LOCUS       NM_052876               4524 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleus accumbens associated 1 (NACC1), mRNA.
ACCESSION   NM_052876
VERSION     NM_052876.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4524)
  AUTHORS   Komulainen-Ebrahim,J., Kangas,S.M., Lopez-Martin,E., Feyma,T.,
            Scaglia,F., Martinez-Delgado,B., Kuismin,O., Suo-Palosaari,M.,
            Carr,L., Hinttala,R., Kurian,M.A. and Uusimaa,J.
  TITLE     Hyperkinetic Movement Disorder Caused by the Recurrent c.892C>T
            NACC1 Variant
  JOURNAL   Mov Disord Clin Pract 11 (6), 708-715 (2024)
   PUBMED   38698576
  REMARK    GeneRIF: Hyperkinetic Movement Disorder Caused by the Recurrent
            c.892C>T NACC1 Variant.
REFERENCE   2  (bases 1 to 4524)
  AUTHORS   Xie,Q., Tong,C. and Xiong,X.
  TITLE     An overview of the co-transcription factor NACC1: Beyond its
            pro-tumor effects
  JOURNAL   Life Sci 336, 122314 (2024)
   PUBMED   38030057
  REMARK    GeneRIF: An overview of the co-transcription factor NACC1: Beyond
            its pro-tumor effects.
            Review article
REFERENCE   3  (bases 1 to 4524)
  AUTHORS   Dong,S., Wang,X., Yang,S., Guo,F., Zhang,J., Ji,C., Shi,L.,
            Cheng,Y., Hu,Y., Li,Z., Peng,L., Guo,L., Zhu,W., Ren,X., Yang,J.M.
            and Zhang,Y.
  TITLE     Mechanistic insights of NAC1 nuclear export and its role in ovarian
            cancer resistance to docetaxel
  JOURNAL   Biochem Pharmacol 211, 115533 (2023)
   PUBMED   37019189
  REMARK    GeneRIF: Mechanistic insights of NAC1 nuclear export and its role
            in ovarian cancer resistance to docetaxel.
REFERENCE   4  (bases 1 to 4524)
  AUTHORS   Yang,T., Shen,P., Chen,Q., Wu,P., Yuan,H., Ge,W., Meng,L.,
            Huang,X., Fu,Y., Zhang,Y., Hu,W., Miao,Y., Lu,Z. and Jiang,K.
  TITLE     FUS-induced circRHOBTB3 facilitates cell proliferation via
            miR-600/NACC1 mediated autophagy response in pancreatic ductal
            adenocarcinoma
  JOURNAL   J Exp Clin Cancer Res 40 (1), 261 (2021)
   PUBMED   34416910
  REMARK    GeneRIF: FUS-induced circRHOBTB3 facilitates cell proliferation via
            miR-600/NACC1 mediated autophagy response in pancreatic ductal
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4524)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4524)
  AUTHORS   Ishibashi,M., Nakayama,K., Yeasmin,S., Katagiri,A., Iida,K.,
            Nakayama,N., Fukumoto,M. and Miyazaki,K.
  TITLE     A BTB/POZ gene, NAC-1, a tumor recurrence-associated gene, as a
            potential target for Taxol resistance in ovarian cancer
  JOURNAL   Clin Cancer Res 14 (10), 3149-3155 (2008)
   PUBMED   18483383
  REMARK    GeneRIF: NAC-1 regulates Taxol resistance in ovarian cancer
REFERENCE   7  (bases 1 to 4524)
  AUTHORS   Yeasmin,S., Nakayama,K., Ishibashi,M., Katagiri,A., Iida,K.,
            Purwana,I.N., Nakayama,N. and Miyazaki,K.
  TITLE     Expression of the bric-a-brac tramtrack broad complex protein NAC-1
            in cervical carcinomas seems to correlate with poorer prognosis
  JOURNAL   Clin Cancer Res 14 (6), 1686-1691 (2008)
   PUBMED   18347169
  REMARK    GeneRIF: NAC-1 may play an important role in cervical carcinomas.
REFERENCE   8  (bases 1 to 4524)
  AUTHORS   Nakayama,K., Nakayama,N., Wang,T.L. and Shih,Ie.M.
  TITLE     NAC-1 controls cell growth and survival by repressing transcription
            of Gadd45GIP1, a candidate tumor suppressor
  JOURNAL   Cancer Res 67 (17), 8058-8064 (2007)
   PUBMED   17804717
  REMARK    GeneRIF: NAC-1 contributes to tumor growth and survival by at least
            inhibiting Gadd45GIP1 expression, which has a tumor suppressor
            effect in cancer cells.
REFERENCE   9  (bases 1 to 4524)
  AUTHORS   Davidson,B., Berner,A., Trope',C.G., Wang,T.L. and Shih,I.M.
  TITLE     Expression and clinical role of the bric-a-brac tramtrack broad
            complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma
            effusions
  JOURNAL   Hum Pathol 38 (7), 1030-1036 (2007)
   PUBMED   17391728
  REMARK    GeneRIF: NAC-1 expression is higher in ovarian carcinoma cells in
            effusions compared with their solid tumor counterparts.
REFERENCE   10 (bases 1 to 4524)
  AUTHORS   Nakayama,K., Nakayama,N., Davidson,B., Sheu,J.J., Jinawath,N.,
            Santillan,A., Salani,R., Bristow,R.E., Morin,P.J., Kurman,R.J.,
            Wang,T.L. and Shih,Ie.M.
  TITLE     A BTB/POZ protein, NAC-1, is related to tumor recurrence and is
            essential for tumor growth and survival
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18739-18744 (2006)
   PUBMED   17130457
  REMARK    GeneRIF: NAC-1 is a tumor recurrence-associated gene with oncogenic
            potential; interactions between BTB/POZ domains of NAC-1 proteins
            are critical to form the discrete NAC-1 nuclear bodies and
            essential for tumor cell proliferation and survival.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005546.1, BX395451.2,
            BU508302.1, AF395817.1, AK094702.1 and BU623112.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052876.3.
            
            Summary: This gene encodes a member of the BTB/POZ protein family.
            BTB/POZ proteins are involved in several cellular processes
            including proliferation, apoptosis and transcription regulation.
            The encoded protein is a transcriptional repressor that plays a
            role in stem cell self-renewal and pluripotency maintenance. The
            encoded protein also suppresses transcription of the candidate
            tumor suppressor Gadd45GIP1, and expression of this gene may play a
            role in the progression of multiple types of cancer. A pseudogene
            of this gene is located on the short arm of chromosome 9. [provided
            by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF395817.1, SRR9304713.275065.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292431.5/ ENSP00000292431.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC005546.1         25919-25942
            25-31               BX395451.2         1-7
            32-73               BU508302.1         1-42
            74-1877             AF395817.1         1-1804
            1878-4011           AK094702.1         454-2587
            4012-4518           AK094702.1         2589-3095
            4519-4524           BU623112.1         19-24               c
FEATURES             Location/Qualifiers
     source          1..4524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..4524
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /note="nucleus accumbens associated 1"
                     /db_xref="GeneID:112939"
                     /db_xref="HGNC:HGNC:20967"
                     /db_xref="MIM:610672"
     exon            1..191
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /inference="alignment:Splign:2.1.0"
     exon            192..1145
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1783
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /note="BEN domain containing 8; nucleus accumbens
                     associated 1, BEN and BTB (POZ) domain containing;
                     transcriptional repressor NAC1; BTB/POZ domain-containing
                     protein 14B"
                     /codon_start=1
                     /product="nucleus accumbens-associated protein 1"
                     /protein_id="NP_443108.1"
                     /db_xref="CCDS:CCDS12294.1"
                     /db_xref="GeneID:112939"
                     /db_xref="HGNC:HGNC:20967"
                     /db_xref="MIM:610672"
                     /translation="MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAH
                     RAVLAASSSYFRDLFNNSRSAVVELPAAVQPQSFQQILSFCYTGRLSMNVGDQFLLMY
                     TAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHAEEAPSSEPQSPVAQTSGWPACSTPL
                     PLVSRVKTEQQESDSVQCMPVAKRLWDSGQKEAGGGGNGSRKMAKFSTPDLAANRPHQ
                     PPPPQQAPVVAAAQPAVAAGAGQPAGGVAAAGGVVSGPSTSERTSPGTSSAYTSDSPG
                     SYHNEEDEEEDGGEEGMDEQYRQICNMYTMYSMMNVGQTAEKVEALPEQVAPESRNRI
                     RVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAG
                     TRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPN
                     FKESEMNAIAADMCTNARRVVRKSWMPKVKVLKAEDDAYTTFISETGKIEPDMMGVEH
                     GFETASHEGEAGPSAEALQ"
     exon            1146..1319
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1425
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1523
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..4524
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4504..4509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /note="hexamer: ACTAAA"
     polyA_site      4524
                     /gene="NACC1"
                     /gene_synonym="BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NECFM"
                     /note="major polyA site"
ORIGIN      
        1 gctcggctgg ggcggcctgg cccacaatga atggccgccg cggctgccgc tgctgctgag
       61 gcggaggccg cggaggccgc ggaggcggag gccgaggccc cggcgcagcg gggcgcgccc
      121 cgggcccagg cccggcccca gccgccgctg cggagcccgc cgggaccccc cggagcgcgg
      181 ccacggcgca gccgctgcca tggcccagac actgcagatg gagatcccga acttcggcaa
      241 cagcatcctg gagtgcctca atgaacagcg gctgcagggc ctgtactgtg acgtgtcagt
      301 ggtggtcaag ggccatgcct tcaaggccca ccgggccgtg cttgctgcca gcagctccta
      361 cttccgggac ctgttcaaca acagccgcag cgccgtggtg gagctgccgg cggctgtgca
      421 gccccagtct ttccagcaga tcctcagctt ctgctacacg ggccggctga gcatgaacgt
      481 gggcgaccag ttcctgctca tgtacacggc tggcttcctg cagatccagg agatcatgga
      541 gaagggcacc gagttcttcc tcaaggtgag ctccccgagc tgcgactccc agggcctgca
      601 tgcggaggag gccccatcgt cggagcccca gagccccgtg gcgcagacat cgggctggcc
      661 agcctgtagc accccgctgc ccctcgtgtc gcgggtgaag acggagcagc aggagtcgga
      721 ctccgtgcag tgcatgcccg tggccaagcg gctgtgggac agtggccaga aggaggctgg
      781 gggcggcggc aatggcagcc gcaagatggc caagttctcc acgccggacc tggctgccaa
      841 ccggcctcac cagcccccgc caccccaaca ggctccggtg gtggcagcag cccagcccgc
      901 cgtggctgcg ggagcagggc agccagccgg tggggtggca gcagcagggg gtgtggtgag
      961 tgggcccagc acgtcggagc ggaccagccc aggcacctca agcgcctaca ccagcgacag
     1021 ccctggctcc taccacaatg aggaggacga ggaggaggat ggtggcgagg agggcatgga
     1081 tgagcagtac cggcagatct gcaacatgta caccatgtac agcatgatga acgtcggcca
     1141 gacagccgag aaggtggagg ccctcccgga gcaggtagcc cccgagtccc gaaatcgcat
     1201 ccgggttcgg caagacctgg cgtctctccc ggctgaactt atcaaccaga ttgggaaccg
     1261 ctgccacccc aagctctacg acgagggcga cccctctgag aagctggagc tggtgacagg
     1321 caccaacgtg tacatcacaa gggcgcagct gatgaactgc cacgtcagcg caggcacgcg
     1381 gcacaaggtc ctactgcggc ggctcctggc ctccttcttt gaccggaaca cgctggccaa
     1441 cagctgcggc accggcatcc gctcttctac caacgatccc cgtcggaagc ccctggacag
     1501 ccgcgtgctc cacgctgtca agtactactg ccagaacttc gcccccaact tcaaggagag
     1561 cgagatgaat gccatcgcgg ccgacatgtg caccaacgcc cgccgcgtcg tgcgcaagag
     1621 ctggatgccc aaggtcaagg tgctcaaggc tgaggatgac gcctacacca ccttcatcag
     1681 tgaaacgggc aagatcgagc cggacatgat gggtgtggag catggcttcg agaccgccag
     1741 ccacgagggc gaggcgggtc cctcggctga agccctgcag taacccgccc agcctcccgc
     1801 ggggccacac acttcccctc ccaacacaca cacacacctg ccatcttggt catgagctac
     1861 tgtctgtccc tccccaggac ccgcggtggg tgctgcatgt tcccggccct ctgcccctcc
     1921 tgtcctaccc cctttcccca ccgagagctg ggccgggaga ggaccgcagg gcaggtggcg
     1981 tgaggtccgt gttgccttct ttaacacaca ctcgtgcagt gggggagttc tggctcccca
     2041 acctaacccc tagccgtcat ctccacactc accaggccca ccaggggagg gggctggcct
     2101 gggggtcttg ggaaggcccc tccccaggcc ctaggccacc tcgcggaagc cttcagcctc
     2161 cgcccctcac tgcagcccct tgggacttga ggggggcccc aggggttctc aggacccctc
     2221 ccaccacctc ccagtgcttc cacgtctcca aaagcgcctt cctgtcaccc tcgtctatcc
     2281 ctgcgcctgg gggctggggt aggcgaggcc gtggggacta cccattttat agctggggaa
     2341 acaggctccg agaaattgca caaccgacct caggtggccg gcagtggcgt gcctggtgcc
     2401 ctttctcctc ttccgcctct gttgctccct ttggtcctct ggggcctcag agaggcaggt
     2461 cctaaaggag ggggggtctc ctgggggcag accgagggtc tcggaggata gaatgagagg
     2521 tttccagggc tggcagagtg tgtgcgtgtg tgtgtgcaga agttttgctt tcaaacaaat
     2581 gaagatacaa gaggcagtag gacctgggtt ggaacccagg ggagcagact ggggggctgt
     2641 tgcccctccc tccatctccc cacacccacc ccaccccaca gcagggctcc tggcccccac
     2701 ccccctgtac ataattttta aaaccttttt ttagcgaatg aaatattgaa gtataagatt
     2761 ccttttattt ttcaaaccaa tggggctgtg tctattgtcc ccctcggtcc ccaggggtgg
     2821 ggggccttgg aaggcagggc ggtgttgggg ggctgggggg caggctgaat gtgtgtgtgt
     2881 gggtgtgtat gtgtggagtg tgtgtgtgtg tttccatggt aggactccag tcccagctgc
     2941 tgcctaggct cctgtgggtc ctgtgggtcc ccctcccctg ttcaccttcc ccaacagggc
     3001 tatagtttaa gggtgtccca ggccttggct ggttggctgg gcccagctcc tgggggctgg
     3061 gcagggcagg gcagggccgg gtccacttcc attgttagca gttgtttgca gaattttctc
     3121 ttttaccatt cctctctttt tgttctcgcc cagagtgggt ggttttttgt tgttgtttta
     3181 gattttcatg tgaaggcagt tttttttctt ttttaactcc ccatccccct atgcagggtg
     3241 tcatttcacc atccacatcc acatccttgt ttgtgtttct ggccctcgtc ctccctgcct
     3301 ctcatctgcc tccccaaccc ccacctaccc actgctccca ggggtctctc caggggcagg
     3361 gggattttag gagatggggt gggggccagc ccctactgga cccttgtaat ctgatttgga
     3421 gaccatcccc ccgatgggac cagcagcccc gccggcccac tgggggtccc tcttaacatc
     3481 tgcttgttgc gggggtcagt catgagtgcc agggtctggc tggggtcttg gcactgtctt
     3541 cctggccggg gcctgaaacc ttagccccca gccggcctga gtgggggata ttgacacccc
     3601 cagctaaagc acaagcacct tagtcacccc tcctctcccc ccgcctcctg gcctgccacc
     3661 ccaccccagc gtttacccca aagcacaatg ccctggtcac ttggcaagcg gctgggcctg
     3721 acggaggccg aggggcagac cggggctcca gccagacccc tgaaaggaag gtgctccccc
     3781 acttccaggc cttagttggg gtgggggggc cagctcctgg gcctggggtc ttctcacccc
     3841 cacccccttg tcctgggtag gcccctgcct gcccctctct gccttttcct cgggtgtccc
     3901 tcctcgagcc cctgtggcat tggcttgggt ggcagagccc acttgtttca gggaccccag
     3961 gaggtgcccc ctggctccca ggactgtgtg tgggtccggg gggtgggggg gtggggagaa
     4021 gggtcgggca gggggtgcag gggaggaaac tcctcaccag gagagccaaa gacagggttg
     4081 tgccttaccc caggagccac ccctgtaccc cccttgccct gccattcacc ctccacccct
     4141 acccctgggc ggcctgctgc tttttccttc tcttcctccc ctgccctgag ctgcatggtt
     4201 cccccaccct gggcagccag gaaggaatct gaatggagaa tcaccaacca ccagagaaaa
     4261 aagactgtgg ggccctcccc tgccaactcc ccttccctgg ccgcccactc aacccacacc
     4321 tctttcacgc aggacaggct gcccaccctg tccacgtgaa gtgccaacgc cctccccacc
     4381 ctgggccgag cccccacccc tccctgggcc cccaagtgag attgcacatt taactactgt
     4441 aaggagagga gcggcgttgg caaatgtgaa ccatgagaat atcagtgata ctgatgagaa
     4501 taaactaaac gcctttgtaa cagc
//
