LOCUS       NM_199290                799 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens nascent polypeptide associated complex subunit alpha 2
            (NACA2), transcript variant 1, mRNA.
ACCESSION   NM_199290 XM_292598
VERSION     NM_199290.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 799)
  AUTHORS   Hradetzky,S., Balaji,H., Roesner,L.M., Heratizadeh,A.,
            Mittermann,I., Valenta,R. and Werfel,T.
  TITLE     The human skin-associated autoantigen alpha-NAC activates monocytes
            and dendritic cells via TLR-2 and primes an IL-12-dependent Th1
            response
  JOURNAL   J Invest Dermatol 133 (9), 2289-2292 (2013)
   PUBMED   23657466
  REMARK    GeneRIF: Alpha-nac is a potent inducer of a Th1 response via IL12
            and TLR2.
REFERENCE   2  (bases 1 to 799)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 799)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   4  (bases 1 to 799)
  AUTHORS   Marques,A.C., Dupanloup,I., Vinckenbosch,N., Reymond,A. and
            Kaessmann,H.
  TITLE     Emergence of young human genes after a burst of retroposition in
            primates
  JOURNAL   PLoS Biol 3 (11), e357 (2005)
   PUBMED   16201836
REFERENCE   5  (bases 1 to 799)
  AUTHORS   Mossabeb,R., Seiberler,S., Mittermann,I., Reininger,R.,
            Spitzauer,S., Natter,S., Verdino,P., Keller,W., Kraft,D. and
            Valenta,R.
  TITLE     Characterization of a novel isoform of alpha-nascent
            polypeptide-associated complex as IgE-defined autoantigen
  JOURNAL   J Invest Dermatol 119 (4), 820-829 (2002)
   PUBMED   12406326
REFERENCE   6  (bases 1 to 799)
  AUTHORS   Beatrix,B., Sakai,H. and Wiedmann,M.
  TITLE     The alpha and beta subunit of the nascent polypeptide-associated
            complex have distinct functions
  JOURNAL   J Biol Chem 275 (48), 37838-37845 (2000)
   PUBMED   10982809
REFERENCE   7  (bases 1 to 799)
  AUTHORS   Wang,S., Sakai,H. and Wiedmann,M.
  TITLE     NAC covers ribosome-associated nascent chains thereby forming a
            protective environment for regions of nascent chains just emerging
            from the peptidyl transferase center
  JOURNAL   J Cell Biol 130 (3), 519-528 (1995)
   PUBMED   7622554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002994.3 and BC062710.1.
            
            On May 17, 2019 this sequence version replaced NM_199290.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189652.156963.1, SRR5189661.12344.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521764.3/ ENSP00000427802.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC002994.3         120288-120304
            18-787              BC062710.1         5-774
            788-799             AC002994.3         121075-121086
FEATURES             Location/Qualifiers
     source          1..799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..799
                     /gene="NACA2"
                     /gene_synonym="ANAC; NACAL"
                     /note="nascent polypeptide associated complex subunit
                     alpha 2"
                     /db_xref="GeneID:342538"
                     /db_xref="HGNC:HGNC:23290"
                     /db_xref="MIM:609274"
     exon            1..799
                     /gene="NACA2"
                     /gene_synonym="ANAC; NACAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..687
                     /gene="NACA2"
                     /gene_synonym="ANAC; NACAL"
                     /note="isoform 1 is encoded by transcript variant 1; IgE
                     autoantigen alpha-nascent polypeptide-associated complex;
                     nascent polypeptide-associated complex, alpha polypeptide,
                     2; alpha-NAC protein; hom s 2.01 protein; nascent
                     polypeptide associated complex alpha subunit 2"
                     /codon_start=1
                     /product="nascent polypeptide-associated complex subunit
                     alpha-2 isoform 1"
                     /protein_id="NP_954984.1"
                     /db_xref="CCDS:CCDS11630.1"
                     /db_xref="GeneID:342538"
                     /db_xref="HGNC:HGNC:23290"
                     /db_xref="MIM:609274"
                     /translation="MPGEATETVPATEQELPQSQAETGSGTASDSGESVPGIEEQDST
                     QTTTQKAWLVAAAEIDEEPVGKAKQSRSEKRARKAMSKLGLLQVTGVTRVTIWKSKNI
                     LFVITKLDVYKSPASDAYIVFGEAKIQDLSQQAQLAAAEKFRVQGEAVGNIQENTQTP
                     TVQEESEEEEVDETGVEVKDVKLVMSQANVSRAKAVRALKNNSNDIVNAIMELTV"
     regulatory      762..767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NACA2"
                     /gene_synonym="ANAC; NACAL"
                     /note="hexamer: CATAAA"
     polyA_site      778
                     /gene="NACA2"
                     /gene_synonym="ANAC; NACAL"
                     /note="major polyA site"
ORIGIN      
        1 ctttctgccg ccatcttgct tccgcgttcc ctgcacaaaa tgccgggcga agccacagaa
       61 accgtccctg ctacagagca ggagttgccg cagtcccagg ctgagacagg gtctggaaca
      121 gcatctgata gtggtgaatc agtaccaggg attgaagaac aggattccac ccagaccacc
      181 acacaaaaag cctggctggt ggcagcagct gaaattgatg aagaaccagt cggtaaagca
      241 aaacagagtc ggagtgaaaa gagggcacgg aaggctatgt ccaaactggg tcttctacag
      301 gttacaggag ttactagagt cactatctgg aaatctaaga atatcctctt tgtcatcaca
      361 aaactggacg tctacaagag ccctgcttcg gatgcctaca tagtttttgg ggaagccaag
      421 atccaagatt tatctcagca agcacaacta gcagctgcgg agaaattcag agttcaaggt
      481 gaagctgtcg gaaacattca agaaaacaca cagactccaa ctgtacaaga ggagagtgaa
      541 gaggaagagg tcgatgaaac aggtgtagaa gttaaagacg tgaaattggt catgtcacaa
      601 gcaaatgtgt cgagagcaaa ggcagtccga gctctgaaga acaacagtaa tgatattgta
      661 aatgcgatta tggaattaac agtgtaacca tctgaaagca actttttttg gtgtctcaaa
      721 ggagtaactg cagcttggtt tgaaatttgt actgtttcta tcataaataa agttatgact
      781 tcttgctgga aaaagaaaa
//
