LOCUS       NP_056501                472 aa            linear   PRI 30-APR-2025
DEFINITION  NALCN channel auxiliary factor 2 [Homo sapiens].
ACCESSION   NP_056501
VERSION     NP_056501.2
DBSOURCE    REFSEQ: accession NM_015686.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 472)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158069.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 16, 2004 this sequence version replaced NP_056501.1.
            
            Summary: This gene encodes a product belonging to a family of
            proteins with unknown function. The presence of two transmembrane
            domains suggests that this protein is a multi-pass membrane
            protein. [provided by RefSeq, Sep 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087142.1, BC136518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252338.5/ ENSP00000252338.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     Protein         1..472
                     /product="NALCN channel auxiliary factor 2"
                     /note="transmembrane protein 28; transmembrane protein
                     FAM155B; bB57D9.1 (TED protein); family with sequence
                     similarity 155 member B"
                     /calculated_mol_wt=52346
     Site            47..67
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O75949.3)"
     Region          77..114
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75949.3)"
     Site            120
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75949.3)"
     Site            193
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75949.3)"
     Site            433..453
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O75949.3)"
     CDS             1..472
                     /gene="NALF2"
                     /gene_synonym="bB57D9.1; CXorf63; FAM155B; TED; TMEM28"
                     /coded_by="NM_015686.3:958..2376"
                     /db_xref="CCDS:CCDS35317.1"
                     /db_xref="GeneID:27112"
                     /db_xref="HGNC:HGNC:30701"
ORIGIN      
        1 mfrgawmwpg kdaaalticc ccccwaprps dkpcadsera qrwrlslasl lfftvlladh
       61 lwlcagarpr arelssamrp pwgagrerqp vppravlplp ppppgepsap pgtcgprysn
      121 ltkaapaags rpvcggvpep tgldaactkl qslqrlfept tpapplrppd slsrapaefp
      181 sakknllkgh frnftlsfcd tytvwdlllg mdrpdsldcs ldtlmgdlla vvaspgsgaw
      241 eacsncieay qrldrhaqek ydefdlvlhk ylqaeeysir sctkgckavy kawlcseyfs
      301 vtqqecqrwv pckqyclevq trcpfilpdn eemvygglpg fictglldts pkrletkccd
      361 vqwvsceakk kkfkeseapk thqqqfhhsy fhhyhqqyhh yhphhdppgr vsnkpallpv
      421 sggsrlspsr irlcvlvlml lhtvvsfssn qgggglglet lpaleegltr ee
//
