LOCUS       NM_005468               2708 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens N-acetylated alpha-linked acidic dipeptidase like 1
            (NAALADL1), mRNA.
ACCESSION   NM_005468
VERSION     NM_005468.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2708)
  AUTHORS   Tykvart,J., Barinka,C., Svoboda,M., Navratil,V., Soucek,R.,
            Hubalek,M., Hradilek,M., Sacha,P., Lubkowski,J. and Konvalinka,J.
  TITLE     Structural and biochemical characterization of a novel
            aminopeptidase from human intestine
  JOURNAL   J Biol Chem 290 (18), 11321-11336 (2015)
   PUBMED   25752612
  REMARK    GeneRIF: characterization of the protein product of the human
            NAALADL1 gene
REFERENCE   2  (bases 1 to 2708)
  AUTHORS   Pangalos,M.N., Neefs,J.M., Somers,M., Verhasselt,P., Bekkers,M.,
            van der Helm,L., Fraiponts,E., Ashton,D. and Gordon,R.D.
  TITLE     Isolation and expression of novel human glutamate carboxypeptidases
            with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl
            peptidase IV activity
  JOURNAL   J Biol Chem 274 (13), 8470-8483 (1999)
   PUBMED   10085079
REFERENCE   3  (bases 1 to 2708)
  AUTHORS   Shneider,B.L., Thevananther,S., Moyer,M.S., Walters,H.C.,
            Rinaldo,P., Devarajan,P., Sun,A.Q., Dawson,P.A. and
            Ananthanarayanan,M.
  TITLE     Cloning and characterization of a novel peptidase from rat and
            human ileum
  JOURNAL   J Biol Chem 272 (49), 31006-31015 (1997)
   PUBMED   9388249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003068.3, AJ012371.1, BG757994.1 and BM681269.1.
            
            On Nov 24, 2018 this sequence version replaced NM_005468.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ012371.1, SRR9304717.301814.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358658.8/ ENSP00000351484.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AP003068.3         18604-18619         c
            17-330              AJ012371.1         1-314
            331-331             AP003068.3         18203-18203         c
            332-2087            AJ012371.1         316-2071
            2088-2187           BG757994.1         548-647
            2188-2703           BM681269.1         17-532              c
            2704-2708           AP003068.3         4884-4888           c
FEATURES             Location/Qualifiers
     source          1..2708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2708
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /note="N-acetylated alpha-linked acidic dipeptidase like
                     1"
                     /db_xref="GeneID:10004"
                     /db_xref="HGNC:HGNC:23536"
                     /db_xref="MIM:602640"
     exon            1..217
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2255
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /EC_number="3.4.17.21"
                     /note="N-acetylated-alpha-linked acidic dipeptidase-like
                     protein; 100 kDa ileum brush border membrane protein;
                     ileal dipeptidylpeptidase; NAALADase L; ileal peptidase
                     I100; peptidase homolog; human ileal aminopeptidase"
                     /codon_start=1
                     /product="aminopeptidase NAALADL1"
                     /protein_id="NP_005459.2"
                     /db_xref="CCDS:CCDS31604.1"
                     /db_xref="GeneID:10004"
                     /db_xref="HGNC:HGNC:23536"
                     /db_xref="MIM:602640"
                     /translation="MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEI
                     LETVMGQLDAHRIRENLRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTY
                     EVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQ
                     GLLVYANRGAEEDFKELQTQGIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTD
                     PADINDGLSSPDETFPNSWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVS
                     GFPPIPTQPIGFQDARDLLCNLNGTLAPATWQGALGCHYRLGPGFRPDGDFPADSQVN
                     VSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTAVLLELSRV
                     LGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFA
                     NATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDNWIRYFNRSSPVYGLVPSLGSLG
                     AGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQ
                     AVARTAGSVILRLSDSFFLPLKVSDYSETLRSFLQAAQQDLGALLEQHSISLGPLVTA
                     VEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVL
                     WAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATLRPVADL
                     "
     exon            218..390
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            391..512
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            513..635
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            636..919
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1024
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1110
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1230
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1316
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1380
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1448
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1540
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1631
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1713
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1887
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1975
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2068
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2708
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2675..2680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /note="hexamer: AATAAA"
     polyA_site      2708
                     /gene="NAALADL1"
                     /gene_synonym="HILAP; I100; NAALADASEL"
                     /note="major polyA site"
ORIGIN      
        1 agtcctaccc cagctggcca agagtccgca ggatgcagtg gacgaaggtg ttggggctgg
       61 ggctgggggc tgctgccctc ttggggctgg ggatcatcct cggccacttt gccatcccca
      121 aaaaagccaa ctcactggcc ccccaggacc tggacctgga gatcctggag accgtcatgg
      181 ggcagctgga tgcccacagg atccgggaga acctcagaga actctccagg gagccacacc
      241 tggcctccag ccctcgggat gaggacctgg tgcagctgct gctgcagcgc tggaaggacc
      301 cagagtcagg cctggactcg gccgaggcct ccacgtacga agtgctgctg tccttcccta
      361 gccaggagca gcccaacgtc gtggacatcg tgggccccac tgggggcatc atccactcct
      421 gccaccggac tgaggagaac gtgaccgggg agcaaggggg gccagatgtg gtacaaccct
      481 atgctgccta tgctccttct ggaaccccac agggcctcct cgtctatgcc aaccggggcg
      541 cggaagaaga ctttaaggag ctacagactc agggcatcaa acttgaaggc accattgccc
      601 tgactcgata tgggggtgta gggcgtgggg ccaaggctgt gaacgctgcc aagcacgggg
      661 tagctggggt gctggtgtac acagaccctg ccgacatcaa cgatgggctg agctcacccg
      721 acgaaacctt tcccaactcc tggtacctgc ccccctcagg agtggagcga ggctcctact
      781 acgagtattt tggggaccct ctgactccct accttccagc cgtcccctct tccttccgcg
      841 tggaccttgc caatgtctcc ggatttcccc caattcctac acagcccatt ggcttccagg
      901 atgcaagaga cctgctctgt aacctcaacg gaactttggc cccagccacc tggcagggag
      961 cactgggctg ccactacagg ttgggtcccg gcttccggcc tgacggagac ttcccagcag
     1021 acagccaggt gaatgtgagc gtctacaacc gcctggagct gaggaactct tccaacgtcc
     1081 tgggcatcat ccgtggggct gtggagcctg atcgctacgt gctgtatggg aaccaccgag
     1141 acagctgggt gcacggggct gtggacccca gcagtggcac cgccgtcctc ctggagctct
     1201 cccgtgtcct ggggaccctg ctgaagaagg gcacctggcg tcctcgcaga tcaatcgtgt
     1261 ttgcgagctg gggggctgag gagtttgggc tcattggctc cacggaattc acagaagagt
     1321 tcttcaacaa gctgcaggag cgcacggtgg cctacatcaa cgtggacatc tcggtgtttg
     1381 ccaacgctac ccttagggtg caggggacgc cccctgtcca gagcgtcgtc ttctctgcaa
     1441 ccaaagagat ccgctcacca ggccctggcg acctgagcat ctacgacaac tggatccggt
     1501 acttcaaccg cagcagcccg gtgtacggcc tggtccccag cttgggttct ctgggtgctg
     1561 gcagcgacta tgcacccttc gttcacttcc tgggcatctc ctccatggac attgcctata
     1621 cctatgaccg gagcaagact tcagccagga tctaccccac ctaccacaca gcctttgaca
     1681 cctttgacta tgtggacaag tttttggacc cgggcttcag cagccatcag gctgtggccc
     1741 ggacagcggg gagtgtgatt ctccggctca gtgacagctt cttcctgccc ctcaaagtca
     1801 gtgactacag tgagacactc cgcagcttcc tgcaggcagc ccagcaagat cttggggccc
     1861 tgctggagca gcacagcatc agcctggggc ctctggtgac tgcagtggag aagtttgagg
     1921 cagaagctgc agccttgggc caacgcatat caacactgca gaagggcagc cctgaccccc
     1981 tgcaggtccg gatgctcaat gaccagttga tgctcttgga acggaccttt ctgaacccta
     2041 gagccttccc agaggaacgc tactacagcc atgtgctctg ggcacctcgc acgggctccg
     2101 tagtcacatt cccgggccta tccaatgcct gctccagggc cagggacaca gcttctggat
     2161 ctgaagcttg ggctgaggtc cagagacagc tcagcattgt ggtgacagcc ctggagggtg
     2221 cggcagccac cctgaggcct gtggctgacc tctgacccca gccctctttc ttcagccctc
     2281 cctttactcc aaccctctcc tgcctgcttt cctgagatgt cctggtcttc cttggtgcca
     2341 gaagagggca ctaccacagg accctctcaa gcttctcagg caacagcttg aggtccctga
     2401 ggggagtggc aagccctaat gcaactcacc ctcatcctgg tgcttaggtg gcagagggtg
     2461 ggcagcaggg gacagggatg ggatggcaaa accaccaact gcccttggtg gcaggtgggt
     2521 ggagatggga tgcgtgccaa cctcagatgc caactcaggt catcaaggcc aaggaccagt
     2581 ggcgaaagtg agtcttgggg taccttaggc cttggctagt ctgcgttcct ctccctgcat
     2641 gctgtgtatc ctaactccct acaacagccc ctcaaataaa tcacatctag tgactggtac
     2701 caacaaaa
//
