LOCUS       NP_001073865             458 aa            linear   PRI 27-APR-2025
DEFINITION  NALCN channel auxiliary factor 1 [Homo sapiens].
ACCESSION   NP_001073865 XP_001128712
VERSION     NP_001073865.1
DBSOURCE    REFSEQ: accession NM_001080396.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 458)
  AUTHORS   Xie,J., Ke,M., Xu,L., Lin,S., Huang,J., Zhang,J., Yang,F., Wu,J.
            and Yan,Z.
  TITLE     Structure of the human sodium leak channel NALCN in complex with
            FAM155A
  JOURNAL   Nat Commun 11 (1), 5831 (2020)
   PUBMED   33203861
  REMARK    GeneRIF: Structure of the human sodium leak channel NALCN in
            complex with FAM155A.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 458)
  AUTHORS   Kschonsak,M., Chua,H.C., Noland,C.L., Weidling,C., Clairfeuille,T.,
            Bahlke,O.O., Ameen,A.O., Li,Z.R., Arthur,C.P., Ciferri,C.,
            Pless,S.A. and Payandeh,J.
  TITLE     Structure of the human sodium leak channel NALCN
  JOURNAL   Nature 587 (7833), 313-318 (2020)
   PUBMED   32698188
  REMARK    GeneRIF: Structure of the human sodium leak channel NALCN.
REFERENCE   3  (residues 1 to 458)
  AUTHORS   Chua,H.C., Wulf,M., Weidling,C., Rasmussen,L.P. and Pless,S.A.
  TITLE     The NALCN channel complex is voltage sensitive and directly
            modulated by extracellular calcium
  JOURNAL   Sci Adv 6 (17), eaaz3154 (2020)
   PUBMED   32494638
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 458)
  AUTHORS   Reichert,M.C., Kupcinskas,J., Schulz,A., Schramm,C., Weber,S.N.,
            Krawczyk,M., Jungst,C., Casper,M., Grunhage,F., Appenrodt,B.,
            Zimmer,V., Tamelis,A., Lukosiene,J.I., Pauziene,N., Kiudelis,G.,
            Jonaitis,L., Goeser,T., Malinowski,M., Glanemann,M., Kupcinskas,L.
            and Lammert,F.
  TITLE     Common variation in FAM155A is associated with diverticulitis but
            not diverticulosis
  JOURNAL   Sci Rep 10 (1), 1658 (2020)
   PUBMED   32015353
  REMARK    GeneRIF: Common variation in FAM155A is associated with
            diverticulitis but not diverticulosis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 458)
  AUTHORS   Huang,G.H., Du,L., Li,N., Zhang,Y., Xiang,Y., Tang,J.H., Xia,S.,
            Zhang,E.E. and Lv,S.Q.
  TITLE     Methylation-mediated miR-155-FAM133A axis contributes to the
            attenuated invasion and migration of IDH mutant gliomas
  JOURNAL   Cancer Lett 432, 93-102 (2018)
   PUBMED   29885519
  REMARK    GeneRIF: Low FAM155A expression is associated with glioma.
REFERENCE   6  (residues 1 to 458)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (residues 1 to 458)
  AUTHORS   Wang,K., Zhang,H., Bloss,C.S., Duvvuri,V., Kaye,W., Schork,N.J.,
            Berrettini,W. and Hakonarson,H.
  CONSRTM   Price Foundation Collaborative Group
  TITLE     A genome-wide association study on common SNPs and rare CNVs in
            anorexia nervosa
  JOURNAL   Mol Psychiatry 16 (9), 949-959 (2011)
   PUBMED   21079607
REFERENCE   8  (residues 1 to 458)
  AUTHORS   Terracciano,A., Tanaka,T., Sutin,A.R., Sanna,S., Deiana,B., Lai,S.,
            Uda,M., Schlessinger,D., Abecasis,G.R., Ferrucci,L. and Costa,P.T.
            Jr.
  TITLE     Genome-wide association scan of trait depression
  JOURNAL   Biol Psychiatry 68 (9), 811-817 (2010)
   PUBMED   20800221
REFERENCE   9  (residues 1 to 458)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
REFERENCE   10 (residues 1 to 458)
  AUTHORS   Li,S.H., McInnis,M.G., Margolis,R.L., Antonarakis,S.E. and
            Ross,C.A.
  TITLE     Novel triplet repeat containing genes in human brain: cloning,
            expression, and length polymorphisms
  JOURNAL   Genomics 16 (3), 572-579 (1993)
   PUBMED   8325628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136964.8, DA779672.1, BC157855.1, AL445204.3, AW592075.1 and
            N69765.1.
            
            On Jan 18, 2007 this sequence version replaced XP_001128712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.12606.1,
                                           SRR1660805.143535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375915.4/ ENSP00000365080.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.3"
     Protein         1..458
                     /product="NALCN channel auxiliary factor 1"
                     /note="transmembrane protein FAM155A; family with sequence
                     similarity 155 member A"
                     /calculated_mol_wt=51362
     Site            40..60
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (B1AL88.1)"
     Region          70..155
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B1AL88.1)"
     Site            217
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:33203861,
                     ECO:0007744|PDB:7CM3; propagated from UniProtKB/Swiss-Prot
                     (B1AL88.1)"
     Region          <269..>314
                     /region_name="Mid1"
                     /note="Stretch-activated Ca2+-permeable channel component;
                     pfam12929"
                     /db_xref="CDD:432882"
     Site            417..437
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (B1AL88.1)"
     CDS             1..458
                     /gene="NALF1"
                     /gene_synonym="FAM155A; NLF-1; NLF1"
                     /coded_by="NM_001080396.3:901..2277"
                     /db_xref="CCDS:CCDS32006.1"
                     /db_xref="GeneID:728215"
                     /db_xref="HGNC:HGNC:33877"
                     /db_xref="MIM:619899"
ORIGIN      
        1 mtrgawmcrq yddglkiwla aprenekpfi dseraqkwrl slasllfftv llsdhlwfca
       61 eakltrardk ehqqqqrqqq qqqqqqrqrq qqqqqrrqqe pswpallasm gesspaaqah
      121 rllsassspt lppspgdggg gggkgnrgkd drgkalflgn sakpvwrlet cypqgassgq
      181 cftvenadav carnwsrgaa ggdgqevrsk hptplwnlsd fylsfcnsyt lwelfsglss
      241 pntlncsldv vlkeggemtt crqcveayqd ydhhaqekye efesvlhkyl qseeysvksc
      301 pedckivyka wlcsqyfevt qfncrktipc kqyclevqtr cpfilpdnde viygglssfi
      361 ctglyetflt ndepeccdvr reeksnnpsk gtveksgsch rtsltvssat rlcnsrlklc
      421 vlvlillhtv ltasaaqnta glsfggintl eenstnee
//
