LOCUS       NM_024068               1400 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleic acid binding protein 2 (NABP2), mRNA.
ACCESSION   NM_024068
VERSION     NM_024068.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Adams,M.N., Croft,L.V., Urquhart,A., Saleem,M.A.M., Rockstroh,A.,
            Duijf,P.H.G., Thomas,P.B., Ferguson,G.P., Najib,I.M., Shah,E.T.,
            Bolderson,E., Nagaraj,S., Williams,E.D., Nelson,C.C., O'Byrne,K.J.
            and Richard,D.J.
  TITLE     hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced
            transcriptional response in prostate cancer
  JOURNAL   Prostate 83 (7), 628-640 (2023)
   PUBMED   36811381
  REMARK    GeneRIF: hSSB1 (NABP2/OBFC2B) modulates the DNA damage and
            androgen-induced transcriptional response in prostate cancer.
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Lin,E., Tsai,S.J., Kuo,P.H., Liu,Y.L., Yang,A.C., Conomos,M.P. and
            Thornton,T.A.
  TITLE     Genome-wide association study in the Taiwan Biobank identifies four
            novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5
  JOURNAL   Hum Mol Genet 30 (23), 2362-2369 (2021)
   PUBMED   34270706
  REMARK    GeneRIF: Genome-wide association study in the Taiwan Biobank
            identifies four novel genes for human height: NABP2, RASA2, RNF41
            and SLC39A5.
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Gustafson,M.A., Perera,L., Shi,M. and Copeland,W.C.
  TITLE     Mechanisms of SSBP1 variants in mitochondrial disease: Molecular
            dynamics simulations reveal stable tetramers with altered DNA
            binding surfaces
  JOURNAL   DNA Repair (Amst) 107, 103212 (2021)
   PUBMED   34464898
  REMARK    GeneRIF: Mechanisms of SSBP1 variants in mitochondrial disease:
            Molecular dynamics simulations reveal stable tetramers with altered
            DNA binding surfaces.
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Croft,L.V., Ashton,N.W., Paquet,N., Bolderson,E., O'Byrne,K.J. and
            Richard,D.J.
  TITLE     hSSB1 associates with and promotes stability of the BLM helicase
  JOURNAL   BMC Mol Biol 18 (1), 13 (2017)
   PUBMED   28506294
  REMARK    GeneRIF: Our data highlights that BLM helicase and hSSB1 function
            in a dynamic complex in cells and that this complex is likely
            required for BLM protein stability and function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Xu,S., Feng,Z., Zhang,M., Wu,Y., Sang,Y., Xu,H., Lv,X., Hu,K.,
            Cao,J., Zhang,R., Chen,L., Liu,M., Yun,J.P., Zeng,Y.X. and Kang,T.
  TITLE     hSSB1 binds and protects p21 from ubiquitin-mediated degradation
            and positively correlates with p21 in human hepatocellular
            carcinomas
  JOURNAL   Oncogene 30 (19), 2219-2229 (2011)
   PUBMED   21242961
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Skaar,J.R., Richard,D.J., Saraf,A., Toschi,A., Bolderson,E.,
            Florens,L., Washburn,M.P., Khanna,K.K. and Pagano,M.
  TITLE     INTS3 controls the hSSB1-mediated DNA damage response
  JOURNAL   J Cell Biol 187 (1), 25-32 (2009)
   PUBMED   19786574
  REMARK    GeneRIF: INTS3 controls the SSB1-mediated DNA damage response.
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Li,Y., Bolderson,E., Kumar,R., Muniandy,P.A., Xue,Y., Richard,D.J.,
            Seidman,M., Pandita,T.K., Khanna,K.K. and Wang,W.
  TITLE     HSSB1 and hSSB2 form similar multiprotein complexes that
            participate in DNA damage response
  JOURNAL   J Biol Chem 284 (35), 23525-23531 (2009)
   PUBMED   19605351
  REMARK    GeneRIF: hSSB1 and hSSB2 form two separate complexes with similar
            structures, and both complexes participate in DNA damage response.
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Huang,J., Gong,Z., Ghosal,G. and Chen,J.
  TITLE     SOSS complexes participate in the maintenance of genomic stability
  JOURNAL   Mol Cell 35 (3), 384-393 (2009)
   PUBMED   19683501
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Richard,D.J., Bolderson,E., Cubeddu,L., Wadsworth,R.I., Savage,K.,
            Sharma,G.G., Nicolette,M.L., Tsvetanov,S., McIlwraith,M.J.,
            Pandita,R.K., Takeda,S., Hay,R.T., Gautier,J., West,S.C.,
            Paull,T.T., Pandita,T.K., White,M.F. and Khanna,K.K.
  TITLE     Single-stranded DNA-binding protein hSSB1 is critical for genomic
            stability
  JOURNAL   Nature 453 (7195), 677-681 (2008)
   PUBMED   18449195
  REMARK    GeneRIF: Cells deficient in hSSB1 exhibit increased
            radiosensitivity, defective checkpoint activation and enhanced
            genomic instability coupled with a diminished capacity for DNA
            repair.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG697807.1, BC006171.1 and AI038029.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024068.3.
            
            Summary: Single-stranded DNA (ssDNA)-binding proteins, such as
            OBFC2B, are ubiquitous and essential for a variety of DNA metabolic
            processes, including replication, recombination, and detection and
            repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied
            by OMIM, Jun 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.311759.1,
                                           SRR1163658.553984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267023.9/ ENSP00000267023.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BG697807.1         4-28
            26-1310             BC006171.1         1-1285
            1311-1400           AI038029.1         4-93                c
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1400
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /note="nucleic acid binding protein 2"
                     /db_xref="GeneID:79035"
                     /db_xref="HGNC:HGNC:28412"
                     /db_xref="MIM:612104"
     exon            1..100
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..202
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..759
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /note="LP3587; sensor of ssDNA subunit B1; single-stranded
                     DNA-binding protein 1; sensor of single-strand DNA complex
                     subunit B1; oligonucleotide/oligosaccharide-binding
                     fold-containing protein 2B; single strand DNA-binding
                     protein 1; oligonucleotide/oligosaccharide-binding fold
                     containing 2B"
                     /codon_start=1
                     /product="SOSS complex subunit B1"
                     /protein_id="NP_076973.1"
                     /db_xref="CCDS:CCDS8911.1"
                     /db_xref="GeneID:79035"
                     /db_xref="HGNC:HGNC:28412"
                     /db_xref="MIM:612104"
                     /translation="MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVA
                     DKTGSINISVWDDVGNLIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVY
                     SEVPNFSEPNPEYSTQQAPNKAVQNDSNPSASQPTTGPSAASPASENQNGNGLSAPPG
                     PGGGPHPPHTPSHPPSTRITRSQPNHTPAGPPGPSSNPVSNGKETRRSSKR"
     exon            203..341
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..413
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..495
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..559
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..1400
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /note="hexamer: AATAAA"
     polyA_site      1400
                     /gene="NABP2"
                     /gene_synonym="hSSB1; OBFC2B; SOSS-B1; SSB1"
                     /note="major polyA site"
ORIGIN      
        1 gcactcccgc gttccacggg gcagcatccg gcggcagcgg agcctgtggc tccccctgcg
       61 ggctgctcag cggcgtgcac agtcctgccg gctggcttgg tggggtgccg aggctcaggc
      121 agcatgacga cggagacctt tgtgaaggat atcaagcctg ggctcaagaa tctgaacctt
      181 atcttcattg tgctggagac aggccgagtg accaagacaa aggacgggca tgaggttcgg
      241 acctgcaaag tggcggacaa aacaggcagc atcaatatct ctgtctggga cgatgttggc
      301 aatctgatcc agcctgggga cattatccgg ctcaccaaag ggtacgcttc agttttcaaa
      361 ggttgtctga cactatatac tggccgtggg ggtgatctgc agaagattgg agaattctgt
      421 atggtttatt ctgaggttcc taacttcagt gagccaaacc cagagtacag cacccagcag
      481 gcacccaaca aggcggtgca gaacgacagc aacccttcag cttcccagcc taccactgga
      541 ccctctgctg cctctccagc ctctgagaac cagaatggga atggactgag tgccccacca
      601 ggtcccggtg gtggcccaca tccccctcat actccctccc acccacccag cacccgaatc
      661 actcgaagcc agcccaacca cacacctgca ggcccgcctg gcccttccag caaccctgtt
      721 agtaacggca aagaaacccg gaggagcagc aagagatagc atgacattct ttcttcctgc
      781 caccaaccac atcccaagtg tcccctggag agcaagatag ccttccactg attggctggt
      841 gtagcagtat tttagccact gaacttcagt ggagggtggt gagcagtgtc cttatccacc
      901 ctaatctcat actccctcat tgtccagctg aactacctgt cccctgggag tcaggaccct
      961 ctgcctgctc tctttcctct ttagaaatgg cagttactgg ctgggcgcag tggctcacgc
     1021 ttgtaatccc agcactttgg gaagccgagg tgggcggatc acctgaggtc gggagttcaa
     1081 gaccagcctg accaacatgg agaaaccccg tgtctactaa aaatacagaa ttagccaggc
     1141 atggtggcgt atgcctgtaa tcccagctac ttaggaggct gaggcaggag aatctcttga
     1201 aaccgggagg cggaggttga ggtgagccga aattgcacca ttgcactcca gcctgggcaa
     1261 taagagcgaa actccatctc aaaaaaaaaa gaaagaaaga aagaaagaaa gaaagaaatg
     1321 gcagttacca tctgtttctt ctgtgtgaga catgggagtc taactgaagt ctctccttcc
     1381 taataaatgt taccactcta
//
