LOCUS       NM_017567               2371 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens N-acetylglucosamine kinase (NAGK), transcript variant
            1, mRNA.
ACCESSION   NM_017567
VERSION     NM_017567.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Nataf,S., Guillen,M. and Pays,L.
  TITLE     The Immunometabolic Gene N-Acetylglucosamine Kinase Is Uniquely
            Involved in the Heritability of Multiple Sclerosis Severity
  JOURNAL   Int J Mol Sci 25 (7), 3803 (2024)
   PUBMED   38612613
  REMARK    GeneRIF: The Immunometabolic Gene N-Acetylglucosamine Kinase Is
            Uniquely Involved in the Heritability of Multiple Sclerosis
            Severity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Timalsina,B., Choi,H.J. and Moon,I.S.
  TITLE     N-Acetylglucosamine Kinase-Small Nuclear Ribonucleoprotein
            Polypeptide N Interaction Promotes Axodendritic Branching in
            Neurons via Dynein-Mediated Microtubule Transport
  JOURNAL   Int J Mol Sci 24 (14), 11672 (2023)
   PUBMED   37511433
  REMARK    GeneRIF: N-Acetylglucosamine Kinase-Small Nuclear Ribonucleoprotein
            Polypeptide N Interaction Promotes Axodendritic Branching in
            Neurons via Dynein-Mediated Microtubule Transport.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Stafford,C.A., Gassauer,A.M., de Oliveira Mann,C.C., Tanzer,M.C.,
            Fessler,E., Wefers,B., Nagl,D., Kuut,G., Sulek,K., Vasilopoulou,C.,
            Schwojer,S.J., Wiest,A., Pfautsch,M.K., Wurst,W., Yabal,M.,
            Frohlich,T., Mann,M., Gisch,N., Jae,L.T. and Hornung,V.
  TITLE     Phosphorylation of muramyl peptides by NAGK is required for NOD2
            activation
  JOURNAL   Nature 609 (7927), 590-596 (2022)
   PUBMED   36002575
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Campbell,S., Mesaros,C., Izzo,L., Affronti,H., Noji,M.,
            Schaffer,B.E., Tsang,T., Sun,K., Trefely,S., Kruijning,S.,
            Blenis,J., Blair,I.A. and Wellen,K.E.
  TITLE     Glutamine deprivation triggers NAGK-dependent hexosamine salvage
  JOURNAL   Elife 10, e62644 (2021)
   PUBMED   34844667
  REMARK    GeneRIF: Glutamine deprivation triggers NAGK-dependent hexosamine
            salvage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Islam,M.A., Choi,H.J., Dash,R., Sharif,S.R., Oktaviani,D.F.,
            Seog,D.H. and Moon,I.S.
  TITLE     N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1 in
            Dynein Motor Complex and Promotes Cell Migration
  JOURNAL   Int J Mol Sci 22 (1), 129 (2020)
   PUBMED   33374456
  REMARK    GeneRIF: N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1
            in Dynein Motor Complex and Promotes Cell Migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Maguire,P.B., Wynne,K.J., Harney,D.F., O'Donoghue,N.M., Stephens,G.
            and Fitzgerald,D.J.
  TITLE     Identification of the phosphotyrosine proteome from thrombin
            activated platelets
  JOURNAL   Proteomics 2 (6), 642-648 (2002)
   PUBMED   12112843
REFERENCE   8  (bases 1 to 2371)
  AUTHORS   Hinderlich,S., Berger,M., Schwarzkopf,M., Effertz,K. and Reutter,W.
  TITLE     Molecular cloning and characterization of murine and human
            N-acetylglucosamine kinase
  JOURNAL   Eur J Biochem 267 (11), 3301-3308 (2000)
   PUBMED   10824116
REFERENCE   9  (bases 1 to 2371)
  AUTHORS   Lowes,W., Walker,M., Alberti,K.G. and Agius,L.
  TITLE     Hexokinase isoenzymes in normal and cirrhotic human liver:
            suppression of glucokinase in cirrhosis
  JOURNAL   Biochim Biophys Acta 1379 (1), 134-142 (1998)
   PUBMED   9468341
REFERENCE   10 (bases 1 to 2371)
  AUTHORS   Weidanz,J.A., Campbell,P., Moore,D., DeLucas,L.J., Roden,L.,
            Thompson,J.N. and Vezza,A.C.
  TITLE     N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate
            deacetylase in normal human erythrocytes and Plasmodium falciparum
  JOURNAL   Br J Haematol 95 (4), 645-653 (1996)
   PUBMED   8982040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK297224.1, BC001029.2 and
            AC007881.4.
            
            On Nov 23, 2018 this sequence version replaced NM_017567.5.
            
            Summary: This gene encodes a member of the N-acetylhexosamine
            kinase family. The encoded protein catalyzes the conversion of
            N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and
            is the major mammalian enzyme which recovers amino sugars.
            [provided by RefSeq, Nov 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.45062.1,
                                           SRR1660803.169264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244204.11/ ENSP00000244204.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-888               AK297224.1         348-1235
            889-889             BC001029.2         901-901
            890-1244            AK297224.1         1237-1591
            1245-1245           AC007881.4         45383-45383
            1246-1431           AK297224.1         1593-1778
            1432-2371           AC007881.4         45570-46509
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..2371
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /note="N-acetylglucosamine kinase"
                     /db_xref="GeneID:55577"
                     /db_xref="HGNC:HGNC:17174"
                     /db_xref="MIM:606828"
     exon            1..65
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1071
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /EC_number="2.7.1.60"
                     /EC_number="2.7.1.59"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acetyl-D-glucosamine kinase; glcNAc kinase; epididymis
                     secretory sperm binding protein; muramyl dipeptide kinase;
                     N-acetyl-D-mannosamine kinase"
                     /codon_start=1
                     /product="N-acetyl-D-glucosamine kinase isoform 1"
                     /protein_id="NP_060037.4"
                     /db_xref="CCDS:CCDS33220.3"
                     /db_xref="GeneID:55577"
                     /db_xref="HGNC:HGNC:17174"
                     /db_xref="MIM:606828"
                     /translation="MAAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDK
                     CVERINEMVNRAKRKAGVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSESY
                     LITTDAAGSIATATPDGGVVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIA
                     HQAVKIVFDSIDNLEAAPHDIGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCR
                     KIAEGAQQGDPLSRYIFRKAGEMLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSW
                     ELLKEGFLLALTQGREIQAQNFFSSFTLMKLRHSSALGGASLGARHIGHLLPMDYSAN
                     AIAFYSYTFS"
     exon            66..150
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     exon            151..249
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     exon            250..391
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     exon            392..502
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     exon            503..615
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     exon            616..703
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     exon            704..801
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     exon            802..880
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     exon            881..2371
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /note="hexamer: AATAAA"
     polyA_site      1204
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /note="major polyA site"
     polyA_site      1425
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
     polyA_site      1430
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
                     /note="hexamer: AATAAA"
     polyA_site      2371
                     /gene="NAGK"
                     /gene_synonym="GNK; HSA242910"
ORIGIN      
        1 gcaaacggcg ggaccagcag cgacggtagc agcagcatgg ccgcgatcta tgggggtgta
       61 gaggggggag gcacacgatc cgaggtcctt ttagtctcag aggatgggaa gatcctggca
      121 gaagcagatg gactgagcac aaaccactgg ctgatcggga cagacaagtg tgtggagagg
      181 atcaatgaga tggtgaacag ggccaaacgg aaagcagggg tggatcctct ggtaccgctg
      241 cgaagcttgg gcctatctct gagcggtggg gaccaggagg acgcggggag gatcctgatc
      301 gaggagctga gggaccgatt tccctacctg agtgaaagct acttaatcac caccgatgcc
      361 gccggctcca tcgccacagc tacaccggat ggtggagttg tgctcatatc tggaacaggc
      421 tccaactgca ggctcatcaa ccctgatggc tccgagagtg gctgcggcgg ctggggccat
      481 atgatgggtg atgagggttc agcctactgg atcgcacacc aagcagtgaa aatagtgttt
      541 gactccattg acaacctaga ggcggctcct catgatatcg gctacgtcaa acaggccatg
      601 ttccactatt tccaggtgcc agatcggcta gggatactca ctcacctgta tagggacttt
      661 gataaatgca ggtttgctgg gttttgccgg aaaattgcag aaggtgctca gcagggagac
      721 cccctttccc gctatatctt caggaaggct ggggagatgc tgggcagaca catcgtagca
      781 gtgttgcccg agattgaccc ggtcttgttc cagggcaaga ttggactccc catcctgtgc
      841 gtgggctctg tgtggaagag ctgggagctg ctgaaggaag gttttcttct ggcgctgacc
      901 cagggcagag agatccaggc tcagaacttc ttctccagct tcaccctgat gaagctgagg
      961 cactcctccg ctctgggtgg ggccagccta ggggccaggc acatcgggca cctcctcccc
     1021 atggactata gcgccaatgc cattgccttc tattcctaca ccttttccta gggggctggt
     1081 cccggctcca ccccctccaa gctcagtgga cactgggtct gaaaggaagg agtcttttgc
     1141 ttcctttctc ctttttacaa aaacaaacat agaagaaaat aaatgcactt tatccactcc
     1201 ccaattggac tgcattatca aacacatgtg ctatgtacat cctcagtgca cctgccagca
     1261 gatatcctgg agggctcatg agtgaattta gtccaagatt taaagccctg cccccaggtg
     1321 ctcagcctgt gatctgtatc cactcagcat gcacttgggc agatgatttg tctgtgtgct
     1381 acccttcccc ccatattacc atacatatgc actgtgtggc tgccagttaa tctgtgacct
     1441 gttttctcct gtcgtgtcaa gtgggtaacg atccctggcg accacagtca gcagaaacaa
     1501 gtgctcacca ttcagaacat cacagggagt aaccttaggt atatcacacc ctctcctgag
     1561 actcccagca agatttaggg gctagagtac aattctagac tgggagcatc tttacctcac
     1621 tggatttagt aactgcaggt aagcaggaca ttttgaagtt tttcctatga atgagttttt
     1681 gaaaggttat gaggatggct gagatccaag aagaccaact aggtaccgct cacctcggta
     1741 gctgacctat tcctggctac tactagcctg gctctgctta cagcgtgaca ctatgtgttg
     1801 tgtgttcctg ggaatgagga gcatcagtga agagcagaca tgattcctgc cctctgggta
     1861 ccatagttca gccagtgaag gcaaacctga agcttcggtt ccacagcctg tgctgcttgg
     1921 tgaagactaa ggacaggagt ctcgatccac aatagctgcc tctccaggtg ttttattaga
     1981 ggcatgtgga tcatgtcctg cacatcagtt ctccaactta cagacatcag ttattctaga
     2041 gtttgtttta aaacacggtt ttggccgggc acggtggctc acgcctgtaa tcccagcact
     2101 ttgggaggcc gaggcaggtg gatcacgagg tcaggagatt gagaccatcc tggctaacac
     2161 ggtgaaactc catctctact aaaaaataca aaaaattaac cgggcgtggt gtcgcgcgcc
     2221 tgtagtccca gctactgggg aggctgaggc aggagaatgg catgaaccca ggaggtggag
     2281 cttgcagtga gccgaggtcg caccactgca ctccagcctg ggcgacagag cgagactctg
     2341 cctcaaaaaa taataaataa aaataaaatc a
//
