgttt ggccctcagc actttgggcc tggtcacata ccccatccct agagtgctct
     4261 tttcagctgg ggaggggaag aggtgctggc tcctttccag acatgcttat gtataagtaa
     4321 aggggcaggt gcttgggctc cagagagacc ctaggtactg ccttctaact cctgcatcct
     4381 cagaagggga aaagggactg ggaagtaaag ggaaaccata tggccccagg gaatggaccc
     4441 ttggagactc ccatcctctc ttccccctca ccaagtgccc aggagacccc tggctcagac
     4501 cagcccaagg ccttgcccag tggcagggga aaggggcacc tcactccacc tcaaagtcat
     4561 ttgactgccc ccatccaccc caccacccta atcttccacc acctctccgg ctgcccctgc
     4621 cctccatcac agacagcaga gccgggcagc tttcttatgc cattttctac actgtgcttc
     4681 atgagtagga ctttcttgca ctagttccta tgactgagtc tccaaactgg tttcctagta
     4741 gtcccccatc ccttcctccc ttacccagct atgattcagt tgtctctgcc ctccctctta
     4801 ccctgcctct gtgtttcggt gagagtctct gtatatgtac tgctttctgt tttgttgcat
     4861 tgtggggcag aggcctctct gctcttgttt aaccccataa agaaataaat ggtaagactt
     4921 gatgataa
//
