LOCUS       NM_014435               1859 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens N-acylethanolamine acid amidase (NAAA), transcript
            variant 1, mRNA.
ACCESSION   NM_014435
VERSION     NM_014435.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Huang,D., Shen,J., Zhai,L., Chen,H., Fei,J., Zhu,X. and Zhou,J.
  TITLE     Insights Into the Prognostic Value and Immunological Role of NAAA
            in Pan-Cancer
  JOURNAL   Front Immunol 12, 812713 (2022)
   PUBMED   35069601
  REMARK    GeneRIF: Insights Into the Prognostic Value and Immunological Role
            of NAAA in Pan-Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Mo,D., Li,J., Peng,L., Liu,Z., Wang,J. and Yuan,J.
  TITLE     Genetic Polymorphisms on 4q21.1 Contributed to the Risk of
            Hashimoto's Thyroiditis
  JOURNAL   Genet Test Mol Biomarkers 23 (12), 837-842 (2019)
   PUBMED   31750736
  REMARK    GeneRIF: The rs2276886 SNP was found to be significantly associated
            with Hashimoto's Thyroiditis susceptibility. However, our findings
            suggest that this SNP which maps to the chromosomal region 4q21.1
            likely effects the NAAA gene (as opposed to the CXCL9 gene), but
            still contributes to the susceptibility to Hashimoto's Thyroiditis
            in Han Chinese populations.
REFERENCE   3  (bases 1 to 1859)
  AUTHORS   Gorelik,A., Gebai,A., Illes,K., Piomelli,D. and Nagar,B.
  TITLE     Molecular mechanism of activation of the immunoregulatory amidase
            NAAA
  JOURNAL   Proc Natl Acad Sci U S A 115 (43), E10032-E10040 (2018)
   PUBMED   30301806
REFERENCE   4  (bases 1 to 1859)
  AUTHORS   Sakura,Y., Tsuboi,K., Uyama,T., Zhang,X., Taoka,R., Sugimoto,M.,
            Kakehi,Y. and Ueda,N.
  TITLE     A quantitative study on splice variants of N-acylethanolamine acid
            amidase in human prostate cancer cells and other cells
  JOURNAL   Biochim Biophys Acta 1861 (12 Pt A), 1951-1958 (2016)
   PUBMED   27693242
  REMARK    GeneRIF: Variants a1 and a2 encoded the same full-length NAAA
            protein.
REFERENCE   5  (bases 1 to 1859)
  AUTHORS   Liu,Y., Chen,J., Sethi,A., Li,Q.K., Chen,L., Collins,B.,
            Gillet,L.C., Wollscheid,B., Zhang,H. and Aebersold,R.
  TITLE     Glycoproteomic analysis of prostate cancer tissues by SWATH mass
            spectrometry discovers N-acylethanolamine acid amidase and protein
            tyrosine kinase 7 as signatures for tumor aggressiveness
  JOURNAL   Mol Cell Proteomics 13 (7), 1753-1768 (2014)
   PUBMED   24741114
  REMARK    GeneRIF: The results suggest that N-acylethanolamine acid amidase
            and protein tyrosine kinase 7 may be used as potential tissue
            biomarkers to avoid overtreatment of non-aggressive prostate cancer
REFERENCE   6  (bases 1 to 1859)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1859)
  AUTHORS   Tsuboi,K., Sun,Y.X., Okamoto,Y., Araki,N., Tonai,T. and Ueda,N.
  TITLE     Molecular characterization of N-acylethanolamine-hydrolyzing acid
            amidase, a novel member of the choloylglycine hydrolase family with
            structural and functional similarity to acid ceramidase
  JOURNAL   J Biol Chem 280 (12), 11082-11092 (2005)
   PUBMED   15655246
REFERENCE   8  (bases 1 to 1859)
  AUTHORS   Huang,Y., Tanimukai,H., Liu,F., Iqbal,K., Grundke-Iqbal,I. and
            Gong,C.X.
  TITLE     Elevation of the level and activity of acid ceramidase in
            Alzheimer's disease brain
  JOURNAL   Eur J Neurosci 20 (12), 3489-3497 (2004)
   PUBMED   15610181
  REMARK    GeneRIF: The level and activity of acid ceramidase in Alzheimer
            disease (AD) brain may play a role in controlling neuronal
            apoptosis and may mediate signalling pathways involved in the
            molecular mechanism of AD.
REFERENCE   9  (bases 1 to 1859)
  AUTHORS   Hong,S.B., Li,C.M., Rhee,H.J., Park,J.H., He,X., Levy,B., Yoo,O.J.
            and Schuchman,E.H.
  TITLE     Molecular cloning and characterization of a human cDNA and gene
            encoding a novel acid ceramidase-like protein
  JOURNAL   Genomics 62 (2), 232-241 (1999)
   PUBMED   10610717
REFERENCE   10 (bases 1 to 1859)
  AUTHORS   Goodchild,N.L., Wilkinson,D.A. and Mager,D.L.
  TITLE     A human endogenous long terminal repeat provides a polyadenylation
            signal to a novel, alternatively spliced transcript in normal
            placenta
  JOURNAL   Gene 121 (2), 287-294 (1992)
   PUBMED   1446826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM763257.1, AB161353.1,
            W47597.1, DR156596.1 and BM682921.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014435.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.3512775.1,
                                           SRR3476690.835066.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286733.9/ ENSP00000286733.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BM763257.1         1-64
            65-1144             AB161353.1         1-1080
            1145-1180           W47597.1           403-438
            1181-1207           DR156596.1         679-705             c
            1208-1859           BM682921.1         22-673              c
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..1859
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /note="N-acylethanolamine acid amidase"
                     /db_xref="GeneID:27163"
                     /db_xref="HGNC:HGNC:736"
                     /db_xref="MIM:607469"
     exon            1..270
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1144
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /EC_number="3.5.1.23"
                     /EC_number="3.5.1.60"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; acid ceramidase-like protein;
                     N-acylethanolamine-hydrolyzing acid amidase; ASAH-like
                     protein; acylsphingosine deacylase NAAA"
                     /codon_start=1
                     /product="N-acylethanolamine-hydrolyzing acid amidase
                     isoform 1 precursor"
                     /protein_id="NP_055250.2"
                     /db_xref="CCDS:CCDS43239.1"
                     /db_xref="GeneID:27163"
                     /db_xref="HGNC:HGNC:736"
                     /db_xref="MIM:607469"
                     /translation="MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVP
                     ELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGM
                     CDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQ
                     FLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSW
                     LIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDP
                     LNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNF
                     TIYTTVMSAGSPDKYMTRIRNPSRK"
     exon            271..435
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            436..562
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            563..653
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            654..730
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            731..903
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            904..966
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1033
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1062
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1180
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1859
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /note="hexamer: AATAAA"
     polyA_site      1859
                     /gene="NAAA"
                     /gene_synonym="ASAHL; PLT"
                     /note="major polyA site"
ORIGIN      
        1 acggcttacc cgggctccga cagcggctgc aggtctccaa gttgcggccg ctggagcccg
       61 agccatgcgg accgcggacc gggaggcgcg cccggggctt ccgtccctgc tgctgctgct
      121 gctggccggg gccgggctgt cagccgcctc gcccccagca gcgccgcgct tcaacgtgag
      181 cctggactcg gtccccgagc tgcgctggct gcccgtgctg cggcactacg acttggactt
      241 ggtgcgcgcc gcgatggcgc aagtcatcgg ggacagagtc cccaagtggg tgcacgtgtt
      301 aatcggaaaa gtggtcctgg agctggagcg cttcctgccc cagcccttca ccggcgagat
      361 ccgcggcatg tgtgacttca tgaacctcag cctggcggac tgccttctgg tcaacctggc
      421 ctacgagtcc tccgtgttct gcaccagtat tgtggctcaa gactccagag gccacattta
      481 ccatggtcgg aatttggatt atccttttgg gaatgtctta cgcaagctga cagtggatgt
      541 gcaattctta aagaatgggc agattgcatt cacaggaact acttttattg gctatgtagg
      601 attatggact ggccagagcc cacacaagtt tacagtttct ggtgatgaac gagataaagg
      661 ctggtggtgg gagaatgcta tcgctgccct gtttcggaga cacattcccg tcagctggct
      721 gatccgcgct accctgagtg agtcggaaaa cttcgaagca gctgttggca agttggccaa
      781 gactcccctt attgctgatg tttattacat tgttggtggc acgtcccccc gggagggggt
      841 ggtcatcacg aggaacagag atggcccagc agacatttgg cctctagatc ctttgaatgg
      901 agcgtggttc cgagttgaga caaattacga ccactggaag ccagcaccca aggaagatga
      961 ccggagaaca tctgccatca aggcccttaa tgctacagga caagcaaacc tcagcctgga
     1021 ggcacttttc cagattttgt cggtggttcc agtttataac aacttcacaa tttatactac
     1081 ggtaatgagc gccggtagcc cagacaagta catgactagg atcagaaacc cgagtagaaa
     1141 gtaagtcagc agaagagcga gttcgcccgt gctgtgaaag atgatttttt aaaaaatgaa
     1201 attcttgaag agctgcacct taaaaaataa gacaaagtga aagtattgta ttatgttaca
     1261 aacaatgcag gctccttcct catttaactt tacaaccttg cgaagtgggt ccaggagatt
     1321 tggagtttgt ggtaaagcca gtaatgggca ttgtcctgca ttcccttccc ttcatggttt
     1381 gcctcgatcc tctctaagct tctatcctgg cctgaataac tcaaagataa ttggtctcag
     1441 agatcaagcc atatcctcag gccttatttc catcttctca tgattctgcc atcatacctt
     1501 tgcttctccg ctaatgaaat gagctggcaa gacctctgtt cattgtgaag tgcttctgaa
     1561 agagcctaag aaaaaaggct catctgaaag aaatggagaa ctctatttcg aaccaagcct
     1621 gtttgaatgt gtgttagtct gatctttgat catgtgtttc catgtaatgg gagtctcgtt
     1681 ttttataatg tttctaacgt tttattgaaa aacctatggc cctccttctt tctcaatagc
     1741 tactttctta ctgctttttg aaaataatat gcaaccaaat tatttcttaa tgtcacataa
     1801 ttaagtaata aaatgtcaaa agaaatgttg gcaaggagaa taaaaaaatt tccaagaaa
//
