LOCUS       NM_001031716            2269 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens nucleic acid binding protein 1 (NABP1), transcript
            variant 1, mRNA.
ACCESSION   NM_001031716
VERSION     NM_001031716.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Boucher,D., Kariawasam,R., Burgess,J., Gimenez,A., Ocampo,T.E.,
            Ferguson,B., Naqi,A., Walker,G.J., Bolderson,E., Gamsjaeger,R.,
            O'Byrne,K.J., Cubeddu,L., Khanna,K.K. and Richard,D.J.
  TITLE     hSSB2 (NABP1) is required for the recruitment of RPA during the
            cellular response to DNA UV damage
  JOURNAL   Sci Rep 11 (1), 20256 (2021)
   PUBMED   34642383
  REMARK    GeneRIF: hSSB2 (NABP1) is required for the recruitment of RPA
            during the cellular response to DNA UV damage.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Li,H., Chi,X., Li,R., Ouyang,J. and Chen,Y.
  TITLE     A Novel lncRNA, AK130181, Contributes to HIV-1 Latency by
            Regulating Viral Promoter-Driven Gene Expression in Primary CD4+ T
            Cells
  JOURNAL   Mol Ther Nucleic Acids 20, 754-763 (2020)
   PUBMED   32408053
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Shen,Z., Ren,W., Bai,Y., Chen,Z., Li,J., Li,B., Jin,T., Cao,P. and
            Shao,Y.
  TITLE     DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal
            squamous cell carcinoma patient survival
  JOURNAL   Oncotarget 7 (48), 79596-79604 (2016)
   PUBMED   27793000
  REMARK    GeneRIF: SNPs rs11903757, with closest proximity to NABP1 and SDPR,
            and rs966423 in DIRC3, were associated with survival in laryngeal
            squamous cell carcinoma patients.
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Peters,U., Jiao,S., Schumacher,F.R., Hutter,C.M., Aragaki,A.K.,
            Baron,J.A., Berndt,S.I., Bezieau,S., Brenner,H., Butterbach,K.,
            Caan,B.J., Campbell,P.T., Carlson,C.S., Casey,G., Chan,A.T.,
            Chang-Claude,J., Chanock,S.J., Chen,L.S., Coetzee,G.A.,
            Coetzee,S.G., Conti,D.V., Curtis,K.R., Duggan,D., Edwards,T.,
            Fuchs,C.S., Gallinger,S., Giovannucci,E.L., Gogarten,S.M.,
            Gruber,S.B., Haile,R.W., Harrison,T.A., Hayes,R.B., Henderson,B.E.,
            Hoffmeister,M., Hopper,J.L., Hudson,T.J., Hunter,D.J.,
            Jackson,R.D., Jee,S.H., Jenkins,M.A., Jia,W.H., Kolonel,L.N.,
            Kooperberg,C., Kury,S., Lacroix,A.Z., Laurie,C.C., Laurie,C.A., Le
            Marchand,L., Lemire,M., Levine,D., Lindor,N.M., Liu,Y., Ma,J.,
            Makar,K.W., Matsuo,K., Newcomb,P.A., Potter,J.D., Prentice,R.L.,
            Qu,C., Rohan,T., Rosse,S.A., Schoen,R.E., Seminara,D.,
            Shrubsole,M., Shu,X.O., Slattery,M.L., Taverna,D., Thibodeau,S.N.,
            Ulrich,C.M., White,E., Xiang,Y., Zanke,B.W., Zeng,Y.X., Zhang,B.,
            Zheng,W. and Hsu,L.
  CONSRTM   Colon Cancer Family Registry and the Genetics and Epidemiology of
            Colorectal Cancer Consortium
  TITLE     Identification of Genetic Susceptibility Loci for Colorectal Tumors
            in a Genome-Wide Meta-analysis
  JOURNAL   Gastroenterology 144 (4), 799-807 (2013)
   PUBMED   23266556
  REMARK    Review article
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Li,Y., Bolderson,E., Kumar,R., Muniandy,P.A., Xue,Y., Richard,D.J.,
            Seidman,M., Pandita,T.K., Khanna,K.K. and Wang,W.
  TITLE     HSSB1 and hSSB2 form similar multiprotein complexes that
            participate in DNA damage response
  JOURNAL   J Biol Chem 284 (35), 23525-23531 (2009)
   PUBMED   19605351
  REMARK    GeneRIF: hSSB1 and hSSB2 form two separate complexes with similar
            structures, and both complexes participate in DNA damage response.
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Huang,J., Gong,Z., Ghosal,G. and Chen,J.
  TITLE     SOSS complexes participate in the maintenance of genomic stability
  JOURNAL   Mol Cell 35 (3), 384-393 (2009)
   PUBMED   19683501
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Richard,D.J., Bolderson,E., Cubeddu,L., Wadsworth,R.I., Savage,K.,
            Sharma,G.G., Nicolette,M.L., Tsvetanov,S., McIlwraith,M.J.,
            Pandita,R.K., Takeda,S., Hay,R.T., Gautier,J., West,S.C.,
            Paull,T.T., Pandita,T.K., White,M.F. and Khanna,K.K.
  TITLE     Single-stranded DNA-binding protein hSSB1 is critical for genomic
            stability
  JOURNAL   Nature 453 (7195), 677-681 (2008)
   PUBMED   18449195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114778.5.
            
            On Aug 14, 2020 this sequence version replaced NM_001031716.4.
            
            Summary: Single-stranded DNA (ssDNA)-binding proteins, such as
            OBFC2A, are ubiquitous and essential for a variety of DNA metabolic
            processes, including replication, recombination, and detection and
            repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied
            by OMIM, Jun 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017114.1, AL833684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425611.9/ ENSP00000403683.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               AC114778.5         135573-136142
            571-709             AC114778.5         136427-136565
            710-781             AC114778.5         139383-139454
            782-857             AC114778.5         141166-141241
            858-924             AC114778.5         141667-141733
            925-2269            AC114778.5         143036-144380
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.3"
     gene            1..2269
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /note="nucleic acid binding protein 1"
                     /db_xref="GeneID:64859"
                     /db_xref="HGNC:HGNC:26232"
                     /db_xref="MIM:612103"
     exon            1..570
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..1094
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /note="isoform 1 is encoded by transcript variant 1; SOSS
                     complex subunit B2; sensor of ssDNA subunit B2;
                     single-stranded DNA-binding protein 2; sensor of
                     single-strand DNA complex subunit B2; NABP1 3'UTR
                     overlapping transcript 1;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 2A; oligonucleotide/oligosaccharide-binding fold
                     containing 2A; lncRNA AK130181"
                     /codon_start=1
                     /product="SOSS complex subunit B2 isoform 1"
                     /protein_id="NP_001026886.1"
                     /db_xref="CCDS:CCDS33352.1"
                     /db_xref="GeneID:64859"
                     /db_xref="HGNC:HGNC:26232"
                     /db_xref="MIM:612103"
                     /translation="MNRVNDPLIFIRDIKPGLKNLNVVFIVLEIGRVTKTKDGHEVRS
                     CKVADKTGSITISVWDEIGGLIQPGDIIRLTRGYASMWKGCLTLYTGRGGELQKIGEF
                     CMVYSEVPNFSEPNPDYRGQQNKGAQSEQKNNSMNSNMGTGTFGPVGNGVHTGPESRE
                     HQFSHAGRSNGRGLINPQLQGTASNQTVMTTISNGRDPRRAFKR"
     exon            571..709
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /inference="alignment:Splign:2.1.0"
     exon            710..781
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..857
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..924
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..2269
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1491..1496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /note="hexamer: ACTAAA"
     polyA_site      1519
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /note="major polyA site"
     regulatory      2239..2244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="NABP1"
                     /gene_synonym="NABP1-OT1; OBFC2A; SOSS-B2; SSB2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctgtt tgggacgctg ggtgtgcggt gttctgtctc cgctcccgtt tcgctgtcac
       61 agcccgttcc ttcccggagc ccgggacagg ctgggcgcgc gcccgtgtga gtgagcggga
      121 ctcagggcag aagtgtcccc tcactgcgtt tttttttcct tttatccaaa gaacggggca
      181 gttagtacgc ttgccttcct gtcgcccggt tgggagcggg gttggtgtgc ggagtggttc
      241 gccttttttt ctttagaact tgtgagcctt tttttttttt tttttttttt ttcttttttt
      301 aggctcagtg ctgtccgggc tggtttgccc ggtccctgac taacggcttt ctgccccttc
      361 tctcgccacc cctgcccaag gtcgcccctc tgccttcgcc cctgtcccgg gagggtggga
      421 agctttgacc ccgccctgcc cactcgcgtc tccgcagccg tagccgcgcc tgtcccaata
      481 tgaatagggt caacgaccca cttattttta taagagatat taagcccgga ctgaaaaact
      541 taaatgtcgt ctttattgtc ctggagatag gacgcgtgac caaaaccaaa gacggccatg
      601 aagtgagatc gtgcaaagta gcagataaaa cgggcagcat cactatttcc gtgtgggatg
      661 agatcggagg tcttatacag ccaggggata ttattcggtt gaccagaggg tatgcatcca
      721 tgtggaaagg atgtctgaca ctttatactg gaaggggtgg tgaacttcaa aaaattgggg
      781 aattttgtat ggtttattca gaagtgccaa atttcagtga acccaaccca gattatcgag
      841 gacagcagaa caaaggggca cagagtgaac agaagaataa ttccatgaat agtaatatgg
      901 gtacaggtac atttggacca gtgggaaatg gtgttcacac tggccctgaa tcaagggaac
      961 accagttttc acatgctggc agaagcaatg gccggggact tataaatcca caactacaag
     1021 gaacagctag taatcaaaca gtgatgacca caataagtaa tggcagggac cctcggagag
     1081 cctttaaaag atgacctatg ctaaatactc atgtgtagtt tttatactac atgccctact
     1141 tgaacactta ttgcactttt atttattgtt aactgtgaaa agtacgtcct ttattgggtt
     1201 tccttttata ttcttggttt gttaagaaga atggtttgtt tttatagcaa aactgttaag
     1261 ctgctcgagt ctcctgttga agaatgggaa cactgaaaag taggggcatt tatttttaga
     1321 gtaaaaagat tattggatag cctttaaaaa acctgcaccc atttcatggg tgagttactt
     1381 aagacatcag ctttatagcc tctatgagtc tatcttctgt ataagttttg taatatttaa
     1441 cataaggctt aatgggagat gttcttttgt cttgtattca gatattgcca actaaagcaa
     1501 taaccatcaa aaaacacaag aacttgtcaa tgctagcagt aatttttgag tgtttgtggc
     1561 tctcggaatg attgacttcg ttcagtgact actattaaga ttttccaagg actgactcat
     1621 cccaaatttt tgttgtatta ccaaaaaaac agattcctta tcagaatttg gaatagaatg
     1681 tgatctctat tgcaacaagt aattttaaaa gaaagctaca tttattttag agtagtgctc
     1741 ctaacatgta ttatcaactt tgtggattac attggaggaa aatttaaaac tggggccttg
     1801 aatatttatt ttttgaaact accatgttaa atactgaagt ataatttggg ggagttataa
     1861 agttatgata aacattcatc tgattatttt aaacaatagt tgtggtagat aaacatactg
     1921 gaggtgagtc aaattgaatt catatagtaa catgcagtct gaagtcctag ttacttaata
     1981 ggtactcagc ctggagtgaa aatcctgggt actgactttg agaggagtga gtgtgcatgt
     2041 tgtcaaagtt tctgaacaca gttcacatag ccttattagc aaaagtttta agaaatggct
     2101 ctatcaaaga agcaattgca gctttattca gaaatataaa agtggaattt atgtacatgt
     2161 cataagtggt acccacttcc cctttttact gtagggtgga taactcttag gatttaactc
     2221 tttgaatatt atctcttgaa taaagcatgt gttaatgtta acaaaccta
//
