LOCUS       NM_005966               4508 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens NGFI-A binding protein 1 (NAB1), transcript variant 1,
            mRNA.
ACCESSION   NM_005966
VERSION     NM_005966.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4508)
  AUTHORS   Zhang,J., Zhang,Y. and Zhang,J.
  TITLE     N6-Methyladenosine modified circ-NAB1 modulates cell cycle and
            epithelial-mesenchymal transition via CDKN3 in endometrial cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (5), 161-169 (2024)
   PUBMED   38814199
  REMARK    GeneRIF: N6-Methyladenosine modified circ-NAB1 modulates cell cycle
            and epithelial-mesenchymal transition via CDKN3 in endometrial
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4508)
  AUTHORS   Kearney,S.J., Delgado,C., Eshleman,E.M., Hill,K.K., O'Connor,B.P.
            and Lenz,L.L.
  TITLE     Type I IFNs downregulate myeloid cell IFN-gamma receptor by
            inducing recruitment of an early growth response 3/NGFI-A binding
            protein 1 complex that silences ifngr1 transcription
  JOURNAL   J Immunol 191 (6), 3384-3392 (2013)
   PUBMED   23935197
  REMARK    GeneRIF: These data suggest that type I IFN stimulation induces a
            rapid recruitment of a repressive Egr3/Nab1 complex that silences
            transcription from the ifngr1 promoter.
REFERENCE   3  (bases 1 to 4508)
  AUTHORS   Mells,G.F., Floyd,J.A., Morley,K.I., Cordell,H.J., Franklin,C.S.,
            Shin,S.Y., Heneghan,M.A., Neuberger,J.M., Donaldson,P.T., Day,D.B.,
            Ducker,S.J., Muriithi,A.W., Wheater,E.F., Hammond,C.J.,
            Dawwas,M.F., Jones,D.E., Peltonen,L., Alexander,G.J., Sandford,R.N.
            and Anderson,C.A.
  CONSRTM   UK PBC Consortium; Wellcome Trust Case Control Consortium 3
  TITLE     Genome-wide association study identifies 12 new susceptibility loci
            for primary biliary cirrhosis
  JOURNAL   Nat Genet 43 (4), 329-332 (2011)
   PUBMED   21399635
  REMARK    Erratum:[Nat Genet. 2011 Nov;43(11):1164. Richardson,Paul [added];
            Nasr, Ikram [added]; Aspinall,Richard [added]]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4508)
  AUTHORS   Zayed,N., El Mansouri,F.E., Chabane,N., Kapoor,M.,
            Martel-Pelletier,J., Benderdour,M., Pelletier,J.P., Duval,N. and
            Fahmi,H.
  TITLE     Valproic acid suppresses interleukin-1ss-induced microsomal
            prostaglandin E2 synthase-1 expression in chondrocytes through
            upregulation of NAB1
  JOURNAL   J Rheumatol 38 (3), 492-502 (2011)
   PUBMED   21239760
  REMARK    GeneRIF: Data show that the suppressive effect of valproic acid on
            chondrocytes is not due to reduced expression or recruitment of
            Egr-1 to the mPGES-1 promoter and involves upregulation of NAB1.
REFERENCE   5  (bases 1 to 4508)
  AUTHORS   Moser,D., Molitor,A., Kumsta,R., Tatschner,T., Riederer,P. and
            Meyer,J.
  TITLE     The glucocorticoid receptor gene exon 1-F promoter is not
            methylated at the NGFI-A binding site in human hippocampus
  JOURNAL   World J Biol Psychiatry 8 (4), 262-268 (2007)
   PUBMED   17853270
  REMARK    GeneRIF: Methylation pattern of the corresponding NGFI-A binding
            site in the human glucocorticoid receptor exon 1-F specific
            promoter in post mortem hippocampal tissue.
REFERENCE   6  (bases 1 to 4508)
  AUTHORS   Qiu,F.H., Devchand,P.R., Wada,K. and Serhan,C.N.
  TITLE     Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate
            transcriptional corepressor NAB1 in human neutrophils
  JOURNAL   FASEB J 15 (14), 2736-2738 (2001)
   PUBMED   11687510
REFERENCE   7  (bases 1 to 4508)
  AUTHORS   Thiel,G., Kaufmann,K., Magin,A., Lietz,M., Bach,K. and Cramer,M.
  TITLE     The human transcriptional repressor protein NAB1: expression and
            biological activity
  JOURNAL   Biochim Biophys Acta 1493 (3), 289-301 (2000)
   PUBMED   11018254
REFERENCE   8  (bases 1 to 4508)
  AUTHORS   Swirnoff,A.H., Apel,E.D., Svaren,J., Sevetson,B.R., Zimonjic,D.B.,
            Popescu,N.C. and Milbrandt,J.
  TITLE     Nab1, a corepressor of NGFI-A (Egr-1), contains an active
            transcriptional repression domain
  JOURNAL   Mol Cell Biol 18 (1), 512-524 (1998)
   PUBMED   9418898
REFERENCE   9  (bases 1 to 4508)
  AUTHORS   Svaren,J., Sevetson,B.R., Apel,E.D., Zimonjic,D.B., Popescu,N.C.
            and Milbrandt,J.
  TITLE     NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by
            proliferative and differentiative stimuli
  JOURNAL   Mol Cell Biol 16 (7), 3545-3553 (1996)
   PUBMED   8668170
REFERENCE   10 (bases 1 to 4508)
  AUTHORS   Russo,M.W., Sevetson,B.R. and Milbrandt,J.
  TITLE     Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 6873-6877 (1995)
   PUBMED   7624335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006460.4, CF137213.1, CN288145.1, BC035724.1, AF045451.1 and
            U47007.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005966.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035724.1, ERR3218372.444766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337386.10/ ENSP00000336894.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC006460.4         60095-60133
            40-89               CF137213.1         8-57
            90-150              CN288145.1         66-126
            151-2440            BC035724.1         1-2290
            2441-2572           AF045451.1         1849-1980
            2573-2850           U47007.1           1978-2255
            2851-4508           AF045451.1         2259-3916
FEATURES             Location/Qualifiers
     source          1..4508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..4508
                     /gene="NAB1"
                     /note="NGFI-A binding protein 1"
                     /db_xref="GeneID:4664"
                     /db_xref="HGNC:HGNC:7626"
                     /db_xref="MIM:600800"
     exon            1..278
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..415
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..592
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..1430
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             612..2075
                     /gene="NAB1"
                     /note="isoform 1 is encoded by transcript variant 1; EGR1
                     binding protein 1; EGR-1-binding protein 1;
                     transcriptional regulatory protein p54"
                     /codon_start=1
                     /product="NGFI-A-binding protein 1 isoform 1"
                     /protein_id="NP_005957.2"
                     /db_xref="CCDS:CCDS2307.1"
                     /db_xref="GeneID:4664"
                     /db_xref="HGNC:HGNC:7626"
                     /db_xref="MIM:600800"
                     /translation="MAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEA
                     GEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEG
                     SPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRL
                     WQGHHATESEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEV
                     KELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTV
                     NEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKV
                     EDGFPDFQDSVQTLFQQARAKSEELAALSSQQPEKVMAKQMEFLCNQAGYERLQHAER
                     RLSAGLYRQSSEEHSPNGLTSDNSDGQGERPLNLRMPNLQNRQPHHFVVDGELSRLYP
                     SEAKSHSSESLGILKDYPHSAFTLEKKVIKTEPEDSR"
     exon            1431..1564
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1616
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1706
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1869
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1986
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..4508
                     /gene="NAB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4485..4490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAB1"
                     /note="hexamer: AATAAA"
     polyA_site      4508
                     /gene="NAB1"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgccg cccgcgcgcc gcagcctgga ggagccgccg ccgccgccgc ggccaagcga
       61 gcgccgtcgg ggcgggtggg cgggaagaag cggcgggccc gaggtggggg ggagcagaga
      121 gagcgcgccc accaccttcc cttcccccct cgatgggagc gggggcgtcc cggctcctgc
      181 agccgccaga ggagggagag ccgggggccg tcgcttcgga gttggggctg agcagtcctc
      241 ggggagagcg cgccaagacc gctgcagccg ctggctgacg gaaggagagt tttacatgga
      301 agtggcttac agaaacttgg cgctgaggtg cagggaagcc agaaactctt tgtgtctcta
      361 aggccgatga ggaatttgga aacacatgtg ggacatacaa gcgttggata tagaggactg
      421 agcaggggga ggaacattta agctgatgga agtggaagtg gaagttgctg tacattggca
      481 gcaaggcctc cgagttagct tttgaatgca gttaactggt ttctcttaac tgtggaattc
      541 attgaaaagt cagactccga gtggtcgttc caggatatct tgaaaagccc aggttaaacc
      601 catccagagt aatggctgcg gccttaccca ggaccctggg ggagttgcag ctgtatagaa
      661 tattacaaaa agccaatcta ctttcttatt ttgatgcctt tatccaacaa ggtggtgatg
      721 atgtccagca actctgtgaa gcaggagaag aggagttttt ggaaatcatg gcactcgtgg
      781 gcatggctag caagcccctt catgttagaa ggctgcagaa ggctttgaga gactgggtca
      841 caaaccctgg gcttttcaat cagccactga cttcccttcc tgtcagtagc atacccatct
      901 ataaattacc agagggatca ccaacatggc tgggaatatc ctgcagtagt tatgaaagga
      961 gtagcaatgc ccgggaacct catttaaaaa tccccaaatg tgctgccacc acctgtgtgc
     1021 agagcttggg acaggggaag tcagatgtgg ttgggagcct agcactgcag agtgttggtg
     1081 agtccagact ctggcaaggc caccatgcca ctgagagcga gcacagcctc tccccagcag
     1141 acctgggctc ccccgcgtcc ccaaaggaga gcagtgaggc gctggatgct gctgctgcgc
     1201 tctctgtggc tgagtgtgtg gagcggatgg cccccacact gccaaaaagt gacttgaatg
     1261 aagtgaaaga gctgctaaaa accaacaaga agttggccaa aatgattggt cacatctttg
     1321 agatgaacga tgatgatcca cacaaagagg aggaaattcg gaaatacagt gcaatatatg
     1381 gcagatttga ctcaaagagg aaggatggga aacatctcac acttcatgag ctcactgtta
     1441 atgaagcggc tgctcaactc tgtgtgaagg ataatgccct gctgacaaga agagatgagc
     1501 tttttgcctt ggctcgacag atttctcgag aagtcaccta taaatatact tacagaacca
     1561 ccaagtcaaa atgtggagaa agagatgaat tatccccaaa gagaattaaa gtggaggatg
     1621 ggtttccaga tttccaggat tctgtgcaaa cactcttcca gcaggctaga gctaagagtg
     1681 aagaacttgc agctcttagt tcacagcagc ctgaaaaggt gatggcaaag cagatggagt
     1741 tcctttgcaa ccaagctggc tatgagagac tgcagcatgc cgagaggagg ttgtctgcag
     1801 ggctttacag gcagagctca gaagagcaca gtcctaacgg cttgacttcc gataactcag
     1861 atggacaagg agaaagacct ttgaatctcc gaatgcctaa tttacagaac agacaacccc
     1921 atcattttgt ggtggatggg gagctgagca gactttaccc cagtgaggca aagtcccact
     1981 catcagagag ccttgggatt ttaaaagact accctcattc agcttttacc ttagaaaaga
     2041 aagtcatcaa aacagagcct gaagattcaa gatagctgtg atttctctca ccgttctctg
     2101 gaaatggcat cagatttaag gataatactc catcatagaa ataagcctta ataaccagtg
     2161 ttgcctcatt cagctcaaac agatttcata gccaaagcaa aaggactggt acggtagtct
     2221 gtggaaacca ggaagataaa acaacagcca caaaagagaa aatcaagagt gttgcaatct
     2281 ataacagtaa tattgattca ttcacattcc tgtgttaagt cattttatat ggaaaggctt
     2341 acaaatcaat attgtaagca ttcattattt aagaatgtac aatgtatttg tgtaatttat
     2401 agaagtaaaa tctagatgtt gagacctgtt tggtctaata gatgtggata cagtttattt
     2461 tacttgaaat tttgttgtct actttgtgtg tttaacgtaa atatatgtca gagtttagaa
     2521 tctgcctgca gttgtgaaaa agaaagctta agtgatgcag ttattggcaa gattgcaatg
     2581 attatggaaa aatagaaagc gaatactcag tttaagccaa ggaaaatatt gtggatttaa
     2641 tatttgataa aactgatttt gtttaacagg aaatttttag cattcagtca tataacatct
     2701 ggttatcaat gcacgtttac acaataaata cttgagtgga ggaaagttaa aaagatgagc
     2761 aatagagtag aaaatatatc ttaaactagt tgacctagat tgtattaata gctacttaag
     2821 atgtttcaaa gataggaagc tattgcttgg acagagaact tgaaataagt ggacccatgt
     2881 ataaaagctt tgacttaaac attgatattt cagaatgtgt taaatagatt aagacacagt
     2941 aagttaaccc tacatgttat aaagatggcg actgttaaca aaggctgtaa cagattaagt
     3001 actattttat atccagaaag tcttctctat gtagagaagt cagagagact agatgctttc
     3061 actagggaat gtcttcccac ccagccatca caaatgtgga caatcactgc atccacatct
     3121 gtaggcatat ttctatggaa gtttaattga cagctatatt cattatttat tttacaattt
     3181 catttttcta cacctttgag atttatgaat gcagtttttt cttaaaattt attttaactt
     3241 gacagtatgt ttttagttcc cccaatttaa ttaatggacc atgtgcatat atatgggagt
     3301 gtgcttacat gttaataatt tacttgcata cttatgagaa tttcacattg gaattcataa
     3361 tggtaaaaca acatacatct gccaatatac gttttttctg ttggtttaag agaagataac
     3421 tgacagcttt acctacttcc tacagatgca tctaaaccca gatattactg agaagagtgt
     3481 attgactctg agtgtaagag agtatgtgtt tttttgtttt tagttctgct ctagatcata
     3541 attgtaaaaa atattaagtc ataatctgtt acactaaaat ttgtcagcca aatgttagat
     3601 gaaatgtctg cactgtagtc tcagatcact gtcacgtata taaattgctt cttcatttta
     3661 atttgtagaa gtactttaca gtaggaaacg ccagtaaaca acttttatac tgttaaaagg
     3721 cttttttccc cttcctaaat gttttaattg taccatagtg ttttgctcac tgaagaagct
     3781 tcttatggac cttgcaactt tgttgctagc ttgaggttga ttattgtggt tgtattgttc
     3841 actgtgtgta gaaatagtat gagtacgatt tcaatagact gttcagtttt taatattagc
     3901 catagcactg gttagtatat ctcagtagtt tcatgaaacg tttcctgtat tctaatctat
     3961 tttgaaacat tttgtttttt tttaattgtg tcttacagtc aagtttgtag attttcataa
     4021 gccacaattt taaaagatgc agtaatcttc caacttccaa tatttatcca ttcgttgtgg
     4081 acccacagat tgcatcttta aattcataat aagtttcctt aactatctta tgtttctagt
     4141 ctttcaagct tagtgataag gtggaagcac aagaaaaatt tcagtagaat acagttttta
     4201 ttttgtaaac actaatgtat taaacttgct atacattaaa gcaaataata tatattttta
     4261 tttgaattgt atatgtgaat tggaagttat aattagttga ttttttcatt ttgttagagg
     4321 tattttcact gaacaaggtc aattggttac ctcagtatta cagccaatat agtccaaggg
     4381 accatttctc cccgagtctc ttacacttta ttgtgcgatg tccacgtttt tgtgactctt
     4441 caagctgttg gtgaggtggg acgaatgcac ttgcttcctg tggcaataaa gattttctgt
     4501 gcctcaca
//
