LOCUS       NM_197956               3398 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens nuclear apoptosis inducing factor 1 (NAIF1), mRNA.
ACCESSION   NM_197956
VERSION     NM_197956.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3398)
  AUTHORS   Guo,Y., Liu,Y., Wang,H. and Liu,P.
  TITLE     Long noncoding RNA SRY-box transcription factor 2 overlapping
            transcript participates in Parkinson's disease by regulating the
            microRNA-942-5p/nuclear apoptosis-inducing factor 1 axis
  JOURNAL   Bioengineered 12 (1), 8570-8582 (2021)
   PUBMED   34607512
  REMARK    GeneRIF: Long noncoding RNA SRY-box transcription factor 2
            overlapping transcript participates in Parkinson's disease by
            regulating the microRNA-942-5p/nuclear apoptosis-inducing factor 1
            axis.
REFERENCE   2  (bases 1 to 3398)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3398)
  AUTHORS   Wu,X., Hu,C., Long,C., Zhai,X., Liang,P. and Yu,Z.
  TITLE     MicroRNA-351 Promotes the Proliferation and Invasion of Glioma
            Cells through Downregulation of NAIF1
  JOURNAL   J Mol Neurosci 70 (10), 1493-1499 (2020)
   PUBMED   32506303
  REMARK    GeneRIF: MicroRNA-351 Promotes the Proliferation and Invasion of
            Glioma Cells through Downregulation of NAIF1.
            Erratum:[J Mol Neurosci. 2020 Oct;70(10):1500. doi:
            10.1007/s12031-020-01655-z.. PMID: 32662048]
REFERENCE   4  (bases 1 to 3398)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3398)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3398)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   7  (bases 1 to 3398)
  AUTHORS   Sinzelle,L., Kapitonov,V.V., Grzela,D.P., Jursch,T., Jurka,J.,
            Izsvak,Z. and Ivics,Z.
  TITLE     Transposition of a reconstructed Harbinger element in human cells
            and functional homology with two transposon-derived cellular genes
  JOURNAL   Proc Natl Acad Sci U S A 105 (12), 4715-4720 (2008)
   PUBMED   18339812
  REMARK    GeneRIF: The functions of two transposon-derived human proteins:
            HARBI1, a domesticated transposase-derived protein, and NAIF1,
            which contains a trihelix motif similar to that described in the
            Myb-like protein, was investigated.
REFERENCE   8  (bases 1 to 3398)
  AUTHORS   Lv,B., Shi,T., Wang,X., Song,Q., Zhang,Y., Shen,Y., Ma,D. and
            Lou,Y.
  TITLE     Overexpression of the novel human gene, nuclear apoptosis-inducing
            factor 1, induces apoptosis
  JOURNAL   Int J Biochem Cell Biol 38 (4), 671-683 (2006)
   PUBMED   16378748
  REMARK    GeneRIF: NAIF1 (C9orf90)is a nuclear protein that induces apoptosis
            when overexpressed
REFERENCE   9  (bases 1 to 3398)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   10 (bases 1 to 3398)
  AUTHORS   Kececioglu,Y.
  TITLE     [The morphological effect of conjugated estrogens on the ovaries of
            old white rats and the selective Lipschutz phenomenon
            (proceedings)]
  JOURNAL   Arch Gynakol 224 (1-4), 425-426 (1977)
   PUBMED   203245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL360268.14.
            
            On Nov 24, 2018 this sequence version replaced NM_197956.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122729.1, AL833392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153980 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373078.5/ ENSP00000362170.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               AL360268.14        76026-76755         c
            731-3398            AL360268.14        70668-73335         c
FEATURES             Location/Qualifiers
     source          1..3398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..3398
                     /gene="NAIF1"
                     /gene_synonym="bA379C10.2; C9orf90"
                     /note="nuclear apoptosis inducing factor 1"
                     /db_xref="GeneID:203245"
                     /db_xref="HGNC:HGNC:25446"
                     /db_xref="MIM:610673"
     exon            1..730
                     /gene="NAIF1"
                     /gene_synonym="bA379C10.2; C9orf90"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1203
                     /gene="NAIF1"
                     /gene_synonym="bA379C10.2; C9orf90"
                     /codon_start=1
                     /product="nuclear apoptosis-inducing factor 1"
                     /protein_id="NP_931045.1"
                     /db_xref="CCDS:CCDS6889.1"
                     /db_xref="GeneID:203245"
                     /db_xref="HGNC:HGNC:25446"
                     /db_xref="MIM:610673"
                     /translation="MAVPAKKRKMNFSEREVEIIVEELELKKHLLVNHFNAGVPLAAK
                     SAAWHGILRRVNAVATCRRELPEVKKKWSDLKTEVRRKVAQVRAAVEGGEAPGPTEED
                     GAGGPGTGGGSGGGGPAVAPVLLTPMQQRICNLLGEATIISLPSTTEIHPVALGPSAT
                     AAAATVTLTQIPTETTYHTLEEGVVEYCTAEAPPPLPPETPVDMMAQHADTSVKPQAL
                     KSRIALNSAKLIQEQRVTNLHVKEIAQHLEQQNDLLQMIRRSQEVQACAQERQAQAME
                     GTQAALSVLIQVLRPMIKDFRRYLQSNTANPAPASDPGQVAQNGQPDSIIQ"
     exon            731..3398
                     /gene="NAIF1"
                     /gene_synonym="bA379C10.2; C9orf90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3370..3375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAIF1"
                     /gene_synonym="bA379C10.2; C9orf90"
                     /note="hexamer: ATTAAA"
     polyA_site      3398
                     /gene="NAIF1"
                     /gene_synonym="bA379C10.2; C9orf90"
                     /note="major polyA site"
ORIGIN      
        1 attacgctgc tggctggcag cggccgggcc ggtcggggct gggccctacg cactttgcgt
       61 agcgaggggg gttaccaaag gcctagtgct tggcctcgag caagcctggc ctatcccctg
      121 tagggggtgg gtgaggggcg aggctgagga agaagagaag gggaattggg gcgcttgagg
      181 ggattataat ttctttaaaa agaggggagg ggagaggcca tggccgtccc agccaagaaa
      241 aggaagatga acttctcaga gcgggaggtg gagatcatcg tggaggagct ggagctgaag
      301 aagcacctgc tggtgaacca cttcaacgcc ggggtacccc tggccgccaa gagtgcggcc
      361 tggcacggca tcctgagaag ggtcaacgcc gtggccacct gccgcagaga gctgcctgag
      421 gtcaagaaga agtggtctga cctcaagacc gaggtccgtc gcaaggttgc ccaggtccgg
      481 gccgccgtgg agggtggtga ggcgccgggg cccactgagg aggacggagc tggggggcct
      541 gggacaggcg gtggcagtgg tggcggtggc ccagctgtag ccccagtgct gctgaccccc
      601 atgcaacaac gtatctgcaa cctgctgggc gaggccacca tcatcagcct gcccagcacc
      661 acagagatcc accctgtggc cctcggaccc tcggccaccg cagccgcagc cacggtcacc
      721 ctgacacaga tccccacaga gaccacctat cacacgctgg aggagggcgt ggtggagtac
      781 tgcacggctg aggcgccccc acctctgcca ccagagaccc ctgtggacat gatggcccag
      841 catgcagaca cgtcggtcaa gccgcaagcg ctcaagagcc gcattgctct caactccgcc
      901 aagctgatac aggagcagcg ggtcaccaac ctgcatgtga aggagatcgc acagcacctg
      961 gaacagcaga acgacctact gcagatgatc cgccgctccc aggaagtgca ggcctgtgcc
     1021 caggagcgcc aggcccaggc catggagggc acacaggctg ccctgagcgt cctcatccag
     1081 gtcctccggc ctatgatcaa agatttccgc cgctacctgc agagcaacac agctaacccg
     1141 gcccccgcct ctgaccctgg gcaggtggcc cagaatgggc agccagacag catcatccag
     1201 tgagggcagg ggtcaggcca gccttctgcc atgatgggat gaaaactcca tggacttgta
     1261 agtgggtcct gtgattggcc ttggccttag accggccacg tgcacagctc cctctttaat
     1321 aaacgcttag gggttgcact gtttttgaga agaggaattt gttgggctcc tgggacccaa
     1381 actcatactc cccctacttg agctgccttg ctaagatcca gaagattggt tagcaggggg
     1441 tcacgtgtgc atgtgatggg acatgtgttg tcatgacccc gggcttgtga catgacccag
     1501 ccttggtctt ggacaactgt aaggaacaac acaacgggct gtcactgggg gccgtcaccc
     1561 agcctgggtc tctactgagc tgcccaaccc caggtgccat cctttcgagt agggtaatgt
     1621 cactgatgct ggcagttgag caataatatc ttcctccttt gggaggtagt gtgactgagg
     1681 aggaaacccc acccttttct cctcactgtg cctcagttct caggggactc caatgactgt
     1741 tgtgctctcc cccgacccca ccccaggcac agcgcaggcc cttgttaggt agtgtgctgg
     1801 gacgcctccg taatacatgc agtgtgcagc cagtctggct caggaatgct gtgtatggtg
     1861 gggacggttt ggccactctc tggttttcaa cagcatctct gggcagccct ttggtggttt
     1921 gtccctagag cttttgactc aggtcaagct ttggatgctg taaatttttg agaaagccaa
     1981 ctagtgtgga agcttgctgc cccactgcag tgggtctgag tgacctgttg gctttgtgcg
     2041 gaggcttgca tccagccagt tgtatttatt ctgtgtgtga acccctccta ggaaggcctc
     2101 caggaaggct gccctgtggc cacacccatc ctcctttcct ctctgctgac tccacatttc
     2161 caaaattcag tgcaaaaaaa gccctgctga gcatcacatg ctggactctt cccctgccac
     2221 accgctcagt gccttctgtt ctcttgagac tccctctgag tagctgagtg aatccaaagc
     2281 cataattgac cctgaacgta ggaggaggaa aaggcgaagc tgacctaaga agtgggaccc
     2341 tggccgggcg aggtggctca agtctgtaat cccagcgctt tgggaggccg aggcgggtgg
     2401 atcacgaggt caagagatca agaccatcct ggccaacatg atgaaacccc gtctctacta
     2461 aaaacacaaa aattagctgg gcgtggtggc acacgcctgt agtcccagct acccgggagg
     2521 ctgaggcagg agaatcgctt gaacccagga ggcggagatt gcagtgagcc gagattgcac
     2581 cgctgcactc cagcctggcg acagagcgag actctgtctc aaaaaaaaaa caaagaaaaa
     2641 accaaaaaaa caaatgggac cctttggatt ctatgctcag ggaagagcag gcagagcctt
     2701 ggagtgctga aggaggtgct gttccctgtt ccatctttac actttctctt ctgagatgtc
     2761 tgtaaggatt ttacccagat gccatttgtc tgtttcattt tcagactcac catcaattac
     2821 caaggccctt gcatctcccc agatcgtttc ccaagtttgg cgatttgctg tcggtgcctc
     2881 agccacatat gaccaatggt tacaactcag ggctccagac ctcagctaaa aagagaagac
     2941 gctgccctcc tgggcacgaa cgtttagaat gctcaactcc tctattgtga ccacaggaag
     3001 gtggccctga agatgcaccg aagacagctg ggaggtgact gctgtactgt cagcctctct
     3061 gtggaggcat tcgtgcagtg ccagctaaaa gggaggtgaa gggggatatc ggacccagcg
     3121 agggagttgc tggtagaagg aaagctcttc tcagtgtggc tggattaaga gcagcctagc
     3181 agcttgggca cctccactct gtgcggtctg atggccccag caaggtcgct gcagggactt
     3241 cctgaggact tggtttggtt tttttctggg gttggaaatc tgagccaata ttgtgtctgt
     3301 tccatttggg tatgaagagg aagtctggat cacttaaact gactagttat ttccgggtca
     3361 taattttaaa ttaaagacat atcacttttt tatacaca
//
