LOCUS       NM_207015               9807 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens N-acetylated alpha-linked acidic dipeptidase like 2
            (NAALADL2), mRNA.
ACCESSION   NM_207015
VERSION     NM_207015.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9807)
  AUTHORS   Kim,S.W., Jung,Y.S., Ahn,J.B., Shin,E.S., Jang,H.W., Lee,H.J., Il
            Kim,T., Kim,D.Y., Bang,D., Kim,W.H. and Cheon,J.H.
  TITLE     Identification of genetic susceptibility loci for intestinal
            Behcet's disease
  JOURNAL   Sci Rep 7, 39850 (2017)
   PUBMED   28045058
  REMARK    GeneRIF: GWAS showed intestinal Behcet's disease-specific
            associations with YIPF7 gene locus rs6838327.  Down-regulation of
            YIPF7 expression was associated with exacerbating intestinal
            inflammatory responses both in vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9807)
  AUTHORS   Whitaker,H.C., Shiong,L.L., Kay,J.D., Gronberg,H., Warren,A.Y.,
            Seipel,A., Wiklund,F., Thomas,B., Wiklund,P., Miller,J.L.,
            Menon,S., Ramos-Montoya,A., Vowler,S.L., Massie,C., Egevad,L. and
            Neal,D.E.
  TITLE     N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 is overexpressed
            in cancer and promotes a pro-migratory and pro-metastatic phenotype
  JOURNAL   Oncogene 33 (45), 5274-5287 (2014)
   PUBMED   24240687
  REMARK    GeneRIF: Data suggest that changes in expression of
            N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 (NAALADL2) can
            impact upon a number of pro-oncogenic pathways and processes,
            making it a useful biomarker for both diagnosis and prognosis.
REFERENCE   3  (bases 1 to 9807)
  AUTHORS   Winham,S.J., Cuellar-Barboza,A.B., Oliveros,A., McElroy,S.L.,
            Crow,S., Colby,C., Choi,D.S., Chauhan,M., Frye,M. and
            Biernacka,J.M.
  TITLE     Genome-wide association study of bipolar disorder accounting for
            effect of body mass index identifies a new risk allele in TCF7L2
  JOURNAL   Mol Psychiatry 19 (9), 1010-1016 (2014)
   PUBMED   24322204
REFERENCE   4  (bases 1 to 9807)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
REFERENCE   5  (bases 1 to 9807)
  AUTHORS   Byrne,E.M., Gehrman,P.R., Medland,S.E., Nyholt,D.R., Heath,A.C.,
            Madden,P.A., Hickie,I.B., Van Duijn,C.M., Henders,A.K.,
            Montgomery,G.W., Martin,N.G. and Wray,N.R.
  CONSRTM   Chronogen Consortium
  TITLE     A genome-wide association study of sleep habits and insomnia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (5), 439-451 (2013)
   PUBMED   23728906
REFERENCE   6  (bases 1 to 9807)
  AUTHORS   Greliche,N., Germain,M., Lambert,J.C., Cohen,W., Bertrand,M.,
            Dupuis,A.M., Letenneur,L., Lathrop,M., Amouyel,P., Morange,P.E. and
            Tregouet,D.A.
  TITLE     A genome-wide search for common SNP x SNP interactions on the risk
            of venous thrombosis
  JOURNAL   BMC Med Genet 14, 36 (2013)
   PUBMED   23509962
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 9807)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 9807)
  AUTHORS   Chung,S.A., Taylor,K.E., Graham,R.R., Nititham,J., Lee,A.T.,
            Ortmann,W.A., Jacob,C.O., Alarcon-Riquelme,M.E., Tsao,B.P.,
            Harley,J.B., Gaffney,P.M., Moser,K.L., Petri,M., Demirci,F.Y.,
            Kamboh,M.I., Manzi,S., Gregersen,P.K., Langefeld,C.D., Behrens,T.W.
            and Criswell,L.A.
  CONSRTM   SLEGEN
  TITLE     Differential genetic associations for systemic lupus erythematosus
            based on anti-dsDNA autoantibody production
  JOURNAL   PLoS Genet 7 (3), e1001323 (2011)
   PUBMED   21408207
REFERENCE   9  (bases 1 to 9807)
  AUTHORS   Burgner,D., Davila,S., Breunis,W.B., Ng,S.B., Li,Y., Bonnard,C.,
            Ling,L., Wright,V.J., Thalamuthu,A., Odam,M., Shimizu,C.,
            Burns,J.C., Levin,M., Kuijpers,T.W. and Hibberd,M.L.
  CONSRTM   International Kawasaki Disease Genetics Consortium
  TITLE     A genome-wide association study identifies novel and functionally
            related susceptibility Loci for Kawasaki disease
  JOURNAL   PLoS Genet 5 (1), e1000319 (2009)
   PUBMED   19132087
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 9807)
  AUTHORS   Tonkin,E.T., Smith,M., Eichhorn,P., Jones,S., Imamwerdi,B.,
            Lindsay,S., Jackson,M., Wang,T.J., Ireland,M., Burn,J.,
            Krantz,I.D., Carr,P. and Strachan,T.
  TITLE     A giant novel gene undergoing extensive alternative splicing is
            severed by a Cornelia de Lange-associated translocation breakpoint
            at 3q26.3
  JOURNAL   Hum Genet 115 (2), 139-148 (2004)
   PUBMED   15168106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ607396.1, AL832144.1, AC008180.15, AC083804.13, AC119040.5 and
            AC104150.6.
            
            On Nov 22, 2018 this sequence version replaced NM_207015.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832144.1, BN000432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454872.6/ ENSP00000404705.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-893               AJ607396.1         55-947
            894-1164            AL832144.1         907-1177
            1165-1308           AC008180.15        116024-116167
            1309-1401           AC008180.15        132196-132288
            1402-1607           AC008180.15        135774-135979
            1608-1727           AC008180.15        140434-140553
            1728-1874           AC083804.13        53032-53178         c
            1875-1970           AC083804.13        1833-1928           c
            1971-2064           AC119040.5         11763-11856
            2065-2263           AC119040.5         29677-29875
            2264-4899           AC104150.6         116138-118773       c
            4900-9807           AC104150.6         111230-116137       c
FEATURES             Location/Qualifiers
     source          1..9807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.31"
     gene            1..9807
                     /gene="NAALADL2"
                     /note="N-acetylated alpha-linked acidic dipeptidase like
                     2"
                     /db_xref="GeneID:254827"
                     /db_xref="HGNC:HGNC:23219"
                     /db_xref="MIM:608806"
     exon            1..117
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2462
                     /gene="NAALADL2"
                     /EC_number="3.4.17.21"
                     /note="N-acetylated alpha-linked acidic dipeptidase 2;
                     NAALADase L2; glutamate carboxypeptidase II-type
                     non-peptidase homologue"
                     /codon_start=1
                     /product="inactive N-acetylated-alpha-linked acidic
                     dipeptidase-like protein 2"
                     /protein_id="NP_996898.2"
                     /db_xref="CCDS:CCDS46960.1"
                     /db_xref="GeneID:254827"
                     /db_xref="HGNC:HGNC:23219"
                     /db_xref="MIM:608806"
                     /translation="MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQAT
                     ALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPATSPKGRFQRLQE
                     ESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTV
                     DPQLYQEILKTIQAEDIKKSFRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYS
                     VLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEV
                     IDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDL
                     PKTVNPSHDTFMVSLNPGGDPSTPGYPSVDESFRQSRSNLTSLLVQPISAPLVAKLIS
                     SPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGS
                     HHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYE
                     WGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASPSLQQLVVEKNNFNCTRRAQCPET
                     NISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSF
                     NLHETITKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAMALRLRES
                     AELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFLVKQAPPGFYRNILYHLDEKT
                     SRFSILIEAWEHCKPLASNETLQEALSEVLNSINSAQVYFKAGLDVFKSVLDGKN"
     exon            118..619
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..893
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1013
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1164
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1308
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1401
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1607
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1727
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1874
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1970
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2064
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2263
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..9807
                     /gene="NAALADL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4878..4883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAALADL2"
                     /note="hexamer: AATAAA"
     polyA_site      4899
                     /gene="NAALADL2"
     regulatory      9788..9793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAALADL2"
                     /note="hexamer: ATTAAA"
     polyA_site      9807
                     /gene="NAALADL2"
                     /note="major polyA site"
ORIGIN      
        1 agaaggtcac aaagcttgca gggtaagtga cacaacttga aactgcttgg ccctctttaa
       61 aaagaaataa taaaatggga gagaatgaag caagtttacc taacacgtct ttgcaaggta
      121 aaaagatggc ctatcagaag gtccatgcag atcaaagagc tccaggacac tcacagtact
      181 tagacaatga tgaccttcaa gccactgccc ttgacttaga gtgggacatg gagaaggaac
      241 tagaggagtc tggttttgac caattccagc tagacggtgc tgagaatcag aacctagggc
      301 attcagagac tatagacctc aatcttgatt ccattcaacc agcaacttca cccaaaggaa
      361 ggttccagag acttcaagaa gaatctgact acattaccca ttatacacga tctgcaccaa
      421 agagcaatcg ctgcaacttt tgccacgtct taaaaatact ttgcacagcc accattttat
      481 ttatttttgg gattttgata ggttattatg tacatacaaa ttgcccttca gatgctccat
      541 cttcaggaac agttgatcct cagttatatc aagagattct caagacaatc caggcagaag
      601 atattaagaa gtctttcaga aatttggtac aactatataa aaatgaagat gacatggaaa
      661 tttcaaagaa gattaagact cagtggacct ctttgggcct agaagatgta cagtttgtaa
      721 attactctgt gctgcttgat ctgccaggcc cttctcccag cactgtgact ctgagcagca
      781 gtggtcaatg ctttcatcct aatggccagc cttgcagtga agaagccaga aaagatagca
      841 gccaagacct gctctattca tatgcagcct attctgccaa aggaactctc aaggctgaag
      901 tcatcgatgt gagttatgga atggcagatg atttaaaaag gattaggaaa ataaaaaacg
      961 taacaaatca gatcgcactc ctgaaattag gaaaattgcc actgctttat aagctttcct
     1021 cattggaaaa ggctggattt ggaggtgttc ttctgtatat cgatccttgt gatttgccaa
     1081 agactgtgaa tcctagccat gataccttca tggtgtcact gaatccagga ggagaccctt
     1141 ctacgcctgg ttacccaagt gtcgatgaaa gttttagaca aagccgatca aacctcacct
     1201 ctctattagt gcagcccatc tctgcacccc tcgttgcaaa actgatctct tcgccaaaag
     1261 ctagaaccaa aaatgaagcg tgtagctctc tagagcttcc aaataatgaa ataagagtcg
     1321 tcagcatgca agttcagaca gtcacaaaat tgaaaacagt tactaatgtt gttggatttg
     1381 taatgggctt gacatctcca gaccggtata tcatagttgg cagccatcat cacactgcac
     1441 acagttataa tggacaagaa tgggccagta gtactgcaat aatcacagcg tttatccgtg
     1501 ccttgatgtc aaaagttaag agagggtgga gaccagaccg aactattgtt ttctgttctt
     1561 ggggaggaac agcttttggc aatattggct catatgaatg gggagaggat ttcaagaagg
     1621 ttcttcagaa aaatgttgtg gcttatatta gcctccacag tcccataagg gggaactcta
     1681 gtctgtatcc tgtagcatca ccatctcttc agcaactggt agtagagaaa aataatttca
     1741 actgtaccag aagagcccag tgcccagaaa ccaatatcag ttctatacag atacaaggtg
     1801 atgctgatta tttcatcaac catcttggag ttcccatcgt gcagtttgct tacgaggaca
     1861 tcaaaacatt agagggtcca agttttctct ccgaggcccg tttttctaca cgagcaacaa
     1921 aaattgaaga aatggatccc tctttcaacc ttcatgaaac cattactaag ctctcaggag
     1981 aagtgatttt gcaaattgcc aacgaacctg ttctgccctt taatgcactt gatatagctt
     2041 tagaagttca aaacaacctt aaaggtgatc aacccaacac tcatcaactg ttagccatgg
     2101 cgttacgcct gcgggagagt gctgaacttt ttcagtctga tgagatgcga cctgctaatg
     2161 atcccaagga gagagcaccc atccgcatcc ggatgctgaa tgacattctc caagacatgg
     2221 agaaaagctt tctggtaaag caggcaccac caggttttta tagaaacatc ctctaccacc
     2281 ttgatgaaaa gacaagccgg ttttcaatac ttatagaggc ttgggaacac tgcaaacccc
     2341 ttgcatcaaa tgagaccctt caagaagccc tgtcagaggt gttgaacagc attaattcag
     2401 ctcaggttta cttcaaagca ggacttgatg tgttcaagag tgtcttggat gggaagaatt
     2461 gagaaaactc tgagcatttt taaaagtttg tttacaattc cacaagcaaa agctctaatt
     2521 taaccagatt ttctgacatt gaaggcttat tttccccaat ggctttttga caagtataaa
     2581 gctattatta cattgtattt tttaaatgta aatatagaaa gaacattttg cacatttaat
     2641 atttttctta tatctacatt tctgaatatg taaagcaagt tattgaaata ggacttaaga
     2701 attacctatt aaaaagaaat ctgatatata aaaatatgta ctattttaag gaaaaatttc
     2761 caagaagttc tggactatct ttgttcctat ggggagggca tataggaaca cagtttattc
     2821 tctctgatag agctattaat gacttagttt ctgtaaaaga aatggagagt tgatatggtt
     2881 cagattaact tcactattaa gtgttcaata tgaagaattc aagtattctg actgagtgat
     2941 tggttgacct aaaccacttt gaatgtttct attttatgaa atgaagtttc tcttcttaac
     3001 acaactagat gtagtaatac actggttatg aaattgtatt tttttaagta ttaatgaaaa
     3061 aagagccata agcattccag gagaaaatct caagggagct acatagagca atttaaatgc
     3121 aaattttttt cctaacaact tacaaggtga ctagctttga aacccctaat ttgcctcagt
     3181 tgattttcta agaatttcag gagtgatgta tgtcttaaga gggagaaaaa aatatttctt
     3241 attacttttt ctcttgtttc tgttggaaac actgaagcag ggactctaaa atgaaagcat
     3301 ctcacattgg ttttctttct tgtatctttt ctgaaactcc ttgctgtaag gcagctttct
     3361 cagagtacta tatattttca acagtaaagt agcagagttt ctctttgaaa cccaaaatgt
     3421 cttctaaaga atcaaatttc tatttctgcc tctgacaaaa agaacttact atgaaagaaa
     3481 tagttgtttt atcaataaaa gccccttaat attatgaaga aacttttcat attttttctt
     3541 ctttatcctt aattgtgact aagatggaaa tctagaaaat attcatgctt ctaagtttct
     3601 gcagtgttac tgtaagagag tgtctcgtct acacttcagt tcttctctca tgtggaaaac
     3661 taagcttttt atattgacat tgccattgaa tagctctagc aactattatt attcccccaa
     3721 accctaaaat tctacctatt aggtgtcagg ttaaagttct aatttatctt tagaaattta
     3781 tgtgaaaaat ggttttccta tactggataa agcaattccc cttaggaaac atagcctcag
     3841 agtatttcat ataaattttc tctatctaat tcaaacatat ctccccatga tacaccgcca
     3901 gagtgacatt gcagacagtc tgtgtatgtt taaattttca ctttttatgg atgagcataa
     3961 acctagtctt agtttaaagg caaactaaag ttgaggggaa ataattaatc aatactgatt
     4021 aattgattta taaggttcaa cactgtctac cctaaataat ttttatatgc tcaaggcaaa
     4081 gcagggaata gaggcaatta gctagataat tcaagcagaa atccattttc atcgaaattg
     4141 cctgtgtgca catattttta gatgaaaaat gaaactacct tacaatatta tttttttaac
     4201 caatgtattt gtttgcaaac atttgccatg ttgaagagtg tgtataggaa aggtctagaa
     4261 ataaataggc ttgtgcatac ctaggcattc atgctctttc ttcctcttca gagatcatca
     4321 gaaaagaggt gggaatacac aagcaggtgc atgtaagccc aaaagctaga aagccttata
     4381 tttaaccaaa ggttgatgtg ttcattccag ttattcactt acagatgaaa ctaaaacaaa
     4441 taaaggcaag ctattatcag tttggtagtt cattatttta gaacaaattt ctaaattaat
     4501 ttattcccat aacctacaat agcactgaga acagaaaaca tgtttcttct tcattttgtt
     4561 taaagattgc gtacctaggt aagtcacact gtatagataa aaaccttctt ctgtattcct
     4621 cacctctaaa ttatatgtta tttgctattt gaaaactgta gttaactatg gttttttatt
     4681 agtctattaa aagatacgtg gagatattaa attataccta aagcagacgt ccaacaaatt
     4741 ctgtacatgc tgctttacat ctttgcaaca aacctcttaa ctagcagcat tatttctata
     4801 gtgtgattac ctgagggtgc ctccaaatgt atatcatttc actcccctcc cctccccacc
     4861 cccaatagat tcaaataaat aaaatcctga gcaaattaat agcaagtgtt aatgtgaatt
     4921 ggtagtaggt ttaagctgtt gctgagtcgt ctatatgcct ggtacttctc acaatctttc
     4981 atacatagaa ttgtgcctag gaaataatga atcataaata ttctctgaag aaaatgtggt
     5041 aaaggtgtaa cggtgaaatt tatgttcagg cagggtacac atgagatact gccctttatg
     5101 gaaaagcata agtctcagaa tcaaaagaaa gcctaataaa gattctggtc taagccctga
     5161 gatcttgcct tcagccagag aaggcattat caattacccc caccagatat agtaactaaa
     5221 cccaaagtga gtaagaaact tggacatagt catgtattta gttagtaaca aaagcaccac
     5281 tggaatttaa gcttctctgc tttctcatgc agtatatctt gcttctccct gaggagacag
     5341 ggttataaat gatcttttcc agtgcattcg atgtaaccag ccattctgtc agatgttgca
     5401 tgggctggaa acactgcttt taattcaagg ctagttcatt ctctgactgt acctgacaaa
     5461 caaaactctc cccgagaatt caggcaaagg acacaaagac tgggtacttg agagaaagtg
     5521 gggagaatcc ttacagaaca ccagaagtca ggaagaagga cattgagcaa aatatatctg
     5581 taagagggca agtcaggcca gtgttaagtc aacaatctaa atcaccgttt ctcaaaatgt
     5641 gaaatttaga aagacagggc taggaatcta catcttcagc aagatttctg gatgtctgtt
     5701 acacacactg aagtttaaga atttccaatc tacgttaatc gtagtttcca agaaaacact
     5761 aattgacatt tctaaataaa ttgaagagtc ataataacaa gaaagacgta aagatttgtt
     5821 attaatggaa tcattatgag aaaagaaaag tggacccatt ttatctctaa gaaaacaatt
     5881 cagttgcagc ttatatttgt gcctgctaca tcccaggcac tggtgtttta gaatttttcc
     5941 catgtatcct tttttttttt tttttttttt tttaattccc acaacaaccc atttcaaaat
     6001 gagaaaacta ggttgagtga cttgtccaca gttccaaagc taataaaaat gatgaggcat
     6061 atttctcttc tgggcccact gtattcagtt ctttgttctt tacactgagt gccgaaaaaa
     6121 aaaatcagac tattttgatt ctagaaagtg agataattga aaatgttaac atatttctcc
     6181 aaaactgatc agactgtgga gtctgtcact tttttggtat aataaaggag tttgaagaaa
     6241 caaatgacat cattcctgat gatggtagcc cactccaaca aaggcgtata tatgtaggca
     6301 agtttgaaga tatctataag agcattaaaa ggcaagtgca ccattgtgga atatcatgac
     6361 gagtaggctt acaaacagta aaaagagacc agaaaccaca agtcttacac tttcattctc
     6421 taaatgctta tataatttca ctaaaaaaag aaaagcaggt gctgtgattt agaacaacag
     6481 ttttatgtta tttttaaaaa ttcagaataa ccaattgact ttttaaatta aataaacgta
     6541 gagcatatag taagtttccc cacaggaaag acagatgtta acaaaaataa aataaatgat
     6601 tatttgtgac catgttacta atgatgaatc agcatctttg cctcaaatga aaatctataa
     6661 ttatttgtat gataaattgg tagacctagc caaaaatgtt ctcatgagac attctgtgat
     6721 atgtgtaatt gattactcca aaaattaagc tttctctgag ggtaacacat tgtcatctca
     6781 ttggtttaat gggctattta aatgtgcctt agccacacat ttgcttaata gaaaggaatt
     6841 attttaaact accaatccat atgttgagtg gaaaggaagt tggcccacat attccaataa
     6901 atatatcagc aatataacag tttcatcatg ggaccatgga tacagtgcag ggaaaaaaca
     6961 aacaaacaat atttgagaaa atatatatat tctgcccagc cacactggtg agtttttatt
     7021 tcttgtatga gtttaaattg ccaacttaaa aaagcctcat tagaatttgc tattcgaaaa
     7081 gaccttaaaa accctcacag agttctaaac atcccattca ttgaaaataa ttttcagtta
     7141 agtagatttg ttttgtgcac ttcacaactt ttaggtgaca tgaatttgaa gcgtagcaaa
     7201 agaaatgtat aaagatagcc ttttctggtc attaccatgt ctactcaagt ttctgttttc
     7261 taggtacact ctagcattgt aactttttcc ccctgagaag taattttaag atctatcagt
     7321 ctcaatttaa atgatctgtt aatcagccag agttttagtt tcataatatc gttccattgc
     7381 ctgacaaaga tatacacact gaagtgcctt tagcagacct gggaccgtca agaatcttgt
     7441 taccctgatt attgcaagat gacatatttc ttaagccatt tataatctca tattcgggtt
     7501 gaatctgaat ttacaaataa aagggttaaa ttgaggcagt ttcaagcagc atttaggaaa
     7561 atgaagtggc ttcaaatttt agtgtttctg gttacattat tttgtttgaa ttatacaatt
     7621 acataatttt ctgtaaccaa aatggtaatt ttgatggatt ttttaaatgc caaaatccaa
     7681 tcatcaaggc caaagaaatg catgattact ctgatttctt atgcaccatt cagtcaagac
     7741 ttaactcaga ggcagttgat tcagtgctta catctagaca aagctttaat gagtgcagac
     7801 ccagcctaac agtatttcat ctaatttctt tgatggctta agccaataag cactgaggta
     7861 gcttttctca gaaggaaaca gattttattt tccaggggct aattaatatg caccacctaa
     7921 gtccccaaag gatcacacag gtgcctgtat catgccatat gtcatgtgct atattcctgc
     7981 aagctcaaga gattaatata caatcattat tatgaattat tatgttgcat tgaagttaat
     8041 gtcggtcttt tgttctaatt aaagtacaaa cgtggcatct gaatagaagc ttagctagag
     8101 aagtggagtt agagtcccta ttttaatgaa ctacatatat ttttcaatca aaatgtgtaa
     8161 ttatttaatt atctagcctg ctcagtaatc ataactctcc aacttcttca aagggccttt
     8221 attcaatatg ttaccactca tatggtcatt acttggtaag tgttttatat tttgaatttc
     8281 ttagatgctt tcagtgtatg tgctagtgtt ttattaatat taaaaatttt tgtttactta
     8341 tatatcaagc tgctgcaaat ggactacctt attttaaaag ttagaataaa atgctattac
     8401 tctctaaaca gaactttagc atatctgttt gataagaaat acacaaacaa aatatttttc
     8461 tatgctattg caaattgtcc gcaggaagca aaatgccaga tggttaagtg tagctcacat
     8521 aattatattc caaaggtgtt ataaacaatt ctatttagca tctgagatag gtctatatta
     8581 ggcaatttca tgtttacatt tctaacagaa aggtttaatg gcaaatattc cttatattct
     8641 aacttgctac ttggagaata tggatattct gaaaagaaaa accctttcta gaacactgtg
     8701 caggactaat ttttttttaa tagacatcca gaaaatagcc tgggcaacaa agtgagaccc
     8761 tgtctctctt aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaagaaaaag tagctaggca
     8821 tgttggtgtg cacctttgta gtccagctac tagggaggct gaggcggaag aatcatttgg
     8881 gcccaaaagt ttgaagctgc agtgagctaa aatcatgcca ctgtagtcca gcctgtgtaa
     8941 cagaacctat ctcaaaaaaa ggaaaagaaa gtcacatgct gttgatagta gttttatatg
     9001 tatttggaat gttaatatgg gacacatgca tttaatactt taatcatgta ttcaatgtag
     9061 cagcatttag atatgtaaga ttttagaagt aaaatctcag tggtataaca tttaaaacac
     9121 agccttaaaa tgaagaatag ggatgagcag gagaaaattt ataaattaac ccagggtaaa
     9181 atttggagga aaatttttcc aaataaattt gctttgatta aaaacacata tctctcaaga
     9241 ggtgtcccaa ttactaaatt atgttgaact gttgtggtgt ttagccttgt tcaaaatgat
     9301 ttgattatca tctggattca gaaatctttt cattgtacag agatttcatt gtcattgtcg
     9361 ttgttgttaa ctgattttta atgatattga tttagaggca tttgtcggta gtttttaaat
     9421 tactatatag ggttgaatgt ctaatttcta taatgtgtgg atgcccatca gatatttagt
     9481 gcattctata tttagcccaa gtgtgatcac aatttatttt ataacttttt atgtgttact
     9541 tacatgactc aatatgcatc ttacttaaga aattatgttg tgatctggag tgacacaaat
     9601 ggattgagat accacatcca ttaaaaatat aagtgaatat tttatattta agttgtttaa
     9661 atatttgcac attattgaaa acatagtact aggaaatgaa ggcaccattt aacaaacgtg
     9721 ttctgaatca taattttcat gagtttgtac gtgaaatgtt aatgtttaaa acacccattt
     9781 tgaaattatt aaatacaggt aaaaaca
//
