LOCUS       NM_004536               7093 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens NLR family apoptosis inhibitory protein (NAIP),
            transcript variant 1, mRNA.
ACCESSION   NM_004536 XM_005248521 XM_005276799 XM_006726218 XM_011546973
            XM_936944
VERSION     NM_004536.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7093)
  AUTHORS   An,Y., Zhai,Z., Wang,X., Ding,Y., He,L., Li,L., Mo,Q., Mu,C.,
            Xie,R., Liu,T., Zhong,W., Wang,B. and Cao,H.
  TITLE     Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4
            inflammasome activation in macrophages attenuates ulcerative
            colitis
  JOURNAL   J Adv Res 52, 219-232 (2023)
   PUBMED   37586642
  REMARK    GeneRIF: Targeting Desulfovibrio vulgaris flagellin-induced
            NAIP/NLRC4 inflammasome activation in macrophages attenuates
            ulcerative colitis.
REFERENCE   2  (bases 1 to 7093)
  AUTHORS   Hussain,N., Alkhateeb,M.A., Bashir,A., Iqbal,R., Hussain,T.,
            Aziz,T., Al-Abbas,N.S., Shaer,N.A., Alamri,A.S., Alhomrani,M.,
            Shakoori,A. and Labban,S.
  TITLE     Deletions of SMNI gene exon 7 and NAIP gene exon 5 in spinal
            muscular atrophy patients in selected population
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (17), 7935-7945 (2023)
   PUBMED   37750622
  REMARK    GeneRIF: Deletions of SMNI gene exon 7 and NAIP gene exon 5 in
            spinal muscular atrophy patients in selected population.
REFERENCE   3  (bases 1 to 7093)
  AUTHORS   Xu,W.B., Kotheeranurak,V., Chen,D.Q., Sun,N.K., Cai,D.X.,
            Chen,C.M., Lin,G.X. and Rui,G.
  TITLE     Pan-cancer analysis of the intervertebral-disc-degeneration-related
            innate immunity gene NAIP
  JOURNAL   PLoS One 18 (6), e0286647 (2023)
   PUBMED   37267294
  REMARK    GeneRIF: Pan-cancer analysis of the
            intervertebral-disc-degeneration-related innate immunity gene NAIP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7093)
  AUTHORS   Naseer,N., Zhang,J., Bauer,R., Constant,D.A., Nice,T.J.,
            Brodsky,I.E., Rauch,I. and Shin,S.
  TITLE     Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and
            NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation
            in Human Intestinal Epithelial Cells
  JOURNAL   Infect Immun 90 (7), e0066321 (2022)
   PUBMED   35678562
  REMARK    GeneRIF: Salmonella enterica Serovar Typhimurium Induces
            NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent
            Inflammasome Activation in Human Intestinal Epithelial Cells.
REFERENCE   5  (bases 1 to 7093)
  AUTHORS   Samperio Ventayol,P., Geiser,P., Di Martino,M.L., Florbrant,A.,
            Fattinger,S.A., Walder,N., Sima,E., Shao,F., Gekara,N.O.,
            Sundbom,M., Hardt,W.D., Webb,D.L., Hellstrom,P.M., Eriksson,J. and
            Sellin,M.E.
  TITLE     Bacterial detection by NAIP/NLRC4 elicits prompt contractions of
            intestinal epithelial cell layers
  JOURNAL   Proc Natl Acad Sci U S A 118 (16) (2021)
   PUBMED   33846244
  REMARK    GeneRIF: Bacterial detection by NAIP/NLRC4 elicits prompt
            contractions of intestinal epithelial cell layers.
REFERENCE   6  (bases 1 to 7093)
  AUTHORS   Romanish,M.T., Lock,W.M., van de Lagemaat,L.N., Dunn,C.A. and
            Mager,D.L.
  TITLE     Repeated recruitment of LTR retrotransposons as promoters by the
            anti-apoptotic locus NAIP during mammalian evolution
  JOURNAL   PLoS Genet 3 (1), e10 (2007)
   PUBMED   17222062
  REMARK    GeneRIF: Multiple, domesticated long terminal repeats (LTRs) of
            endogenous retroviral elements provide NAIP promoter function in
            human, mouse, and rat.
REFERENCE   7  (bases 1 to 7093)
  AUTHORS   Monani,U.R., Lorson,C.L., Parsons,D.W., Prior,T.W., Androphy,E.J.,
            Burghes,A.H. and McPherson,J.D.
  TITLE     A single nucleotide difference that alters splicing patterns
            distinguishes the SMA gene SMN1 from the copy gene SMN2
  JOURNAL   Hum Mol Genet 8 (7), 1177-1183 (1999)
   PUBMED   10369862
REFERENCE   8  (bases 1 to 7093)
  AUTHORS   Liston,P., Roy,N., Tamai,K., Lefebvre,C., Baird,S.,
            Cherton-Horvat,G., Farahani,R., McLean,M., Ikeda,J.E., MacKenzie,A.
            and Korneluk,R.G.
  TITLE     Suppression of apoptosis in mammalian cells by NAIP and a related
            family of IAP genes
  JOURNAL   Nature 379 (6563), 349-353 (1996)
   PUBMED   8552191
REFERENCE   9  (bases 1 to 7093)
  AUTHORS   Roy,N., Mahadevan,M.S., McLean,M., Shutler,G., Yaraghi,Z.,
            Farahani,R., Baird,S., Besner-Johnston,A., Lefebvre,C., Kang,X. et
            al.
  TITLE     The gene for neuronal apoptosis inhibitory protein is partially
            deleted in individuals with spinal muscular atrophy
  JOURNAL   Cell 80 (1), 167-178 (1995)
   PUBMED   7813013
REFERENCE   10 (bases 1 to 7093)
  AUTHORS   van der Steege,G., Draaijers,T.G., Grootscholten,P.M., Osinga,J.,
            Anzevino,R., Velona,I., Den Dunnen,J.T., Scheffer,H., Brahe,C., van
            Ommen,G.J. et al.
  TITLE     A provisional transcript map of the spinal muscular atrophy (SMA)
            critical region
  JOURNAL   Eur J Hum Genet 3 (2), 87-95 (1995)
   PUBMED   7552146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC044797.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 21, 2019 this sequence version replaced NM_004536.2.
            
            Summary: This gene is part of a 500 kb inverted duplication on
            chromosome 5q13. This duplicated region contains at least four
            genes and repetitive elements which make it prone to rearrangements
            and deletions. The repetitiveness and complexity of the sequence
            have also caused difficulty in determining the organization of this
            genomic region. This copy of the gene is full length; additional
            copies with truncations and internal deletions are also present in
            this region of chromosome 5q13. It is thought that this gene is a
            modifier of spinal muscular atrophy caused by mutations in a
            neighboring gene, SMN1. The protein encoded by this gene contains
            regions of homology to two baculovirus inhibitor of apoptosis
            proteins, and it is able to suppress apoptosis induced by various
            signals. Alternative splicing and the use of alternative promoters
            results in multiple transcript variants. [provided by RefSeq, Nov
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U19251.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517649.6/ ENSP00000428657.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-725               AC044797.5         121601-122325       c
            726-814             AC044797.5         121304-121392       c
            815-940             AC044797.5         117645-117770       c
            941-1511            AC044797.5         109334-109904       c
            1512-1611           AC044797.5         108261-108360       c
            1612-1693           AC044797.5         100762-100843       c
            1694-1745           AC044797.5         99078-99129         c
            1746-1865           AC044797.5         98684-98803         c
            1866-1965           AC044797.5         95710-95809         c
            1966-2047           AC044797.5         84779-84860         c
            2048-2105           AC044797.5         83731-83788         c
            2106-4217           AC044797.5         80761-82872         c
            4218-4385           AC044797.5         76855-77022         c
            4386-4538           AC044797.5         73892-74044         c
            4539-4625           AC044797.5         73146-73232         c
            4626-4790           AC044797.5         71115-71279         c
            4791-7093           AC044797.5         65152-67454         c
FEATURES             Location/Qualifiers
     source          1..7093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..7093
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /note="NLR family apoptosis inhibitory protein"
                     /db_xref="GeneID:4671"
                     /db_xref="HGNC:HGNC:7634"
                     /db_xref="MIM:600355"
     exon            1..725
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            726..814
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            815..940
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1511
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             944..5155
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal apoptosis inhibitory protein; nucleotide-binding
                     oligomerization domain, leucine rich repeat and BIR domain
                     containing 1; baculoviral IAP repeat-containing protein 1;
                     psi neuronal apoptosis inhibitory protein"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 1
                     isoform 1"
                     /protein_id="NP_004527.2"
                     /db_xref="CCDS:CCDS4009.1"
                     /db_xref="GeneID:4671"
                     /db_xref="HGNC:HGNC:7634"
                     /db_xref="MIM:600355"
                     /translation="MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQK
                     ERAKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSL
                     ILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEE
                     ARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHA
                     KWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFA
                     YEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDD
                     HTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQG
                     EAQWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQ
                     EPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSS
                     TRPDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKL
                     IQKNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRK
                     FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATA
                     EILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFY
                     RFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSL
                     PSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYF
                     SMVSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNLQYFFDHPESLSLLR
                     SIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVK
                     SYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRI
                     ELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTI
                     QSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSK
                     LVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVASLPN
                     FISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQL
                     HCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNM
                     PNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMK
                     ERHPQSKYLTILQKWILPFSPIIQK"
     exon            1512..1611
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1693
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1745
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1865
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1965
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2047
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2105
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..4217
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4218..4385
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..4538
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4539..4625
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..4790
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4791..7093
                     /gene="NAIP"
                     /gene_synonym="BIRC1; NLRB1; psiNAIP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacatcagg taaaagtaca gactagccag atcactggtt aaccttaacc cctatgtgct
       61 tgagtttcct tatctgtaat atggagatga tatagcaata gctgattttg gactgttaaa
      121 ggaattaagt ggacacatgt aaagtgctta gaattgtgcc tggcaagtag taggctgcaa
      181 tattgtgata taataaatat atatatttga tcttcatcca gttcctggca cagatctcca
      241 gaaacccttg taatttcctg agtgacaggg gtgatagaaa catcttttat tagaatactt
      301 ggtcttggtt cctgacacaa gagcttctaa gacctttgga atctccaagt gataagagtg
      361 tatgacagtg agctaactgg tggctgggat cctttagaca acttcaggat gggggctatc
      421 ccctgaaaga ctaaggcatg attagaggtc tgggatttgc agccccacgc ctcgacctcc
      481 agagagggta aaagggctgg agattgatta accaccagtt gccagtgatt taaccaatca
      541 tgcctaagtg atggcacctc cattaaaaaa taaaccacag gtttggagag ctttcggttt
      601 ggttaacccc aaccacatac caagaaggcg atgcacctca aactgcatga agacaaaagg
      661 tcctgtgctc acctgggacc cttctggacg ttgccctgtg tacctcttcg actgcctgtt
      721 catctacgac gaaccccggg tattgacccc agacaacaat gccacttcat attggggact
      781 tcgtctggga ttccaaggtg cattcattgc aaagttcctt aaatattttc tcactgcttc
      841 ctactaaagg acggacagag catttgttct tcagccacat actttccttc cactggccag
      901 cattctcctc tattagacta gaactgtgga taaacctcag aaaatggcca cccagcagaa
      961 agcctctgac gagaggatct cccagtttga tcacaatttg ctgccagagc tgtctgctct
     1021 tctgggccta gatgcagttc agttggcaaa ggaactagaa gaagaggagc agaaggagcg
     1081 agcaaaaatg cagaaaggct acaactctca aatgcgcagt gaagcaaaaa ggttaaagac
     1141 ttttgtgact tatgagccgt acagctcatg gataccacag gagatggcgg ccgctgggtt
     1201 ttacttcact ggggtaaaat ctgggattca gtgcttctgc tgtagcctaa tcctctttgg
     1261 tgccggcctc acgagactcc ccatagaaga ccacaagagg tttcatccag attgtgggtt
     1321 ccttttgaac aaggatgttg gtaacattgc caagtacgac ataagggtga agaatctgaa
     1381 gagcaggctg agaggaggta aaatgaggta ccaagaagag gaggctagac ttgcgtcctt
     1441 caggaactgg ccattttatg tccaagggat atccccttgt gtgctctcag aggctggctt
     1501 tgtctttaca ggtaaacagg acacggtaca gtgtttttcc tgtggtggat gtttaggaaa
     1561 ttgggaagaa ggagatgatc cttggaagga acatgccaaa tggttcccca aatgtgaatt
     1621 tcttcggagt aagaaatcct cagaggaaat tacccagtat attcaaagct acaagggatt
     1681 tgttgacata acgggagaac attttgtgaa ttcctgggtc cagagagaat tacctatggc
     1741 atcagcttat tgcaatgaca gcatctttgc ttacgaagaa ctacggctgg actcttttaa
     1801 ggactggccc cgggaatcag ctgtgggagt tgcagcactg gccaaagcag gtcttttcta
     1861 cacaggtata aaggacatcg tccagtgctt ttcctgtgga gggtgtttag agaaatggca
     1921 ggaaggtgat gacccattag acgatcacac cagatgtttt cccaattgtc catttctcca
     1981 aaatatgaag tcctctgcgg aagtgactcc agaccttcag agccgtggtg aactttgtga
     2041 attactggaa accacaagtg aaagcaatct tgaagattca atagcagttg gtcctatagt
     2101 gccagaaatg gcacagggtg aagcccagtg gtttcaagag gcaaagaatc tgaatgagca
     2161 gctgagagca gcttatacca gcgccagttt ccgccacatg tctttgcttg atatctcttc
     2221 cgatctggcc acggaccact tgctgggctg tgatctgtct attgcttcaa aacacatcag
     2281 caaacctgtg caagaacctc tggtgctgcc tgaggtcttt ggcaacttga actctgtcat
     2341 gtgtgtggag ggtgaagctg gaagtggaaa gacggtcctc ctgaagaaaa tagcttttct
     2401 gtgggcatct ggatgctgtc ccctgttaaa caggttccag ctggttttct acctctccct
     2461 tagttccacc agaccagacg aggggctggc cagtatcatc tgtgaccagc tcctagagaa
     2521 agaaggatct gttactgaaa tgtgcgtgag gaacattatc cagcagttaa agaatcaggt
     2581 cttattcctt ttagatgact acaaagaaat atgttcaatc cctcaagtca taggaaaact
     2641 gattcaaaaa aaccacttat cccggacctg cctattgatt gctgtccgta caaacagggc
     2701 cagggacatc cgccgatacc tagagaccat tctagagatc aaagcatttc ccttttataa
     2761 tactgtctgt atattacgga agctcttttc acataatatg actcgtctgc gaaagtttat
     2821 ggtttacttt ggaaagaacc aaagtttgca gaagatacag aaaactcctc tctttgtggc
     2881 ggcgatctgt gctcattggt ttcagtatcc ttttgaccca tcctttgatg atgtggctgt
     2941 tttcaagtcc tatatggaac gcctttcctt aaggaacaaa gcgacagctg aaattctcaa
     3001 agcaactgtg tcctcctgtg gtgagctggc cttgaaaggg tttttttcat gttgctttga
     3061 gtttaatgat gatgatctcg cagaagcagg ggttgatgaa gatgaagatc taaccatgtg
     3121 cttgatgagc aaatttacag cccagagact aagaccattc taccggtttt taagtcctgc
     3181 cttccaagaa tttcttgcgg ggatgaggct gattgaactc ctggattcag ataggcagga
     3241 acatcaagat ttgggactgt atcatttgaa acaaatcaac tcacccatga tgactgtaag
     3301 cgcctacaac aattttttga actatgtctc cagcctccct tcaacaaaag cagggcccaa
     3361 aattgtgtct catttgctcc atttagtgga taacaaagag tcattggaga atatatctga
     3421 aaatgatgac tacttaaagc accagccaga aatttcactg cagatgcagt tacttagggg
     3481 attgtggcaa atttgtccac aagcttactt ttcaatggtt tcagaacatt tactggttct
     3541 tgccctgaaa actgcttatc aaagcaacac tgttgctgcg tgttctccat ttgttttgca
     3601 attccttcaa gggagaacac tgactttggg tgcgcttaac ttacagtact ttttcgacca
     3661 cccagaaagc ttgtcattgt tgaggagcat ccacttccca atacgaggaa ataagacatc
     3721 acccagagca catttttcag ttctggaaac atgttttgac aaatcacagg tgccaactat
     3781 agatcaggac tatgcttctg cctttgaacc tatgaatgaa tgggagcgaa atttagctga
     3841 aaaagaggat aatgtaaaga gctatatgga tatgcagcgc agggcatcac cagaccttag
     3901 tactggctat tggaaacttt ctccaaagca gtacaagatt ccctgtctag aagtcgatgt
     3961 gaatgatatt gatgttgtag gccaggatat gcttgagatt ctaatgacag ttttctcagc
     4021 ttcacagcgc atcgaactcc atttaaacca cagcagaggc tttatagaaa gcatccgccc
     4081 agctcttgag ctgtctaagg cctctgtcac caagtgctcc ataagcaagt tggaactcag
     4141 cgcagccgaa caggaactgc ttctcaccct gccttccctg gaatctcttg aagtctcagg
     4201 gacaatccag tcacaagacc aaatctttcc taatctggat aagttcctgt gcctgaaaga
     4261 actgtctgtg gatctggagg gcaatataaa tgttttttca gtcattcctg aagaatttcc
     4321 aaacttccac catatggaga aattattgat ccaaatttca gctgagtatg atccttccaa
     4381 actagtaaaa ttaattcaaa attctccaaa ccttcatgtt ttccatctga agtgtaactt
     4441 cttttcggat tttgggtctc tcatgactat gcttgtttcc tgtaagaaac tcacagaaat
     4501 taagttttcg gattcatttt ttcaagccgt cccatttgtt gccagtttgc caaattttat
     4561 ttctctgaag atattaaatc ttgaaggcca gcaatttcct gatgaggaaa catcagaaaa
     4621 atttgcctac attttaggtt ctcttagtaa cctggaagaa ttgatccttc ctactgggga
     4681 tggaatttat cgagtggcca aactgatcat ccagcagtgt cagcagcttc attgtctccg
     4741 agtcctctca tttttcaaga ctttgaatga tgacagcgtg gtggaaattg ccaaagtagc
     4801 aatcagtgga ggtttccaga aacttgagaa cctaaagctt tcaatcaatc acaagattac
     4861 agaggaagga tacagaaatt tctttcaagc actggacaac atgccaaact tgcaggagtt
     4921 ggacatctcc aggcatttca cagagtgtat caaagctcag gccacaacag tcaagtcttt
     4981 gagtcaatgt gtgttacgac taccaaggct cattagactg aacatgttaa gttggctctt
     5041 ggatgcagat gatattgcat tgcttaatgt catgaaagaa agacatcctc aatctaagta
     5101 cttaactatt ctccagaaat ggatactgcc gttctctcca atcattcaga aataaaagat
     5161 tcagctaaaa actgctgaat caataatttg tcttggggca tattgaggat gtaaaaaaag
     5221 ttgttgatta atgctaaaaa ccaaattatc caaaattatt ttattaaata ttgcatacaa
     5281 aagaaaatgt gtaaggcttg ctaaaaaaca aaacaaaaca aaacacagtc ctgcatactc
     5341 accaccaagc tcaagaaata aatcatcacc aatacctttg aggtccctga gtaatccacc
     5401 ccagctaaag gcaaaccctt caatcaagtt tatacagcaa accctccatt gtccatggtc
     5461 aacagggaag gggttgggga caggtctgcc aatctatcta aaagccacaa tatggaagaa
     5521 gtattcaatt tatataataa atggctaact taacggttga atcactttca tacatggatg
     5581 aaacgggttt aacacaggat ccacatgaat cttctgtggg ccaagagatg ttccttaatc
     5641 cttgtagaac ctgttttcta tattgaacta gctttggtac agtagagtta acttactttc
     5701 catttatcca ctgccaatat aaagaggaaa caggggttag ggaaaaatga cttcattcca
     5761 gaggcttctc agagttcaac atatgctata atttagaatt ttcttatgaa tccactctac
     5821 ttgggtagaa aatattttat ctctagtgat tgcatattat ttccatatca tagtatttca
     5881 tagtattata tttgatatga gtgtctatat caatgtcagt gtccagaatt tcgttcctac
     5941 cagttaagta gttttctgaa cggccagaag accattcgaa attcatgata ctactataag
     6001 ttggtaaaca accatacttt tatcctcatt tttattctca ctaagaaaaa agtcaactcc
     6061 cctccccttg cccaagtatg aaatataggg acagtatgta tggtgtggtc tcatttgttt
     6121 agaaaaccac ttatgactgg gtgcggtggc tcacacctgt aatcccagca ctttgggagg
     6181 ctgaggcggg cgaatcattt gaggtgagga attcgagacc agcctggcca gcatggtgaa
     6241 accccatctc tactaaaaat acaaaaatta gccaggtgtg gtggcacatg cctgtagtcc
     6301 cagccactag ggcggctgag acgcaagact tgcttgaacc cgggaggcag aggttgcagt
     6361 gagccaagat ggcgccactg cattccagcc tgggcaacag agcaagaccc tgtctgtctc
     6421 aaaacaaaaa acaaaaccac ttatattgct agctacatta agaatttctg aatatgttac
     6481 tgagcttgct tgtggtaacc atttataata tcagaaagta tatgtacacc aaaacatgtt
     6541 gaacatccat gttgtacaac tgaaatataa ataattttgt caattatacc taaataaaac
     6601 tggaaaaaaa tttctggaag tttatatcta aaaatgttaa tagtgcgtac ctctaggaag
     6661 tgggcctgga agccattctt acttttcagt ctctcccatt ctgtactgtt ttttgtttta
     6721 ctttcgtgcc tgcattattt ttctatttaa aacaaaaata aatctagttt agcactaaaa
     6781 tattaactgg agctacctct ggagggcaag agtactagaa ggtgggatgg attgtcttct
     6841 tgcttgtctg attttatatg taataccttt gtaattagaa aggttgttaa gcattatatc
     6901 agaatccagt caggagacag aaaccacaca gaaatttgaa tggggaaagt ttaatataca
     6961 gatgctcggc ctgacgcagt ggctcacgcc tgtaattcca gcactttggg aggccgaggt
     7021 gggcagatca cttgaggtca ggagttcgag accagcctgg ccaacatggt gaaatcctgt
     7081 ctctactaaa aat
//
